Alcohol-preferring and alcohol-avoiding C57BL mice (original) (raw)

Abstract

Three sublines of the high alcohol preference C57BL strain were compared in twochoice alcohol-water testing. As indicated by other investigators, C57BL/10J and C57BL/6J mice prefer 10% alcohol to water. In contrast. C57BL/6A mice prefer water to alcohol. This subline originated from homozygous Jackson Laboratory stock and was maintained by brother-sister inbreeding. Hence a gene mutation is offered as a probable explanation for this behavioral difference.

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References

• Falconer, D. S. (1960).Introduction to Quantitative Genetics, Ronald Press, New York.
  Google Scholar
• Fuller, J. L. (1964). Measurement of alcohol preference in genetic experiments.J. Comp. Physiol. Psychol. 57: 85–88.
  Google Scholar
• McClearn, G. E., and Rodgers, D. A. (1959). Differences in alcohol preference among inbred strains of mice.Quart. J. Stud. Alcohol 20: 691–695.
  Google Scholar
• Poley, W., Yeudall, L. T., and Royce, J. R. (1970). Factor analyses of alcohol and water consumption in laboratory mice.Can. J. Psychol. 24: 34–41.
  Google Scholar
• Rodgers, D. A., McClearn, G. E., Bennett, E. L., and Hebert, M. (1963). Alcohol preference as a function of its caloric utility in mice.J. Comp. Physiol. Psychol. 56: 666–672.
  Google Scholar
• Rodgers, D. A., Ward, P. A., Thiessen, D. D., and Whitworth, N. S. (1967). Pathological effects of prolonged voluntary consumption of alcohol by mice.Quart. J. Stud. Alcohol 28: 618–630.
  Google Scholar
• Sheppard, J. R., Albersheim, P., and McClearn, G. E. (1968). Enzyme activities and ethanol preference in mice.Biochem. Genet. 2: 205–212.
  Google Scholar
• Sheppard, J. R., Albertsheim, P., and McClearn, G. E. (1970). Aldehyde dehydrogenase and ethanol preference in mice.J. Biol. Chem. 245: 2876–2882.
  Google Scholar

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Author notes

1. Wayne Poley
   Present address: Laboratory Animal Service, University of Alberta, Alberta, Canada

Authors and Affiliations

1. University of Alberta, Edmonton, Alberta, Canada
   Wayne Poley

Additional information

This research was supported by a grant from the Licensed Beverage Industries, New York.

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Poley, W. Alcohol-preferring and alcohol-avoiding C57BL mice.Behav Genet 2, 245–248 (1972). https://doi.org/10.1007/BF01065693

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• Received: 15 October 1971
• Issue date: June 1972
• DOI: https://doi.org/10.1007/BF01065693

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