A potential role for apoptosis in neurodegeneration and Alzheimer's disease (original) (raw)
References
Abate C., Luk D., Gentz R., Rauscher F. J., and Curran T. (1989) Expression and purification of the leucine zipper and DNA binding domains of Fos and Jun: both Fos and Jun contact DNA directly.Proc. Natl. Acad. Sci. USA87, 1032–1036. Google Scholar
Abate C., Patel L., Rauscher F., and Curran T. (1990) Redox regulation of fos and jun DNA-binding activity in vitro.Science249(4973), 1157–1161. PubMedCAS Google Scholar
Alnemri E. S. and Litwack G. (1990) Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).J. Biol. Chem.265(28), 17,323–17,333. CAS Google Scholar
Ames B. N., Shigenaga M. K., and Hagen T. M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging.Proc. Natl. Acad. Sci. USA90(17), 7915–7922. PubMedCAS Google Scholar
Anderson A. J., Cummings B. J., and Cotman C. W. (1994) Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology.Exp. Neurol.125(2), 286–295. PubMedCAS Google Scholar
Anderson A. J., Pike C. J., and Cotman C. W. (submitted) Differential induction of immediate early gene proteins in cultured neurons by β-amyloid: association of c-Jun with Aβ-induced apoptosis.Neuroscience.
Angel P., Allegretto E. A., Okino S. T., Hattori K., Boyle W. J., Hunter T., and Karin M. (1988) Oncogene_jun_ encodes a sequence-specific_trans_-activator similar to AP-1.Nature332, 166–171. PubMedCAS Google Scholar
Arends M. J. and Wyllie A. H. (1991) Apoptosis: mechanisms and roles in pathology.Int. Rev. Exp. Path.32, 223–255. PubMedCAS Google Scholar
Arispe N., Rojas E., and Pollard H. B. (1993a) Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.Proc. Natl. Acad. Sci. USA90(2), 567–571. PubMedCAS Google Scholar
Arispe N., Pollard H. B., and Rojas E. (1993b) Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1–40)] in bilayer membranes.Proc. Natl. Acad. Sci. USA90(22), 10,573–10,577. CAS Google Scholar
Bannister A. J., Cook A., and Kouzarides T. (1991) In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes.Oncogene6(7), 1243–1250. PubMedCAS Google Scholar
Bansal N., Houle A. G., and Melnykovych G. (1990) Dexamethasone-induced killing of neoplastic cells of lymphoid derivation: lack of early calcium involvement.J. Cell. Physiol.143(1), 105–109. PubMedCAS Google Scholar
Batistatou A. and Greene L. A. (1991) Aurintri-carboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.J. Cell Biol.115(2), 461–471. PubMedCAS Google Scholar
Beal M. F., Hyman B. T., and Koroshetz W. (1993) Do deficits in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?TINS16(4), 178–184. Google Scholar
Behl C., Davis J., Cole G. M., and Schubert D. (1992) Vitamin E protects nerve cells from amyloid beta protein toxicity.Biochem. Biophys. Res. Commun.186(2), 944–950. PubMedCAS Google Scholar
Behl C., Davis J. B., Klier F. G., and Schubert D. (1994a) Amyloid beta peptide induces necrosis rather than apoptosis.Brain Res.645(1–2), 253–264. PubMedCAS Google Scholar
Behl C., Davis J. B., Lesley R., and Schubert D. (1994b) Hydrogen peroxide mediates amyloid beta protein toxicity.Cell77(6), 817–827. PubMedCAS Google Scholar
Bhalla K., Tang C., Ibrado A., Grant S., Tourkina E., Holladay C., Hughes M., Mahoney M., and Huang Y. (1992) Granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells.Blood80(11), 2883–2890. PubMedCAS Google Scholar
Bissonnette R. P., Echeverri F., Mahboubi A., and Green D. R. (1992) Apoptotic cell death induced by_c-myc_ is inhibited by_Bcl-2_.Nature359, 552–554. PubMedCAS Google Scholar
Boise L. H., Gonzalez G. M., Postema C. E., Ding L., Lindsten T., Turka L. A., Mao X., Nunez G., and Thompson C. B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.Cell74(4), 597–608. PubMedCAS Google Scholar
Brach M. A., Herrmann F., Yamada H., Bauerle P. A., and Kufe D. W. (1992) Identification of NF-jun, a novel inducible transcription factor that regulates_c-jun_ gene transcription.Embo J.11(4), 1479–1486. PubMedCAS Google Scholar
Bullock G., Tang C., Tourkina E., Ibrado A. M., Lutzky J., Huang Y., Mahoney M. E., and Bhalla K. (1993) Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclo-phosphamide-induced programmed cell death or apoptosis in human myeloid leukemia cells.Exp. Hematol.21(13), 1640–1647. PubMedCAS Google Scholar
Burdick D., Soreghan B., Kwon M., Kosmoski J., Knauer M., Henschen A., Yates J., Cotman C., and Glabe C. (1992) Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs.J. Biol Chem.267, 546–554. PubMedCAS Google Scholar
Bursch W., Dusterberg B., and Schulte H. R. (1986) Growth, regression and cell death in rat liver as related to tissue levels of the hepatomitogen cyproterone acetate.Arch Toxicol.59(4), 221–227. PubMedCAS Google Scholar
Bursch W., Oberhammer F., and Schulte-Hermann R. (1992) Cell death by apoptosis and its protective role against disease.TIPS13, 245–251. PubMedCAS Google Scholar
Busciglio J., Gabuzda D. H., Matsudaira P., and Yankner B. A. (1993) Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.Proc. Natl. Acad. Sci. USA90(5), 2092–2096. PubMedCAS Google Scholar
Busciglio J., Lorenzo A., and Yankner B. A. (1992) Methodological variables in the assessment of beta amyloid neurotoxicity.Neurobiol. Aging13, 609–612. PubMedCAS Google Scholar
Buttyan R., Zakeri Z., Lockshin R., and Wolgemuth D. (1988) Cascade induction of_c-fos, c-myc_, and heat shock 70K transcripts during regression of the rat ventral prostate gland.Mol. Endocrinol.2(7), 650–657. PubMedCAS Google Scholar
Chartier-Harlin M., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J., et al. (1991) Earlyonset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.Nature353(6347), 844–846. PubMedCAS Google Scholar
Chuang L. Y., Hung W. C., Chang C. C., and Tsai J. H. (1994) Characterization of apoptosis induced by transforming growth factor beta 1 in human hepatoma cells.Anticancer Res.14(1A), 147–52. PubMedCAS Google Scholar
Coleman P. D. and Flood D. G. (1987) Neuron numbers and dendritic extent in normal aging and Alzheimer's disease.Neurobiol. Aging8, 521–545. PubMedCAS Google Scholar
Colotta F., Polentarutti N., Sironi M., and Mantovani A. (1992) Expression and involvement of_c-fos_ and_c-jun_ protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.J. Biol. Chem.267(26), 18,278–18,283. CAS Google Scholar
Copani A., Koh J., and Cotman C. W. (1991) β-amyloid increases neuronal susceptibility to injury by glucose deprivation.Neuroreport2, 763–765. PubMedCAS Google Scholar
Corder E. H., Saunders A. M., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Small G. W., Roses A. D., Haines J. L., and Pericak V. M. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families (see comments).Science261(5123), 921–923. PubMedCAS Google Scholar
Cotman C. W. and Anderson A. J. (1995) Retention of function in the aged brain: the pivotal role of Aβ, in_Brain and Memory: Modulation and Mediation of Neural Plasticity_ (McGaugh, J. L., Weinberger N. M., and Lynch G., eds.), Oxford University Press, New York. Google Scholar
Cotman C. W., Cummings B. J., and Whitson J. S. (1991) The role of misdirected plasticity in plaque biogenesis and Alzheimer's disease pathology, in_Growth Factors and Alzheimer's Disease_ (Hefti F., Brachet P., Will B., and Christen Y., eds.), Springer-Verlag, Berlin, pp. 222–233. Google Scholar
Cotter T. G., Glynn J. M., Echeverri F., and Green D. R. (1992) The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle.Anticancer Res.12(3), 773–779. PubMedCAS Google Scholar
Cummings B. J., Su J. H., and Cotman C. W. (1993a) Neuritic involvement within bFGF immunopositive plaques in Alzheimer's disease.Exp. Neurol.124(2) 315–325. PubMedCAS Google Scholar
Cummings B. J., Su J. H., Cotman C. W., White R., and Russell M. J. (1993b) b-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease.Neurobiol. Aging14, 547–560. PubMedCAS Google Scholar
Deckwerth T. L. and Johnson E. (1993) Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.J. Cell Biol.123(5), 1207–1222. PubMedCAS Google Scholar
De Gioia L., Selvaggini C., Ghibaudi E., Diomede L., Bugiani O., Forloni G., Tagliavini F., and Salmona M. (1994) Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106–126 of the prion protein.J. Biol. Chem.269(11), 7859–7862. PubMed Google Scholar
Deshpande J., Bergstedt K., Linden T., Kalimo H., and Wieloch T. (1992) Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death.Exp. Brain Res.88(1), 91–105. PubMedCAS Google Scholar
Dessi F., Charriaut M. C., and Ben A. Y. (1992) Anisomycin and cycloheximide protect cerebellar neurons in culture from anoxia.Brain Res.581(2), 323–326. PubMedCAS Google Scholar
Diedrich J. F., Minnigan H., Carp R. I., Whitaker J. N., Race R., Frey W., and Haase A. T. (1991) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.J. Virol.65(9), 4759–4768. PubMedCAS Google Scholar
Dornan W. A., Kang, D. E., McCampbell A., and Kang E. E. (1993) Bilateral injections of βA(25–35)+IBO into the hippocampus disrupts acquisition of spatial learning in the rat.NeuroReport5, 165–168. PubMedCAS Google Scholar
Dragunow M., Beilharz E., Sirimanne E., Lawlor P., Williams C., Bravo R., and Gluckman P. (1994) Immediate-early gene proteins expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain.Mol. Brain Res.25, 19–33. PubMedCAS Google Scholar
Dragunow M., Young D., Hughes P., MacGibbon G., Lawlor P., Singleton K., Sirimanne E., Beilharz E., and Gluckman P. (1993) Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?Mol. Brain Res.18(4), 347–352. PubMedCAS Google Scholar
Duke R. C., Chervenak R., and Cohen J. J. (1983) Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.Proc. Natl. Acad. Sci. USA80(20), 6361–6365. PubMedCAS Google Scholar
Ellis R. E., Yuan J. Y., and Horvitz H. R. (1991) Mechanisms and functions of cell death.Ann. Rev. Cell. Biol.7(663), 663–698. PubMedCAS Google Scholar
Emre M., Geula C., Ransil B. J., and Mesulam M. M. (1992) The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain.Neurobiol. Aging13(5), 553–559. PubMedCAS Google Scholar
Enokido Y. and Hatanaka H. (1993) Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere.Neuroscience57(4), 965–972. PubMedCAS Google Scholar
Evan G. I., Wyllie A. H., Gilbert C. S., Littlewood T. D., Land H., Brooks M., Waters C. M., Penn L. Z., and Hancock D. C. (1992) Induction of apoptosis in fibroblasts by_c-myc_ protein.Cell69, 119–128. PubMedCAS Google Scholar
Forloni G., Angeretti N., Chiesa R., Monzani E., Salmona M., Bugiani O., and Tagliavini F. (1993a) Neurotoxicity of a prion protein fragment.Nature362(6420), 543–546. PubMedCAS Google Scholar
Forloni G., Chiesa R., Smiroldo S., Verga L., Salmona M., Tagliavini F., and Angeretti N. (1993b) Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25–35.Neuroreport4(5), 523–526. PubMedCAS Google Scholar
Frangione B. (1989) Systemic and cerebral amyloidosis.Ann. Med.21, 69–72. PubMedCAS Google Scholar
Fraser P. E., Levesque L., and McLachlan D. R. (1994) Alzheimer Aβ amyloid forms an inhibitory neuronal substrate.J. Neurochem.62(3), 1227–1230. PubMedCAS Google Scholar
Frautschy S. A., Baird A., and Cole G. M. (1991) Effects of injected Alzheimer beta-amyloid cores in rat brain.Proc. Natl. Acad. Sci. USA88(19), 8362–8866. PubMedCAS Google Scholar
Freeman R. S., Estus S., and Johnson E. J. (1994) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death.Neuron12(2), 343–355. PubMedCAS Google Scholar
Garcia I., Martinou I., Tsujimoto Y., and Martinou J. (1992) Prevention of programmed cell death of sympathetic neurons by the_bcl-2_ proto-oncogene.Science258, 302–304. PubMedCAS Google Scholar
Glenner G. G. and Wong C. W. (1984) Alzheimer's disease: initial report of the purification of a novel cerebrovascular amyloid protein.Biochem. Biophys. Res. Comm.120, 885–890. PubMedCAS Google Scholar
Goate A., Chartier-Harlin M., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease (see comments).Nature349(6311) 704–706. PubMedCAS Google Scholar
Goldgaber D., Lerman M. I., McBride O. W., Saffioti U., and Gajdusek D. C. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.Science235, 877–880. PubMedCAS Google Scholar
Goldstone S. D. and Lavin M. F. (1994) Prolonged expression of_c-jun_ and associated activity of the transcription factor AP-1, during apoptosis in a human leukaemic cell line.Oncogene9(8), 2305–2311. PubMedCAS Google Scholar
Goto I., Taniwaki T., Hosokawa S., Otsuka M., Ichiya Y., and Ichimiya A. (1993) Positron emission tomographic (PET) studies in dementia.J. Neurol. Sci.114(1), 1–6. PubMedCAS Google Scholar
Goto K., Ishige A., Sekiguchi K., Iizuka S., Sugimoto A., Yuzurihara M., Aburada M., Hosoya E., and Kogure K. (1990) Effects of cycloheximide on delayed neuronal death in rat hippocampus.Brain Res.534(1–2), 299–302. PubMedCAS Google Scholar
Gowing E., Roher A. E., Woods A. S., Cotter R. J., Chaney M., Little S. P., and Ball M. J. (1994) Chemical characterization of Aβ 17–42 peptide, a component of diffuse amyloid deposits of Alzheimer's disease.J. Biol. Chem.269, 10,987–10,990. CAS Google Scholar
Grassilli E., Carcereri de Prati A., Monti D., Troiano L., Menegazzi M., Barbieri D., Franceschi C., and Suzuki H. (1992) Studies of the relationship between cell proliferation and cell death II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes.Biochem. Biophys. Res. Commun.188(3), 1261–1266. PubMedCAS Google Scholar
Gunji H., Kharbanda S., and Kufe D. (1991) Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-β-D-arabinofuranosylcytosine.Cancer Res.51, 741–743. PubMedCAS Google Scholar
Haass C., Schlossmacher M., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberberg I., Koo E. H., Schenk D., Teplow D. B., and Selkoe D. (1992) Amyloid β-peptide is produced by cultured cells during normal metabolism.Nature359, 322–325. PubMedCAS Google Scholar
Halliwell B. (1989) Oxidants and the central nervous system: some fundamental questions.Acta Neurol. Scand.126, 23–33. CAS Google Scholar
Haxby J. V. and Rapoport S. I. (1986) Abnormalities of regional brain metabolism in Alzheimer's disease and their relation to functional impairment.Prog. Neuropsychopharmacol. Biol. Psychiatry.10(3–5), 427–438. PubMedCAS Google Scholar
Hensley K., Carney J. M., Matsson M. P., Aksenova M., Harris M., Wu J. F., Floyd R. A., and Butterfield D. A. (1994) A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.Proc. Natl. Acad. Sci. USA91(8), 3270–3274. PubMedCAS Google Scholar
Hermeking H. and Eick D. (1994) Mediation of c-Myc-induced apoptosis by p53.Science265(5181), 2091–2093. PubMedCAS Google Scholar
Heron A., Pollard H., Dessi F., Moreau J., Lasbennes F., Ben A. Y., and Charriaut M. C. (1993) Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain.J. Neurochem.61(5), 1973–1976. PubMedCAS Google Scholar
Hilbich C., Kisters-Woike B., Reed J., Masters C. L., and Beyreuther K. (1991) Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease.J. Mol. Biol.218, 149–163. PubMedCAS Google Scholar
Hockenbery D. M., Oltvai Z. N., Yin X. M., Milliman C. L., and Korsmeyer S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis.Cell75(2), 241–251. PubMedCAS Google Scholar
Hoyer S., Oesterreich K., and Wagner O. (1988) Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?J. Neurol.235, 143–148. PubMedCAS Google Scholar
Ijiri K. and Potten C. S. (1983) Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation.Br. J. Cancer47(2), 175–185. PubMedCAS Google Scholar
Johnson E. M., Koike, T., and Franklin J. (1992) A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor.Exp. Neurol.115, 163–166. PubMed Google Scholar
Kane D. J., Sarafian T. A., Anton R., Hahn H., Gralla E. B., Valentine J. S., Ord T., and Bredesen D. E. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.Science262(5137), 1274–1277. PubMedCAS Google Scholar
Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Master C. L., Grezeschik K. H., Multhaup G., Beyruther K., and Müller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.Nature325, 733–736. PubMedCAS Google Scholar
Kerr J. F., Wyllie A. H., and Currie A. R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.Br. J. Cancer26(4), 239–257. PubMedCAS Google Scholar
Kerr J. F. R. and Harmon B. V. (1991) Definition and incidence of apoptosis: an historical perspective, in_Apoptosis, The Molecular Basis of Cell Death_, vol. 3 (Tomei L. D. and Cope F. O., eds.) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 5–29. Google Scholar
Kharbanda S., Rubin E., Gunji H., Hinz H., Giovanella B., Pantazis P., and Kufe D. (1991) Camptothecin and its derivatives induce expression of the_c-jun_ protooncogene in human myeloid leukemia cells.Cancer Res.51, 6636–6642. PubMedCAS Google Scholar
Kiessling M., Xie Y., Ullrich B., and Thilmann R. (1991) Are the neuroprotective effects of the protein synthesis inhibitor cycloheximide due to prevention of apoptosis?J. Cereb. Blood Flow Metab.11, S357. Google Scholar
Kizaki H., Tadakuma T., Odaka C., Muramatsu J., and Ishimura Y. (1989) Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.J. Immunol.143(6), 1790–1794. PubMedCAS Google Scholar
Knox K. A., Finney M., Milner A. E., Gregory C. D., Wakelam M. J., Michell R. H., and Gordon J. (1992) Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines.Int. J. Cancer52(6), 959–966. PubMedCAS Google Scholar
Koh J.-Y. and Choi D. W. (1987) Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase afflux assay.J. Neurosci. Meth.20, 83–90. CAS Google Scholar
Koh J. Y., Yang L. L., and Cotman C. W. (1990) β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage.Brain Res.533, 315–320. PubMedCAS Google Scholar
Koike T., Martin D. P., and Johnson E. M. (1989) Role of Ca++ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca++ determine nerve growth factor dependence of sympathetic ganglion cells.Proc. Natl. Acad. Sci. USA86, 6421–6425. PubMedCAS Google Scholar
Kowall N. W., McKee A. C., Yankner B. A., and Beal M. F. (1992) In vivo neurotoxocity of beta-amyloid [beta(1–40)] and the beta(25–35) fragment.Neurobiol. Aging13(5), 537–542. PubMedCAS Google Scholar
Kruman I. I., Gukovskaya A. S., Petrunyaka V. V., Beletsky I. P., and Trepakova E. S. (1992) Apoptosis of murine BW 5147 thymoma cells induced by cold shock.J. Cell Physiol.153(1) 112–117. PubMedCAS Google Scholar
Kunimoto M. (1994) Mathyelmercury induces apoptosis of rat cerebellar neurons in primary culture.Biochem. Biophys. Res. Comm.204(1), 310–317. PubMedCAS Google Scholar
Kure S., Tominaga T., Yoshimoto T., Tada K., and Narisawa K. (1991) Glutamate triggers internucleosomal DNA cleavage in neuronal cells.Biochem. Biophys. Res. Commun.179(1), 39–45. PubMedCAS Google Scholar
Lennon S. V., Kilfeather S. A., Hallett M. B., Campbell A. K., and Cotter T. G. (1992) Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukemia cells.Cell. Exp. Immunol.87(3), 465–471. CAS Google Scholar
Lennon S. V., Martin S. J., and Cotter T. G. (1991) Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.Cell Prolif.24(2), 203–214. PubMedCAS Google Scholar
Liu Z. G., Smith S. W., McLaughlin K. A., Schwartz L. M., and Osborne B. A. (1994) Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene_nur 77_.Nature367(6460), 281–284. PubMedCAS Google Scholar
Loo D. T., Copani A. G., Pike C. J., Whittemore E. R., Walencewicz A. J., and Cotman C. W. (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.Proc. Natl. Acad. Sci. USA90(17), 7951–7955. PubMedCAS Google Scholar
Lorenzo A., Razzaboni B., Weir G. C., and Yankner B. A. (1994) Pancreatic islet cell toxicity to amylin associated with type-2 diabetes mellitus.Nature368(6473), 756–760. PubMedCAS Google Scholar
Lowe S. L., Francis P. T., Procter A. W., Palmer A. M., Davison A. N., and Bowen D. M. (1988) Gamma-aminobutyric acid concentration in brain tissue at two stages of Alzheimer's disease.Brain111, 785–799. PubMed Google Scholar
Malorni W., Rivabene R., Santini M. T., and Donelli G. (1993) N-acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells.FEBS Lett.327(1), 75–78. PubMedCAS Google Scholar
Mann D. M. A., Yates P. O., and Marcynuik B. (1985a) Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of the Alzheimer's type and Down's syndrome in middle age.Neurosci. Lett.56, 51–55. PubMedCAS Google Scholar
Mann D. M. A., Yates P. O., and Marcyniuk B. (1985b) Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease.J. Neurol. Sci.69, 139–159. PubMedCAS Google Scholar
Manome Y., Datta R., and Fine H. A. (1993a) Early response gene induction following DNA damage in astrocytoma cell lines.Biochem. Pharmacol.45(8), 1677–1684. PubMedCAS Google Scholar
Manome Y., Datta R., Taneja N., Shafman T., Bump E., Hass R., Weichselbaum R., and Kufe D. (1993b) Coinduction of_c-jun_ gene expression and internucleosomal DNA fragmentation by ionizing radiation.Biochemistry32(40), 10,607–10,613. CAS Google Scholar
Marti A., Jehn B., Costello E., Keon N., Ke G., Martin F., and Jaggi R. (1994) Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells.Oncogene9(4), 1213–1223. PubMedCAS Google Scholar
Martin D. P., Schmidt R. E., DiStefano P. S., Lowry O. H., Carter J. G., and Johnson E. M. (1988) Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.J. Cell Biol.106, 829–844. PubMedCAS Google Scholar
Martin S. J., Green D. R., and Cotter T. G. (1994) Dicing with death: dissecting the components of the apoptosis machinery.Trends Biochem. Sci.19(1), 26–30. PubMedCAS Google Scholar
Martin S. J., Lennon S. V., Bonham A. M., and Cotter T. G. (1990) Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.J. Immunol.145(6), 1859–1867. PubMedCAS Google Scholar
Masters C. L., Multhaup G., Simms G., Rottgiesser J., Martins R. N., and Beyreuther K. (1985a) Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.EMBO J.4, 2757–2763. PubMedCAS Google Scholar
Masters C. L., Simms G., Weinman N. A., Multhaup G., McDonald B. L., and Beyreuther K. (1985b) Amyloid plaque core protein in Alzheimer disease and Down syndrome.Proc. Natl. Acad. Sci. USA82, 4245–4249. PubMedCAS Google Scholar
Mattson M. P., Barger S. W., Cheng B., Lieberburg I., Smith S. V., and Rydel R. E. (1993a) beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.TINS16(10), 409–414. PubMedCAS Google Scholar
Mattson M. P., Tomaselli K. J., and Rydel R. E. (1993b) Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF.Brain Res.621, 35–49. PubMedCAS Google Scholar
Mattson M. P., Cheng B., Davis D., Bryant K., Lieberberg I., and Rydel R. E. (1992) β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.J. Neurosci.12(2), 376–389. PubMedCAS Google Scholar
May P. C., Boggs L. N., and Fuson K. S. (1993) Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-β neurotoxicity.J. Neurochem.61(6), 2330–2333. PubMedCAS Google Scholar
Mayeux R., Stern Y., Ottman R., Tatemichi T. K., Tang M. X., Maestre G., Ngai C., Tycko B., and Ginsberg H. (1993) The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease.Ann. Neurol.34(5), 752–754. PubMedCAS Google Scholar
McCabe M. J. J., Nicotera P., and Orrenius S. (1992) Calcium-dependent cell death. Role of the endonuclease, protein kinase C, and chromatin conformation.Ann. NY Acad. Sci.663(269), 269–278. PubMedCAS Google Scholar
McConkey D. J., Hartzell P., Duddy S. K., Hakansson H., and Orrenius S. (1988) 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.Science242(4876), 256–259. PubMedCAS Google Scholar
McConkey D. J., Hartzell P., Jondal M., and Orrenius S. (1989a) Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.J. Biol. Chem.264(23), 13,399–13,402. CAS Google Scholar
McConkey D. J., Hartzell P., Nicotera P. L., and Orrenius S. (1989b) Calcium-activated DNA fragmentation kills immature thymocytes.FASEB J.3, 1843–1846. PubMedCAS Google Scholar
McConkey D. J., Nicotera P., Hartzell P., Bellomo G., Wyllie A. H., and Orrenius S. (1989c) Glucocorticoids activate a suicide process in thymo cytes through an elevation of cytosolic calcium concentration.Arch. Biochem. Biophys.269(1), 365–370. PubMedCAS Google Scholar
McConkey D. J., Orrenius S., and Jondal M. (1990) Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.J. Immunol.145(4), 1227–1230. PubMedCAS Google Scholar
McConkey D. J., Jondal M., and Orrenius S. (1992) Cellular signaling in thymocyte apoptosis.Sem. Immunol.4, 371–377. CAS Google Scholar
McConkey D. J., Orrenius S., Okret S., and Jondal M. (1993) Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes.FASEB J.7(6), 580–585. PubMedCAS Google Scholar
McGeer P. L., Kamo H., Harrop R., Li D. K., Tuokko H., McGeer E. G., Adam M. J., Ammann W., Beattie B. L., Calne D. B., et al. (1986) Positron emission tomography in patients with clinically diagnosed Alzheimer's disease.Can. Med. Assoc. J.134(6), 597–607. CAS Google Scholar
Miura M., Zhu H., Rotello R., Hartwieg E. A., and Yuan J. (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3.Cell75(4), 653–660. PubMedCAS Google Scholar
Miyashita T., Krajewski S., Krajewska M., Wang H. G., Lin H. K., Liebermann D. A., Hoffman B., and Reed J. C. (1994) Tumor suppressor p53 is a regulator of_bcl-2_ and_bax_ gene expression in vitro and in vivo.Oncogene9(6), 1799–1805. PubMedCAS Google Scholar
Monti D., Troiano L., Tropea F., Grassilli E., Cossarizza A., Barozzi D., Pelloni M. C., Tamassia M. G., Bellomo G., and Franceschi C. (1992) Apoptosis—programmed cell death: a role in the aging process?Am. J. Clin. Nutr.55(6 Suppl.), 12,08S-12,14S. CAS Google Scholar
Morgan J. I. and Curran T. (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes_fos_ and_jun_.Ann. Rev. Neurosci.14, 421–451. PubMedCAS Google Scholar
Mountjoy C. Q., Rossor M. N., Iversen L. L., and Roth M. (1984) Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia.Brain107, 507–518. PubMed Google Scholar
Mountjoy C. Q., Roth M., Evans J. R., and Evans H. M. (1983) Cortical neuronal counts in normal elderly controls and demented patients.Neurobiol. Aging4, 1–11. PubMedCAS Google Scholar
Mullan M., Houlden H., Windelspecht M., Fidani L., Lombardi C., Diaz P., Rossor M., Crook R., Hardy J., Duff K., et al. (1992a) A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.Nat. Genet.2(4), 340–342. PubMedCAS Google Scholar
Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., and Lannfelt L. (1992b) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.Nat. Genet.1(5), 345–347. PubMedCAS Google Scholar
Murrell J., Farlow M., Ghetti B., and Benson M. D. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.Science254(5028), 97–99. PubMedCAS Google Scholar
Namba Y., Tomonaga M., Kawasaki H., Otomo E., and Ikeda K. (1991) Apolipoprotein E immuno-reactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.Brain Res.541(1), 163–166. PubMedCAS Google Scholar
Nechiporuk A., Fain P., Kort E., Nee L. E., Frommelt E., Polinsky R. J., Korenberg J. R., and Pulst S. M. (1993) Linkage of familial Alzheimer disease to chromosome 14 in two large early-onset pedigrees: effects of marker allele frequencies on lod scores.Am. J. Med. Genet.48(1), 63–66. PubMedCAS Google Scholar
Neve R. L., Dawes L. R., Yankner B. A., Benowitz L. I., Rodriguez W., and Higgens G. A. (1990) Genetics and biology of the Alzheimer amyloid precursor.Prog. Brain Res.86, 257–267. PubMedCAS Google Scholar
Nunez G., London L., Hockenbery D., Alexander M., McKearn J. P., and Korsmeyer S. J. (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.J. Immunol.144, 3602–3610. PubMedCAS Google Scholar
Oberhammer F., Bursch W., Parzefall W., Breit P., Erber E., Stadler M., and Schulte H. R. (1991) Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.Cancer Res.51(9), 2478–2485. PubMedCAS Google Scholar
Oberhammer F. A., Pavelka M., Sharma S., Tiefenbacher R., Purchio A. F., Bursch W., and Schulte-Hermann R. (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-β1.Proc. Natl. Acad. Sci. USA89, 5408–5412. PubMedCAS Google Scholar
Ojeda F., Guarda M. I., Maldonado C., and Folch H. (1990) Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone.Cell Immunol.125, 535–539. PubMedCAS Google Scholar
Olanow C. W. (1993) A radical hypothesis for neuro-degeneration.Trends Neurosci.16(11), 439–444. PubMedCAS Google Scholar
Oltvai Z. N., Milliman C. L., and Korsmeyer S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.Cell74(4), 609–619. PubMedCAS Google Scholar
Oppenheim R. W., Prevette D., Tytell M., and Homma S. (1990) Naturally occurring and induced neuronal death in the chick embryo_in vivo_ requires protein and RNA synthesis: evidence for the role of cell death genes.Dev. Biol.138, 104–113. PubMedCAS Google Scholar
Orrenius S., McConkey D. J., Bellomo G., and Nicotera P. (1989) Role of Ca++ in toxic cell killing.TIPS10, 281–285. PubMedCAS Google Scholar
Owens G. P., Hahn W. E., and Cohen J. J. (1991) Identification of mRNAs associated with programmed cell death in immature thymocytes.Mol. Cell Biol.11(8), 4177–4188. PubMedCAS Google Scholar
Pappolla M. A., Omar R. A., Kim K. S., and Robakis N. K. (1992) Immunohistochemical evidence of antioxidant stress in Alzheimer's disease.Am. J. Pathol.140(3), 621–628. PubMedCAS Google Scholar
Pike C. J., Burdick D., Walencewicz A., Glabe C. G., and Cotman C. W. (1993) Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly site.J. Neurosci.13(4), 1676–1687. PubMedCAS Google Scholar
Pike C. J. and Cotman C. W. (1993) Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid.Neuroscience56(2), 269–274. PubMedCAS Google Scholar
Pike C. J., Cummings B. J., and Cotman C. W. (1992) β-amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology.Neuroreport3, 769–772. PubMedCAS Google Scholar
Pike C. J., Walencewicz A. J., Glabe C. G., and Cotman C. W. (1991a) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity.Brain Res.563, 311–314. PubMedCAS Google Scholar
Pike C. J., Walencewicz A. J., Glabe C. G., and Cotman C. W. (1991b) Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures.Euro. J. Pharm.207, 367–368. CAS Google Scholar
Pittman R. N., Wang S., DiBenedetto A. J., and Mills J. C. (1993) A system for characterizing cellular and molecular events in programmed neuronal cell death.J. Neurosci.13(9), 3669–3680. PubMedCAS Google Scholar
Pollard H., Cantagrel S., Charriaut-Marlangue C., Moreau J., and Ben Ari Y. (1994) Apoptosis associated DNA fragmentation in epileptic brain damage.Neuroreport5, 1053–1055. PubMedCAS Google Scholar
Prelli F., Castaño E., Glenner G., and Frangione B. (1988) Differences between vascular and plaque core amyloid in Alzheimer's disease.J. Neurochem.51, 648–651. PubMedCAS Google Scholar
Rabizadeh S., LaCount D. J., Friesen P. D., and Bredesen D. E. (1993) Expression of the baculovirus p35 gene inhibits mammalian neural cell death.J. Neurochem.61(6), 2318–2321. PubMedCAS Google Scholar
Raff M. C., Barres B. A., Burne J. F., Coles H. S., Ishizaki Y., and Jacobson M. D. (1993) Programmed cell death and the control of cell survival: lessons from the nervous system.Science262(5134), 695–700. PubMedCAS Google Scholar
Ratan R. R., Murphy T. H., and Baraban J. M. (1994) Oxidative stress induces apoptosis in embryonic cortical neurons.J. Neurochem.62, 376–379. PubMedCAS Google Scholar
Rauscher P. J., Voulalas P. J., Franza R., and Curran T. (1988) Fos and Jun bind cooperatively to the AP-1 site: reconstruction in vitro.Genes & Devel.2, 1687–1699. CAS Google Scholar
Rebeck G. W., Reiter J. S., Strickland D. K., and Hyman B. T. (1993) Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions.Neuron11(4), 575–580. PubMedCAS Google Scholar
Robakis N. K., Ramakrishna N., Wolfe G., and Wisniewski H. M. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides [published erratum appears in_Proc. Natl. Acad. Sci. USA_ (1987)84(20), 7221].Proc. Natl. Acad. Sci. USA84(12) 4190–4194. PubMedCAS Google Scholar
Rossor M. N., Garrett N. J., Johnson A. L., Mountjoy C. Q., Roth M., and Iverson L. L. (1982) A postmortem study of the cholinergic and GABA systems in senile dementia.Brain105, 313–330. PubMedCAS Google Scholar
Rubin E., Kharbanda, S., Gunji H., and Kufe D. (1991) Activation of the_c-jun_ protooncogene in human myeloid leukemia cells treated with etoposide.Mol. Pharmacol.39, 697–701. PubMedCAS Google Scholar
Rubin E., Kharbanda S., Gunji H., Weichelbaum R., and Kufe D. (1992)cis_-diamminedichloroplatinum (II) induces_c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway.Cancer Res.52, 878–882. PubMedCAS Google Scholar
Saitoh T., Horsburgh K., and Masliah E. (1993) Hyperactivation of signal transduction systems in Alzheimer's disease.Ann. NY Acad. Sci.695, 34–41. PubMedCAS Google Scholar
Saunders A. M., Strittmatter W. J., Schmechel, D., George H. P., Pericak V. M., Joo S. H., Rosi B. L., Gusella J. F., Crapper M. D., Alberts M. J., et al. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.Neurology43(8), 1467–1472. PubMedCAS Google Scholar
Schellenberg G. D., Bird T. D., Wijsman E. M., Orr H. T., Anderson L., Nemens E., White J. A., Bonnycastle L., Weber J. L., Alonso E., Potter H., Heston L. L., and Martin G. M. (1992) Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14.Science258, 668–671. PubMedCAS Google Scholar
Schellenberg G. D., Payami H., Wijsman E. M., Orr H. T., Goddard K. A., Anderson L., Nemens E., White J. A., Alonso M. E., Ball M. J., et al. (1993) Chromosome 14 and late-onset familial Alzheimer disease (FAD).Am. J. Hum. Genet.53(3), 619–628. PubMedCAS Google Scholar
Schmechel D. E., Saunders A. M., Strittmatter W. J., Crain B. J., Hulette C. M., Joo S. H., Pericak V. M., Goldgaber D., and Roses A. D. (1993) Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.Proc. Natl. Acad. Sci. USA90(20), 9649–9653. PubMedCAS Google Scholar
Schwab C. Bondada V., Sparks D. L., Cahan L. D., and Geddes J. W. (1994) Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus.Hippocampus4(2), 210–225. PubMedCAS Google Scholar
Scott S. A. and Davies A. M. (1990) Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor_in vitro_.J. Neurobiol.21(4), 630–638. PubMedCAS Google Scholar
Selkoe D. J., Abraham C. R., Podlisny M. B., and Duffy L. D. (1986) Isolation of low molecular weight proteins from amyloid plaque fibers in Alzheimer's disease.J. Neurochem.46, 1820–1834. PubMedCAS Google Scholar
Selvaggini C., De G. L., Cantu L., Ghibaudi E., Diomede L., Passerini F., Forloni G., Bugiani O., Tagliavini F., and Salmona M. (1993) Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106–126 of the prion protein.Biochem. Biophys. Res. Commun.194(3), 1380–1386. PubMedCAS Google Scholar
Shaw P., Bovey R., Tardy S., Sahli R., Sordat B., and Costa J. (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.Proc. Natl. Acad. Sci. USA89(10), 4495–4499. PubMedCAS Google Scholar
Sheng M. and Greenberg M. E. (1990) The regulation and function of c-fos and other immediate early genes in the nervous system.Neuron4, 477–485. PubMedCAS Google Scholar
Shi Y., Glynn J. M., Guilbert L. J., Cotter T. G., Bissonnette R. P., and Green D. R. (1992) Role for c-myc in activation-induced apoptotic cell death in T-cell hybridomas.Science257, 212–214. PubMedCAS Google Scholar
Shigeno T., Mima T., Takakura K., Graham D. I., Kato G., Hashimoto Y., and Furukawa S. (1991) Amelioration of delayed neuronal death in the hippocampus by nerve growth factor.J. Neurosci.11(9), 2914–2919. PubMedCAS Google Scholar
Shigeno T., Yamasaki Y., Kato G., Kusaka K., Mima T., Takakura K., Graham D. I., and Furukawa S. (1990) Reduction of delayed neuronal death by inhibition of protein synthesis.Neurosci. Lett.120(1), 117–119. PubMedCAS Google Scholar
Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shafer L. M., Cai X., McKay D. M., Tintner R., Frangione B., and Younkin S. G. (1992) Production of the Alzheimer Amyloid β protein by normal proteolytic processing.Science258, 126–129. PubMedCAS Google Scholar
Sikora E., Grassilli E., Bellesia E., Troiano L., and Franceschi C. (1993a) Studies of the relationship between cell proliferation and cell death. III. AP-I DNA-binding activity during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes.Biochem. Biophys. Res. Commun.192(2), 386–391. PubMedCAS Google Scholar
Sikora E., Grassilli E., Radziszewska E., Bellesia E., Barbieri D., and Franceschi C. (1993b) Transcription factors DNA-binding activity in rat thymocytes undergoing apoptosis after heat-shock or dexamethasone treatment.Biochem. Biophys. Res. Commun.197(2), 709–715. PubMedCAS Google Scholar
Smeyne R. J., Vendrell M., Hayward M., Baker S. J., Miao G. G., Schilling K., Robertson L. M., Curran T., and Morgan J. I. (1993) Continuous_c-fos_ expression precedes programmed cell death in vivo.Nature363(6425), 166–169. PubMedCAS Google Scholar
Smith C. A., Grimes E. A., McCarthy N. J., and Williams G. T. (1994) Multiple gene regulation of apoptosis: significance in immunology and oncology, in_Apoptosis II, The Molecular Basis of Apoptosis in Disease_, vol. 8 (Tomei L. D. and Cope F. O., eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 43–87. Google Scholar
Smith C. C., Bowen D. M., Sims N. R., Neary D., and Davison A. N. (1983) Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.Brain Res.264(1), 138–141. PubMedCAS Google Scholar
Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., Floyd R. A., and Markesbery W. R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer’s disease.Proc. Natl. Acad. Sci. USA88, 10,540–10,543. CAS Google Scholar
Sonnenberg J. L., Rauscher F. J. III, Morgan J. I., and Curran T. (1989) Regulation of proenkephalin by Fos and Jun.Science246, 1622–1625. PubMedCAS Google Scholar
Spillane J. A., White P., Goodhardt M. J., Flack R. H. A., Bowen D. M., and Davison A. N. (1977) Selective vulnerability of neurones in organic dementia.Nature266, 558–559. PubMedCAS Google Scholar
St. George-Hyslop P., Haines J., Rogaev E., Mortilla M., Vaula G., Pericak V. M., Foncin J. F., Montesi M., Bruni A., Sorbi S., et al. (1992) Genetic evidence for a novel familial Alzheimer’s disease locus on chromosome 14.Nat. Genet.2(4), 330–334. PubMedCAS Google Scholar
Strittmatter W. J., Saunders A. M., Schmechel D., Pericak V. M., Enghild J., Salvesen G. S., and Roses A. D. (1993a) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proc. Natl. Acad. Sci. USA90(5), 1977–1981. PubMedCAS Google Scholar
Strittmatter W. J., Weisgraber K. H., Huang D. Y., Dong L. M., Salvesen G. S., Pericak V. M., Schmechel D., Saunders A. M., Goldgaber D., and Roses A. D. (1993b) Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.Proc. Natl. Acad. Sci. USA90(17), 8098–8102. PubMedCAS Google Scholar
Su J. H., Anderson A. J., Cummings B. J., and Cotman C. W. (1994) Evidence for DNA fragmentation in neurons in the AD brain.Neuroreport5, 2529–2533. PubMedCAS Google Scholar
Tagliavini F., Prelli F., Verga L., Giaccone G., Sarma R., Gorevic P., Ghetti B., Passerini F., Ghibaudi E., Forloni G., et al. (1993) Synthetic peptides homologous to prion protein residues 106–147 form amyloid-like fibrils in vitro.Proc. Natl. Acad. Sci. USA90(20), 9678–9682. PubMedCAS Google Scholar
Takadera T., Sakura N., Mohri T., and Hashimoto T. (1993) Toxic effect of a beta-amyloid peptide (beta 22–35) on the hippocampal neuron and its prevention.Neurosci. Lett.161(1), 41–44. PubMedCAS Google Scholar
Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A. P., St. George-Hyslop P., Van-Keuren M. L., Patterson D., Pagan S., Kurnit D. M., and Neve R. L. (1987) Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.Science235, 880–884. PubMedCAS Google Scholar
Terry R. D., Peck A., DeTheresa R., Schechter R., and Horoupian D. S. (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type.Ann. Neurol.10, 184–192. PubMedCAS Google Scholar
Uemura Y., Kowall N. W., and Moskowitz M. A. (1991) Focal ischemia in rats causes time-dependent expression of c-Fos protein immuno-reactivity in widespread regions of ipsilateral cortex.Brain Res.552(1), 99–105. PubMedCAS Google Scholar
Van Broeckhoven C., Backhovens H., Cruts M., De Winter G., Bruyland M., Cras P., and Martin J. J. (1992) Mapping of a gene predisposing to early-onset Alzheimer’s disease to chromosome 14q24.3.Nat. Genet.2(4), 335–339. PubMed Google Scholar
Vigo P. C., Lee D., Keim P., Lieberburg I., and Schenk D. B. (1993) Characterization of beta-amyloid peptide from human cerebrospinal fluid.J. Neurochem.61(5), 1965–1968. Google Scholar
Walker P. R., Kwast W. J., Gourdeau H., Leblanc J., Neugebauer W., and Sikorska M. (1993) Relationship between apoptosis and the cell cycle in lymphocytes: roles of protein kinase C, tyrosine phosphorylation, and AP1.Exp. Cell Res.207(1), 142–151. PubMedCAS Google Scholar
Waring P. (1990) DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.J. Biol. Chem.265(24), 14,476–14,480. CAS Google Scholar
Watt J., Pike C. J., Walencewicz A. J., and Cotman C. W. (1994) Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons.Brain Res.661(1–2), 147–156. PubMedCAS Google Scholar
Whitson J. S., Selkoe D. J., and Cotman C. W. (1989) Amyloid beta protein enhances the survival of hippocampal neurons in vitro.Science243(4897), 1488–1490. PubMedCAS Google Scholar
Whittemore E. R., Loo D. T., and Cotman C. W. (1994) Hydrogen peroxide induces apoptosis in cultured neurons.Neuroreport5(12), 1485–1488. PubMedCAS Google Scholar
Whyte M. K., Hardwick S. J., Meagher L. C., Savill J. S., and Haslett C. (1993) Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.J. Clin. Invest.92(1), 446–455. PubMedCAS Google Scholar
Wisniewski T., Ghiso J., and Frangione B. (1994) Alzheimer’s disease and soluble Ab.Neurobiol. Aging15(2), 143–152. PubMedCAS Google Scholar
Wisniewski T., Golabek A., Matsubara E., Ghiso J., and Frangione B. (1993) Apolipoprotein E: binding to soluble Alzheimer’s beta-amyloid.Biochem. Biophys. Res. Commun.192(2), 359–365. PubMedCAS Google Scholar
Wyllie A. H., Kerr J. F. R., and Currie A. R. (1980) Cell death: the significance of apoptosis.Int. Rev. Cytol.68, 251–306. PubMedCAS Google Scholar
Wyllie A. H., Morris R. G., Smith A. L., and Dunlop D. (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.J. Pathol.142(1), 67–77. PubMedCAS Google Scholar
Yankner B. A., Dawes L. R., Fisher S., Villa K. L., Oster G. M. L., and Neve R. L. (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer’s disease.Science245(4916), 417–420. PubMedCAS Google Scholar
Yankner B. A., Duffy L. K., and Kirschner D. A. (1990) Neurotrophic and neurotoxic effects of amyloid β-protein: reversal by tachykinin neuropeptides.Science250, 279–282. PubMedCAS Google Scholar
Yonish R. E., Grunwald D., Wilder S., Kimchi A., May E., Lawrence J. J., May P., and Oren M. (1993) p53-mediated cell death: relationship to cell cycle control.Mol. Cell Biol.13(3), 1415–1423. Google Scholar
Yuan J., Shaham S., Ledoux S., Ellis H. M., and Horvitz H. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.Cell75(4), 641–652. PubMedCAS Google Scholar
Zakeri Z. F., Quaglino D., Latham T., and Lockshin R. A. (1993) Delayed internucleosomal DNA fragmentation in programmed cell death.FASEB J.7(5), 470–478. PubMedCAS Google Scholar
Zhang P., Hirsch E. C., Damier P., Duyckaerts C., and Javoy-Agid F. (1992) c-Fos protein-like immuno-reactivity: distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer’s disease.Neuroscience46(1), 9–21. PubMedCAS Google Scholar
Zhong L. T., Sarafian T., Kane D. J., Charles A. C., Mah S. P., Edwards R. H., and Bredesen D. E. (1993)_bcl_-2 inhibits death of central neural cells induced by multiple agents.Proc. Natl. Acad. Sci. USA90(10), 4533–4537. PubMedCAS Google Scholar