Mechanisms controlling production of membrane and secreted immunoglobulin during B cell development (original) (raw)
Lin Y, Wong K, Calame K: Repression of c-myc transcription by Blimp-1, and inducer of terminal B cell differentiation. Science 1997;276:596–599. ArticlePubMedCAS Google Scholar
Schliephake DE, Schimpl A: Blimp-1 overcomes the block in IgM secretion in lipopolysaccharide/anti-μ F(ab′)2-costimulated B lymphycytes. Eur J Immunol 1996;26:268–271. ArticlePubMedCAS Google Scholar
Turner CA Jr, Mack DH, Davis MM: Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 1994;77:297–306. ArticlePubMedCAS Google Scholar
Lin K-I, Angelin-Duclos C, Kuo TC, Calame K: Blimp-1-dependent repression of Pax-5 is required for differentialtion of B cells to immunogloblulin M-secreting plasma cells. Mol Cell Biol 2002;22:4771–4780 ArticlePubMedCAS Google Scholar
Sciammas R, Davis MM: Modular natura of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol 2004;172:5427–5440. PubMedCAS Google Scholar
Shaffer AL, Lin KI, Kuo TC, et al: Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002;17 (1):51–62. ArticlePubMedCAS Google Scholar
Yu J, Angelin-Duclos C, Greenwood J, Liao J, Calame K: Transcriptional repression by Blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol Cell Biol 2000;20:2592–2603. ArticlePubMedCAS Google Scholar
Calame KL: Plasma cells: finding new light at the end of B cell development. Nat Immunol 2001;2(12): 1103–1108. ArticlePubMedCAS Google Scholar
Calame KL, Lin KI, Tunyaplin C: Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 2003;21:205–230. ArticlePubMedCAS Google Scholar
Sciammas R, Davis MM: Blimp-1; Immunoglobulin secretion and the switch to plasma cells. Curr Top Microbiol Immunol 2005;290:201–224. ArticlePubMedCAS Google Scholar
Shapiro-Shelef M, Calame K: Regulation of plasmacell development. Nat Rev Immunol 2005;5(3): 230–242. ArticlePubMedCAS Google Scholar
Brewer JW, Hendershot LM: Building an antibody factory: a job for the unfolded protein response. Nat Immunol 2005;6(1):23–29. ArticlePubMedCAS Google Scholar
Koshland ME: The immuoglobulin helper: the J chain; in: Honjo T, Alt FW, Rabbitts TH (eds): Immunoglobulin Genes. London, Academic Press, 1989, pp. 345–359. Google Scholar
Sidman C: B lymphocyte differentiation and the control of IgM mu chain expression. Cell 1981;23 (2):379–389. ArticlePubMedCAS Google Scholar
Hombach J, Sablitzky F, Rajewsky K, Reth M: Transfected plasmacytoma cells do not transport the membrane form of IgM to the cell surface. J Exp Med 1988;167(2):652–657. ArticlePubMedCAS Google Scholar
Hombach J, Tsubata T, Leclercq L, Stappert H, Reth M: Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 1990;343(6260): 760–762. ArticlePubMedCAS Google Scholar
Kelley DE, Perry RP: Transcriptional and post-transcriptional control of immunoglobulin mRNA production during B lymphocyte development. Nucleic Acids Res 1986;14:5431–5447. ArticlePubMedCAS Google Scholar
Lamson G, Koshland ME: Changes in J chain and μ chain RNA expression as a function of B cell differentiation. J Exp Med 1984;160:877–892. ArticlePubMedCAS Google Scholar
Perry RP, Kelley DE: Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytes. Cell 1979;18:1333–1339. ArticlePubMedCAS Google Scholar
Yuan D, Tucker PW: Transcriptional regulation of μ-δ heavy chain locus in normal murine B lymphocytes. J Exp Med 1984;160:564–583. ArticlePubMedCAS Google Scholar
Mason JO, Williams GT, Neuberger MS: The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound ribosomes. Genes Dev 1988;2:1003–1011. ArticlePubMedCAS Google Scholar
Reed DJ, Hawley J, Dang T, Yuan D: Role of differential mRNA stability in the regulated expression of IgM and IgD. J Immunol 1994;152:5330–5336. PubMedCAS Google Scholar
Jack HM, Wabl M: Immunoglobulin mRNA stability varies during B lymphocyte differentiation. EMBO J 1988;7(4):1041–1046. PubMedCAS Google Scholar
Yuan D, Dang T: Regulation of μm vs μs mRNA expression in an inducible B cell line. Mol Immunol 1989;26:1059–1067. ArticlePubMedCAS Google Scholar
Milcarek C, Suda-Hartman M, Croll SC: Changes in abundance of IgG 2a mRNA in the nucleus and cytoplasm of a murine B-lymphoma before and after fusion to a myeloma cell. Mol Immunol 1996;33:691–701. ArticlePubMedCAS Google Scholar
Mather EL, Nelson KJ, Haimovich J, Perry RP: Mode of regulation of immunoglobulin μ and δ-chain expression varies during B-lymphocyte maturation. Cell 1984;35:329–338. Article Google Scholar
Alt FW, Bothwell ALM, Knapp M, et al: Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends. Cell 1980;20:293–301. ArticlePubMedCAS Google Scholar
Early P, Rogers J, Davis M, et al: Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways. Cell 1980; 20:313–319. ArticlePubMedCAS Google Scholar
Rogers J, Early P, Carter C, et al: Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain. Cell 1980;20: 303–312. ArticlePubMedCAS Google Scholar
Smith CWJ, Valcarcel J: Alternative pre-mRNA splicing: the logic of combinatorial control. TIBS 2000;25:381–388. PubMedCAS Google Scholar
Garcia-Blanco MA, Baraniak AP, Lasda EL: Alternative splicing in disease and therapy. Nat Biotechnol 2004;22(5):535–546. ArticlePubMedCAS Google Scholar
Edwald-Gilbert G, Veraldi KL, Milcarek C: Alternative poly (A) site selection in complex transcription units: means to an end? Nucleic Acids Res 1997;25:2547–2561. Article Google Scholar
Peterson ML. RNA processing and expression of immunoglobulin genes; in: Snow EC (ed) Handbook of B and T Lymphocytes. San Diego, Academic Press, 1994, pp. 321–342. Google Scholar
Peterson ML: Balanced efficiencies of splicing and cleavage-polyadenylation are required for μs and μm mRNA regulation. Gene Expr 1992;2:319–327. PubMedCAS Google Scholar
Peterson ML, Bertolino S, Davis F: An RNA polymerase pause site is associated with the immunoglobulin μs poly(A) site. Mol Cell Biol 2002;22:5606–5615. ArticlePubMedCAS Google Scholar
Peterson ML, Bingham GL, Cowan C: Multiple features contribute to the use of the immunoglobulin M secretion-specific poly(A) signal but are not required for developmental regulation. Mol Cell Biol 2006;26(18):6762–6771. ArticlePubMedCAS Google Scholar
Peterson ML, Bryman MB, Peiter M, Cowan C: Exon size affects competition between splicing and cleavagepolyadenylation in the immunoglobulin μ gene. Mol Cell Biol 1994;14:77–86. PubMedCAS Google Scholar
Peterson ML, Perry RP: Regulated production of μm and μs mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the μs-μm intron. Proc Natl Sci USA 1986;83:8883–8887. ArticleCAS Google Scholar
Peterson ML, Perry RP: The regulated production of μm and μm mRNA is dependent on the relative efficiencies of μs poly(A) site usage and the Cμ4-to-MI splice. Mol Cell Biol 1989;9:726–738. PubMedCAS Google Scholar
Peterson ML: Regulated immunoglobulin (Ig) RNA processing does not require specific cis-acting sequences: non-Ig genes can be alternatively processed in B cells and plasma cells. Mol Cell Biol 1994; 14:7891–7898. PubMedCAS Google Scholar
Seipelt RL, Spear BT, Snow EC, Peterson ML: A nonimmunoglobulin transgene and the endogenous immunoglobulin μ gene are coordinately regulated by alternative RNA processing during B-cell maturation. Mol Cell Biol 1998;18:1042–1048. PubMedCAS Google Scholar
Lassman CR, Milcarek C: Regulated expression of the mouse γ2bIgH chain gene is influenced by poly(A) site order and strength. J Immunol 1992;148:2578–2585. PubMedCAS Google Scholar
Flaspohler JA, Milcarek C: Myelomas and lymphomas expressing the Ig γ2a H chain gene have similar transcription termination regions. J Immunol 1990;144:2802–2810. PubMedCAS Google Scholar
Lassman CR, Matis S, Hall BL, Toppmeyer DL, Milcarek C: Plasma cell-regulated polyadenylation at the Igμ2b secretion-specific poly(A) site. J Immunol 1992;148:1251–1260. PubMedCAS Google Scholar
Flaspohler JA, Boczkowski D, Hall BL, Milcarek C: The 3′-untranslated region of membrane exon 2 from the gamma 2a immunoglobulin gene contributes to efficient transcription termination. J Biol Chem 1995;270 (20):11903–11911. ArticlePubMedCAS Google Scholar
Seipelt RL, Peterson ML: Alternative RNA processing of IgA pre-mRNA responds like IgM to alterations in the efficiency of the competing splice and cleavage-polyadenylation reactions. Mol Immunol 1995;32: 277–285. ArticlePubMedCAS Google Scholar
Lebman DA, Park MJ, Fatica R, Zhang Z: Regulation of usage of membrane and secreted 3′ termini of α mRNA differs from μ mRNA. J. Immunol 1992:148: 3282–3289. PubMedCAS Google Scholar
Coyle JH, Borinstein SC, Woodward EO, Lebman DA: Predominant usage of the proximal poly(A) site in alpha mRNAs is not intrinsic to the 3′ termini. Int Immunol 1998;10(5):669–678. ArticlePubMedCAS Google Scholar
Coyle JH, Lebman DA: Correct immunoglobulin α mRNA processing depends on specific sequence in the Cα3-αM intron. J Immunol 2000;164:3659–3665. PubMedCAS Google Scholar
Burnside RD, Peterson ML: The IgA gene contains multiple RNA polymerase pause sites downstream of the secretory-specific poly(A) site, 2006, to be published.
Proudfoot NJ: How RNA polymerase II terminates transcription in higher eukaryotes. TIBS 1989; 14:105–110. PubMedCAS Google Scholar
Galli G, Guise JW, McDevitt MA, Tucker PW, Nevins JR: Relative position and strengths of poly(A) sites as well as trancription termination are critical to membrane versus secreted μ-chain expression during B-cell development. Genes Dev 1987;1:471–481. ArticlePubMedCAS Google Scholar
Weiss EA, Michael A, Yuan D: Role of transcriptional termination in the regulation of μ mRNA expression in B lymphocytes. J Immunol 1989;143:1046–1052. PubMedCAS Google Scholar
Tisch R, Kondo N, Hozumi N: Parameters that govern the regulation of immunoglobulin δ heavy-chain gene expression. Mol Cell Biol 1990;10:5340–5348. PubMedCAS Google Scholar
Colgan DF, Manley JL: Mechanism and regulation of mRNA polyadenylation. Genes Dev 1997;11:2755–2766. PubMedCAS Google Scholar
Zhao J, Hyman L, Moore C: Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and inter-relationships with other steps in mRNA synthesis. Microbiol Mol Biol Rev 1999;63:405–445. PubMedCAS Google Scholar
Berget S: Exon recognition in vertebrate splicing. J Biol Chem 1995;270:2411–2414. PubMedCAS Google Scholar
Krecic AM, Swanson MS: hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 1999;11:363–371. ArticlePubMedCAS Google Scholar
Charlet BN, Logan P, Singh G, Cooper TA: Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell 2002;9(3): 649–658. Article Google Scholar
Mayeda A, Krainer AR: Regulation of alternative splicing by hnRNP A1 and splicing factor SF2. Cell 1992;68:365–375. ArticlePubMedCAS Google Scholar
Matis SA, Martincic K, Milcarek C: B-lineage regulated polyadenylation occurs on weak poly(A) sites regardless of sequence composition at the cleavage and downstream regions. Nucleic Acids Res 1996;24: 4684–4692. ArticlePubMedCAS Google Scholar
Peterson ML, Gimmi ER, Perry RP: The developmentally regulated shift from membrane to secreted μ mRNA production is accompanied by an increase in cleavage-polyadenylation efficiency but no measurable change in splicing efficiency. Mol Cell Biol 1991;11:2324–2327. PubMedCAS Google Scholar
Yan D-H, Weiss EA, Nevins JR: Identification of an activity in B-cell extracts that selectively impairs the formation of an immunoglobulin μs poly(A) site processing complex. Mol Cell Biol 1995;15(4): 1901–1906. PubMedCAS Google Scholar
Takagaki Y, Seipelt RL, Peterson, ML, Manley JL: The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell 1996;87:941–952. ArticlePubMedCAS Google Scholar
Edwalds-Gilbert G, Milcarek C: Regulation of poly(A) site use during mouse B-cell development involves a change in the binding of a general polyadenylation factor in a B-cell stage-specific manner. Mol Cell Biol 1995;15(11):6420–6429. PubMedCAS Google Scholar
Takagaki Y, Manley JL: Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Mol Cell 1998;2:761–771. ArticlePubMedCAS Google Scholar
Takami Y, Kikuchi H, Nakayama T: Chicken histone deacetylase-2 controls the amount of the IgM H-chain at the steps of both transcription of its gene and alternative processing of its pre-mRNA in the DT40 cell line. J Biol Chem 1999;274:23977–23990. ArticlePubMedCAS Google Scholar
Martincic K, Campbell R, Edwalds-Gilbert G, Souan L, Lotze MT, Milcarek C: Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. Proc Natl Acad Sci USA 1998;95:11095–11100. ArticlePubMedCAS Google Scholar
Veraldi KL, Arhin G, Martincic K, Chung-Ganster L-H, Wilusz J, Milcarek C: hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells. Mol Cell Biol 2001;21:1228–1238. ArticlePubMedCAS Google Scholar
Bagga PS, Arhin GK, Wilusz J: DSEF-1 is a member of the hnRNP H family of RNA-binding proteins and stimulates pre-mRNA cleavage and polyadenylation in vitro. Nucleic Acids Res 1998;26(23):5343–5350. ArticlePubMedCAS Google Scholar
Matunis MJ, Xing J, Dreyfuss G. The hnRNP F protein: unique primary structure nucleicacid-binding properties, and subcellular localization. Nucleic Acids Res 1994;22(6):1059–1067. ArticlePubMedCAS Google Scholar
Caputi M, Zahler AM: Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family. J Biol Chem 2001;276:43850–43859. ArticlePubMedCAS Google Scholar
Phillips C, Jung S, Gunderson SI: Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA. EMBO J 2001; 20(22):6443–6452. ArticlePubMedCAS Google Scholar
Phillips C, Pachikara N, Gunderson SI: U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions. Mol Cell Biol 2004;24(14): 6162–6171. ArticlePubMedCAS Google Scholar
Ma J, Gunderson SI, Phillips C: Non-snRNP U1A levels decrease during mammalian B-cell differentiation and release the IgM secretory poly(A) site from repression. RNA 2006;12(1):122–132. ArticlePubMedCAS Google Scholar
Milcarek C, Martinçic K, Chung-Ganster L-H, Lutz CS: The snRNP-associated U1A levels change following IL-6 stimulation of human B cells. Mol Immunol 2003;39:809–814. ArticlePubMedCAS Google Scholar
Tsurushita N, Ho L, Korn LJ: Nuclear factors in B lymphoma enhance splicing of mouse membrane-bound μ mRNA in Xenopus oocytes. Science 1988;239:494–497. ArticlePubMedCAS Google Scholar
Bruce SR, Dingle RWC, Peterson ML: B-cell and plasma-cell splicing differences: a potential role in regulated immunoglobulin RNA processing. RNA 2003; 9:1264–1273. ArticlePubMedCAS Google Scholar
Niwa M, Berget SM: Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns. Genes Dev 1991;5: 2086–2095. ArticlePubMedCAS Google Scholar
Niwa M, Rose SD, Berger SM: In vitro polyadenylation is stimulated by the presence of an upstream intron. Genes Dev 1990;4:1552–1559. ArticlePubMedCAS Google Scholar
Ashe MP, Griffin P, James W, Proudfoot NJ: Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site. Genes Dev 1995;9:3008–3025. ArticlePubMedCAS Google Scholar
Furth P, Choe W, Rex J, Byrne JC, Baker C: Sequences homologous to 5′ splice sites are required for the inhibitory activity of papillomavirus late 3′ untranslated regions. Mol Cell Biol 1994;14:5278–5289. PubMedCAS Google Scholar
Kornblihtt AR, de la Mata M, Fededa JP, Munoz MJ, Nogues G: Multiple links between transcription and splicing. RNA 2004;10(10):1489–1498. ArticlePubMedCAS Google Scholar
Bentley D: Coupling RNA polymerase II transcription with pre-mRNA processing. Curr Opin Cell Biol 19:11:347–351.
Hirose Y, Manley JL: RNA polymerase II and the integration of nuclear events. Genes Dev 2000;14: 1415–1429. PubMedCAS Google Scholar
Proudfoot NJ: Connecting transcription to messenger RNA processing. Trends Biochem Sci 2000;25:290–293. ArticlePubMedCAS Google Scholar
Proudfoot NJ, Furger A, Dye MJ: Integrating mRNA processing with transcription. Cell 2002;108:501–512. ArticlePubMedCAS Google Scholar
Roberts GC, Gooding C, Mak HY, Proudfoot NJ, Smith CWJ: Co-transcriptional commitment to alternative splice site selection. Nucleic Acids Res 1998;26:5568–5572. ArticlePubMedCAS Google Scholar
de la Mata M, Alonso CR, Kadener S et al: A slow RNA polymerase II affects alternative splicing in vivo. Mol Cell 2003;12(2):525–532. ArticlePubMed Google Scholar
Robson-Dixon ND, Garcia-Blanco MA: MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb. J Biol Chem 2004;279:29075–29084. ArticlePubMedCAS Google Scholar
Chalfant CE, Watson JE, Bisnauth LD et al: Insulin regulates protein kinase CβII expression through enhanced exon inclusion in L6 skeletal muscle cells. J Biol Chem 1998;273:910–916. ArticlePubMedCAS Google Scholar
van der Houven, van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J, Caceres JF: The MK 3/6-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol 2000;149:307–316. Article Google Scholar
Alizadeh AA, Eisen MB, Davis RE, et al Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000;403(6769):503–511. ArticlePubMedCAS Google Scholar
Alizadeh A, Eisen M, Davis RE, et al: The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harb Symp Quant Biol 1999;64:71–78. ArticlePubMedCAS Google Scholar