Expression of the whey acidic protein in transgenic pigs impairs mammary development (original) (raw)

References

• Araki, K., Kuroki, J., Ito, O., Kuwada, M. and Tachibana, S. (1989) Novel peptide inhibitor (SPAI) of Na+, K+-ATPase from porcine intestine.Biochem. Biophys. Res. Commun. 164, 496–502.
  Article CAS PubMed Google Scholar
• Archibald, A.L., McClenaghan, M., Hornsey, V., Simons, J.P. and Clark, A.J. (1990) High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice.Proc. Natl Acad. Sci. USA 87, 5178–82.
  Article CAS PubMed Google Scholar
• Bayna, E.M. and Rosen, J.M. (1990) Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice.Nucl. Acids Res.,18, 2977–85.
  CAS PubMed Google Scholar
• Burdon, T., Sankaran, L., Wall, R.J., Spencer, M. and Hennighausen, L. (1991a) Expression of a whey acidic protein transgene during mammary development: evidence for different mechanisms of regulation during pregnancy and lactation.J. Biol. Chem. 256, 6909–14.
  Google Scholar
• Burdon, T., Wall, R.J., Shamay, A., Smith, G.H. and Hennighausen, L. (1991b) Overexpression of an endogeous milk protein gene in transgenic mice is associated with impaired mammary development and a milchlos phenotype.Mech. Dev. 36, 67–74.
  Article CAS PubMed Google Scholar
• Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction.Anal. Biochem. 162, 156–9.
  Article CAS PubMed Google Scholar
• Dear, T.N. and Kefford, R.F. (1991) The WDNM1 gene product is a novel member of the ‘four-disulfide core’ family of proteins.Biochem. Biophys. Res. Commun. 176, 247–54.
  Article CAS PubMed Google Scholar
• Ebert, K.M., Selgrath, J.P., DiTullio, P., Denman, J., Smith, T.E., Memon, M.A., Schindler, J.E., Monastersky, G.M., Vitale, J.A. and Gordon, K. (1991) Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression.Biotechnology 9, 835–838.
  Article CAS PubMed Google Scholar
• Farmer, S.J., Fliss, A.E. and Simmen, R.C.M. (1990) Complementary DNA cloning and regulation of expression of the messenger RNA encoding a pregnancy-associated porcine uterine protein related to human antileukoproteinase.Mol. Endocrinol. 4, 1095–104.
  CAS PubMed Google Scholar
• Franco, B., Guioli, S., Pragliola, A., Incerti, B., Bardoni, B., Tonlorenzi, R., Carrozzo, R., Maestrini, E., Pieratti, M., Taillon-Miller, P., Brown, C.J., Willard, H.F., Lawrence, C., Persico, M.G., Camerino, G. and Ballabio, A. (1991) A gene deleted in Kallmann’s syndrome shares homology with neural cell adhesion and axonal path-finding molecules.Nature 353, 529–36.
  Article CAS PubMed Google Scholar
• Gertler, A., Cohen, N. and Maoz, A. (1983) Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolactin-like activity in organ culture from bovine lactating mammary gland.Mol. Cell. Endocrinol. 33, 169–82.
  Article CAS PubMed Google Scholar
• Gordon, K., Lee, E., Vitale, J.A., Smith, A.E., Westphal, H. and Hennighausen, L. (1987) Production of human tissue plasminogen activator in mouse milk_Bio/Technology_ 5, 1183–7.
  Article CAS Google Scholar
• Hennighausen, L.G. and Sippel, A.E. (1982) The mouse whey acidic protein is a novel member of the family of ‘four-disulfide core’ proteins.Nucl. Acids Res. 10, 2677–84.
  CAS PubMed Google Scholar
• Hobbs, A.A., Richards, D.A., Kessler, D.J., and Rosen, J.M. (1982) Complex hormonal regulation of rat casein gene expression.J. Biol. Chem. 257, 3598–605.
  CAS PubMed Google Scholar
• Kroczek, R.A. and Siebert, E. (1990) Optimization of northern analysis by vacuum blotting RNA transfer visualization and ultraviolet fixation.Anal. Biochem.,184, 90–5.
  Article CAS PubMed Google Scholar
• Lee, K.F., DeMayo, F.J., Aitee, S.H. and Rosen, J.M. (1988) Tissue-specific expression of the rat β-casein gene in transgenic mice.Nucl. Acids Res. 16, 1027–41.
  CAS PubMed Google Scholar
• Legouis, R., Hardelin, J.-P., Levilliers, J., Claverie, J.-M., Compain, S., Wunderle, V., Millasseau, P., LePaslier, D., Cohen, D., Caterina, D., Bougueleret, L., Delemarre-Van de Waal, H., Lutfalla, G., Weissenbach, J. and Petit, C. (1991) The candidate gene for the x-linked Kallmann syndrome encodes a protein related to adhesion molecules.Cell 67, 423–35.
  Article CAS PubMed Google Scholar
• Maschio, A., Brickell, P.M., Kioussis, D., Mellor, A.L., Katz, D. and Craig, R.K. (1991) Transgenic mice carrying the guinea pig α-lactalbumin gene, and normal mice, express milk protein genes in their sabaceous glands during lactation.Biochem. J. 275, 459–67.
  CAS PubMed Google Scholar
• McKnight, R.A., Burdon, T., Pursel, V.G., Shamay, A., Wall, R.J. and Hennighausen, L. (1992) The whey acidic protein. In Dickson and Lippman, eds,Breast Cancer: Molecular and Cellular Biology. Boston: Kluwer, Academic Publishers, (in press)
  Google Scholar
• Meade, H., Gates, L., Lacy, E. and Lonberg, N. (1990) Bovine αS1-casein gene sequences direct high level expression of active human urokinase in mouse milk.Bio/Technology 8, 443–6.
  Article CAS PubMed Google Scholar
• Pittius, C.W., Sankaran, S., Topper, Y.J. and Hennighausen, L. (1988) Comparison of the regulation of the whey acidic protein gene to a hybrid gene containing the whey acidic protein gene promoter in transgenic mice.Mol. Endocrinol. 2, 1027–32.
  CAS PubMed Google Scholar
• Rahm, S., Geyer, H. and Neuburger, D. (1985) Histologische und histochemische Untersuchungen zur Involution der Schweinemilchdrüse.Zbl. Vet. Med. A.31, 776–91.
  Google Scholar
• Shamay, A., Zeelon, E., Ghez, Z., Cohen, N., Mackinlay, A.G. and Gertler, A. (1987) Inhibition of casein and fat synthesis and α-lactlabumin secretion by progesterone in explants from bovine lactating mammary glands.J. Endocrinol. 113, 81–8.
  Article CAS PubMed Google Scholar
• Shamay, A., Salinas, S., Pursel, V.G., McKnight, R.A., Alexander, L., Beattie, C., Hennighausen, L. and Wall, R.J. (1991) Production of the mouse whey acidic protein in transgenic pigs during lactation.J. An. Sci. 69, 4552–62.
  CAS Google Scholar
• Shamay, A., Pursel, V.G., Wall, R.J. and Hennighausen, L. (1992) Induction of lactogenesis in transgenic virgin pigs: evidence for gene and integration site specific hormonal regulation.Mol. Endocrinol.,6, 191–7.
  Article CAS PubMed Google Scholar
• Simons, J.P., McClenaghan, M. and Clark, A.J. (1987) Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice.Nature 328, 530–2.
  Article CAS PubMed Google Scholar
• Topper, Y.J. and Freeman, C.S. (1980) Multiple hormone interactions in the developmental biology of the mammary gland.Physiol. Rev. 60, 1049–156.
  CAS PubMed Google Scholar
• Vilotte, J.-L., Soulier, S., Sinnakre, M.-G., Massoud, M. and Mercier, J.-C. (1989) Efficient tissue-specific expression of bovine α-lactalbumin in transgenic mice.Eur. J. Biochem. 186, 43–8.
  Article CAS PubMed Google Scholar
• Wall, R.J., Pursel, V.G., Shamay, A., McKnight, R.A., Pittius, C.W. and Hennighausen, L. (1991) High-level synthesis of a heterologous milk protein in the mammary glands of swine.Proc. Natl Acad. Sci. USA 88, 1701–5.
  Article Google Scholar
• Wiedow, O., Schroder, J.M., Gregory, H., Young, J.A. and Christophers, E. (1990) Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino-acid sequence.J. Biol. Chem. 265, 14791–5.
  CAS PubMed Google Scholar
• Wright, G., Carver, A., Cottom, D., Reeves, D., Scott, A., Simons, P., Wilmut, I., Garner and Colman, A. (1991) High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep.Bio/Technology 9, 830–834.
  Article CAS PubMed Google Scholar

Download references