Study of androgen and androgen receptor in relation to insulin resistance in polycystic ovary syndrome (original) (raw)

Summary

In order to investigate the relationship between serum testosterone level and expression of androgen receptors in ovary in relation to insulin resistance in polycystic ovary syndrome (PCOS). Serum testosterone levels were determined by radioimmunoassay in 17 patients with PCOS and 20 cases as control group. The expression of androgen receptor in ovary was detected by immunohistochemistry method. The results showed that serum testosterone level [(3.1±1.5) nmol/L] and insulin resistance index (0.85±0.49) in patients with PCOS were significantly higher than in control group (P<0.05), and showed a positive relation (_r_=0.65,P<0.01). The expression levels of androgen receptor in ovary of patients with PCOS were significantly higher than that in control group (P<0.05). The optical density value was positively related with insulin resistance index (_r_=0.59,P<0.01). It was concluded that androgen and androgen receptor could accelerate insulin resistance and the interaction of them might aggravate the pathophysiological change in PCOS.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Solomon C G. The epidemiology of polycystic ovary syndrome: Prevalence and associated disease risks. Endocrinol Metab Clin North Am, 1999, 28(2):247
    Article CAS PubMed Google Scholar
  2. Birdsall M A, Farquhar C M. Polycystic ovaries in pre and post-menopausal women. Clin Endocrinol, 1996, 44 (3):269
    Article CAS Google Scholar
  3. Haffner S M, Miettinen H, Stern M P. The homeostasis model in the San Antonio Heart Study. Diabetes Care, 1997, 20(7):1087
    Article CAS PubMed Google Scholar
  4. Hotel J. Polycystic ovary syndrome and insulin resistance: thrifty genes struggling with overfeeding and secondary life style?. J Endocrinol Invest, 1998, 21(9):589
    Article Google Scholar
  5. Preelevic G M. Insulin resistance in polycystic ovary syndrome. Curr Opin Qnstel Gynecol, 1997, 9(3):193
    Article Google Scholar
  6. Dale P O, Tanbo T, Huang E_et al._ The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome. Hum Repro, 1998, 13 (3):567
    Article CAS Google Scholar
  7. Toprak S, Yonem A, Cakir B_et al._ Insulin resistance in nonobese patients with polycystic ovary syndrome. Horm Res, 2001, 55(2):65
    CAS PubMed Google Scholar
  8. Arslanian S A, Lewy V, Danadian K_et al._ Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab, 2002, 87(4):1555
    Article CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Xiehe Hosipital Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan
    Chu Yongli, Sun Yongyu & Qiu Hongyu

Authors

  1. Chu Yongli
    You can also search for this author inPubMed Google Scholar
  2. Sun Yongyu
    You can also search for this author inPubMed Google Scholar
  3. Qiu Hongyu
    You can also search for this author inPubMed Google Scholar

Additional information

CHU Yongli, female, born in 1973, M. D., Ph. D.

This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30100200).

Rights and permissions

About this article

Cite this article

Yongli, C., Yongyu, S. & Hongyu, Q. Study of androgen and androgen receptor in relation to insulin resistance in polycystic ovary syndrome.Current Medical Science 23, 52–54 (2003). https://doi.org/10.1007/BF02829462

Download citation

Key words