Interleukin 6: presence and future (original) (raw)

References

  1. Akira S, Hirano T, Taga T, Kishimoto T, Biology of multifunctional cytokines: IL-6 and related molecules. FASEB J 4: 2860, 1990
    PubMed CAS Google Scholar
  2. Andus T, Geiger T, Hirano T, Northoff H, Ganten U, Bauer J, Kishimoto T, Heinrich PC, Recombinant human B-cell stimulatory factor (BSF-1/IFNβ2) regulates fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Lett 221: 18, 1987
    Article PubMed CAS Google Scholar
  3. Andus T, Gross V, Cäsar I, Krumm D, Hosp J, David M, Schölmerich J, Activation of monocytes during inflammatory bowel disease. Pathobiology 59: 113, 1991
    Article Google Scholar
  4. Bataille R, Jourdan M, Zhang YG, Klein B, Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflection of disease severity in plasma cell dyscrasias. J Clin Invest 84: 2008, 1989
    Article PubMed CAS Google Scholar
  5. Bauer J, Herrmann F, Interleukin-6 in clinical medicine. Ann Hematol 62: 1203, 1991
    Article Google Scholar
  6. Bauer J, Ganter U, Geiger T, Jacobshagen UM, Hirano T, Matsuda T, Kishimoto T, Andus T, Acs G, Gerok W, Ciliberto G, Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood 72: 1134, 1988
    PubMed CAS Google Scholar
  7. Bauer J, Bauer TM, Kalb T, Taga T, Lengyel G, Hirano T, Kishimoto T, Acs G, Mayer L, Gerok W, Regulation of interleukin-6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes. J Exp Med 170: 1537, 1989
    Article PubMed CAS Google Scholar
  8. Bauer J, Strauss S, Schreiter-Gasser U, Ganter U, Schlegel P, Witt I, Yolk B, Berger M, Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett 285: 111, 1991
    Article PubMed CAS Google Scholar
  9. Bender S, Haubeck HD, Van den Leur E, Dufhues G, Schiel X, Lauweriins J, Greiling H, Heinrich PC, Interleukin-1β induces synthesis and secretion of interleukin-6 in human chondrocytes. FEBS Lett 263: 321, 1990
    Article PubMed CAS Google Scholar
  10. Bot FJ, Eijk L van, Broeders L, Aarden LA, Löwenberg B, Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells. Blood 73: 135, 1989
    Google Scholar
  11. Brach MA, Cicco NA, Riedel D, Hirano T, Kishimoto T, Mertelsmann R, Herrmann F, Mechanisms of differential regulation of interleukin-6 mRNA accumulation by tumor necrosis factor alpha and lymphotoxin during monocytic differentiation. FEBS Lett 263: 349, 1990
    Article PubMed CAS Google Scholar
  12. Brach MA, Löwenberg B, Mantovani L, Schwulera U, Mertelsmann R, Herrmann F, Interleukin-6 (IL-6) is an intermediate in IL-1 induced proliferation of leukemic human megakaryoblasts. Blood 76: 1972, 1990
    PubMed CAS Google Scholar
  13. Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum R, Kufe DW, Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest 88: 639, 1991.
    Article Google Scholar
  14. Brach MA, DeVos S, Arnold C, Gruss HJ, Herrmann F, Leukotriene B4 induces interleukin-6 engaging NF-χB and NF-IL6, but not AP-1 in an H2O2 dependent pathway by human peripheral blood monocytes. Eur J Immunol (in press)
  15. Brach MA, Gruss HJ, Kaisho T, DeVos S, Mertelsmann R, Hirano T, Herrmann F, Ionizing radiation induces expression of IL-6 by human fibroblasts involving activation of nuclear factor-kB. FEBS Lett (in press)
  16. Brakenhoff JP, Hart M, Aarden LA, Analysis of human IL-6 mutants expressed in_Escherichia coli_. Biologic activities are not affected by deletion of amino acids 1–28. J Immunol 143: 1175, 1989
    PubMed CAS Google Scholar
  17. Brandt SJ, Bodine DM, Dunbar CE, Nienhius AW, Dysregulated interleukin-6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest 86: 592, 1990
    Article PubMed CAS Google Scholar
  18. Breen EC, Rezai AR, Nakajima K, Beall GN, Mitsuyasu RT, Hirano T, Kishimoto T, Martinez-Maza O, Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 144: 480, 1990
    PubMed CAS Google Scholar
  19. Brown JT, Rowe JM, Liu J, Shoab M, Regulation of IL-6 expression by oncostatin M. J Immunol 147:2175, 1991
    PubMed CAS Google Scholar
  20. Caracciolo D, Clark SC, Rovera F, Human interleukin-6 supports granulocyte differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF. Blood 73: 666, 1989
    PubMed CAS Google Scholar
  21. Castell J, Andus V, Geiger T, Gomez-Lechon M, David M, Klapproth J, Hirano T, Kishimoto T, Heinrich P, Interleukin-6 is the major regulator of the acute phase protein synthesis in rat and man. Adv Immunopharmacol 4: 191, 1988
    Google Scholar
  22. Chiu CP, Lee F, IL-6 is a differentiation factor for M1 and WEHI-3B myeloid leukemic cells. J Immunol 142: 1909, 1989
    PubMed CAS Google Scholar
  23. Cicco NA, Lindemann A, Content JH, Vandenbussche J, Lübbert M, Gauss J, Mertelsmann R, Hermann F, Inducible production of interleukin-6 by human polymorphonuclear neutrophils: role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Blood 75: 2059, 1989
    Google Scholar
  24. Content J, DeWitt L, Pierard D, Derynck R, DeClerq E, Fiers W, Secretory proteins induced in human fibroblasts under conditions used for the production of interferon-beta. Proc Natl Acad Sci USA 79: 2768, 1982
    Article PubMed CAS Google Scholar
  25. DeVos S, Krutmann J, Trefzer U, Herrmann F, Brach MA, Involvement of AP-1 in the transcriptional activation of interleukin-6 in keratinocytes exposed to ultraviolet-B light. J Biol Chem (in press)
  26. Everson MP, Brown CB, Lilly MB, Interleukin-6 and granulocyte macrophage colony-stimulating factor are candidate growth factors for chronic myelomonocytic leukemia cells. Blood 74: 1472, 1989
    PubMed CAS Google Scholar
  27. Feldman GM, Ruhl S, Bickel M, Finbloom DS, Pluznik DH, Regulation of interleukin-4 receptors on murine myeloid progenitor cells by interleukin-6. Blood 78: 1678, 1991
    PubMed CAS Google Scholar
  28. Fong YM, Moldawer LL, Marano MM, Wei H, Tatter SB, Clarick RH, Santhanam U, Sheris D, May LT, Sehgal PB, Lowry SF, Endotoxemia elicits increased circulating β2-interferon/interleuken-6 in man. J Exp Med (in press)
  29. Frei K, Malipoero UV, Leist TP, Zinkernagel RM, Schwab ME, Fontana A. On the cellular source and function of interleukin-6 in the central nervous system in viral disease. Eur J Immunol 19: 689, 1989
    Article PubMed CAS Google Scholar
  30. Ganapathi MK, Schulz D, Mackiewicz A, Samols D, Hu SI, Brabenec S, MacIntyre SS, Kushner I, Heterogenous nature of the acute phase response. Differential regulation of serum amyloid A, C-reactive protein, and other acute phase proteins by cytokines in Hep 3B cells. J Immunol 141: 564, 1988
    PubMed CAS Google Scholar
  31. Ganter U, Strauss S, Jonas U, Weisemann A, Beyreuther K, Volk B, Berger M, Bauer J, Alpha-2 macroglobulin synthesis in interleukin-6 stimulated human neuronal (SH-SY5Y neuroblastoma) cells. FEBS Lett 282: 127, 1991
    Article PubMed CAS Google Scholar
  32. Gauldie J, Richards C, Harnish D, Landsdorf O, Baumann H, Interferon β2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the acute phase protein response in liver cells. Proc Natl Acad Sci USA 84: 7251, 1987
    Article PubMed CAS Google Scholar
  33. Grossmann RM, Krueger J, Yourish D, Granell-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB, Interleukin-6 is expressed at high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 86: 6367, 1989
    Article Google Scholar
  34. Gruss HJ, Brach MA, Mertelsmann RH, Herrmann F, Interferon-gamma interrupts autocrine growth mediated by endogenous interleukin-6 in renal cell carcinoma. Int J Cancer 49: 770, 1991
    Article PubMed CAS Google Scholar
  35. Guerne PA, Cyrson DA, Lotz M, IL-6 production by human articular chondrocytes. J Immunol 144: 499, 1990
    PubMed CAS Google Scholar
  36. Helfgott DC, Tatter SB, Santhanam U, Clarick RH, Bhardwaj N, May LT, Sehgal PB, Multiple forms of IFN-β2/IL-6 in serum and body fluids during the acute bacterial infection. J Immunol 142: 948, 1989
    PubMed CAS Google Scholar
  37. Herrmann F, Andreef M, Gruss HJ, Brach MA, Lübbert M, Mertelsmann R, Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression. Blood 8: 2070, 1991
    Google Scholar
  38. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T, Molecular cloning and expression of an IL-6 signal transducer, gp130 Cell 1149, 1990
  39. Hill RJ, Warren MK, Levin J, Stimulation of thrombopoiesis in mice by human recombinant interleukin-6. J Clin Invest 85: 1242, 1990
    Article PubMed CAS Google Scholar
  40. Hirano T, Interleukin-6 in immune response and hematopoiesis. In: Mertelsmann R, Herrmann F (eds) Hematopoietic growth factors in clinical application. Dekker, New York, p 471, 1990
    Google Scholar
  41. Hirano T, Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasia. Int J Cell Cloning 9: 166, 1991
    Article PubMed CAS Google Scholar
  42. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunawasa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T, Complementary DNA for a novel human interleukin (BSF-2) that induces B-lymphocytes to produce immunoglobulin. Nature 324: 73, 1986
    Article PubMed CAS Google Scholar
  43. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldman M, Kishimoto T, Excessive production of interleukin-6/B-cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 18: 1797, 1988
    Article PubMed CAS Google Scholar
  44. Hoang T, Haman A, Goncalves O, Wong GG, Clark SC, Interleukin-6 enhances growth factor dependent proliferation of blast cells of acute myeloblastic leukemia. Blood 72: 823, 1988
    PubMed CAS Google Scholar
  45. Horii Y, Muraguchi A, Suematu S, Matsuda T, Yoshizaki K, Hirano T, Kishimoto T, Regulation of BSF-2/IL-6 production by human mononuclear cells: macrophage dependent synthesis of BSF-2/IL-6 by T-cells. J Immunol 141: 1529, 1988
    PubMed CAS Google Scholar
  46. Horii Y, Muraguchi A, Iwano M, Matsuda T, Hirayama T, Yamada H, Fuji Y, Dohi K, Ishikawa H, Ohmommot Y, Yoshizaki K, Hirano T, Kishimoto T, Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol 143: 3949, 1989
    PubMed CAS Google Scholar
  47. Houssiau FA, Bukasa K, Sindic CJM, Van Damme J, Van Snick J, Elevated levels of the 24 K human hybridoma growth factor (interleukin-6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol 71: 320, 1988
    PubMed CAS Google Scholar
  48. Houssiau FA, Coulie PG, Olive D, Van Snick J, Synergistic activation of human T cells by interleukin-1 and interleukin-6. Eur J Immunol 18: 653, 1988
    Article PubMed CAS Google Scholar
  49. Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M, Interleukin-6 enhancement of interleukin-3 dependent proliferation of multi-potent hematopoietic progenitors. Proc Natl Acad Sci USA 84: 9035, 1988
    Article Google Scholar
  50. Ishibashi T, Kimura H, Uchida T, Kariyone S, Friese P, Burstein SA, Human interleukin-6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci USA 86: 5953, 1989
    Article PubMed CAS Google Scholar
  51. Ishikawa H, Tanaka H, Iwato K, Tanabe O, Assaoku H, Nobuyosji M, Yamamoto I, Kawano M, Kuramoto A, Effect of glucocorticoids on the biological activities of myeloma cells: inhibition of interleukin-1 β osteoclast activating factor-induced bone-resorption. Blood 75: 715, 1990
    PubMed CAS Google Scholar
  52. Ishimi Y, Miyaura L, Jin C, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T, IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145: 3297, 1990
    PubMed CAS Google Scholar
  53. Isshiki H, Akira S, Tanabe O, Nakajuma T, Shimamoto T, Hirano T, Kishimoto T, Constitutive and IL-1 inducible factors interact with the IL-1 responsive element in the IL-6 gene. Mol Cell Biol 10: 2757, 1990
    PubMed CAS Google Scholar
  54. Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B, Constitutive production of interleukin-6 and immunologic features in cardiac myxoma. Arthritis Rheum 33: 398, 1990
    Article PubMed CAS Google Scholar
  55. Kato K, Yokoi T, Takano N, Kanegane H, Yachie A, Miyawaki T, Taniguchi N, Detection by in situ hybridization and phenotypic characterization of cells expressing IL-6 mRNA in human stimulated blood. J Immunol 144: 1317, 1990
    PubMed CAS Google Scholar
  56. Kirnbauer R, Köck A, Schwarz T, Urbanski A, Krutman J, Borth W, Damm D, Shipley G, Ansel JC, Luger TA, IFN β2, BSF-2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J Immunol 142: 1922, 1989
    PubMed CAS Google Scholar
  57. Kirnbauer R, Köck A, Neuner P, Förster E, Krutman J, Urbanski A, Achauer E, Ansel JC, Schwarz T, Luger TA, Regulation of epidermal cell interleukin-6 production by UV-light and corticosteroids. J Invest Dermatol 96: 484, 1991
    Article PubMed CAS Google Scholar
  58. Klein B, Zhan XG, Jourdan M, Content J, Houssian F, Aarden L, Piechaczyk M, Bataille R, Paracrine rather than autocrine regulation of myeloma—cell growth and differentiation by IL-6. Blood 73: 517, 1989
    PubMed CAS Google Scholar
  59. Klein H, Becher R, Lübbert M, Oster W, Schleiermacher E, Brach MA, Souza L, Lindemann A, Mertelsmann R, Herrmann F, Synthesis of granulocyte colony stimulating factor and its requirement for terminal divisions in chronic myelogenous leukemia. J Exp Med 171: 1785, 1990
    Article PubMed CAS Google Scholar
  60. Klein B, Zhang XG, Jourdan M, Boiron JM, Portier M, Lu ZY, Wijdenes J, Brochier J, Bataille R, Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma. Eur Cytokine Netw 1: 193, 1990
    PubMed CAS Google Scholar
  61. Krüttgen A, Roshenjohn S, Möller C, Wroblowski B, Wolner A, Müllberg J, Hirano T, Kishimoto T, Heinrich PC, Structure-function analysis of human interleukin 6: evidence for the involvement of the carboxyl-terminus in function. FEBS Lett 262: 323, 1990
    Article PubMed Google Scholar
  62. Lee F, Choy-Pik C, Wideman J, Hodgkin P, Hudak S, Troutt L, Ng T, Moulds C, Coffman R, Zlotnik A, Rennick D, Interleukin 6: a multifunctional regulator of growth and differentiation. Ann NY Acad Sci 557: 215, 1989
    Article PubMed CAS Google Scholar
  63. Leutz A, Beug H, Graf T, Purification and characterization of cMGF, a novel chicken myelomonocytic growth factor, EMBO J 3: 3191, 1984
    PubMed CAS Google Scholar
  64. Lieberman TA, Baltimore D, Activation of interleukin-6 gene expression through the NF-kappa-B transcription factor. Mol Cell Biol 10:2327, 1990
    Google Scholar
  65. Lindemann A, Ganser A, Hoelzer D, Mertelsmann R, Herrmann F, In vivo administration of recombinant human interleukin (IL)-3 elicits an acute phase response involving endogenous synthesis of IL-6. Eur Cytokine Netw 2:173, 1991
    PubMed CAS Google Scholar
  66. Loppnow H, Libby P, Proliferating or interleukin-1 activated human vascular smooth muscle cells secrete copious interleukin-6. J Clin Invest 85:731, 1990
    Article PubMed CAS Google Scholar
  67. Luger TA, Schwarz T, Krutmann J, Kirnbauer R, Neuner P, Köck A, Urbanski A, Borth W, Schauer E, Interleukin-6 is produced by epidermal cells and plays an important role in the activation of human T-lymphocytes and natural killer cells. Ann NY Acad Sci 557:405, 1989
    Article PubMed CAS Google Scholar
  68. Mantovani L, Henschler R, Brach MA, Wieser R, Lübbert M, Lindeman A, Mertelsmann R, Herrmann F, Differential regulation of interleukin-6 expression in human fibroblasts by tumor necrosis factor alpha and lymphotoxin. FEBS Lett 270:152, 1990
    Article PubMed CAS Google Scholar
  69. Matsuda T, Hirano T, Kishimoto T, Establishment of interleukin 6 (IL-6)/B cell stimulatory factor 2 (BSF-2)-dependent cell line and prevention of anti-IL-6/BSF-2 monoclonal antibodies. Eur J Immunol 18:951, 1988
    Article PubMed CAS Google Scholar
  70. Miki S, Iwano M, Miki Y, Yamamoto M, Tang B, Yokohawa K, Sonoda T, Hirano T, Kishimoto T, Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal carcinomas. FEBS Lett 250:607, 1989
    Article PubMed CAS Google Scholar
  71. Miles SA, Rezai AR, Saazar-Gonzales JF, Meyden M van der, Stevens RH, Logan DM, Mitszyasu TRT, Taga T, Hirano T, Kishimoto T, Martinez-Maza O, AIDS Kaposi-sarcoma derived cells produce and respond to interleukin-6. Proc Natl Acad Sci USA 87:4068, 1990
    Article PubMed CAS Google Scholar
  72. Mooshage HJ, Roelofs HNJ, Van Pelt JF, Hazenberg BPC, Van Leewen M, Limburger PC, Aarden LA, Yarp SH, The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes. Biochem Biophys Res Commun 155:112, 1988
    Article Google Scholar
  73. Motro B, Itin A, Sachs L, Keshet E, Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 87:3092, 1990
    Article PubMed CAS Google Scholar
  74. Mulé JJ, McIntosh JK, Jablons DM, Rosenberg SA, Antitumor activity of recombinant interleukin-6 in mice. J Exp Med 171:629, 1990
    Article PubMed Google Scholar
  75. Musso T, Esoinoza-Delgado J, Pulkki K, Gussela GL, Longo DL, Varesio L, Transforming growth factor beta downregulates interleukin-1 induced IL-6 production by human monocytes. Blood 76:2466, 1990
    PubMed CAS Google Scholar
  76. Nordan RP, Pumphrey JG, Rudikoff S, Purification and NH2-terminal sequencing of a plasmocytoma growth factor derived from the murine macrophage cell line p388D1. J Immunol 139:813, 1987
    PubMed CAS Google Scholar
  77. Oers MHJ van, Heyden AAPAM van der, Aarden LA, Interleukin-6 (IL-6) in serum and urine of renal transplant recipients. Clin Exp Immunol 71:314, 1988
    PubMed Google Scholar
  78. Oster W, Cicco NA, Klein H, Hirano T, Kishimoto T, Lindemann A, Mertelsmann R, Herrmann F, Participation of the cytokines interleukin-6, tumor necrosis factor-alpha, and interleukin-1β secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. J Clin Invest 84:451, 1989
    Article PubMed CAS Google Scholar
  79. Poli G, Bressler P, Kinter T, Duh E, Rimmer WC, Rabson A, Justement S, Stanley S, Fauci AS, Interleukin-6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and posttranscriptional mechanisms. J Exp Med 172:151, 1990
    Article PubMed CAS Google Scholar
  80. Poupart P, Vandenabele P, Cayphas S, Van Snick J, Hagemann G, Kruys V, Fries W, Content J, B cell growth modulating and differentiating activity of recombinant human 25-kD protein (BSF-2/Hu-IFNβ2, HPGF). EMBO J 6:1219, 1987
    PubMed CAS Google Scholar
  81. Ray A, Tatter SB, May LT, Sehgal PB, Activation of the human β2-interferon/hepatocyte-stimulating factor/interleukin 6 promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci USA 85:6701, 1988
    Article PubMed CAS Google Scholar
  82. Ray A, Sassone-Corsi P, Sehgal PB, A multiple cytokine- and second messenger responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation. Mol Cell Biol 9:5537, 1989
    PubMed CAS Google Scholar
  83. Reis LF, Le J, Hirano T, Kishimoto T, Vilcek J, Antiviral action of tumor necrosis factor in human fibroblasts is not mediated by B-cell stimulatory factor 2 and is inhibited by specific antibodies to IFNβ. J Immunol 140:1566, 1988
    PubMed CAS Google Scholar
  84. Rennick D, Jackson J, Yang G, Wideman J, Lee F, Hudak S, Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid and multipotential progenitor cells. Blood 73:1828, 1989
    PubMed CAS Google Scholar
  85. Revel M, Chen L, Novivk D, Shulman LM, Gotthelf Y, Cohen B, Raber J, Chebath J, Michaelevicz R, The growth-promoting, differentiative and cytostatic properties of interleukin-6. Proc Am Assoc Cancer Res 31:499, 1989
    Google Scholar
  86. Romero R, Avila C, Santhanam U, Sehgal PB, Amniotic fluid interleukin-6 in preterm labor. J Clin Invest 85:1392, 1990
    Article PubMed CAS Google Scholar
  87. Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder A, Smith JF, Singer FR, Interleukin 6—a potential autocrine/paracrine factor in Paget's disease of the bone. J Clin Invest 89:46, 1992
    Article PubMed CAS Google Scholar
  88. Rose TM, Bruce G, Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte-macrophage colony-stimulating factor, and interleukin-6. Proc Natl Acad Sci USA 88:8641, 1991
    Article PubMed CAS Google Scholar
  89. Schoot CE van der, Jansen P, Poorter M, Wester MR, Borne AEG von dem, Aarden LA, Oers RHJ von, Interleukin-6 and interleukin-1 production in acute myeloid leukemia with monocytic differentiation. Blood 74:2081, 1989
    PubMed Google Scholar
  90. Sehgal PB, Zilberstein A, Ruggieri R, May LT, Ferguson-Smith A, Slate DL, Revel M, Ruddle FH, Human chromosome 7 carries the beta2 interferon gene. Proc Natl Acad Sci USA 83:5219, 1986
    Article PubMed CAS Google Scholar
  91. Serve H, Steinhauser G, Oberberg D, Flegel W, Northoff N, Berdel WE, Studies on the interaction between interleukin-6 and human malignant nonhematopoietic cell lines. Cancer Res 51:3862, 1991
    PubMed CAS Google Scholar
  92. Siegall CB, Chaudhary VK, Fitzgerald DJ, Pastan I, Cytotoxic activity of an interleukin-6-Pseudomonas exotoxin fusion protein on human myeloma cells. Proc Natl Acad Sci USA 85:9738, 1988
    Article PubMed CAS Google Scholar
  93. Sironi M, Breviaro F, Proserpio P, Biondi A, Vecchi J, Van Damme E, Mantovani A, IL-1 stimulates IL-6 production in endothelial cells. J Immunol 142:549, 1989
    PubMed CAS Google Scholar
  94. Tabibzadeh SS, Poubpouridis D, May LT, Sehgal PB, Interleukin-6 immunoreactivity in human tumors. Am J Pathol (in press)
  95. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T, Interleukin (IL)-6 triggers the association of its receptor (IL-6R) with a possible signal transduction transducer, gp130. Cell 58:573, 1989
    Article PubMed CAS Google Scholar
  96. Tamm I, Cardinale I, Krueger J, Murphy JS, May LT, Sehgal PB, IL-6 decreases cell-cell association and increases motility of ductural breast carcinoma cells. J Exp Med 170:1649, 1989
    Article PubMed CAS Google Scholar
  97. Tanabe O, Akira S, Kamiya T, Wong GG, Hirano T, Kishimoto T, Genomic structure of the murine IL-6 gene: high degree conservation of potential regulatory sequences between mouse and human. J Immunol 41:3875, 1988
    Google Scholar
  98. Ulich TA, Castillo J, Guo K, In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood 73:108, 1989
    PubMed CAS Google Scholar
  99. Ulich TR, Guo K, Remick D, Castillo J, Yin S, Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6. J Immunol 146:2316, 1991
    PubMed CAS Google Scholar
  100. Utsumi K, Takai Y, Tada T, Ohzeki S, Fujiwara H, Hamaoka T, Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production. J Immunol 145:397, 1990
    PubMed CAS Google Scholar
  101. Van Damme J, Cayphas S, Van Snick J, Conings R, Put W, Lenaerts JP, Simpson RJ, Billiau A, Purification and characterization of human fibroblast-derived hybridoma growth factor identical to T-cell derived B-cell stimulatory factor-2. Eur J Biochem 168:543, 1987
    Article PubMed Google Scholar
  102. Villinger PM, Cronin MT, Amenomori T, Wachsman W, Lotz M, IL-6 production by human T-lymphocytes. J Immunol 146:550, 1991
    Google Scholar
  103. Walther Z, May LT, Sehgal PB. Transcriptional regulation of the interferon-β2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J Immunol 140:974, 1988
    PubMed CAS Google Scholar
  104. Weissenbach J, Chernajovski Y, Zeevi M, Shulman L, Soreq H, Nir U, Wallach D, Perricaudet M, Tiollais P, Revel M, Two interferon mRNAs in human fibroblasts: in vitro translation and_Escherichia coli_ cloning studies. Proc Natl Acad Sci USA 77:7152, 1980
    Article PubMed CAS Google Scholar
  105. Wong G, Witek-Gianotti JS, Temple PA, Driz R, Ferenz R, Hewick RM, Clark SC, Ikebuchi K, Ogawa M, Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol 140:3040, 1988
    PubMed CAS Google Scholar
  106. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Hirano T, Kishimoto T, Cloning and expression of the human interleukin-6 (BSF-2/IFNβ2) receptor. Science 241:825,1988
    Article PubMed CAS Google Scholar
  107. Yasukawa HL, Hirano T, Watanabe Y, Muratoni K, Matsuda T, Nakai S, Kishimoto T. Structure and expression of human B-cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J 6:2939, 1987
    PubMed CAS Google Scholar
  108. Yoshika K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, Nakahate T, Kawai H, Tagoh H, Komori T, Kishimoto S, Hirano T, Kishimoto T, Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74:1360, 1989
    Google Scholar
  109. Zilberstein R, Ruggieri R, Korn JH, Revel M, Structure and expression of cDNA and genes for human interferon-beta2, a distinct species inducible by growth stimulatory cytokines. EMBO J 5:2629, 1986
    Google Scholar

Download references