The rate of spontaneous mutation of a human gene (original) (raw)
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Summary
The rate of mutation at which the gene for haemophilia appears in the population of London is estimated at about once in 50,000 human life cycles. There are probably two distinct allelomorphs at the same locus, the milder type arising less frequently by mutation than the severe type.
I have to thank Dr Julia Bell and Dr C. V. Green for most generously placing at my disposal data collected on behalf of the Medical Research Council and the Research Committee of the American Medical Association.
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References
- Bulloch, W. andFildes, P. (1912).Treasury of Human Inheritance,1, 169.
Google Scholar - Cockayne, E. A. (1933).Inherited Abnormalities of the Skin and Appendages. Oxford.
- Davenfort, C. B. (1930), “Sex linkage in man.”Genetics,15, 401.
Google Scholar - Haldane, J. B. S. (1927). “A mathematical theory of natural and artificial selection. Part V.”Proc. Camb. phil. Soc. 23, 838.
Article Google Scholar - Hogben, L. T. (1931).Genetic Principles in Medicine and Social Science. London.
- Komai, T. (1934).Pedigrees of Hereditary Diseases and Abnormalities found in the Japanese Race. Kyoto.
- Manson, J. S. (1928).Observations on Human Heredity. London.
- Muller, H. J. (1928). “The measurement of gene mutation rate in_Drosophila_, its high variability, and its dependence upon temperature.”Genetics,13, 279.
PubMed CAS Google Scholar - Patterson, J. T. andMuller, H. J. (1930). “Are ‘progressive’ mutations produced by X-rays?”Ibid. 15, 495.
PubMed CAS Google Scholar - Penrose, L. S. (1934).The Influence of Heredity on Disease. London.
- Stadler, L. J. (1932). “On the genetic nature of induced mutations in plants.”Proc. 6th Int. Cong. Genet. Menasha, Wis.
Authors
- J. B. S. Haldane
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Haldane, J.B.S. The rate of spontaneous mutation of a human gene.J Genet 83, 235–244 (2004). https://doi.org/10.1007/BF02717892
- Issue Date: December 2004
- DOI: https://doi.org/10.1007/BF02717892