The immune S ystem in the elderly (original) (raw)

• Cossarizza A, Ortolani C, Monti D, Franceschi C: Cytometric analysis of immunosenescence. Cytometry 1997;27:297–313.
  Article PubMed CAS Google Scholar
• Makinodan T, Kay MMB: Age influence on the immune system. Adv. Immunol. 1980;29:287–330.
  PubMed CAS Google Scholar
• Pawelec G, Rehbein A, Haehnel K, Merl A, Adibzadeh M: Human T-cell clones in long-term culture as a model of immunosenescence. Immunol. Rev. 1997;160:31–42.
  Article PubMed CAS Google Scholar
• Roberts-Thomson IC, Whittingham S, Young-Chaiyud U, Mackay IR: Ageing, immune response and mortality. Lancet 1974;ii:368–370.
  Article Google Scholar
• Wayne SJ, Rhyne RL, Garry PJ, Goodwin JS: Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol. 1990;45:45–48.
  Google Scholar
• Doria G, Frasca D: Genes, immunity, and senescence: looking for a link. Immunol. Rev. 1997;160:159–170.
  Article PubMed CAS Google Scholar
• Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B: Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J. Gerontol. A Biol. Sci. Med. Sci. 1995;50:B378-B382.
  PubMed CAS Google Scholar
• Medvedev ZA: An attempt at a rational classification of theories of aging. Biol. Rev. 1990;65:375–398.
  PubMed CAS Google Scholar
• Saltzman RL, Peterson PK: Immunodeficiency of the elderly. Rev. Infect. Dis. 1987;9:1127–1139.
  PubMed CAS Google Scholar
• Thoman ML, Weigle WO: The cellular and subcellular basis of immunosenescence. Adv. Immunol. 1989;46:221–261.
  PubMed CAS Google Scholar
• Hirokawa K: Understanding the mechanism of age-related decline in immune function. Nutr. Rev. 1992;50:361–366.
  Article PubMed CAS Google Scholar
• Pawelec G, Solana R: Immunosenescence. Immunol. Today 1997;18:514–516.
  Article PubMed CAS Google Scholar
• Monti D, Grassilli E, Troiano L, Cossarizza A, Salvioli S, Barbieri D, et al.: Senescence, immortalization and apoptosis: an intriguing relationship. Ann. N.Y. Acad. Sci. 1992;673:70–82.
  Article PubMed CAS Google Scholar
• Franceschi C, Monti D, Sansoni P, Cossarizza A: The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today 1995;16:12–16.
  Article PubMed CAS Google Scholar
• Olshansky SJ, Carnes BA, Cassel C: In search of Methuselah: estimating the upper limits to human longevity. Science 1990;250:634–648.
  Article PubMed CAS Google Scholar
• Barinaga M: How long is the human life-span? Science 1991;254:936–938.
  Article PubMed CAS Google Scholar
• Leech SH: Cellular Immunosenescence. Gerontology 1980;26:330–345.
  Article PubMed CAS Google Scholar
• Kay MMB, Makinodan T: Relationship between ageing and the immune system. Prog. Allergy 1981;29:134–181.
  PubMed CAS Google Scholar
• Sansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, et al.: Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993;80:2767–2773.
  Google Scholar
• Quaglino D, Ginaldi L, Furia N, De Martinis M: The effect of age on hemopoiesis. Aging Clin. Exp. Res. 1996;8:1–12.
  CAS Google Scholar
• Ligthart GJ, Corberand JX, Fournier C, Garanaud P, Hijmans W, Kennes B, et al.: Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 1984;28:47–55.
  Article PubMed CAS Google Scholar
• Ligthart GJ, Corberand JX, Geertzen HGM, Meinders AE, Knook DL, Hijmans W: Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech. Ageing Dev. 1990;55:89–105.
  Article CAS Google Scholar
• Rowe JW, Kahn RL: Human age: usual and successful. Science 1987;237:143–149.
  Article PubMed CAS Google Scholar
• Franceschi C, Monti D, Cossarizza A, Fagnono F, Passeri G, Sansoni P: Aging, longevity and cancer. Studies in Down’s syndrome and in centenarians. Ann. N.Y. Acad. Sci. 1991;621:428–440.
  Article PubMed CAS Google Scholar
• Kirkwood TBL, Franceschi C: Is ageing as complex as it would appear? New perspectives in gerontological research. Ann. N.Y. Acad. Sci. 1992;663:412–417.
  Article PubMed CAS Google Scholar
• Morellini M, Trabace S, Lulli P, Cappellacci S, Brioli G, Orrù D, et al.: HLA antigens and aging. Ann. N.Y. Acad. Sci. 1992;663:499–500.
  Article PubMed CAS Google Scholar
• Chandra RK: Nutritional regulation of immunity and risk of infection in old age. Immunology 1989;67:141–147.
  PubMed CAS Google Scholar
• Roecker EB, Kemnitz JW, Ershler WB, Weindruch R: Reduced immune responses in rhesus monkeys subjected to dietary restriction. J. Gerontol. A. Biol. Sci. Med. Sci. 1996;51:B276–279.
  PubMed CAS Google Scholar
• Wick G, Grubeck-Loebenstein B: Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease. Immunol. Rev. 1997;160:171–184.
  Article PubMed CAS Google Scholar
• Callard RE, Basten A, Waters LK: Immune function in aged mice. II. B cell function. Cell. Immunol. 1977;31:26–36.
  Article PubMed CAS Google Scholar
• Miller RA: Aging and immune function. Int. Rev. Cytol. 1991;124:187–215.
  PubMed CAS Google Scholar
• Nicoletti C, Borghesi-Nicoletti C, Yang X, Schulze D, Cerny J: Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. J. Immunol. 1991;147:2750–2755.
  PubMed CAS Google Scholar
• Yang X, Stedra J, Cerny J:Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH-VL gene utilization in splenic anti body foci by in situ hybridization. J. Immunol. 1994; 152:2214–2221.
  PubMed CAS Google Scholar
• Stephan RP, Sanders VM, Witte PL. Stage specific alterations in murine B-lymphopoiesis with age. Int. Immunol. 1996;8:509–518.
  Article PubMed CAS Google Scholar
• Miller C, Kelsoe G: Ig VH hyper mutation is absent in the germinal centers of aged mice. J. Immunol. 1995;155:3377–3384.
  PubMed CAS Google Scholar
• Yang X, Sterda J, Cerny J: Relative contribution of T and B cells to hypermutation and selection of antibody in germinal centers of aged mice. J. Exp. Med. 1996;183:959–970.
  Article PubMed CAS Google Scholar
• Klinman NR, Kline GH: The Bcell biology of aging. Immunol. Rev. 1997;160:103–114.
  Article PubMed CAS Google Scholar
• Ligthart GJ, Radl J, Corberand JX, Van Nieuwkoop JE, Van Staalduinen GJ, Van Helmond DJW, Hijmans W: Monoclonal gammopathies in human aging: increased occurrence with age and correlation with healthy status. Mech. Ageing Dev. 1990;52:235–243.
  Article PubMed CAS Google Scholar
• Paganelli R, Scala E, Quinti I, Ansotegui IJ: Humoral immunity in aging. Aging Clin. Exp. Res. 1994;6:143–150.
  CAS Google Scholar
• Louria DB, Sen P, Sherer CB, Farrer WE: Infections in older patients: a systematic clinical approach. Geriatrics 1993;48:28–34.
  PubMed CAS Google Scholar
• Arreaza EE, Gibbons JJ, Siskind GW, Weksler ME: Lower antibody response to tetanus toxoid associated with higher auto-antiidiotypic antibody in old compared with young humans. Clin. Exp. Immunol. 1993;92:169–173.
  Article PubMed CAS Google Scholar
• Powers DC, Belshe RB. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J. Infect. Dis. 1993;167:584–592.
  PubMed CAS Google Scholar
• Mariotti S, Sansoni P, Barbesino G, Caturegli P, Monti D, Cossarizza A, et al.: Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 1992;339:1506–1508.
  Article PubMed CAS Google Scholar
• Paganelli R, Quinti I, Fagiolo U, Cossarizza A, Ortolani C, Guerra E, et al.: Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin. Exp. Immunol. 1992;90:351–354.
  Article PubMed CAS Google Scholar
• Al-Rayes H, Pachas W, Mirza N, Ahern DJ, Geha RS, Vercelli D: IgE regulation and lymphokine patterns in aging humans. J. Allergy Clin. Immunol. 1992;90:630–636.
  Article PubMed CAS Google Scholar
• De Greef GE, Van Tol MJ, Van Den Berg JW, Van Staalduinen GJ, Janssen CJ, Radl J, Hijmans W: Serum immunoglobulin class and IgG subclass levels and the occurrence of homogeneous immunoglobulins during the course of aging in humans. Mech. Ageing Dev. 1992;66:29–44.
  Article PubMed Google Scholar
• Lehtonen L, Eskola J, Vainio O, Lehtonen A: Changes in lymphocyte subsets and immune competence in very advanced age. J. Gerontol. Med. Sci. 1990;45:108–112.
  Google Scholar
• Stall AM, Wells SM: Introduction: B-1 cells: Origins and functions. Sem. Immunol. 1996;8:1–2.
  Article CAS Google Scholar
• Chen X, Kearney JF: Generation and function of natural self-reactive B cells. Sem. Immunol. 1996;8:19–27.
  Article CAS Google Scholar
• Mariotti S, Franceschi C, Cossarizza A, Pinchera A: The aging thyroid. Endocr. Rev. 1995;16:686–715.
  Article PubMed CAS Google Scholar
• Thoman ML, Weigle WO: Lymphokines and aging:interleukin-2 production and activity in aged animals. J. Immunol. 1981;127:2101–2107.
  Google Scholar
• Liu JJ, Segre M, Segre D: Changes in suppressor, helper, and B-cell functions in aging mice. Cell. Immunol. 1982;66: 372–340.
  Article PubMed CAS Google Scholar
• Li SP, Verma S, Miller RA: Age-re-lated defects in T cell expression of CD40 ligand and induction of in vitro B cell activation. Aging Immunol. Infect. Dis. 1995;6:79–93.
  CAS Google Scholar
• Grabstein KH, Maliszewski CR, Shanebeck K, Sato TA, Spriggs MK, Fanslow WC, Armitage RJ: The regulation of T cell-dependent antibody formation in vitro by CD40 ligand and IL-2. J. Immunol. 1993;150:3141–3147.
  PubMed CAS Google Scholar
• Dustin ML, Springer TA: T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989;341:619–624.
  Article PubMed CAS Google Scholar
• Thoma S, Hirohata S, Lipsky PE: The role of CD11a/CD18-54 interactions in human T cell-dependent B cell activation. J. Immunol. 1991;146:492–499.
  Google Scholar
• Paul WE, Ohara J: B-cell stimulatory factor-1/interleukin 4. Annu. Rev. Immunol. 1987;5:429–459.
  PubMed CAS Google Scholar
• Nagelkerken L, Hertogh-Huijbregts A, Dobber R, Drager A: Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells. Eur. J. Immunol. 1991;21:273–281.
  Article PubMed CAS Google Scholar
• Haq JA, Szewczuk MR: Regional dichotomy of interleukin-4 and -5 regulation of senescent B cell responses specific for cholera toxin in Peyer’s patches, lamina propria, and mesenteric lymph nodes. Reg. Immunol. 1993;5:60–67.
  PubMed CAS Google Scholar
• Li SP, Miller RA: Age-associated decline in IL-4 production by murine T lymphocytes in extended culture. Cell. Immunol. 1993;151:187–195.
  Article PubMed Google Scholar
• Song H, Price PW, Cerny J: Age-related changes in antibody repertoire: contribution from T-cells. Immunol. Rev. 1997;160:55–62.
  Article PubMed CAS Google Scholar
• Swenson CD, Thorbecke GJ: The effect of aging on IgD receptor expression by T cells and its functional implications. Immunol. Rev. 1997;160:145–157.
  Article PubMed CAS Google Scholar
• Zheng B, Han S, Takahashi Y, Kelsoe G: Immunosenescence and germinal center reaction. Immunol. Rev. 1997;160:63–77.
  Article PubMed CAS Google Scholar