Molecular biology of cadherins in the nervous system (original) (raw)

• Amagai M., Klaus-Kovtun V., and Stanley J. R. (1991) Autoantibodies against a novel epithelial cadherin in_Pemphigus vulgaris_, a disease of cell adhesion.Cell 67, 869–877.
  PubMed CAS Google Scholar
• Angres B., Müller A. H. J., Kellermann J., and Hausen P. (1991) Differential expression of two cadherins in_Xenopus laevis_.Development 111, 829–844.
  PubMed CAS Google Scholar
• Bailly A., Le Page C., Raunch M., and Milgrom E. (1986) Sequence-specific DNA binding of the progesterone receptor to the uteroglobin gene: effects of hormone, antihormone and receptor phosphorylation.EMBO J. 5, 32–35.
  Google Scholar
• Behrens J., Birchmeier W., Goodman S.L., and Imhof B. A. (1985) Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-Arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.J. Cell Biol. 101, 1307–1315.
  PubMed CAS Google Scholar
• Behrens J., Löwrick O., Klein-Hitpass L., and Birchmeier W. (1991) The E-cadherin promoter: functional analysis of a G·C-rich region and an epithelial cell-specific palindromic regulatory element.Proc. Natl. Acad. Sci. USA 88, 11,495–11,499.
  CAS Google Scholar
• Behrens J., Vakaet L., Friis R., Winter E., Van Roy F., Mareel M. M., and Birchmeier W. (1993) Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.J. Cell Biol. 120, 757–766.
  PubMed CAS Google Scholar
• Bertolotti R., Rutishauser U. S., and Edelman G. M. (1980) A cell surface molecule involved in aggregation of embryonic liver cells.Proc. Natl. Acad. Sci. USA 77, 4831–4835.
  PubMed CAS Google Scholar
• Biddlestone L. R. and Fleming S. (1991) Morphological evidence that A-CAM is a major intercellular adhesion molecule in human kidney.J. Pathol. 164, 9–15.
  PubMed CAS Google Scholar
• Bixby J. L., and Harris W. A. (1991) Molecular mechanisms of axon growth and guidance.Ann. Rev. Cell Biol. 7, 117–159.
  PubMed CAS Google Scholar
• Bixby J. L. and Jhabvala P. (1990) Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms.J. Cell Biol. 111, 2725–2732.
  PubMed CAS Google Scholar
• Bixby J. L. and Zhang R. (1990) Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.J. Cell. Biol. 110, 1253–1260.
  PubMed CAS Google Scholar
• Bixby J. L., Pratt R. S., Lilien J., and Reichardt L. F. (1987) Neurite outgrowth on muscle cell surfaces involves extracellular matrix receptors as well as Ca2+-dependent and-independent cell adhesion molecules.Proc. Natl. Acad. Sci. USA 84, 2555–2559.
  PubMed CAS Google Scholar
• Bixby J. L., Lilien J., and Reichardt L. F. (1988) Identification of the major proteins that promote neuronal process outgrowth on Schwann cells_in vitro_.J. Cell. Biol. 107, 353–361.
  PubMed CAS Google Scholar
• Blaschuk O. W. and Farookhi R. (1989) Estradiol stimulates cadherin expression in rat granulosa cells.Dev. Biol. 136, 564–567.
  PubMed CAS Google Scholar
• Blaschuk O. W., Pouliot Y., and Holland P. C. (1990a) Identification of a conserved region common to cadherins and influenza strain A hemagglutinins.J. Mol. Biol. 211, 679–682.
  PubMed CAS Google Scholar
• Blaschuk O. W., Sullivan D. S., and Pouliot Y. (1990b) Identification of a cadherin cell adhesion recognition sequences.Dev. Biol. 139, 227–229.
  PubMed CAS Google Scholar
• Bock E. (1991) Cell-cell adhesion molecules.Biochem. Soc. Trans. 19, 1076–1080.
  PubMed CAS Google Scholar
• Boller K., Vestweber D., and Kemlers R. (1985) Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.J. Cell Biol. 100, 327–332.
  PubMed CAS Google Scholar
• Butz S., Stappert J., Weissig H., and Kemler R. (1992) Plakoglobin and β-catenin: distinct but closely related.Science 257 1142–1143.
  PubMed CAS Google Scholar
• Chen B., Blaschuk O. W., and Hales B. F. (1991) Cadherin mRNAs during rat embryo development in vivo and_in vitro_.Teratology 44, 581–590.
  PubMed CAS Google Scholar
• Choi Y. S. and Gumbiner B. (1989) Expression of cell adhesion molecule E-cadherin in_Xenopus_ embryos begins at gastrulation and predominates in the ectoderm.J. Cell Biol. 108, 2449–2458.
  PubMed CAS Google Scholar
• Choi Y. S., Sehgal R., McCrea P., and Gumbiner B. (1990) A cadherin-like protein in eggs and cleaving embryos of_Xenopus laevis_ is expressed in oocytes in response to progesterone.J. Cell Biol. 110, 1575–1582.
  PubMed CAS Google Scholar
• Chuah M. I., David S., and Blaschuk O. (1991) Differentiation and survival of rat olfactory epithelial neurons in dissociated cell culture.Dev. Brain Res. 60, 123–132.
  CAS Google Scholar
• Covault J., Liu Q. Y., and El D. S. (1991) Calcium-activated proteolysis of intercellular domains in the cell adhesion molecules NCAM and N-cadherin.Mol. Brain Res. 11, 11–16.
  PubMed CAS Google Scholar
• Crittenden S. L., Rutishauser U., and Lilien J. (1988) Identification of two structural types of calcium-dependent adhesion molecules in the chicken embryo.Proc. Natl. Acad. Sci. USA 85, 3464–3468.
  PubMed CAS Google Scholar
• Crossin K. L., Chuong C. M., and Edelman G. M. (1985) Expression sequences of cell adhesion molecules.Proc. Natl. Acad. Sci. USA 82, 6942–6946.
  PubMed CAS Google Scholar
• Dalseg A. M., Andersson A. M., and Bock E. (1990) Characterization of N-cadherin mRNA in chicken brain and heart by means of oligonucleotide probes.FEBS Lett. 262, 234–236.
  PubMed CAS Google Scholar
• Damsky C. H., Richa J., Solter D., Knudsen K., and Buck C. A. (1983) Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue.Cell 34, 455–466.
  PubMed CAS Google Scholar
• Detrick R. J., Dickey D., and Kintner C. R. (1990) The effects of N-cadherin misexpression on morphogenesis in_Xenopus_ embryos.Neuron 4, 493–506.
  PubMed CAS Google Scholar
• Doherty P., Rowett L. H., Moore S. E., Mann D. A., and Walsh F. S. (1991a) Neurite outgrowth in response to transfected NCAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs.Neuron 6, 247–258.
  PubMed CAS Google Scholar
• Doherty P., Ashton S. V., Moore S. E., and Walsh F. S. (1991b) Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L-and N-type neuronal Ca2+-channels.Cell 67, 21–33.
  PubMed CAS Google Scholar
• Doherty P., Ashton S. V., Skaper S. D., Leon A., and Walsh F. S. (1992) Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth.J. Cell Biol. 117, 1093–1099.
  PubMed CAS Google Scholar
• Donalies M., Cramer M., Ringwald M., and Starzinski-Powitz A. (1991) Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.Proc. Natl. Acad. Sci. USA 88, 8024–8028.
  PubMed CAS Google Scholar
• Drazba J. and Lemmon V. (1990) The role of cell adhesion molecules in neurite outgrowth on Müller cells.Dev. Biol. 138, 82–93.
  PubMed CAS Google Scholar
• Duband J. L., Dufour S., Hatta K., Takeichi M., Edelman G. M. and Thiery J. P. (1987) Adhesion molecules during somitogenesis in the avian embryo.J. Cell Biol. 104, 1361–1374.
  PubMed CAS Google Scholar
• Duband J. L., Volberg T., Sabanay I., Thiery J. P., and Geiger B. (1988) Spatial and temporal distribution of the adherens junction-associated adhesion molecule A-CAM during avian embryogenesis.Development 103, 325–344.
  PubMed CAS Google Scholar
• Dunia I., Nicolas J. F., Jacob H., Benedetti E. L., and Jacob F. (1979) Junctional modulation in mouse embryonal carcinoma cells by Fab fragments of rabbit anti-embryonal carcinoma cell serum.Proc. Natl. Acad. Sci. USA 76, 3387–3391.
  PubMed CAS Google Scholar
• Edelman G. M., Murray B. A., Mège R. M., Cunningham B. A., and Gallin W. J. (1987) Cellular expression of liver and neural cell adhesion molecules after transfection with their cDNAs results in specific cell-cell binding.Proc. Natl. Acad. Sci. USA 84, 8502–8506.
  PubMed CAS Google Scholar
• Edelman G. M. and Crossin K. L. (1991) Cell adhesion molecules: implications for a molecular histology.Ann. Rev. Biochem. 60, 155–190.
  PubMed CAS Google Scholar
• Edelman G. M. and Cunningham B. A. (1990) Place-dependent cell adhesion, process retraction, and spatial signaling in neural morphogenesis.Cold Spring Harbor Symposium on Quantitative Biol. LV, 303–318.
  Google Scholar
• Eidelman S., Damsky C. H., Wheelock M. J., and Damjanov I. (1989) Expression of the cell-cell adhesion glycoprotein Cell-CAM 120/80 in normal human tissues and tumors.Am. J. Pathol. 135, 101–111.
  PubMed CAS Google Scholar
• Eistetter H. R., Adolph S., Ringwald M., Simon-Chazottes D., Schuh R., Guénet J. L., and Kemler R. (1988) Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin.Proc. Natl. Acad. Sci. USA 85, 3489–3493.
  PubMed CAS Google Scholar
• Fisher G. and Schachner M. (1988) Characterization of Ca2+-dependent and-independent aggregation mechanisms among mouse cerebellar cells.Dev. Brain Res. 43, 39–47.
  Google Scholar
• Friedlander D. R., Mège R. M., Cunningham B. A., and Edelman G. M. (1989) Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces.Proc. Natl. Acad. Sci. USA 86, 7043–7047.
  PubMed CAS Google Scholar
• Fujimori T., Miyatani S., and Takeichi M. (1990) Ectopic expression of N-cadherin perturbs histogenesis in_Xenopus_ embryos.Development 110, 97–104.
  PubMed CAS Google Scholar
• Gallin W. J., Edelman G. M., and Cunningham B. A. (1983) Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells.Proc. Natl. Acad. Sci. USA 80, 1038–1042.
  PubMed CAS Google Scholar
• Gallin W. J., Prediger E. A., Edelman G. M., and Cunningham B. A. (1985) Isolation of a cDNA clone for the liver cell adhesion molecule (L-CAM).Proc. Natl. Acad. Sci. USA 82, 2809–2813.
  PubMed CAS Google Scholar
• Gallin W. J., Sorkin B. C., Edelman G. M., and Cunningham B. A. (1987) Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM.Proc. Natl. Acad. Sci. USA 84, 2808–2812.
  PubMed CAS Google Scholar
• Geiger B. (1989) Cytoskeleton-associated cell contacts.Curr. Opin. Cell Biol. 1, 103–109.
  PubMed CAS Google Scholar
• Geiger B., Volk T., Volberg T., and Bendori R. (1987) Molecular interactions in adherens-type contacts.J. Cell Sci. Suppl. 8, 251–272.
  PubMed CAS Google Scholar
• Geiger B., Volberg T., Ginsberg D., Bitzur S., Sabanay I., and Hynes R. O. (1990a) Broad spectrum pancadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin.J. Cell Sci. 7, 607–614.
  Google Scholar
• Geiger B., Ginsberg D., Salomon D., and Volberg T. (1990b) The molecular basis for the assembly and modulation of adherens-type junctions.Cell. Differ. Dev. 32, 343–353.
  PubMed CAS Google Scholar
• Ginsberg D., DeSimone D., and Geiger B. (1991) Expressionof a novel cadherin (EP-cadherin) in unfertilized eggs and early_Xenopus_ embryos.Development 111, 315–325.
  PubMed CAS Google Scholar
• Grunwald G. B., Pratt R. S., and Lilien J. (1982) Enzymic dissection of embryonic cell adhesive mechanisms. III. immunological identification of a component of the calcium-dependent adhesive system of embryonic chick neural retina cells.J. Cell Sci. 55, 69–83.
  PubMed CAS Google Scholar
• Gumbiner B and Simons K. (1986) A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.J. Cell Biol. 102, 457–468.
  PubMed CAS Google Scholar
• Hatta K. and Takeichi M. (1986) Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development.Nature 320, 447–449.
  PubMed CAS Google Scholar
• Hatta K., Okada T. S., and Takeichi M. (1985) A monoclonal antibody disrupting calcium-dependent cell-cell adhesion of brain tissues: possible role of its target antigen in animal patter formation.Proc. Natl. Acad. Sci. USA 87, 2789–2793.
  Google Scholar
• Hatta K., Takagi S., Fujisawa H., and Takeichi M. (1987) Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos.Dev. Biol. 120, 215–227.
  PubMed CAS Google Scholar
• Hatta K., Nose A., Nagafuchi A., and Takeichi M. (1988) Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family.J. Cell Biol. 106, 873–881.
  PubMed CAS Google Scholar
• Hatta M., Miyatani S., Copeland N. G., Gilbert D. J., Jenkins N. A., and Takeichi M. (1991) Genomic organization and chromosomal mapping of the mouse P-cadherin gene.Nucleic Acids Res. 19, 4437–4441.
  PubMed CAS Google Scholar
• Heimark R. L., Degner M., and Schwartz S. M. (1990) Identification of a Ca2+-dependent cell-cell adhesion molecule in endothelial cells.J. Cell Biol. 110, 1745–1756.
  PubMed CAS Google Scholar
• Herrenknecht K., Ozawa M., Eckerskorn C., Lottspeich F., Lenter M., and Kemler R. (1991) The uvomorulin-anchorage protein α-catenin is a vinculin homolog.Proc. Natl. Acad. Sci. USA 88, 9156–9160.
  PubMed CAS Google Scholar
• Herzberg F., Poting A., and Wedlich D. (1990) Identification of Ca2+-dependent cell adhesion molecules in_Xenopus_ by the use of interspecies homology.Differentiation 44, 1–7.
  PubMed CAS Google Scholar
• Herzberg F., Wildermuth V., and Wedlich D. (1991) Expression of XBcad, a novel cadherin, during oogenesis and early development of_Xenopus_.Mech. Dev. 35, 33–42.
  PubMed CAS Google Scholar
• Heslip J., Bagchi M., Zhang S., Alousi S., and Maisel H. (1986) An intrinsic membrane glycoprotein of the lens.Curr. Eye Res. 12, 949–958.
  Google Scholar
• Hirano S., Nose A., Hatta K., Kawakami A., and Takeichi M. (1987) Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles.J. Cell Biol. 105, 2501–2510.
  PubMed CAS Google Scholar
• Hirano S., Kimoto N., Shimoyama Y., Hirohashi S., and Takeichi M. (1992) Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization.Cell 70, 293–301.
  PubMed CAS Google Scholar
• Hyafil F., Morello D., Babinet C., and Jacob F. (1980) A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos.Cell 21, 927–934.
  PubMed CAS Google Scholar
• Hyafil F., Babinet C., and Jacob F. (1981) Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium.Cell 26, 447–454.
  PubMed CAS Google Scholar
• Hynes R. O. and Lander A. D. (1992) Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons.Cell 68, 303–322.
  PubMed CAS Google Scholar
• Imhof B. A., Vollmers H. P., Goodman S. L., and Birchmeier W. (1983) Cell-cell interactions and polarity of epithelial cells: specific pertubation using a monoclonal antibody.Cell 35, 667–675.
  PubMed CAS Google Scholar
• Inuzuka H., Miyatani S., and Takeichi M. (1991a) R-cadherin: a novel Ca2+-dependent cell-cell adhesion molecule expressed in the retina.Neuron 7, 69–79.
  PubMed CAS Google Scholar
• Inuzuka H., Redies C., and Takeichi M. (1991b) Differential expression of R- and N-cadherin in neural and mesodermal tissues during early chicken development.Development 113, 959–967.
  PubMed CAS Google Scholar
• Itoh M., Yonemura S., Nagafuchi A., and Tsukita S. (1991) A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites.J. Cell Biol. 115, 1449–1462.
  PubMed CAS Google Scholar
• Kemler R., Babinet C., Eisen H., and Jacob F. (1977) Surface antigen in early differentiation.Proc. Natl. Acad. Sci. USA 74, 4449–4452.
  PubMed CAS Google Scholar
• Kemler R. and Ozawa M. (1989) Uvomorulin-catenin complex: cytoplasmic anchorage of a Ca2+-dependent cell adhesion molecule.BioEssays 11, 88–91.
  PubMed CAS Google Scholar
• Knudsen K. A. and Wheelock M. J. (1992) Plakoglobin, or an 83-kD homolog distinct from β-catenin, interacts with E-cadherin and N-cadherin.J. Cell Biol. 118, 671–679.
  PubMed CAS Google Scholar
• Korman N. J., Russel M. D., Eyre W., Klaus-Kovtun V., and Stanley J. R. (1989) Demonstration of an adhering-junction molecule (plakoglobin) in the autoantigens of_pemphigus foliaceus_ and_Pemphigus vulgaris_.N. Engl. J. Med. 321, 631–635.
  PubMed CAS Google Scholar
• Lagunowich L. A. and Grunwald G. B. (1989) Expression of calcium-dependent cell adhesion during ocular development: a biochemical, histochemical, and functional analysis.Dev. Biol. 135, 158–171.
  PubMed CAS Google Scholar
• Lagunowich L. A. and Grunwald G. B. (1991) Tissue- and age-specificity of post-translational modifications of N-cadherin during chick embryo development.Differentiation 47, 19–27.
  PubMed CAS Google Scholar
• Lagunowich L. A., Donoso L. A., and Grunwald G. B. (1990) Identification of mammalian and invertebrate analogs of the avian calcium-dependent cell adhesion protein N-cadherin with synthetic-peptide directed antibodies against a conserved cytoplasmic domain.Biochem. Biophys. Res. Commun. 172, 313–320.
  PubMed CAS Google Scholar
• Lagunowich L. A., Schneider J. C., Chasen S., and Grunwald G. (1992) Immunohistochemical and biochemical analysis of N-cadherin expression during CNS development.J. Neurosci. Res. 32, 202–208.
  PubMed CAS Google Scholar
• Leask A., Rosenberg M., Vassar R., and Fuchs E. (1990) Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription.Genes Dev. 4, 1985–1998.
  PubMed CAS Google Scholar
• Lemmon V., Burden S. M., Payne H. R., Elmslie G. J., and Hlavin M. L. (1992) Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength.J. Neurosci. 12, 818–826.
  PubMed CAS Google Scholar
• Letourneau P. C., Shattuck T. A., Roche F. K., Takeichi M., and Lemmon V. (1990) Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin.Dev. Biol. 138, 430–442.
  PubMed CAS Google Scholar
• Letourneau P. C., Roche F. K., Shattuck T. A., Lemmon V., and Takeichi M. (1991) Interactions of Schwann cells with neurites and with other Schwann cells involve the calcium-dependent adhesion molecule, N-cadherin.J. Neurobiol. 22, 707–720.
  PubMed CAS Google Scholar
• Levi G., Crossin K. L., and Edelman G. M. (1987) Expression sequences and distribution of two primary cell adhesion molecules during embryonic development of_Xenopus laevis_.J. Cell Biol. 105, 2359–2372.
  PubMed CAS Google Scholar
• Levi G., Ginsberg D., Girault J-M., Sabanay I., Thiery J. P., and Geiger B. (1991) EP-cadherin in muscles and epithelia of_Xenopus laevis_ embryos.Development 113, 1335–1344.
  PubMed CAS Google Scholar
• Liaw C. W., Cannon C., Power M. D., Kiboneka P. K., and Rubin L. L. (1990) Identification and cloning of two species of cadherins in bovine endothelial cells.EMBO J. 9, 2701–2708.
  PubMed CAS Google Scholar
• Mahoney P. A., Weber U., Onofrechuk P., Biessmann H., Bryant P. J., and Goodman C. S. (1991) The_fat_ tumor suppressor gene in_Drosophila_ encodes a novel member of the cadherin gene superfamily.Cell 67, 853–868.
  PubMed CAS Google Scholar
• Maisel H. and Atreya P. (1990) N-cadherin detected in the membrane fraction of lens fiber cells.Experientia 46, 222–223.
  PubMed CAS Google Scholar
• Mansouri A., Spurr N., Goodfellow P. N., and Kemler R. (1988) Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.Differentiation 38, 67–71.
  PubMed CAS Google Scholar
• Mareel M., Vleminckx K., Vermeulen S., Bracke M., and van Roy F. (1992) Expression of E-cadherin: a counterbalance for cancer cell invasion.Bull. Cancer 79, 347–355.
  PubMed CAS Google Scholar
• Matsunaga M., Hatta K., and Takeichi M. (1988a) Role of N-cadherin cell adhesion molecules in the histogenesis of neural retina.Neuron 1, 289–295.
  PubMed CAS Google Scholar
• Matsunaga M., Hatta K., Nagafuchi A., and Takeichi M. (1988b) Guidance of optic nerve fibres by N-cadherin adhesion molecules.Nature 334, 62–64.
  PubMed CAS Google Scholar
• Matsuzaki F., Mège R. M., Jaffe S. H., Friedlander D. R., Gallin W. J., Goldberg J. I. Cunningham B. A., and Edelman G. M. (1990) cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells.J. Cell Biol. 110, 1239–1252.
  PubMed CAS Google Scholar
• Matsuyoshi N., Hamaguchi M., Taniguchi S., Nagafuchi A., Tsukita S., and Takeichi M. (1992) Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.J. Cell Biol. 118, 703–714.
  PubMed CAS Google Scholar
• McCrea P. D. and Gumbiner B. M. (1991) Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure.J. Biol. Chem. 266, 4514–4520.
  PubMed CAS Google Scholar
• McCrea P. D., Turck C. W., and Gumbiner B. (1991) A homolog of the armadillo protein in_Drosophila_ (plakoglobin) associated with E-cadherin.Science 254, 1359–1361.
  PubMed CAS Google Scholar
• McNeill H., Ozawa M., Kemler R., and Nelson W. J. (1990) Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity.Cell 62, 309–316.
  PubMed CAS Google Scholar
• Mège R. M., Matsuzaki F., Gallin W. J., Golberg J. I., Cunningham B. A., and Edelman G. M. (1988) Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.Proc. Natl. Acad. Sci. USA 85, 7274–7278.
  PubMed Google Scholar
• Miyatani S., Shimamura K., Hatta M., Nagafuchi A., Nose A., Matsunaga M., Hatta K., and Takeichi M. (1989) Neural cadherin: role in selective cell-cell adhesion.Science 245, 631–635.
  PubMed CAS Google Scholar
• Miyatani S., Copeland N. G., Gilbert D. J. Jenkins N. A., and Takeichi M. (1992) Genomic structure and chromosomal mapping of the mouse N-cadherin gene.Proc. Natl. Acad. Sci. USA 89, 8443–8447.
  PubMed CAS Google Scholar
• Müller A. H. J., Angres B., and Hausen P. (1992) U-cadherin in_Xenopus_ oogenesis and oocyte maturation,Development 114, 533–543.
  Google Scholar
• Møller C. J., Christgau S., Williamsson M. R., Madsen O. D., Zhan-Po N., Bock E., and Bækkeskov S. (1992) Differential expression of NCAM and cadherins in pancreatic islets, glucagonomas and insulinomas cells evidences sequential lineage and differences in neuronal traits.Mol. Endocrinol. 6, 1332–1342.
  PubMed Google Scholar
• Nagafuchi A. and Takeichi M. (1988) Cell binding function of E-cadherin is regulated by the cytoplasmic domain.EMBO J. 7, 3679–3684.
  PubMed CAS Google Scholar
• Nagafuchi A. and Takeichi M. (1989) Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.Cell Reg. 1, 37–44.
  CAS Google Scholar
• Nagafuchi A., Shirayoshi Y., Okazaki K., Yasuda K., and Takeichi M. (1987) Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA.Nature 329, 341–343.
  PubMed CAS Google Scholar
• Nagafuchi A., Takeichi M., and Tsukita S. (1991) The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.Cell 65, 849–857.
  PubMed CAS Google Scholar
• Napolitano E. W., Venstrom K., Wheeler E. F., and Reichardt L. F. (1991) Molecular cloning and characterization of β-cadherin, a novel chick cadherin.J. Cell Biol. 113, 893–905.
  PubMed CAS Google Scholar
• Neugebauer K. M., Tomaselli K. J., Lilien J., and Reichardt L. F. (1988) N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes_in vitro_.J. Cell Biol. 107, 1177–1187.
  PubMed CAS Google Scholar
• Nicholson L. J., Pei X. F., and Watt F. M. (1991) Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture.Carcinogenesis 12, 1345–1349.
  PubMed CAS Google Scholar
• Nomura K., Tajima T., Nomura H., Shiraishi H., Uchida M., and Yamana K. (1988) Cell to cell adhesion systems in_Xenopus laevis_, the South African clawed toad. II: Monoclonal antibody against a novel Ca2+-dependent cell-cell adhesion glycoprotein on amphibian cells.Cell Differ. 23, 207–212.
  PubMed CAS Google Scholar
• Nose A. and Takeichi M. (1986) A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos.J. Cell Biol. 103, 2649–2658.
  PubMed CAS Google Scholar
• Nose A., Nagafuchi A., and Takeichi M. (1987) Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules.EMBO J. 6, 3655–3661.
  PubMed CAS Google Scholar
• Nose A., Nagafuchi A., and Takeichi M. (1988) Expressed recombinant cadherins mediate cell sorting in model systems.Cell 54, 993–1001.
  PubMed CAS Google Scholar
• Nose A., Tsuji K., and Takeichi M. (1990) Localization of specificity determining sites in cadherin cell adhesion molecules.Cell 61, 147–155.
  PubMed CAS Google Scholar
• Ozawa M. and Kemler R. (1992) Molecular organization of the uvomorulin-catenin complex.J. Cell Biol. 116, 989–996.
  PubMed CAS Google Scholar
• Ozawa M., Baribault H., and Kemler R. (1989) The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.EMBO J. 8, 1711–1717.
  PubMed CAS Google Scholar
• Ozawa M., Engel J., and Kemler R. (1990a) Single amino acid substitutions in one Ca2+-binding site of uvomorulin abolish the adhesive function.Cell 63, 1033–1038.
  PubMed CAS Google Scholar
• Ozawa M., Ringwald M., and Kemler R. (1990b) Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.Proc. Natl. Acad. Sci. USA 87, 4246–4250.
  PubMed CAS Google Scholar
• Ozawa M., Hoschützky H., Herrenknecht K., and Kemler R. (1991) A possible new adhesive site in the cell-adhesion molecule uvomorulin.Mech. Dev. 33, 49–56.
  Google Scholar
• Payne H. R., Burden S. M., and Lemmon V. (1992) Modulation of growth cone morphology by substrate-bound adhesion molecules.Cell Motil. Cyt. 21, 65–73.
  CAS Google Scholar
• Peifer M., McCrea P. D., Green K. J., Wieschaus E., and Gumbiner B. (1992) The vertebrate adhesive junction proteins, β-catenin and plakoglobin and the_Drosophila_ segment polarity gene armadillo form a multigene family with similar properties.J. Cell Biol. 118, 681–691.
  PubMed CAS Google Scholar
• Peyriéras N., Hyafil F., Louvard D., Ploegh H. L., and Jacob F. (1983) Uvomorulin: a nonintegral membrane protein of early mouse embryo.Proc. Natl. Acad. Sci. USA 80, 6274–6277.
  PubMed Google Scholar
• Peyriéras N., Louvard D., and Jacob F. (1985) Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin.Proc. Natl. Acad. Sci. USA 82, 8067–8071.
  PubMed Google Scholar
• Ranscht B. and Bronner-Fraser M. (1991) T-cadherin expression alternates with migrating neural crest cells in the trunk of the avian embryo.Development 111, 15–22.
  PubMed CAS Google Scholar
• Ranscht B. and Dours-Zimmermann M. T. (1991) T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region.Neuron 7, 391–402.
  PubMed CAS Google Scholar
• Redies C., Inuzuka H., and Takeichi M. (1992) Restricted expression of N- and R-cadherin on neurities of the developing chicken CNS.J. Neurosci. 12, 3525–3534.
  PubMed CAS Google Scholar
• Reichardt L. F., Bossy B., Carbonetto S., de Curtis I., Emmet C., Hall D. E., Ignatius M. J., Lefcort F., Napolitano E., Large T., Neugebauer K. M., and Tomaselli K. J. (1990) Neuronal receptors that regulate axon growth.Cold Spring Harbor Symposium on Quantitative Biol. LV, 341–350.
  Google Scholar
• Reid R. A. and Hemperly J. J. (1990) Human N-cadherin: nucleotide and deduced amino acid sequence.Nucleic Acid Res. 18, 5896.
  PubMed CAS Google Scholar
• Ringwald M., Schuh R., Vestweber D., Eistetter H., Lottspeich F., Engel J., Dölz R., Jähnig F., Epplen J., Mayer S., Müller C., and Kemler R. (1987) The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion.EMBO J. 6, 3647–3653.
  PubMed CAS Google Scholar
• Ringwald M., Baribault H., Schmidt C., and Kemler R. (1991) The structure of the gene coding for the mouse cell adhesion molecule uvomorulin.Nucleic Acid Res. 19, 6533–6539.
  PubMed CAS Google Scholar
• Salomon D., Ayalon O., Patel King R., Hynes R. O., and Geiger B. (1992) Extrajunctional distribution of N-cadherin in cultured human endothelial cells.J. Cell Biol. 102, 7–17.
  CAS Google Scholar
• Sefton M., Johnson M. H., and Clayton L. (1992) Synthesis and phosphorylation of uvomorulin during mouse early development.Development 115, 313–318.
  PubMed CAS Google Scholar
• Schuh R., Vestweber D., Riede I., Ringwald M., Rosenberg U. B., Jäckle H., and Kemler R. (1986) Molecular cloning of the mouse cell adhesion molecule uvomorulin: cDNA contains a B1-related sequence.Proc. Natl. Acad. Sci. USA 83, 1364–1368.
  PubMed CAS Google Scholar
• Serbedzija G. N., Bronner-Fraser M., and Fraser S. E. (1989) A vital dye analysis of the timing and pathways of avian trunk neural crest cell migration.Development 106, 809–816.
  PubMed CAS Google Scholar
• Shimoyama Y., Hirohashi S., Hirano S., Noguchi M., Shimosato Y., Takeichi M., and Abe O. (1989a) Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.Cancer Res. 49, 2128–2133.
  PubMed CAS Google Scholar
• Shimoyama Y., Yoshida T., Terada M., Shimosato Y., Abe O., and Hirohashi S. (1989b) Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues,J. Cell Biol. 109, 1787–1794.
  PubMed CAS Google Scholar
• Shirayoshi Y., Nose A., Iwasaki K., and Takeichi M. (1986) N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin.Cell Struct. Funct. 11, 245–252.
  PubMed CAS Google Scholar
• Smale S. T. and Baltimore D. (1989) The “initiator” as a transcription control element.Cell 57, 103–113.
  PubMed CAS Google Scholar
• Smale S. T., Schmidt M. C., Berk A. J., and Baltimore D. (1990) Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.Proc. Natl. Acad. Sci. USA 87, 4509–4513.
  PubMed CAS Google Scholar
• Snape A. M., Jonas E. A., and Sargent T. D. (1990) KTF-1, a transcriptional activator of_Xenopus_ embryonic keratin expression.Development 109, 157–165.
  PubMed CAS Google Scholar
• Sorkin B. C., Hemperly J. J., Edelman G. M., and Cunningham B. A. (1988) Structure of the gene for the liver cell adhesion molecule, L-CAM.Proc. Natl. Acad. Sci. USA 85, 7617–7621.
  PubMed CAS Google Scholar
• Sorkin B. C., Gallin W. J., Edelman G. M., and Cunningham B. A. (1991) Genes for two calcium-dependent cell adhesion molecules have similar structures and are arranged in tandem in the chicken genome.Proc. Natl. Acad. Sci. USA 88, 11,545–11,549.
  CAS Google Scholar
• Suzuki S., Sano K., and Tanihara H. (1991) Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.Cell Reg. 2, 261–270.
  CAS Google Scholar
• Takeichi M. (1977) Functional correlation between cell adhesive properties and some cell surface proteins.J. Cell Biol. 75, 464–474.
  PubMed CAS Google Scholar
• Takeichi M. (1988) The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.Development 102, 639–655.
  PubMed CAS Google Scholar
• Takeichi M. (1990) Cadherins: a molecular family important in selective cell-cell adhesion.Ann. Rev. Biochem. 59, 237–252.
  PubMed CAS Google Scholar
• Takeichi M. (1991) Cadherin cell adhesion receptors as a morphogenetic regulator.Science 251, 1451–1455.
  PubMed CAS Google Scholar
• Takeichi M., Atsumi T., Yoshida C., Uno K., and Okada T. S. (1981) Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites.Dev. Biol. 87, 340–350.
  PubMed CAS Google Scholar
• Takeichi M., Inuzuka H., Shimamura K., Fujimori T., and Nagafuchi A. (1990a) Cadherin subclasses: differential expression and their roles in neural morphogenesis.Cold Spring Harbor Symposium on Quantitative Biol. 55, 319–325.
  CAS Google Scholar
• Takeichi M., Inuzuka H., Shimamura K., Matsunaga M., and Nose A. (1990b) Cadherin-mediated cell-cell adhesion and neurogenesis.Neurosci. Res. Suppl. 13, S92-S96.
  PubMed CAS Google Scholar
• Teillet M. A., Kalcheim C., and Le Douarin N. M. (1987) Formation of the dorsal root ganglia in the avian embryo: segmental origin and migratory behavior of neural crest progenitor cells.Dev. Biol. 120, 329–347.
  PubMed CAS Google Scholar
• Thiery J. P., Delouvee A., Gallin W. J., Cunningham B. A., and Edelman G. M. (1984) Ontogenetic expression of cell adhesion molecules: L-CAM is found in epithelial derived from the three primary germ layers.Dev. Biol. 102, 61–78.
  PubMed CAS Google Scholar
• Tomaselli K. J., Neugebauer K. M., Bixby J. L., Lilien J., and Reichardt L. F. (1988) N-cadherin and integrins: two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces.Neuron 1, 33–43.
  PubMed CAS Google Scholar
• Tsukita S., Tsukita S., and Nagafuchi A. (1990) The undercoat of adherens junctions: a key specialized structure in organogenesis and carcinogenesis.Cell. Struct. Funct. 15, 7–12.
  PubMed CAS Google Scholar
• Van Roy F. and Mareel M. (1992) Tumour invasion: effects of cell adhesion and motility.Trends Cell Biol. 2, 163–169.
  PubMed Google Scholar
• Vestal D. J. and Ranscht B. (1992) Glycosyl phosphatidylinositol-anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.J. Cell Biol. 119, 451–461.
  PubMed CAS Google Scholar
• Vestweber D. and Kemler R. (1984) Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues.Exp. Cell Res. 152, 169–178.
  PubMed CAS Google Scholar
• Vestweber D. and Kemler R. (1985) Identification of a putative cell adhesion domain of uvomorulin.EMBO J. 4, 3393–3398.
  PubMed CAS Google Scholar
• Volk T. and Geiger B. (1984) A 135-kd membrane protein of intercellular adherens junctions.EMBO J. 3, 2249–2260.
  PubMed CAS Google Scholar
• Volk T. and Geiger B. (1986a) A-CAM: a 135-kD receptor of intercellular adherens junctions. I. Immunoelectron microscopic localization and biochemical studies.J. Cell Biol. 103, 1441–1450.
  PubMed CAS Google Scholar
• Volk T. and Geiger B. (1986b) A-CAM: a 135-kD receptor of intercellular adherens junctions. II. Antibody-mediated modulation of junction formation.J. Cell Biol. 103, 1451–1464.
  PubMed CAS Google Scholar
• Volk T., Cohen O., and Geiger B. (1987) Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM-containing lens cells.Cell 50, 987–994.
  PubMed CAS Google Scholar
• Volk T., Volberg T., Sabanay I., and Geiger B. (1990) Cleavage of A-CAM by endogenous proteinases in cultured lens cells and in developing chick embryos.Dev. Biol. 139, 314–326.
  PubMed CAS Google Scholar
• Wagner A. P., Beck K. D., and Reck G. (1992) Neural cell adhesion molecule (NCAM) and N-cadherin mRNA during development and aging: selective reduction in the 7.4-kb and 6.7kb NCAM mRNA levels in the hippocampus of adult and old rats.Mech. Aging Dev. 62, 201–208.
  PubMed CAS Google Scholar
• Walsh F. S., Barton C. H., Putt W., Moore S. E., Kelsell D., Spurr N., and Goodfellow P. N. (1990) N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.J. Neurochem. 55, 805–812.
  PubMed CAS Google Scholar
• Wheeler G. N., Buxton R. S., Parker A. E., Arnemann J., Rees D. A., King I. A., and Magee A. I. (1991) Desmosomal glycoproteins, I, II and III: novel members of the cadherin superfamily.Biochem. Soc. Trans. 19, 1060–1064.
  PubMed CAS Google Scholar
• Wheelock M. J. and Knudsen K. A. (1991) N-cadherin-associated proteins in chicken muscle.Differentiation 5, 505–513.
  CAS Google Scholar
• Wheelock M. J., Buck C. A., Bechtol K. B., and Damsky C. H. (1987) Soluble 80-kd fragment of Cell-CAM 120/80 disrupts cell-cell adhesion.J. Cell. Biochem. 34, 187–202.
  PubMed CAS Google Scholar
• Yoshida C. and Takeichi M. (1982) Teratocarcinoma cell adhesion: identification of a cell-surface protein involved in calcium-dependent cell aggregation.Cell 28, 217–224.
  PubMed CAS Google Scholar
• Yoshida-Noro C., Suzuki N., and Takeichi M. (1984) Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody.Dev. Biol. 101, 19–27.
  PubMed CAS Google Scholar