Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization (original) (raw)

References

  1. European Working Party on High Blood Pressure in the Elderly (EWPHE): An international trial of antihypertensive therapy in elderly patients. Objectives, protocol and organization. Arch. Int. Pharmacodyn. Ther. 275: 300–334, 1985.
    Google Scholar
  2. Amery A., Birkenhäger W., Brixko P., Bulpitt C., Clement D., Deruyttere M., De Schaepdryver A., Dollery C., Fagard R., Forette F., Forte J., Hamdy R., Henry J.F., Joossens J.V., Leonetti G., Lund-Johansen P., O’Malley K., Petrie J., Strasser T., Tuomilehto J., Williams B.: Mortality and morbidity results from the European Working Party on high blood pressure in the Elderly Trial. Lancet I: 1349–1354, 1985.
    Article Google Scholar
  3. Amery A., Birkenhäger W., Brixko P., Bulpitt C., Clement D., Deruyttere M., De Schaepdryver A., Dollery C., Fagard R., Forette F., Forte J., Hamdy R., Henry J.F., Joossens J.V., Leonetti G., Lund-Johansen P., O’Malley K., Petrie J.C., Strasser T., Tuomilehto J., Williams B.: Efficacy of antihypertensive drug treatment according to age, sex, blood pressure and previous cardiovascular disease in patients above the age of 60. Lancet II: 589–592, 1986.
    Article Google Scholar
  4. Coope J., Warrender T.S.: Randomized trial of treatment of hypertension in elderly patients in primary care. Br. Med. J. 293: 1145–1151, 1986.
    Article CAS Google Scholar
  5. Kuramoto K., Matsushita S., Kuwajima I., Murakawi M.: Prospective study on the treatment of mild hypertension in the aged. Jpn. Heart J. 22: 75–85, 1981.
    Article PubMed CAS Google Scholar
  6. Hypertension Detection and Follow-up Program Cooperative Group: Five-year findings of the Hypertension Detection and Follow-up Program. II. Mortality by race-sex and age. JAMA 242: 2572–2577, 1979.
    Article Google Scholar
  7. Management Committee: Treatment of mild hypertension in the elderly. A study initiated and administered by the National Heart Foundation of Australia. Med. J. Aust. 2: 398–402, 1981.
    Google Scholar
  8. Staessen J., Fagard R., Van Hoof R., Amery A.: Mortality in various intervention trials in elderly hypertensive patients: a review. Eur. Heart J. 9: 215–222, 1988.
    PubMed CAS Google Scholar
  9. Kannel W.B., Gordon T.: Evaluation of cardiovascular risk in the elderly: the Framingham Study. Bull. N.Y. Acad. Med. 54: 573–591, 1978.
    PubMed CAS Google Scholar
  10. Staessen J., Bulpitt C., Fagard R., Joossens J.V., Lijnen P., Amery A.: Four urinary cations and blood pressure: a population study in two Belgian towns. Am. J. Epidemiol. 117: 676–687, 1983.
    PubMed CAS Google Scholar
  11. M’Buyamba-Kabangu J.R., Fagard R., Lijnen P., Mbuy wa Mbuy R., Staessen J., Amery A.: Blood pressure and urinary cations in urban Bantu of Zaire. Am. J. Epidemiol. 124: 957–968, 1986.
    PubMed Google Scholar
  12. Staessen J., Amery A., Fagard R.: Editorial review: isolated systolic hypertension in the elderly. J. Hypertension 8: 393–405, 1990.
    Article CAS Google Scholar
  13. Kannel W.B., Gordon T., Schwartz M.J.: Systolic versus diastolic blood pressure and risk of coronary heart disease. The Framingham Study. Am. J. Cardiol. 27: 335–346, 1971.
    Article PubMed CAS Google Scholar
  14. Kannel W.B., Dawber T.R., Sorlie P., Wolf P.A.: Components of blood pressure and risk of atherothrombotic brain infarction: the Framingham Study. Stroke 7: 327–331, 1976.
    Article PubMed CAS Google Scholar
  15. Rabkin S.W., Mathewson F.A., Tate R.B.: Predicting risk of ischemic heart disease and cerebrovascular disease from systolic and diastolic blood pressures. Ann. Intern. Med. 88: 342–345, 1978.
    Article PubMed CAS Google Scholar
  16. O’Malley K., McCormack P., O’Brien E.T.: Isolated systolic hypertension: data from the European Working Party on High Blood Pressure in the Elderly. J. Hypertension 6 (suppl. 1): S105–S108, 1988.
    Google Scholar
  17. Menotti A., Seccareccia F., Giampaolo S., Giuli B.: The predictive role of systolic, diastolic and mean blood pressure on cardiovascular and all causes death. J. Hypertension 7: 595–599, 1989.
    Article CAS Google Scholar
  18. Ueda K., Omae T., Hasuo Y., Kiyohara Y.: Impact of high blood pressure on morbidity and mortality. In: Amery A., Staessen J. (Eds.), Handbook of Hypertension. Hypertension in the Elderly, Vol. 12. Elsevier, Amsterdam, 1989, pp. 174–185.
    Google Scholar
  19. Petrie J.C., O’Brien E.T., Littler W.A., de Swiet M.: Blood pressure measurement. British Medical Journal, London, 1987.
    Google Scholar
  20. Katz S., Down T.D., Cash H.R., Grotz R.C.: Gerontologist 1: 20–30, 1970.
    Article Google Scholar
  21. Keith N.M., Wagener H.P., Barker N.W.: Some different types of essential hypertension: their course and prognosis. Am. J. Med. Sci. 197: 332–343, 1939.
    Article Google Scholar
  22. Pipberger H.V., Artsbaecher R.E., Berson A.S.: Recommendations for standardization of leads and of specifications for instruments in electrocardiography and vectorcardiography. American Heart Association Committee on Electrocardiography. Circulation 52: 11–31, 1975.
    Google Scholar
  23. World Health Organization: Arterial Hypertension. Report of a WHO Expert Committee. World Health Organization Technical Report Series 628, Geneva, 1978.
  24. Kendall M.J., Lobo J., Jack D.B., Main A.N.H.: The influence of age on the pharmacokinetics of nitrendipine. J. Cardiovasc. Pharmacol. 9 (Suppl. 4): S96–S100, 1987.
    Article Google Scholar
  25. Lettieri J., Krol G., Yeh S., Ryan J., Jain A., McMahon F.G., Burkholder D., Birkett J.P.: Pharmacokinetics of nitrenidipine in elderly and young healthy volunteers. J. Cardiovasc. Pharmacol. 9 (Suppl. 4): S142–S147, 1987.
    Article Google Scholar
  26. Ferreira-Filho S.R., Saragoça M.A., Oliveira P.C., Moriguti J., Ajzen H., Ramos O.L.: Use of nitrendipine in the treatment of systolic hypertension in elderly patients. J. Cardiovasc. Pharmacol. 9 (Suppl. 4): S218–S220, 1987.
    Google Scholar
  27. Borzellino M., Homes G., Finizola A., Graterol S., Kobelt R., Rojas Z., Rodriguez I.E., Rodriguez E., Finizola B.: Nitrendipine in elderly hypertensives. J. Cardiovasc. Pharmacol. 9 (Suppl 4): S290–S294, 1987.
    Google Scholar
  28. Hulthén U.L., Katzman P.L.: Review of long-term trials with nitrendipine. J. Cardiovasc. Pharmacol. 12 (Suppl. 4): S11–S15, 1988.
    Article PubMed Google Scholar
  29. Davies R.O., Irvin J.D., Kramsch D.K., Walker J.F., Moncloa F.: Enalapril worldwide experience. Am. J. Med. 77: 23–35, 1984.
    Article PubMed CAS Google Scholar
  30. Moncloa F., Sromovsky J.A., Walker J.F., Davies R.O.: Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety. Drugs 30 (Suppl. 1): 82–89, 1985.
    Article PubMed Google Scholar
  31. Lees K.R., Reid J.L.: Age and the pharmacokinetics and pharmacodynamics of chronic enalapril treatment. Clin. Pharmacol. Ther. 41: 597–602, 1987.
    Article PubMed CAS Google Scholar
  32. Conway J., Lauwers P.: Hemodynamic and hypotensive effects of long-term therapy with chlorothiazide. Circulation 21: 21–27, 1960.
    Article PubMed CAS Google Scholar
  33. Wikstrand J., Westergren G., Berglund G., Bracchetti D., Van Couter A., Feldstein C.A., Ming K.S., Kuramoto K., Landahl S., Meaney E., Pedersen E.B., Rahn K.H., Shaw J., Smith A., Waal-Manning H.: Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. JAMA 255: 1304–1310, 1986.
    Article PubMed CAS Google Scholar
  34. World Health Organization: International Classification of Diseases, 1975 Revision. Vol. 1, Geneva 1978.
  35. Aho K., Harmsen P., Hatano S., Marquardsen J., Smirnov V.E.: Cerebrovascular disease in the community: results of a WHO collaborative study. Bull. WHO 58: 113–130, 1980.
    PubMed CAS Google Scholar
  36. Genton E., Barnett H.J.M., Fields W.S., et al.: Cerebral ischemia: the role of thrombosis and antithrombotic therapy. Joint Committee for Stroke Resources. Stroke 8: 147, 1977.
    Article Google Scholar
  37. Heyman A., Leviton A., Millikan C.H., Nefzger M.D., Ostfeld A.M., Sahs A.L., Stallones A.R., Whisnant J.P.: Transient focal cerebral ischemia: epidemiological and clinical aspects. Stroke 5: 277–287, 1977.
    Google Scholar
  38. Rose G.A., Blackburn H.: Méthodes d’enquête sur les maladies cardio-vasculaires. Organisation mondiale de la Santé. Genève, 1969.
  39. Pocock S.J.: Group sequential methods in the design and analysis of clinical trials. Biometrika 64: 191–199, 1977.
    Article Google Scholar
  40. O’Brien P.C., Fleming T.R.: A multiple testing procedure for clinical trials. Biometrics 35: 549–556, 1979.
    Article PubMed Google Scholar
  41. Staessen J., Fagard R., Lijnen P., Van Hoof R., Amery A.: Review of the major intervention trials in the elderly. Cardiovasc. Drugs Ther. 4: 1237–1242, 1990.
    Article Google Scholar
  42. Kannel W.B., Dawber T.R., McGee D.L.: Perspectives on systolic hypertension: the Framingham Study. Circulation 61: 1179–1182, 1980.
    Article PubMed CAS Google Scholar
  43. Kannel W.B., Wolf P.A., McGee D.L., Dawber T.R., McNamara P., Castelli W.P.: Systolic pressure, arterial rigidity, and risk of stroke. JAMA 245: 1225–1229, 1981.
    Article PubMed CAS Google Scholar
  44. Garland C., Barret-Connor E., Suarez L., Criqui M.H.: Isolated systolic hypertension and mortality after age 60 years: a prospective population-based study. Am. J. Epidemiol. 118: 365–376, 1983.
    PubMed CAS Google Scholar
  45. Colandrea M.A., Friedman G.D., Nichaman M.Z., Lynd C.N.: Systolic hypertension in the elderly. An epidemiologic assessment. Circulation 41: 239–245, 1970.
    Article PubMed CAS Google Scholar
  46. Dyer A.R., Stamler J., Shekelle R.B., Schoenberger J.A., Farinaro E.: Hypertension in the elderly. Med. Clin. North Am. 61: 513–529, 1977.
    PubMed CAS Google Scholar
  47. Curb D.J., Borhani N.O., Entwisle G., Tung B., Kass E., Schnaper H., Williams W., Berman: Isolated systolic hypertension in 14 communities. Am. J. Epidemiol. 121: 362–370, 1985.
    Article PubMed CAS Google Scholar
  48. McClellan W., Hall W.D., Brogan D., Martinez B., Wilber J.A.: Isolated systolic hypertension: declining prevalence in the elderly. Prev. Med. 16: 686–695, 1987.
    Article PubMed CAS Google Scholar
  49. Rutan G.H., Kuller L.H., Neaton J.D., Wentworth D.N., McDonald R.H., McFate Smith W.: Mortality associated with diastolic hypertension and isolated systolic hypertension among men screened for the Multiple Risk Factor Intervention Trial. Circulation 77: 504–514, 1988.
    Article PubMed CAS Google Scholar
  50. Vogt T.M., Curtis Ireland C., Black D., Camel G., Hughes G.: Recruitment of elderly volunteers for a multicenter clinical trial: the SHEP pilot study. Controlled Clin. Trials 7: 118–133, 1986.
    Article PubMed CAS Google Scholar
  51. Wing S., Aubert R.E., Hansen J.P., Harnes C.G., Slome C., Tyroler H.A.: Isolated systolic hypertension in Evans county. I. Prevalence and screening considerations. J. Chronic Dis. 35: 735–742, 1982.
    Article PubMed CAS Google Scholar
  52. Kannel W.B., Wolf P.A., McGee D.L., Dawber T.R., McNamara P., Castelli W.P.: Systolic blood pressure, arterial rigidity, and risk of stroke. JAMA 245: 1225–1229, 1981.
    Article PubMed CAS Google Scholar
  53. Wilking S.V.B., Belanger A., Kannel W.B., D’Agostino R.B., Steel K.: Determinants of isolated systolic hypertension. JAMA 260: 3451–3455, 1988.
    Article PubMed CAS Google Scholar
  54. The WHO/ISH (International Society of Hypertension) Mild Hypertension Liaison Committee: 1989 Guidelines for the management of mild hypertension: memorandum from a WHO/ISH meeting. Bull. WHO 67: 493–498, 1989.
    Google Scholar
  55. Davies B.R., Ford C.E., Remington R.D., Stamler R., Hawkins C.M.: The Hypertension Detection and Follow-up Program design: methods, and baseline characteristics and blood pressure response of the study population. Prog. Cardiovasc. Dis. 29 (Suppl. 1): 11–28, 1986.
    Article Google Scholar
  56. Folstein M.F., Folstein S.E., McHugh R.P.: “Mini Mental State”. A practical method for grading the cognitive function state of patients for the clinician. J. Psychiatr. Res. 12: 189–198, 1975.
    Article PubMed CAS Google Scholar
  57. Applegate W., Dismuke E., Runyan J.W. Jr: Treatment of hypertension in the elderly: a time of caution? J. Am. Geriatr. Soc. 32: 21–23, 1984.
    PubMed CAS Google Scholar
  58. The Working Group on Hypertension in the Elderly: Statement on hypertension in the elderly. JAMA 256: 70–74, 1986.
    Article Google Scholar
  59. Gifford R.W. Jr: Geriatric hypertension: Chairman’s comments on the NIH Working Group report. Geriatrics 42: 45–50, 1987.
    PubMed Google Scholar
  60. The Joint National Committee: The 1988 report of the Joint National Committee on detection, evaluation, and treatment of high blood pressure. Arch. Intern. Med. 148: 1023–1038, 1988.
    Article Google Scholar
  61. McFate-Smith W.: The case for treating hypertension in the elderly. Am. J. Hypertens. 1 (Suppl. 1): 173s–178s, 1988.
    Article Google Scholar
  62. Saltzberg S., Stroh J.A., Frishman W.H.: Isolated systolic hypertension in the elderly: pathophysiology and treatment. Med. Clin. North Am. 72: 523–547, 1988.
    PubMed CAS Google Scholar
  63. Breckenridge M.B., Kostis J.B.: Isolated systolic hypertension in the elderly: results of a statewide survey of clinical practice in New Jersey. Am. J. Med. 86: 370–375, 1989.
    Article PubMed CAS Google Scholar
  64. Schnall C., Weiner J.S.: Clinical evaluation of blood pressure in alcoholics. Q. J. Stud. Alcohol 19: 432–446, 1958.
    PubMed CAS Google Scholar
  65. deVries H.A.: Physiological effects of an exercise training regimen upon men aged 52 to 88. J. Gerontol. 25: 325–336, 1970.
    Article PubMed Google Scholar
  66. Weber F., Banard R.J., Roy D.: Effects of a high-complex-carbohydrate, low-fat diet and daily exercise on individuals 70 years of age and older. J. Gerontol. 38: 155–161, 1983.
    Article PubMed CAS Google Scholar
  67. Niarchos A.P., Weinstein D.L., Laragh J.H.: Comparison of the effects of diuretic therapy and low sodium intake in isolated systolic hypertension. Am. J. Med. 77: 1061–1068, 1984.
    Article PubMed CAS Google Scholar
  68. Seals D.R., Hurley B.F., Hagberg J.M., Schultz J., Linder B.J., Natter L., Ehsani A.A.: Effects of training on systolic time intervals at rest and during isometric exercise in men and women 61 to 64 years old. Am. J. Cardiol. 55: 797–800, 1985.
    Article PubMed CAS Google Scholar
  69. Posner J.D., Gorman K.M., Klein H.S., Woldow A.: Exercise capacity in the elderly. Am. J. Cardiol. 57: 52C-58C, 1986.
    Article Google Scholar
  70. Cunningham D.A., Rechnitzer P.A., Howard J.H., Donner A.P.: Exercise training of men at retirement: a clinical trial. J. Gerontol. 42: 17–23, 1987.
    Article PubMed CAS Google Scholar
  71. Potter J.F., Beevers G.D.: Non-pharmacological reduction of blood pressure in the elderly. In: Amery A., Staessen J. (Eds.), Handbook of Hypertension. Hypertension in the Elderly, Vol. 12. Elsevier, Amsterdam, 1989, pp. 352–367.
    Google Scholar
  72. Mattila K., Haavisto M., Rajala S., Heikinheimo R.: Blood pressure and five-year survival in the very old. Br. Med. J. 296: 887–889, 1988.
    Article CAS Google Scholar
  73. Staessen J., Bulpitt C., De Leeuw P., Fagard R., Fletcher A., Fqrette F., Leonetti G., Nissinen A., O’Malley K., Tuomilehto J., Webster J., Williams B.O.: Relation between mortality and treated blood pressure in elderly patients with hypertension: report from the European Working Party on High Blood Pressure in the Elderly. Br. Med. J. 298: 1552–1556, 1989.
    Article CAS Google Scholar
  74. Forette B., Tortrat D., Wolmark Y.: Cholesterol as risk factor for mortality in elderly women. Lancet I: 868–870, 1989.
    Article Google Scholar
  75. Staessen J., Amery A., Birkenhäger W., Bulpitt C., Clement D., de Leeuw P., De Schaepdryver A., Dollery C., Fagard R., Fletcher A., Forette F., Forte J., Henry J.F., Koistinen A., Leonetti G., Nissinen A., O’Brien E., O’Malley K., Pelemans W., Petrie J.C., Strasser T., Terzoli L., Thijs L., Tuomilehto J., Webster J., Williams B.: Is a high serum cholesterol level associated with longer survival in elderly hypertensives? J. Hypertension 8: 755–761, 1990.
    Article CAS Google Scholar
  76. Levenson J., Simon A., Maarek B., Totomoukouo J., Gitelman R., Bouthier J., Safar M.: Comparative effects of beta-adrenergic blockade in systolic hypertension according to age. Eur. Heart J. 4 (Suppl. G): 51–54, 1983.
    Article PubMed Google Scholar
  77. Vardan S., Mookherjee S., Warner R., Smulyan H.: Systolic hypertension in the elderly. Hemodynamic response to long-term thiazide diuretic therapy and its side effects. JAMA 250: 2807–2813, 1983.
    Article PubMed CAS Google Scholar
  78. Gray D.R., Weber M.A., Drayer J.I.M.: Effects of low-dose antihypertensive therapy in elderly patients with predominant systolic hypertension. J. Gerontol. 38: 302–306, 1983.
    Article PubMed CAS Google Scholar
  79. Boyles P.W.: Hydrochlorothiazide plus methyldopa in the treatment of isolated systolic hypertension in the elderly. Clin. Ther, 6: 793–799, 1984.
    PubMed CAS Google Scholar
  80. Niarchos A.P., Laragh J.H.: Effects of diuretic therapy in low-normal- and high-renin isolated systolic systemic hypertension. Am. J. Cardiol. 53: 797–801, 1984.
    Article PubMed CAS Google Scholar
  81. Vaicaitis J.S.: Methyldopa: an agent for the treatment of older patients with isolated systolic hypertension. Clin. Ther. 6: 451–456, 1984.
    PubMed CAS Google Scholar
  82. Hulley S.B., Furberg C.D., Gurland B., McDonald R., Perry H.M., Schnaper H.W., Schoenberger J.A., McFate Smith W., Vogt T.M.: Systolic hypertension in the elderly program (SHEP): antihypertensive efficacy of chlorthalidone. Am, J. Cardiol. 56: 913–920, 1985.
    Article CAS Google Scholar
  83. Morledge J.H., Ettinger B., Aranda J., McBarron F., Barra P., Gorwit J., Davidov M.: Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. J. Am. Geriatr. Soc. 34: 199–206, 1986.
    PubMed CAS Google Scholar
  84. McFate Smith W., Feigal D.W., Furberg C.D., Greenlick M., Kuller L., Perry H.M., Schnaper H.W., Schoenberger J.A.: Use of diuretics in treatment of hypertension in the elderly. Drugs 31 (Suppl. 4): 154–164, 1986.
    Google Scholar
  85. Shapiro DA, Liss C.L., Walker J.F., Lewis J.L., Lengerich R.A., Irvin J.D.: Enalapril and hydrochlorothiazide as antihypertensive agents in the elderly. J. Cardiovasc. Pharmacol. 10 (Suppl. 7): 5160–162, 1987.
    Google Scholar
  86. Duchier J., Iannascoli F., Safar M.: Antihypertensive effect of sustained-release isosorbide dinitrate for isolated systolic systemic hypertension in the elderly. Am. J. Cardiol. 60: 99–102, 1987.
    Article PubMed CAS Google Scholar
  87. O’Malley K., McCormack P., O’Brien E.T.: Isolated systolic hypertension: data from the European Working Party on High Blood Pressure in the Elderly. J. Hypertension 6 (Suppl. 1):S105–S108, 1988.
    Google Scholar
  88. Murray G.D., Lesaffre E.: Statistical pitfalls in the analysis of age-related effects in antihypertensive therapy: J. Cardiovasc. Pharmacol. 12 (Suppl. 8): S167–S172, 1988.
    PubMed Google Scholar
  89. Thijs L., Amery A., Birkenhäger W., Bulpitt C.J., Clement D., Dall J., De Leeuw P., De Schaepdryver A., Dollery C., Forette F., Henry J.F., Koistinen A., Leonetti G., Nissinen A., O’Brien E., O’Malley K., Staessen J., Strasser T., Terzoli L., Tuomilehto J., Webster J., Williams B.O., Zanchetti A.: Age-related effects of placebo and active treatment in patients beyond the age of 60 years: the need of a proper control group. J. Hypertension 8: 997–1002, 1990.
    Article CAS Google Scholar
  90. Buhler F.R.: Age and pathophysiology-oriented antihypertensive response to calcium antagonists. J. Cardiovasc. Pharmacol. 12 (Suppl. 8): S156–S162, 1988.
    PubMed Google Scholar
  91. Levenson J.A., Safar M.E., Simon A.C., Bouthier J.A., Griener L.: Central and arterial hemodynamic effects of nifedipine (20 mg) in mild to moderate hypertension. Hypertension 5 (Suppl. V): V57–V60, 1983.
    PubMed CAS Google Scholar
  92. Safar M.E., Simon A.C., Levenson J.A., Cazor J.L.: Hemodynamic effects of diltiazem in hypertension. Circ. Res. 52 (Suppl. 1): 169–173, 1983.
    Google Scholar
  93. Kohno M., Kumada T., Ozaki M.: Evaluation of aortic wall distensibility by aortic pressure-diameter relation: effects of nifedipine on aortic wall. Cardiovasc. Res. 21: 305–312, 1987.
    Article PubMed CAS Google Scholar
  94. Simon A.C., Levenson J.A., Bouthier J.A.: Comparison of oral MK 412 and propranolol in mild to moderate essential hypertension and their effects on arterial and venous vessels of the forearm. Am. J. Cardiol. 53: 781–785, 1984.
    Article PubMed CAS Google Scholar
  95. Safar M.E., Laurent S., Bouthier J.A., London G.M.: Comparative effects of captopril and isosorbide dinitrate on the arterial wall of hypertensive human brachial arteries. J. Cardiovasc. Pharmacol. 8: 1257–1261, 1986.
    Article PubMed CAS Google Scholar
  96. Levy B.I., Michel J.B., Salzmann J.L., Azizi M., Poitevin P., Safar M., Camilleri J.P.: Effects of chronic inhibition of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension. Circ. Res. 63: 227–239, 1988.
    Article PubMed CAS Google Scholar
  97. Safar M.E.: Editorial review. Pulse pressure in essential hypertension: clinical and therapeutical implications. J. Hypertension 7: 769–776, 1989.
    Article CAS Google Scholar
  98. Staessen J., Cattaert A., Fagard R., Lijnen P., Vanhees L., Amery A.: Epidemiology of treated, compared to untreated hypertension. In: Genest J., Kuchel O., Hamet P., Cantin M. (Eds.), Hypertension. McGraw-Hill Book Company, New York, 1983, pp. 1069–1093.
    Google Scholar
  99. Fletcher A., Amery A., Birkenhager W., Bulpitt C., Clement D., De Leeuw P., Deruyttere M., De Schaepdryver A., Dollery C., Fagard Lund-Johansen P., Nissinen A., O’Brien E., O’Malley K., Pelemans W., Petrie J.C., Staessen J., Strasser T., Terzoli L., Thijs L., Tuomilehto J., Webster J., Williams B.O.: Risks and benefits in the European Working Party on High Blood Pressure in the Elderly Trial. J. Hypertension 9: 225–230, 1990.
    Article Google Scholar
  100. Vogt T.M., Curtis Ireland C., Black D., Camel G., Hughes G.: Recruitment of elderly volunteers for a multicenter clinical trial: the SHEP pilot study. Controlled Clin. Trials 7: 118–133, 1986.
    Article PubMed CAS Google Scholar
  101. Black D.M., Brand R.J., Greenlick M., Hughes G., Smith J., for the SHEP Pilot Research Group: Compliance to treatment for hypertension in elderly patients: the SHEP Pilot Study. J. Gerontol. 42: 552–557, 1987.
    Article PubMed CAS Google Scholar
  102. Perry Jr. H.M., McDonald R.H., Hulley S.B., McFate-Smith W., Furberg C.D., Greenlick M.R., Kuller L.H., Schnaper H.W., Schoenberger J.A., Vogt T.M.: Systolic Hypertension in the Elderly Program, Pilot Study (SHEP-PS). J. Hypertension 4 (Suppl. 6): S21–S23, 1986.
    Google Scholar
  103. Furberg C.D., Black D.M., for the SHEP Research Group: The systolic hypertension in the elderly pilot program: methodological issues. Eur. Heart J. 9: 223–227, 1988.
    PubMed CAS Google Scholar
  104. Perry H.M., Smith W.M., McDonald R.H., Black D., Cutler J.A., Furberg C.D., Greenlick M.R., Kuller L.H., Schnaper H.W., Schoenberger J.A., Vogt T.M., Wolf P.A., Hulley S.B.: Morbidity and mortality in the Systolic Hypertension in the Elderly Program (SHEP) Pilot Study. Stroke 20: 4–13, 1989.
    Article PubMed Google Scholar
  105. Miall W.E., Greenberg G.: Mild hypertension: is there pressure to treat? Cambridge University Press, Cambridge 1987, pp. 153–178.
    Google Scholar
  106. Dahlöf B., Hansson L., Lindholm L., Schersten B., Wester P.O.: STOP-Hypertension — Preliminary communication from the Pilot Study of the Swedish Trial in Old Patients with Hypertension. J. Hypertension 5 (Suppl. 5): S607–S610, 1987.
    Google Scholar
  107. Wu Y.K., Lu C.Q., Gao R.C., Yu J.S., Liu G.C.: Nation-wide hypertension screening in China during 1979–1980. Chin. Med. J. 95: 101–108, 1982.
    PubMed CAS Google Scholar
  108. Tao S.C., Zhang X.G., Wang S.Y., Yu X.H., Wu X., Lu C.Q.: Incidence of acute myocardial infarction and stroke in the capital iron and steel region of Beijing, China. Magnesium 1: 144–150, 1982.
    Google Scholar
  109. Wu Z.S., Hong Z.G., Yao C.H., Chen D.Y., Nan L., Min Z., Wu Y.Y., Wu Y.K.: Sino-Monica-Beijing Study: report of the results between 1983–1985. Chin. Med. J. 100: 611–620, 1987.
    PubMed CAS Google Scholar

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