Intestinal microsporidiosis in a German patient with AIDS (original) (raw)

Summary

Since intestinal microsporidiosis might be of importance in the pathogenesis of gastrointestinal symptoms in patients infected with HIV, we examined duodenal biopsies of HIV-infected patients by electron microscopy. Enterocytozoon bieneusi infection of the small intestine was found in one of 23 patients studied, which gives a 95% confidence interval for the prevalence rate between 0.1 % and 22%. The infected patient was a 24-year-old homosexual male with AIDS who underwent upper endoscopy because of acute epigastric pain, nausea, and vomiting. These symptoms were obviously due to mesenterial Kaposi's sarcoma obstructing the duodenal passage, as was later revealed at autopsy. However, microsporidiosis might have caused the patient's eight-month history of diarrhea and weight loss, since infected cells showed signs of degeneration, and no other pathogens were ever detected in stool or biopsy. Our finding of Enterocytozoon bieneusi infection in a German AIDS patient supports the concept of a worldwide distribution of this parasite; further studies are needed to define its exact prevalence in HIV-infected patients and its pathogenic relevance.

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Abbreviations

HIV:

human immunodeficiency virus type I

AIDS:

acquired immunodeficiency syndrome

E. bieneusi:

Enterocytozoon bieneusi

References

1. Cali A, Owen RL (1990) Intracellular development of Enterocytozoon, a unique microsporidian found in the intestine of AIDS patients. J Protozool 37:145–155
   Article CAS PubMed Google Scholar
2. Canning EU, Hollister WS (1990) Enterocytozoon bieneusi (Microspora): prevalence and pathogenicity in AIDS patients. Trans R Soc Trop Med Hyg 84:181–186
   Article CAS PubMed Google Scholar
3. Dobbins WO, Weinstein WM (1985) Electron microscopy of the intestine and rectum in acquired immunodeficiency syndrome. Gastroenterology 88:738–749
   Article PubMed Google Scholar
4. Friedman SL, Wright TL, Altman DF (1985) Gastrointestinal Kaposi's sarcoma in patients with acquired immunodeficiency syndrome. Gastroenterology 89:102–108
   Article CAS PubMed Google Scholar
5. Modigliani R, Bories C, Le Charpentier Y et al. (1985) Diarrhoea and malabsorption in acquired immune deficiency syndrome: a study of four cases with special emphasis on opportunistic protozoan infestations. Gut 26:179–187
   Article CAS PubMed PubMed Central Google Scholar
6. Orenstein JM, Chiang J, Steinberg W, Smith PD, Rotterdam H, Kotler DP (1990) Intestinal microsporidiosis as a cause of diarrhea in human immunodeficiency virus-infected patients: a report of 20 cases. Hum Pathol 21:475–481
   Article CAS PubMed Google Scholar
7. Riecken EO, Zeitz M, Ullrich R (1990) Non-opportunistic causes of diarrhoea in HIV infection. Baillieres Clin Gastroenterol 4:385–403
   Article CAS PubMed Google Scholar
8. Shadduck JA, Greeley E (1989) Microsporidia and human infections. Clin Microbiol Rev 2:158–165
   Article CAS PubMed PubMed Central Google Scholar
9. Ullrich R, Zeitz M, Heise W, L'age M, Höffken G, Riecken EO (1989) Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy. Ann Intern Med 111:15–21
   Article CAS PubMed Google Scholar
10. Zeitz M, Menge H, Riecken EO (1985) Early ultrastructural adaptive changes of ileal enterocytes after proximal small bowel resection as determined morphometrically. Res Exp Med (Berl) 185:259–268
    Article CAS Google Scholar

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Authors and Affiliations

1. Medizinische Klinik, Klinikum Steglitz, Freie Universität Berlin, Deutschland
   R. Ullrich, M. Zeitz, C. Bergs & E. O. Riecken
2. Fachgebiet Klinische Parasitologie, Robert-Koch-Institut Berlin, Deutschland
   K. Janitschke

Authors

1. R. Ullrich
2. M. Zeitz
3. C. Bergs
4. K. Janitschke
5. E. O. Riecken

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Ullrich, R., Zeitz, M., Bergs, C. et al. Intestinal microsporidiosis in a German patient with AIDS.Klin Wochenschr 69, 443–445 (1991). https://doi.org/10.1007/BF01666833

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• Received: 15 March 1991
• Accepted: 12 April 1991
• Published: 23 July 2016
• Issue date: July 1991
• DOI: https://doi.org/10.1007/BF01666833

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