Physiological relevance and functional potential of central nervous system-derived cell lines (original) (raw)
Walsh C. (1993) Cell lineage and regional specification in the mammalian neocortex.Perspectives Dev. Neurobiol.1, 75–80. CAS Google Scholar
McKay R. D. G. (1989) The origins of cellular diversity in the mammalian central nervous system.Cell58, 815–821. ArticlePubMedCAS Google Scholar
Gage F. H., Ray J., and Fisher L. J. (1995) Isolation, characterization, and use of stem cells from the CNS.Ann. Rev. Neurosci.18, 159–192. ArticlePubMedCAS Google Scholar
McConnell S. K. (1991) The generation of neuronal diversity in the central nervous system.Ann. Rev. Neurosci.14, 269–300. ArticlePubMedCAS Google Scholar
Luskin M. B. (1994) Neuronal cell lineage in the vertebrate central nervous system.FASEB J.8, 722–739. PubMedCAS Google Scholar
Cepko C. L., Ryder E. F., Austin C. P., Walsh C., and Fekete D. M. (1993) Lineage analysis using retrovirus vectors.Meth. Enzymol.225, 933–960. ArticlePubMedCAS Google Scholar
Cepko C. L. (1989) Immortalization of neural cells via retrovirus-mediated oncogene transduction.Ann. Rev. Neurosci.12, 47–65. ArticlePubMedCAS Google Scholar
Lendahl U. and McKay R. D. G. (1990) The use of cell lines in neurobiology.Trends Neurosci.13, 132–137. ArticlePubMedCAS Google Scholar
Whittemore S. R., White L. A., Shihabuddin L. S., and Eaton M. J. (1995) Phenotypic diversity in neuronal cell lines derived from raphe nucleus by retroviral transduction.Methods: Companion Meth. Enzymol.7, 285–293. ArticleCAS Google Scholar
Snyder E. Y. (1995) Retroviral vectors for the study of neuroembryology: immortalization of neural cells, in_Viral Vectors: Tools for Analysis and Genetic Manipulation of the Nervous System_ (Kaplit M. G. and Loewy A. D., eds.) Academic, New York, pp. 435–475. Google Scholar
Whittemore S. R., Neary J. T., Kleitman N., Sanon H. R., Benigno A., Donahue R. P., and Norenberg M. D. (1994) Isolation and characterization of conditionally immortalized astrocyte cell lines derived from adult human spinal cord.Glia10, 211–226. ArticlePubMedCAS Google Scholar
Moura Neto V., Mallat M., Chneiweiss H., Premont J., Gros F., and Prochiantz A. (1986) Two simian virus 40 (SV40)-transformed cell lines from the mouse striatum and mesencephalon presenting astrocytic characteristics. I. Immunological and pharmacological properties.Dev. Brain Res.26, 11–22. ArticleCAS Google Scholar
Trotter J., Boulter C. A., Sontheimer H., Schachner M., and Wagner E. F. (1989) Expression of v-src arrests murine glial cell differentiation.Oncogene4, 457–464. PubMedCAS Google Scholar
Rabotti G. F., Gogusev J., Teutsch B., Mongiat-Lardemer F., and Haguenau F. (1978) Transformation in vitro of glial hamster cells by rous sarcoma virus.J. Natl. Cancer Inst.60, 113–124. PubMedCAS Google Scholar
Geller H. M. and Dubois-Dalcq M. (1988) Antigenic and functional characterization of a rat central nervous system-derived cell line immortalized by a retroviral vector.J. Cell Biol.107, 1977–1986. ArticlePubMedCAS Google Scholar
Evrard C., Galiana E., and Rouget P. (1986) Establishment of ‘normal’ nervous cell lines after transfer of polyoma virus and adenovirus early genes into murine brain cells.EMBO J.5, 3157–3162. PubMedCAS Google Scholar
Galiana E., Borde I., Marin P., Rassoulzadegan M., Cuzin F., Gros F., Rouget P., and Evrard C. (1990) Establishment of permanent astroglial cell lines, able to differentiate in vitro, from transgenic mice carrying the polyoma virus large T gene: an alternative approach to brain cell immortalization.J. Neurosci. Res.26, 269–277. ArticlePubMedCAS Google Scholar
Major E. O., Miller A. E., Mourrain P., Traub R. G., DeWidt E., and Sever J. (1985) Establishment of a line of human fetal glial cells that supports JC virus multiplication.Proc. Natl. Acad. Sci. USA82, 1257–1261. ArticlePubMedCAS Google Scholar
Giotta G. J., Heitzmann J., and Cohn M. (1980) Properties of two temperature-sensitive rous sarcoma virus transformed cerebellar cell lines.Brain Res.202, 445–458. ArticlePubMedCAS Google Scholar
Goodman M. N., Silver J., and Jacobberger J. W. (1993) Establishment and neurite outgrowth properties of neonatal and adult rat olfactory bulb glial cell lines.Brain Res.619, 199–213. ArticlePubMedCAS Google Scholar
Yoshida T. and Takeuchi M. (1993) Establishment of an astrocyte progenitor cell line: induction of glial fibrillary acidic protein and fibronectin by transforming growth factor-ß1.J. Neurosci. Res.35, 129–137. ArticlePubMedCAS Google Scholar
Kasai H., Fukuda J., and Segawa K. (1987) Transformation of glial cells in mouse embryonic brain cell in vitro with simian virus 40.Neurosci. Lett.76, 239–244. ArticlePubMedCAS Google Scholar
Jensen N. A., Smith G. M., Garvey J. S., Shine H. D., and Hood L. (1993) Cyclic AMP has a differentiative effect on an immortalized oligodendrocyte cell line.J. Neurosci. Res.35, 288–296. ArticlePubMedCAS Google Scholar
Verity A. N., Bredesen D., Vonderscher C., Handley V. W., and Campagnoni A. T. (1993) Expression of myelin protein genes and other myelin components in an oligodendrocytic cell line conditionally immortalized with a temperature-sensitive retrovirus.J. Neurochem.60, 577–587. ArticlePubMedCAS Google Scholar
Russo T., Mogavero A. R., Ammendola R., Mesuraca M., Fiore F., Fatatis A., Salvatore G., and Cimino F. (1993) Immortalization of a cell line showing some characteristics of the oligodendrocyte phenotype.Neurosci. Lett.159, 159–162. ArticlePubMedCAS Google Scholar
Almazan G. and McKay R. (1992) An oligodendrocyte precursor cell line from rat optic nerve.Brain Res.579, 234–245. ArticlePubMedCAS Google Scholar
Barnett S. C., Franklin R. J. M., and Blakemore W. F. (1993) In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature-sensitive mutant gene of the SV40 large T antigen.Eur. J. Neurosci.5, 1247–1260. ArticlePubMedCAS Google Scholar
Redies G., Lendahl U., and McKay R. G. D. (1991) Differentiation and heterogeneity in T-antigen immortalized precursor cell lines from mouse cerebellum.J. Neurosci. Res.30, 601–615. ArticlePubMedCAS Google Scholar
Aloisi F., Sun D., Levi G., and Wekerle H. (1990) Establishment of a permanent rat brain-derived glial cell line as a source of purified oligodendrocyte-type 2 astrocyte lineage cell populations.J. Neurosci. Res.27, 16–24. ArticlePubMedCAS Google Scholar
Trotter J., Crang A. J., Schachner M., and Blakemore W. F. (1993) Lines of glial precursor cells immortalised with a temperature-sensitive oncogene give rise to astrocytes and oligodendrocytes following transplantation into demyelinated lesions in the central nervous system.Glia9, 25–40. ArticlePubMedCAS Google Scholar
Galiana E., Bernard R., Borde I., Rouget P., and Evrard C. (1993) Proliferation and differentiation properties of bipotent glial progenitor cell lines immortalized with the adenovirus E1A gene.J. Neurosci. Res.36, 133–146. ArticlePubMedCAS Google Scholar
Louis J. C., Magal E., Muir D., Manthorpe M., and Varon S. (1995) CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligo-dendrocytes or type-2 astrocytes.J. Neurosci. Res.31, 193–204. Article Google Scholar
Bocchini V., Mazzolla R., Barluzzi R., Blasi E., Sick P., and Kettenmann H. (1992) An immortalized cell line expresses properties of activated microglial cells.J. Neurosci. Res.31, 616–621. ArticlePubMedCAS Google Scholar
Calof A. L. and Guevara J. L. (1993) Cell lines derived from retrovirus-mediated oncogene transduction into olfactory epithelium cultures.Neuroprotocols3, 222–231. Article Google Scholar
Birren S. J. and Anderson D. J. (1990) A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF.Neuron4, 189–201. ArticlePubMedCAS Google Scholar
Birren S. J., Verdi J. M., and Anderson D. J. (1992) Membrane depolarization induces p140trk and NGF responsiveness, but not p75LNGFR, in MAH cells.Science257, 395–397. ArticlePubMedCAS Google Scholar
Ip N. Y., Nye S. H., Boulton T. G., Davis S., Taga T., Li Y., Birren S. J., Yasukawa K., Kishimoto T., Anderson S. J., Stahl N., and Yancopoulos G. D. (1992) CNTF and LIF act on neuronal cells via shared signaling pathways that involve IL-6 signal trans-ducing receptor component gp130.Cell69, 1121–1132. ArticlePubMedCAS Google Scholar
Ip N. Y., Boulton T. G., Li Y., Verdi J. M., Birren S. J., Anderson D. J., and Yancopoulos G. D. (1994) CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons.Neuron13, 443–455. ArticlePubMedCAS Google Scholar
Anderson D. J. (1994) Stem cells and transcription factors in the development of the mammalian neural crest.FASEB J.8, 707–713. PubMedCAS Google Scholar
Heath J. K. and Smith A. G. (1988) Regulatory factors of embryonic stem cells.J. Cell. Sci. Suppl.10, 257–266. PubMedCAS Google Scholar
MacPherson P. A. and McBurney M. W. (1995) P19 embryonal carcinoma cells: a source of cultured neurons amenable to genetic manipulation.Methods: Companion Meth. Enymol.7, 222–237. Google Scholar
Stains W. A., Morassutti D. J., Reuhl K. R., Ally A. I., and McBurney M. W. (1994) Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters.Neuroscience58, 735–751. Article Google Scholar
Morrassutti D. J., Stains W. A., Magnuson D. S. K., Marshall K. C., and McBurney M. W. (1994) Murine embryonal carcinoma-derived neurons survive and mature following transplantation into adult rat striatum.Neuroscience58, 753–763. Article Google Scholar
Wojcik B. E., Nothias F., Lazar M., Jouin H., Nicholas J.-F., and Peschanski M. (1993) Catecholaminergic neurons result from intracerebral implantation of embryonal carcinoma cells.Proc. Natl. Acad. Sci. USA90, 1305–1309. ArticlePubMedCAS Google Scholar
Andrews P. W., Damjanov I., Simon D., Banting G. S., Carlin C., Dracopoli N. C., and Fogh J. (1984) Pluripotent embryonal carcinoma clones derived from human teratocarcinoma cell line Tera-2.Lab. Invest.50, 147–162. PubMedCAS Google Scholar
Pleasure S. J., Page C., and Lee V. M.-Y. (1992) Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons.J. Neurosci.12, 1802–1815. PubMedCAS Google Scholar
Trojanowski J. Q., Mantione J. R., Lee J. H., Seid D. P., You T., Inge L. J., and Lee V. M.-Y. (1993) Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain.Exp. Neurol.122, 283–294. ArticlePubMedCAS Google Scholar
Kleppner S. R., Robinson K. A., Trojanowski J. Q., and Lee V. M.-Y. (1995) Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over one year in the nude mouse brain.J. Comp. Neurol.357, 618–632. ArticlePubMedCAS Google Scholar
Masayuki M., Lee V. M.-Y., and Trojanowski J. Q. (1995) Proliferation, cell death and neuronal survival in transplanted human teratocarcinoma (NTera2) cells depend on the graft site in nude and SCID mice.Lab. Invest.73, 1–14. Google Scholar
Ronnett G. V., Hester L. D., Nye J. S., Connor K., and Snyder S. H. (1990) Human cortical neuronal cell line: establishment from a patient with unilateral megalencephaly.Science248, 603–605. ArticlePubMedCAS Google Scholar
Poltorak M., Isono M., Freed W. J., Ronnett G. V., and Snyder S. H. (1992) Human cortical neuronal cell line (HCN-1): further in vitro characterization and suitability for brain transplantation.Cell Transplant.1, 3–15. PubMedCAS Google Scholar
Truckenmiller M. E., Kulaga H., Coggiano M., Wyatt R., Snyder S. H., and Sweetnam P. M. (1993) Human cortical neuronal cell line: a model for HIV-1 infection in an immature neuronal system.AIDS Res. Human Retroviruses9, 445–453. ArticleCAS Google Scholar
Mizachi Y., Rodriguez I., Sweetnam P. M., Rubinstein A., and Volsky D. J. (1994) HIV type 1 infection of human cortical neuronal cells: enhancement by select neuronal growth factors.AIDS Res. Human Retroviruses10, 1593–1596 Google Scholar
White L. A., Keane R. W., and Whittemore S. R. (1994) Differentiation of an immortalized CNS neuronal cell line decreases their susceptibility to cytotoxic T lymphocyte cell lysis in vitro.J. Neuroimmunol.49, 135–143. ArticlePubMedCAS Google Scholar
Sorieul S. and Ephrussi B. (1961) Karylogical demonstration of hybridization of mammalian cells in vitro.Nature190, 653–654. Article Google Scholar
Pontecorvo G. (1975) Production of mammalian somatic cell hybrids by means of polyethylene glycol treatment.Som. Cell Genet.1, 397–400. ArticleCAS Google Scholar
Lee H. J., Hammond D. N., Large T. H., Roback J. D., Sim J. A., Brown D. A., Otten U. H., and Wainer B. H. (1990) Neuronal properties and trophic activities of immortalized hippocampal cells from embryonic and young adult mice.J. Neurosci.10, 1779–1767. PubMedCAS Google Scholar
Cashman N. R., Durham H. D., Blusztajn J. K., Oda K., Tabira T., Shar I. T., Dahrouge S., and Antel J. P. (1992) Neuroblastoma X spinal cord (NSC) hybrid cell lines resemble developing motor neurons.Devel. Dynam.194, 209–221. CAS Google Scholar
Choi H. K., Won L. A., Kontur P. J., Hammond D. N., Fox A. P., Wainer B. H., Hoffmann P. C., and Heller A. (1991) Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion.Brain Res.552, 67–76. ArticlePubMedCAS Google Scholar
Smith R. G., Alexianu M. E., Crawford G., Nyormoi O., Stefani E., and Appel S. H. (1994) Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line.Proc. Natl. Acad. Sci. USA91, 3393–3397. ArticlePubMedCAS Google Scholar
Choi H. K., Won L., Roback J. D., Wainer B. H., and Heller A. (1992) Specific modulation of dopamine expression in neuronal hybrid cells by primary cells from different brain regions.Proc. Natl. Acad. Sci. USA89, 8943–8947. ArticlePubMedCAS Google Scholar
Crawford G. D. Jr., Le W.-D., Smith R. G., Xie W.-J., Stefani E., and Appel S. H. (1992) A novel N18TG2 X mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin.J. Neurosci.12, 3392–3398. PubMedCAS Google Scholar
Blusztajn J. K., Venturini A., Jackson D. A., Lee H. J., and Wainer B. H. (1992) Acetylcholine synthesis and release is enhanced by dibutyryl cyclic AMP in a neuronal cell line derived from mouse septum.J. Neurosci.12, 793–799. PubMedCAS Google Scholar
Hammond D. N., Wainer B. H., Tonsgard J. H., and Heller A. (1986) Neuronal properties of clonal hybrid cell lines derived from central cholinergic neurons.Science234, 1237–1240. ArticlePubMedCAS Google Scholar
Lee H. J., Hammond D. N., Large T. H., and Wainer B. H. (1990) Immortalized young adult neurons from the septal region: generation and characterization.Dev. Brain Res.52, 219–228. ArticleCAS Google Scholar
Eves E. M., Marsden K. M., Downen M., Sheman L., Rosner M. R., and Wainer B. H. (1993) A novel hybrid immortalization strategy yields a more mature neuronal phenotype.Absts. Am. Soc. Neurosci.19, 243. Google Scholar
Botteri F. M., van der Putter H., Wong, D. F., Sauvage C. A., and Evans R. M. (1987) Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen.Mol. Cell. Biol.7, 3178–3184. PubMedCAS Google Scholar
Efrat S., Teitelman G., Anwar M., Ruggiero D., and Hanahan D. (1988) Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic α-cells.Neuron1, 605–613. ArticlePubMedCAS Google Scholar
Baetge E. E., Behringer R. R., Messing A., Brinster R. L., and Palmiter R. D. (1988) Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.Proc. Natl. Acad. Sci. USA85, 3648–3652. ArticlePubMedCAS Google Scholar
Hammang J. P., Baetge E. E., Behringer R. R., Brinster R. L., Palmiter R. D., and Messing A. (1990) Immortalized retinal neurons derived from SV40 T-antigen-induced tumors in transgenic mice.Neuron4, 775–782. ArticlePubMedCAS Google Scholar
Mandel G. and McKinnon D. (1993) Molecular basis of neural-specific gene expression.Ann. Rev. Neurosci.164, 323–345. Article Google Scholar
Mellon P. L., Windle J. J., Goldsmith P. C., Padula C. A., Roberts J. L., and Weiner R. I. (1990) Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.Neuron5, 1–10. ArticlePubMedCAS Google Scholar
Martinez de la Escalera G., Choi A. L., and Weiner R. I. (1992) Beta 1-adrenergic regulation of the GT1 gonadotrophin-releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via receptors positively coupled to adenylate cyclase.Endocrinology131, 1397–1402. ArticlePubMedCAS Google Scholar
Martinez de la Escalera G., Gallo F., Choi A. L., and Weiner R. I. (1992) Dopaminergic regulation of the GT1 gonadotrophin-releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via D1-receptors positively coupled to adenylate cyclase.Endocrinology131, 2965–2971. ArticlePubMedCAS Google Scholar
Milenkovic L., D’Angelo G., Kelly P. A., and Weiner R. I. (1994) Inhibition of gonadotropin hormone-releasing hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors.Proc. Natl. Acad. Sci. USA91, 1244–1247. ArticlePubMedCAS Google Scholar
Martinez de la Escalera G., Choi A. L. H., and Weiner R. I. (1994) Biphasic GABAergic regulation of GnRH secretion in GT1 cell lines.Neuronal Reg.59, 420–425. CAS Google Scholar
Wetsel W. C., Eraly S. A., Whyte D. B., and Mellon P. L. (1993) Regulation of gonadotropin-releasing hormone by protein kinase-A and-C in immortalized hypothalamic neurons.Endocrinology132, 2360–2370. ArticlePubMedCAS Google Scholar
Mellon P. L., Eraly S. A., Belsham D. D., Lawson M. A., Clark M. E., Whyte D. B., and Windle J. J. (1995) An immortal cell culture model of hypothalamic gonadotropin-releasing hormone neurons.Methods: Companion Meth. Enzymol.7, 303–310. ArticleCAS Google Scholar
Miller G. M., Silverman A.-J., Roberts J. L., Dong K. W., and Gibson M. J. (1993) Functional assessment of intrahypothalamic implants of immortalized gonadotropin-releasing hormone-secreting cells in female hypogonadal mice.Cell Transplant.2, 251–257. Google Scholar
Suri C., Fung B. P., Tischler A. S., and Chikaraishi D. M. (1993) Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice.J. Neurosci.13, 1280–1291. PubMedCAS Google Scholar
Largent B. L., Sosnowski R. G., and Reed R. R. (1993) Directed expression of an oncogene to the olfactory neuronal lineage in transgenic mice.J. Neurosci.13, 300–312. PubMedCAS Google Scholar
Jat P. S., Noble M. D., Ataliotis P., Tanaka Y., Yannoutsos N., Larsen L., and Kioussis D. (1991) Direct derivation of conditionally immortal cell lines from an H-2kb-tsA58 transgenic mouse.Proc. Natl. Acad. Sci. USA88, 5096–5100. ArticlePubMedCAS Google Scholar
Kershaw T. R., Rashid-Doubell F., and Sinden J. D. (1994) Immunocharacterization of H-2Kb-tsA58 transgenic mouse hippocampal neuroepithelial cells.Neuroreport5, 2197–2200. ArticlePubMedCAS Google Scholar
Eves E. M., Kwon J., Downen M., Tucker M. S., Wainer B. H., and Rosner M. R. (1994) Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.Brain Res.656, 396–404. ArticlePubMedCAS Google Scholar
Kilpatrick T. J. and Bartlett P. F. (1995) Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF.J. Neurosci.15, 3563–3661. Google Scholar
Cattaneo E. and McKay R. (1990) Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor.Nature347, 762–765. ArticlePubMedCAS Google Scholar
Deloulme J. C., Baudier J., and Sensenbrenner M. (1991) Establishment of pure neuronal cultures from fetal rat spinal cord and proliferation of the neuronal precursor cells in the presence of fibroblast growth factor.J. Neurosci. Res.29, 499–509. ArticlePubMedCAS Google Scholar
Ray J. and Gage F. H. (1994) Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor.J. Neurosci.14, 3548–3564. PubMedCAS Google Scholar
Murphy M., Drago J., and Bartlett P. F. (1990) Fibroblast growth factor stimulates the proliferation and differentiation of neural precursors in vitro.J. Neurosci. Res.25, 463–475. ArticlePubMedCAS Google Scholar
Ray J., Peterson D. A., Schinstine M., and Gage F. H. (1993) Proliferation, differentiation, and long-term culture of primary hippocampal neurons.Proc. Natl. Acad. Sci. USA90, 3602–3606. ArticlePubMedCAS Google Scholar
Vicario-Abejon C., Johe K. K., Hazel T. G., Collazo D., and McKay R. D. G. (1995) Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons.Neuron15, 105–114. ArticlePubMedCAS Google Scholar
DeHamer M. K., Guevera J. L., Hannon K., Olwin B. B., and Calof A. L. (1994) Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors.Neuron13, 1083–1097. ArticlePubMedCAS Google Scholar
Reynolds B. A., Tetzlaff W., and Weiss S. (1992) A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes.J. Neurosci.12, 4565–4574. PubMedCAS Google Scholar
Davis A. A. and Temple S. (1994) A self-renewing multipotential stem cell in embryonic rat cerebral cortex.Nature372, 263–266. ArticlePubMedCAS Google Scholar
Reynolds B. A. and Weiss S. (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.Science255, 1707–1710. ArticlePubMedCAS Google Scholar
Frederiksen K. and McKay R. D. G. (1988) Proliferation and differentiation of rat neuro-epithelial precursor cells in vivo.J. Neurosci.8, 1144–1151. PubMedCAS Google Scholar
Richards L. J., Kilpatrick T. J., and Bartlett P. F. (1992) De novo generation of neuronal cells from the adult mouse brain.Proc. Natl. Acad. Sci. USA89, 8591–8595. ArticlePubMedCAS Google Scholar
Kilpatrick T. J. and Bartlett P. F. (1993) Cloning and growth of multipotential neural precursors: requirements for proliferation and differentiation.Neuron10, 255–265. ArticlePubMedCAS Google Scholar
Temple S. and Davis A. A. (1994) Isolated rat cortical progenitor cells are maintained in division in vitro by membrane-associated factors.Development120, 999–1008. PubMedCAS Google Scholar
Drago J., Murphy M., Carrol S. M., Harvey R. P., and Bartlett P. F. (1991) Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor.Proc. Natl. Acad. Sci. USA88, 2199–2203. ArticlePubMedCAS Google Scholar
Drago J., Nurcombe V., Pearse M. J., Murphy M., and Bartlett P. F. (1991) Basic fibroblast growth factor upregulates steady state levels of laminin B1 and B2 chain mRNA in cultured neuroepithelial cells.Exp. Cell Res.196, 246–254. ArticlePubMedCAS Google Scholar
Vescovi A. L., Reynolds B. A., Fraser D. D., and Weiss S. (1993) bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.Neuron11, 951–966. ArticlePubMedCAS Google Scholar
Ahmed S., Reynolds B. A., and Weiss S. (1995) BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors.J. Neurosci.15, 5765–5778. PubMedCAS Google Scholar
Ghosh A. and Greenberg M. E. (1995) Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis.Neuron15, 89–103. ArticlePubMedCAS Google Scholar
Guillemot, F., Lo L.-C., Johnson J. E., Auerbach A., Anderson D. J., and Joyner A. L. (1993) Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.Cell75, 463–476. ArticlePubMedCAS Google Scholar
Lee J. E., Hollenberg S. M., Snider L., Turner D. L., Lipnick N., and Weintraub H. (1995) Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.Science12, 836–843. Article Google Scholar
Gage F. H., Coates P. W., Palmer T. D., Kuhn H. G., Fisher L. J., Suhonen J. O., Peterson D. A., Suhr S. T., and Ray J. (1995) Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.Proc. Natl. Acad. Sci. USA92, 11,879–11,883. ArticleCAS Google Scholar
Ray J., Fisher L. J., Kuhn H. G., Peterson D. A., Tuszynski M., and Gage F. H. (1994) Neuroblasts cultured from embryonic hippocampus and spinal cord can survive and express neural markers after grafting in the adult CNS.Absts. Am. Soc. Neurosci.20, 670. Google Scholar
Nishikawa R., Xiang-Dong J., Harmon R. C., Lazar C. S., Gill G. N., Cavenee W. K., and Su Huang J. S. (1994) A mutant epidermal growth factor receptor common in human gliomas confers enhanced tumorigenicity.Proc. Natl. Acad. Sci. USA91, 7727–7731. ArticlePubMedCAS Google Scholar
Schlegel J., Merdes A., Stumm G., Albert F. K., Forsting M., Hynes N., and Kiessling M. (1994) Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma.Int. J. Cancer56, 72–77. ArticlePubMedCAS Google Scholar
Rolelj S., Weinberg R. A., Fanning P., and Klagsbrun M. (1988) Basic fibroblast growth factor fused to a signal peptide transforms cells.Nature331, 173–175. Article Google Scholar
Calof A. L., ed. (1993)Neuroprotocols, vol. 3: Immortalizing Neural Cells. Academic, San Diego, CA. Google Scholar
Cepko C. L. (1992) Transduction of genes using retrovirus vectors, in_Current Protocols in Molecular Biology_ (Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A., and Struhl K., eds.), Wiley, New York, pp. 9.10.1–9.14.3. Google Scholar
Miller D. G., Adam M. A., and Miller A. D. (1990) Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.Mol. Cell. Biol.10, 4239–4242. PubMedCAS Google Scholar
Bartlett P. F., Reid H. H., Bailey K. A., and Bernard O. (1988) Immortalization of mouse neural precursor cells by the c-myc oncogene.Proc. Natl. Acad. Sci. USA85, 3255–3259. ArticlePubMedCAS Google Scholar
Murphy M., Bernard O., Reid K., and Bartlett P. F. (1990) Cell lines derived from mouse neural crest are representative of cells at various stages of differentiation.J. Neurobiol.22, 522–535. Article Google Scholar
Bernard O., Reid H. H., and Bartlett P. F. (1992) Role of the c-myc and the N-myc proto-oncogenes in the immortalization of neural precursors.J. Neurosci. Res.24, 9–20. Article Google Scholar
Ryder E. F., Snyder E. Y., and Cepko C. L. (1990) Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer.J. Neurobiol.21, 356–375. ArticlePubMedCAS Google Scholar
Eves E. M., Tucker M. S., Roback J. D., Downen M., Rosner M. R., and Wainer B. H. (1992) Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.Proc. Natl. Acad. Sci. USA89, 4373–4377. ArticlePubMedCAS Google Scholar
Giordano M., Takashima H., Herranz A., Poltorak M., Geller H. M., Marone M., and Freed W. J. (1993) Immortalized GABAergic cell lines derived from rat striatum using a temperature-sensitive allele of the SV40 large T antigen.Exp. Neurol.124, 395–400. ArticlePubMedCAS Google Scholar
Pessac B., Girard A., Romey G., Crisanti P., Lorinet A. M., and Calothy G. (1983) A neuronal clone derived from a rous sarcoma virus-transformed quail embryo neuroretina established culture.Nature302, 616–618. ArticlePubMedCAS Google Scholar
DeVitry F., Camier M., Czernichow P., Benda P. H., Cohen P., and Tixier-Vidal A. (1974) Establishment of a clone of mouse hypothalamic neurosecretory cells synthesizing neurophysin and vasopressin.Proc. Natl. Acad. Sci. USA71, 3575–3579. ArticleCAS Google Scholar
Frederiksen K., Jat P. S., Valtz N., Levy D., and McKay R. (1988) Immortalization of precursor cells from the mammalian CNS.Neuron1, 439–448. ArticlePubMedCAS Google Scholar
Evrard C., Borde I., Marin P., Galiana E., Prèmont F., Gros F., and Rouget P. (1990) Immortalization of bipotential and plastic glio-neuronal precursor cells.Proc. Natl. Acad. Sci. USA87, 3062–3066. ArticlePubMedCAS Google Scholar
Mehler M. F., Rozental R., Dougherty M., Spray D. C., and Kessler J. A. (1993) Cytokine regulation of neuronal differentiation of hippocampal progenitor cells.Nature362, 62–65. ArticlePubMedCAS Google Scholar
Soula C., Foulquier F., Duprat A. M., and Cochard P. (1993) Lineage analysis of early neural plate cells: cells with purely neuronal fate coexist with bipotential neuroglial progenitors.Dev. Biol.159, 196–207. ArticlePubMedCAS Google Scholar
Turner D. L. and Cepko C. L. (1987) A common progenitor for neurons and glia persists in rat retina late in development.Nature328, 131–136. ArticlePubMedCAS Google Scholar
Leber S. M., Breedlove S. M., and Sanes J. R. (1990) Lineage, arrangement, and death of clonally related motoneurons in chick spinal cord.J. Neurosci.10, 2451–2462. PubMedCAS Google Scholar
Turner D. L., Snyder E. Y., and Cepko C. L. (1990) Lineage-independent determination of cell type in the embryonic mouse retina.Neuron4, 833–845. ArticlePubMedCAS Google Scholar
White L. A., Eaton M. J., Castro M. C., Klose K. J., Globus M. Y., Shaw G., and Whittemore S. R. (1994) Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons.J. Neurosci.14, 6744–6753. PubMedCAS Google Scholar
Eaton M. J., Staley J. K., Globus M. Y.-T., and Whittemore S. R. (1995) Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization.Dev. Biol.170, 169–182. ArticlePubMedCAS Google Scholar
Eaton M. J. and Whittemore S. R. (1995) ACTH activation of adenylate cyclase in raphe neurons: multiple regulatory pathways control serotonergic neuronal differentiation.J. Neurobiol.28, 465–481. ArticlePubMedCAS Google Scholar
Azmitia E. C. and de Kloet E. R. (1987) ACTH neuropeptide stimulation of serotonergic neuronal maturation in tissue culture: modulation by hippocampal cells, in_Progress in Brain Research_ (de Kloet E. R., Wiegant V. M., and de Wied D., eds.), Elsevier, Amsterdam, pp. 311–318. Google Scholar
Ramaekers F., Rigter H., and Leonard B. E. (1978) Parallel changes in behavior and hippocampal monoamine metabolism in rats after administration of ACTH analogues.Pharmacol. Biochem. Behav.8, 547–551. ArticlePubMedCAS Google Scholar
Kitchens D. L., Snyder E. Y., and Gottlieb D. I. (1994) FGF and EGF are mitogens for immortalized neural progenitors.J. Neurobiol.25, 797–807. ArticlePubMedCAS Google Scholar
Kornblum H. I., Raymon H. K., Morrison R. S., Cavanaugh K. P., Bradshaw R. A., and Leslie F. M. (1990) Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro.Brain Res.535, 255–263. ArticlePubMedCAS Google Scholar
Whittemore S. R. and White L. A. (1993) Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe.Brain Res.615, 27–40. ArticlePubMedCAS Google Scholar
Gao W.-Q. and Hatten M. E. (1994) Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum.Development120, 1059–1070. PubMedCAS Google Scholar
Snyder E. Y. (1994) Grafting immortalized neurons to the CNS.Curr. Opin. Neurobiol.4, 742–751. ArticlePubMedCAS Google Scholar
Suhr S. and Gage F. H. (1994) Gene therapy for neurological disorders.Trends Genet.10, 210–214. Article Google Scholar
Snyder E. Y. (1996) Use of non-neuronal cells for gene delivery.Neuroreport (in press).
Renfranz P. J., Cunningham M. G., and McKay R. D. G. (1991) Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain.Cell66, 713–729. ArticlePubMedCAS Google Scholar
Snyder E. Y., Deitcher D. L., Walsh C., Arnold-Aldea S., Hartwieg E. A., and Cepko C. L. (1992) Multipotent neural cell lines can engraft and participate in development of mouse cerebellum.Cell66, 33–51. Article Google Scholar
Shihabuddin L. S., Hertz J. A., Holets V. R., and Whittemore S. R. (1995) The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line.J. Neurosci.15, 6666–6678. PubMedCAS Google Scholar
Shihabuddin L. S., Brunschwig J.-P., Holets V. R., Bunge M. B., and Whittemore S. R. (1996) Induction of mature neuronal properties in immortalized neuronal precursor cells following grafting in the neonatal CNS.J. Neurocytol.25, 101–111. ArticlePubMedCAS Google Scholar
Snyder E. Y., Yandava B. D., Pan Z.-H., Yoon C., and Macklis J. D. (1993) Immortalized postnatally-derived cerebellar progenitors can engraft and participate in the development of multiple structures at multiple stages along the mouse neuraxis.Absts. Am. Soc. Neurosci.19, 613. Google Scholar
Onifer S. M., Whittemore S. R., and Holets V. R. (1993) Variable morphological differentiation of a raphe-derived neuronal cell line following transplantation into the adult rat CNS.Exp. Neurol.122, 130–142. ArticlePubMedCAS Google Scholar
Macklis J. D. (1993) Transplanted neocortical neurons migrate selectively into regions of neuronal degeneration produced by chromophore-targeted laser photolysis.J. Neurosci.13, 3848–3863. PubMedCAS Google Scholar
Sheen V. L. and Macklis J. D. (1994) Apoptotic mechanisms in targeted photolytic neuronal cell death by chromophore-activated photolysis.Exp. Neurol.130, 67–81. ArticlePubMedCAS Google Scholar
Macklis J. D., Yoon C. H., and Snyder E. Y. (1994) Immortalized neural progenitors differentiate toward repletion of a neuronal population selectively eliminated from adult mouse neocortex by targeted photolysis.Exp. Neurol.127, 9. Article Google Scholar
Gage F. H., Kawaja M. D., and Fisher L. J. (1991) Genetically modified cells: applications for intracerebral grafting.Trends Neurosci.14, 328–333. ArticlePubMedCAS Google Scholar
Glorioso J. C., Goins W. F., Meany C. A., Fink D. A., and DeLuca N. A. (1994) Gene transfer to brain using herpes simplex virus vectors.Ann. Neurol.35, S28-S34. ArticlePubMedCAS Google Scholar
Freese A., Geller A. I., and Neve R. (1990) HSV-1 vector mediated neuronal gene delivery.Biochem. Pharmacol.40, 2189–2199. ArticlePubMedCAS Google Scholar
Le Gal La Salle G., Robert J. J., Berrard S., Ridous V., Stratford-Perricaudet L. D., Perricaudet M., and Mallet J. (1993) An adenovirus vector for gene transfer into neurons and glia in the brain.Science259, 988–990. Article Google Scholar
Anton R., Kordower J. H., Maidment N. T., Manaster J. S., Kane D. J., Rabizadeh S., Schueller S. B., Yang J., Edwards R. H., Markham C. H., and Bredesen D. E. (1994) Neural-targeted gene therapy for rodent and primate hemiparkinsonism.Exp. Neurol.127, 207–218. ArticlePubMedCAS Google Scholar
Snyder E. Y., Taylor R. M., and Wolfe J. H. (1995) Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain.Nature374, 367–370. ArticlePubMedCAS Google Scholar
Lacorazza H. D., Flax J. D., Snyder E. Y., and Jendoubi M. (1996) Expression of human β-hexosaminidase α-subunit gene (the gene defect of Tay Sachs disease) in mouse brains upon engraftment of transduced progenitor cells.Nat. Med.2, 424–429. ArticlePubMedCAS Google Scholar
Martinez-Serrano A., Lundberg C., Horellou P., Fischer W., Bentiage C., Campbell K., McKay R. D. G., Mallet J., and Björklundt A. (1995) CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult brains complete rescue of axotomized cholinergic neurons after transplantation into the septum.J. Neurosci.15, 5668–5680. PubMedCAS Google Scholar
Martinez-Serrano A., Fischer W., and Björklund A. (1995) Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain.Neuron15, 473–484. ArticlePubMedCAS Google Scholar
Snyder E. Y. and Flax J. D. (1995) Transplantation of neural progenitors and stem-like cells as a strategy for gene therapy and repair of neurodegenerative diseases.Mental Retard. Dev. Disabil. Res. Rev.1, 27–38. Article Google Scholar
Wright W. E., Pereira-Smith O. M., and Shay J. W. (1989) Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.Mol. Cell. Biol.9, 3088–3092. PubMedCAS Google Scholar
Stewart N. and Bacchetti S. (1991) Expression of SV40 large T antigen, but not small tantigen, is required for the induction of chromosomal aberrations in transformed human cells.Virology180, 49–57. ArticlePubMedCAS Google Scholar
Ray F. A., Peabody D. S., Cooper J. L., Cram I. S., and Kraemer P. M. (1990) SV40 antigen alone drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts.J. Cell Biochem.42, 13–31. ArticlePubMedCAS Google Scholar
Wainwright M. S., Perry B. D., Won L. A., O’Malley K. L., Wang W.-Y., Ehrlich M. E., and Heller A. (1995) Immortalized murine striatal neuronal cell lines expressing dopamine receptors and cholinergic properties.J. Neurosci.15, 676–688. PubMedCAS Google Scholar
Bottenstein J. E. and Sato G. H. (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented media.Proc. Natl. Acad. Sci. USA76, 514–517. ArticlePubMedCAS Google Scholar
Rudge J. S., Eaton M. J., Mather P., Lindsay R. M., and Whittemore S. R. (1996) CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro.Mol. Cell Neurosci., in press.