Coupled reductions in brain oxidative phosphorylation and synaptic function can be quantified and staged in the course of Alzheimer disease (original) (raw)
Akiyama H, S Barger, S Barnum, B Bradt, J Bauer, GM Cole, NR Cooper, P Eikelenboom, M Emmerling, BL Fiebich, CE Finch, S Frautschy, WS Griffin, H Hampel, M Hull, G Landreth, L Lue, R Mrak, IR Mackenzie, PL McGeer, MK O'Banion, J Pachter, G Pasinetti, C Plata-Salaman, J Rogers, R Rydel, Y Shen, W Streit, R Strohmeyer, I Tooyoma, FL Van Muiswinkel, R Weerhuis, D Walker, S Webster, B Wegrzyniak, G Wenk and T Wyss-Coray (2000) Inflammation and Alzheimer's disease.Neurobiol. Aging21, 383–421. ArticlePubMedCAS Google Scholar
Barger SW and AS Basile (2001) Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.J. Neurochem.76, 846–854. ArticlePubMedCAS Google Scholar
Beal MF (1998) Mitochondrial dysfunction in neurodegenerative diseases.Biochim. Biophys. Acta1366, 211–223. ArticlePubMedCAS Google Scholar
Bookheimer SY, MH Strojwas, MS Cohen, AM Saunders, MA Pericak-Vance, JC Mazziotta, and GW Small (2000) Patterns of brain activation in people at risk for Alzheimer's disease.N. Engl. J. Med.343, 450–456. ArticlePubMedCAS Google Scholar
Braak H and E Braak (1998) Evolution of neuronal changes in the course of Alzheimer's disease.J. Neural Transm. Suppl.53, 127–140. PubMedCAS Google Scholar
Brodal A (1981)Neurological Anatomy in Relation to Clinical Medicine, 3rd Ed. (Oxford University Press, Oxford). Google Scholar
Burggren AC, GW Small, FW Sabb and SY Bookheimer (2002) Specificity of brain activation patterns in people at genetic risk for Alzheimer disease.Am. J. Geriatr. Psychiatry10, 44–51. PubMed Google Scholar
Calingasan NY, K Uchida and GE Gibson (1999) Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.J. Neurochem.72, 751–756. ArticlePubMedCAS Google Scholar
Chandrasekaran K, J Stoll, DR Brady and SI Rapoport (1992) Localization of cytochrome oxidase (COX) activity and COX mRNA in the hippocampus and entorhinal cortex in the monkey brain: correlation with specific neuronal pathways.Brain Res.579, 333–336. ArticlePubMedCAS Google Scholar
Chandrasekaran K, J Stoll, SI Rapoport and DR Brady (1993) Localization of cytochrome oxidase (COX) activity and COX mRNA in the perirhinal and superior temporal sulci of the monkey brain.Brain Res.606, 213–219. ArticlePubMedCAS Google Scholar
Chandrasekaran K, T Giordano, DR Brady, J Stoll, LJ Martin and SI Rapoport (1994) Impairment of mitochondrial cytochrome oxidase gene expression in Alzheimer disease.Brain Res. Mol. Brain Res.24 (S-1), 336–340. ArticlePubMedCAS Google Scholar
Chandrasekaran K, K Hatanpää, DR Brady and SI Rapoport (1996) Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease.Exp. Neurol.142, 80–88. ArticlePubMedCAS Google Scholar
Chandrasekaran K, K Hatanpää, SI Rapoport and DR Brady (1997) Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex of Alzheimer disease.Brain Res. Mol. Brain Res.44, 99–104. ArticlePubMedCAS Google Scholar
Chandrasekaran K, K Hatanpää, DR Brady, J Stoll and SI Rapoport (1998) Downregulation of oxidative phosphorylation in Alzheimer disease: loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex.Brain Res.796, 13–19. ArticlePubMedCAS Google Scholar
Chandrasekaran K and SI Rapoport (unpublished observations).
Chrzanowska-Lightowlers ZM, T Preiss and RN Lightowlers (1994) Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcripts.J. Biol. Chem.269, 27322–27328. PubMedCAS Google Scholar
Davies CA, DMA Mann, PQ Sumpter and PO Yates (1987) A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.J. Neurol. Sci.78, 151–164. ArticlePubMedCAS Google Scholar
DeCarli CS, JR Atack, MJ Ball, JA Kaye, CL Grady, P Fewster, KD Pettigrew, SI Rapoport and MB Schapiro (1992) Post-mortem regional neurofibrillary tangle densities but not senile plaque densities are related to regional cerebral metabolic rates for glucose during life in Alzheimer's disease patients.Neurodegeneration1, 113–121. Google Scholar
DeCarli C, DG Murphy, JA Gillette, JV Haxby, D Teichberg, MB Schapiro and B Horwitz (1994) Lack of age-related differences in temporal lobe volume of very healthy adults.Am. J. Neuroradiol.15, 689–696. PubMedCAS Google Scholar
DeKosky ST and SW Scheff (1990) Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.Ann. Neurol.27, 457–464. ArticlePubMedCAS Google Scholar
Folstein MF, SE Folstein and PR McHugh (1975) Mini Mental State. A practical method for grading the cognitive state of patients for the clinician.J. Psychiatr. Res.12, 189–198. ArticlePubMedCAS Google Scholar
Fukuyama R, K Hatanpää, SI Rapoport and K Chandrasekaran (1996) Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients.Brain Res.713, 290–293. ArticlePubMedCAS Google Scholar
Gaines G, C Rossi and G Attardi (1987) Markedly different ATP requirements for rRNA synthesis and mtDNA light strand transcription versus mRNA synthesis in isolated human mitochondria.J. Biol. Chem.262, 1907–1915. PubMedCAS Google Scholar
Gelfand R and G Attardi (1981) Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable.Mol. Cell. Biol.1, 497–511. PubMedCAS Google Scholar
Gong Y, L Chang, KL Viola, PN Lacor, MP Lambert, CE Finch, GA Krafft and WL Klein (2003) Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDLs) suggests a molecular basis for reversible memory loss.Proc. Natl. Acad. Sci. USA100, 10417–10422. ArticlePubMedCAS Google Scholar
Grady CL (2002) Age-related differences in face processing: a meta-analysis of three functional neuroimaging experiments.Can. J. Exp. Psychol.56, 208–220. PubMed Google Scholar
Grady CL, B Sonies, J Haxby, J Luxenberg, R Friedland and S Rapoport (1988) Cerebral metabolic asymmetries predict decline in language performance in dementia of the Alzheimer type (DAT).J. Clin. Exp. Neuropsychol.10, 39. Google Scholar
Grady CL, JV Haxby, B Horwitz, J Gillette, JA Salerno, A Gonzalez-Aviles, RE Carson, P Herscovitch, MB Schapiro and SI Rapoport (1993) Activation of cerebral blood flow during a visuoperceptual task in patients with Alzheimer-type dementia.Neurobiol. Aging14, 35–44. ArticlePubMedCAS Google Scholar
Greenamyre JT, WF Maragos, RL Albin, JB Penney and AB Young (1988) Glutamate transmission and toxicity in Alzheimer's disease.Prog. Neuropsychopharmacol. Biol. Psychiatry12, 421–430. ArticlePubMedCAS Google Scholar
Greene JG and JT Greenamyre (1996) Bioenergetics and glutamate excitotoxicity.Prog. Neurobiol.48, 613–634. ArticlePubMedCAS Google Scholar
Hake AM and MR Farlow (2001) New concepts in the drug therapy of Alzheimer's disease.Expert Opin. Pharmacother.2, 1975–1983. ArticlePubMedCAS Google Scholar
Hatanpää K, DR Brady, J Stoll, SI Rapoport and K Chandrasekaran (1996) Neuronal activity and early neurofibrillary tangles in Alzheimer's disease.Ann. Neurol.40, 411–420. ArticlePubMed Google Scholar
Hatanpää K, K Chandrasekaran, D Brady and SI Rapoport (1998) No association between Alzheimer plaques and decreased levels of cytochrome oxidase subunit mRNA, a marker of neuronal energy metabolism.Brain Res. Mol. Brain Res.59, 13–21. ArticlePubMed Google Scholar
Hatanpää K, KR Isaacs, T Shirao, DR Brady and SI Rapoport (1999) Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease.J. Neuropathol. Exp. Neurol.58, 637–643. ArticlePubMed Google Scholar
Haxby JV, R Duara, CL Grady, NR Cutler and SI Rapoport (1985) Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease.J. Cereb. Blood Flow Metab.5, 193–200. PubMedCAS Google Scholar
Hevner RF and MTT Wong-Riley (1991) Neuronal expression of nuclear and mitochondrial genes for cytochrome oxidase (CO) subunits analyzed by_in situ_ hybridization: comparison with CO activity and protein.J. Neurosci.11, 1942–1958. PubMedCAS Google Scholar
Hevner RF and MTT Wong-Riley (1993) Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionately regulated by functional activity in neurons.J. Neurosci.13, 1805–1819. PubMedCAS Google Scholar
Hevner RF, RS Duff and MT Wong-Riley (1992) Coordination of ATP production and consumption in brain: Parallel regulation of cytochrome oxidase and Na+, K+-ATPase.Neurosci. Lett.138, 188–192. ArticlePubMedCAS Google Scholar
Ibanez V, P Pietrini, GE Alexander, ML Furey, D Teichberg, JC Rajapakse, SI Rapoport, MB Schapiro and B Horwitz (1998) Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.Neurology50, 1585–1593. PubMedCAS Google Scholar
Iqbal K, C Alonso Adel, E El-Akkad, CX Gong, N Haque, S Khatoon, I Tsujio and I Grundke-Iqbal (2002) Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration.J. Neural Transm. Suppl.62, 309–319. PubMedCAS Google Scholar
Irizarry MC, F Soriano, M McNamara, KJ Page, D Schenk, D Games and BT Hyman (1997) Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.J. Neurosci.17, 7053–7059. PubMedCAS Google Scholar
Katzman R (1976) The prevalence and malignancy of Alzheimer disease: a major killer.Arch. Neurol.33, 217–218. PubMedCAS Google Scholar
Kennedy AM, RSJ Frackowiak, SK Newman, PM Bloomfield, J Seaward, P Roques, G Lewington, VJ Cunningham and MN Rossor (1995) Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease.Neurosci. Lett.186, 17–20. ArticlePubMedCAS Google Scholar
Kumar A, MB Schapiro, C Grady, JV Haxby, E Wagner, JA Salerno, RP Friedland and SI Rapoport (1991) High-resolution PET studies in Alzheimer's disease.Neuropsychopharmacology4, 35–46. PubMedCAS Google Scholar
Lehninger AL, DL Nelson and MM Cox (1993)Principles of Biochemistry, 2nd Ed., Chapter 15, pp. 446–448; Chapter 20, pp. 669–683 (Worth Press: New York). Google Scholar
Lewis DA, MJ Campbell, RD Terry and JH Morrison (1987) Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices.J. Neurosci.7, 1799–1808. PubMedCAS Google Scholar
Liu LI, SI Rapoport and K Chandrasekaran (1999) Regulation of mitochondrial gene expression in differentiated PC12 cells.Ann. NY Acad. Sci.893, 341–344. ArticlePubMedCAS Google Scholar
Mann DMA, B Marcyniuk, PO Yates, D Neary and JS Snowden (1988) The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy.Neuropathol. Appl. Neurobiol.14, 177–195. ArticlePubMedCAS Google Scholar
Masliah E and E Rockenstein (2000) Genetically altered transgenic models of Alzheimer's disease.J. Neurol. Transm. Suppl.59, 175–183. CAS Google Scholar
Mattson MP, DS Gary, SL Chan, W Duan, SW Barger and AS Basile (2001) Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.Biochem. Soc. Symp.76, 151–162. Google Scholar
Mecocci P, U MarGarvey and MF Beal (1994) Oxidative damage to mitochondria DNA is increased in Alzheimer disease.Ann. Neurol.36, 747–751. ArticlePubMedCAS Google Scholar
Mentis MJ, B Horwitz, CL Grady, GE Alexander, JW VanMeter, JM Maisog, P Pietrini, MB Schapiro and SI Rapoport (1996) Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded “stress test” during PET.Am. J. Psychiatry153, 32–40. PubMedCAS Google Scholar
Mentis MJ, GE Alexander, CL Grady, B Horwitz, J Krasuski, P Pietrini, T Strassburger, H Hampel, MB Schapiro and SI Rapoport (1997) Frequency variation of a pattern-flash visual stimulus during PET differentially activates brain from striate through frontal cortex.Neuroimage5, 116–128. ArticlePubMedCAS Google Scholar
Mentis MJ, GE Alexander, J Krasuski, P Pietrini, ML Furey, MB Schapiro and SI Rapoport (1988) Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation.Am. J. Psychiatry155, 785–794. Google Scholar
Mentis MJ, T Sunderland, J Lai, C Connolly, J Krasuski, B Levine, J Friz, S Sobti, M Schapiro and SI Rapoport (2001) Muscarinic versus nicotinic modulation of a visual task. A PET study using drug probes.Neuropsychopharmacology25, 555–564. ArticlePubMedCAS Google Scholar
Micol V, P Fernandez-Silva and G Attardi (1997) Functional analysis of_in vivo_ and_in organello_ footprinting of HeLa cell mitochondrial DNA in relationship to ATP and ethidium bromide effects on transcription.J. Biol. Chem.272, 18896–18904. ArticlePubMedCAS Google Scholar
Montoya J, T Christianson, D Levens, M Rabinowitz and G Attardi (1982) Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA.Proc. Natl. Acad. Sci. USA79, 7195–7199. ArticlePubMedCAS Google Scholar
Mrak RE and WS Griffin (2001) Interleukin-1, neuroinflammation, and Alzheimer's disease.Neurobiol. Aging22, 903–908. ArticlePubMedCAS Google Scholar
Nagy Z, MM Esiri, M LeGris and PM Matthews (1999) Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology.Acta Neuropathol. (Berl.)97, 346–354. ArticleCAS Google Scholar
Parker Jr WD, J Parks, CM Filley and BK Kleinschmidt-DeMasters (1994) Electron transport chain defects in Alzheimer's disease brain.Neurology44, 1090–1096. PubMed Google Scholar
Pellmar TC, DA Schauer and GH Zeman (1990) Time-and dosedependent changes in neuronal activity produced by X radiation in brain slices.Radiation Res.122, 209–214. ArticlePubMedCAS Google Scholar
Peterson E (2003)Mild Cognitive Impairment: Aging to Alzheimer's Disease (Oxford University Press: New York), p. 269. Google Scholar
Pietrini P, GE Alexander, ML Furey, A Dani, MJ Mentis, B Horwitz, M Guazzelli, MB Shapiro and SI Rapoport (2000) Cerebral metabolic response to passive audiovisual stimulation in patients with Alzheimer's disease and healthy volunteers assessed by PET.J. Nucl. Med.41, 575–583. PubMedCAS Google Scholar
Purdon AD and SI Rapoport (1998) Energy requirements for two aspects of phospholipid metabolism in mammalian brain.Biochem. J.335, 313–318. PubMedCAS Google Scholar
Rapoport SI (1990) Integrated phylogeny of the primate brain, with special reference to humans and their diseases.Brain Res. Rev.15, 267–294. ArticlePubMedCAS Google Scholar
Rapoport SI (1991) Positron emission tomography in Alzheimer's disease in relation to disease pathogenesis: a critical review.Cerebrovasc. Brain Metab. Rev.3, 297–335. PubMedCAS Google Scholar
Rapoport SI (1995) Anatomic and functional brain imaging in Alzheimer's disease, In:Psychopharmacology: the Fourth Generation of Progress, Bloom FE and DJ Kupfer, Eds. (Raven: New York), pp. 1401–1415. Google Scholar
Rapoport SI (1997) Deux stades, réversible et irréversible, de l'insuffisance fonctionnelle dans le cerveau Alzheimerien, In:De la Neurophysiologie à la Maladie D'Alzheimer: Symposium en Hommage à Yvon Lamour, Y. Christien, Eds. (Solal: Marseille), pp. 165–172. Google Scholar
Rapoport SI and CL Grady (1993) Parametric_in vivo_ brain imaging during activation to examine pathological mechanisms of functional failure in Alzheimer disease.Int. J. Neurosci.70, 39–56. ArticlePubMedCAS Google Scholar
Rapoport SI, K Hatanpää, DR Brady and K Chandrasekaran (1996) Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.Neurodegeneration5, 473–476. ArticlePubMedCAS Google Scholar
Reiman EM, RJ Caselli, LS Yun, K Chen, D Bandy, S Minoshima, SN Thibodeau and D Osbome (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.N. Engl. J. Med.334, 752–758. ArticlePubMedCAS Google Scholar
Reivich M (1974) Blood flow metabolism couple in brain.Res. Publ. Assoc. Res. Nerv. Ment. Dis.53, 125–140. PubMedCAS Google Scholar
Rojas-Fernandez CH, M Chen and HL Fernandez (2002) Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's disease.Pharmacotherapy22, 1547–1563. ArticlePubMedCAS Google Scholar
Roy CS and CS Sherrington (1890) On the regulation of the blood supply of the brain.J. Physiol. (Lond.)11, 85–105. CAS Google Scholar
Rutten BP, O Wirths, WD Van de Berg, SF Lichtenthaler, J Vehoff, HW Steinbusch, H Korr, K Beyreuther, G Multhaup, TA Bayer and C Schmitz (2003) No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.Neurobiol. Dis.12, 110–120. ArticlePubMedCAS Google Scholar
Sato M, T Kawarabayashi, M Shoji, T Kobayashi, N Tada, E Matsubara and S Hirai (1997) Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor.Dement. Geriatr. Cogn. Disord.8, 296–307. ArticlePubMedCAS Google Scholar
Scheff SW, ST DeKosky and DA Price (1990) Quantitative assessment of cortical synaptic density in Alzheimer's disease.Neurobiol. Aging11, 29–37. ArticlePubMedCAS Google Scholar
Scheff SW, DL Sparks and DA Price (1996) Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease.Dementia7, 226–232. ArticlePubMedCAS Google Scholar
Sheetz MP, ER Steuer and TA Schroer (1989) The mechanism and regulation of fast axonal transport.Trends Neurosci.12, 474–478. ArticlePubMedCAS Google Scholar
Sims NR, JM Finegan, JP Blass, DM Bowen and D Neary (1987) Mitochondrial function in brain tissue in primary degenerative dementia.Brain Res.436, 30–38. ArticlePubMedCAS Google Scholar
Small GW, JC Mazziotta, MT Collins, LR Baxter, ME Phelps, MA Mandelkern, A Kaplan, A La Rue, CF Adamson, L Chang, BH Guze, EH Corder, AM Saunders, JL Haines, MA Pericak-Vance and AD Roses (1995) Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.JAMA273, 942–947. ArticlePubMedCAS Google Scholar
Sokoloff L (1999) Energetics of functional activation in neural tissues.Neurochem. Res.24, 321–329. ArticlePubMedCAS Google Scholar
Sorensen L, M Ekstrand, JP Silva, E Lindqvist, B Xu, P Rustin, L Olson and NG Larsson (2001) Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.J. Neurosci.21, 8082–8090. PubMedCAS Google Scholar
Talairach J and P Tournoux (1988) Co-planar stereotaxic atlas of the human brain (Thieme Medical Publishers, Inc.: New York). Google Scholar
Tamataini M, K Chandrasekaran and CR Filburn (1987) unpublished observations.
Terry RD, E Masliah, DP Salmon, N Butters, R DeTeresa, R Hill, LA Hansen and R Katzman (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.Ann. Neurol.30, 572–580. ArticlePubMedCAS Google Scholar
VanMeter JW, JM Maisog, TA Zeffiro, M Hallett, P Herscovitch and SI Rapoport (1995) Parametric analysis of functional neuroimages: application to a variable-rate motor task.Neuroimage2, 272–383. Article Google Scholar
Wang SS, A Becerra-Arteaga and TA Good (2002) Development of a novel diffusion-based method to estimate the size of the aggregated Abeta species responsible for neurotoxicity.Biotechnol. Bioeng.80, 50–59. ArticlePubMedCAS Google Scholar
Wong-Riley MTT (1989) Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.Trends Neurosci.12, 94–101. ArticlePubMedCAS Google Scholar
Yaffe MP (1999) The machinery of mitochondrial inheritance and behavior.Science283, 1493–1497. ArticlePubMedCAS Google Scholar
Yao PJ, M Zhu, EI Pyun, AI Brooks, S Therianos, VE Meyers and PD Coleman (2003) Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease.Neurobiol. Dis.12, 97–109. ArticlePubMedCAS Google Scholar
Zhang C and MT Wong-Riley (2000) Synthesis and degradation of cytochrome oxidase subunit mRNAs in neurons: differential bigenomic regulation by neuronal activity.J. Neurosci. Res.60, 338–344. ArticlePubMedCAS Google Scholar