Macrolide antibiotics as antiinflammatory agents: Roxithromycin in an unexpected role (original) (raw)

References

1. A. L. Barry, C. Thornsberry and R. N. Jones,In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin and clindamycin, Antimicrob. Agents Chemoter.31, 343–345 (1987).
   Google Scholar
2. R. A. Young, J. P. Gonzalez and E. M. Sorkin,Roxithromycin: A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs_37_, 8–41 (1989).
   PubMed Google Scholar
3. T. Tomomasa, T. Kuroume, H. Arai, K. Wakabayashi and Z. Itoh,Erythromycin induces migrating motor complex in human gastrointestinal tract. Dig. Dis. Sci.31, 157–161 (1986).
   PubMed Google Scholar
4. V. Annese, J. Janssens, G. Vantrappen, J. Tack, T. C. Peeters, P. Willemse and E. Van Cutsem,Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination. Gastroenterology_102_, 823–828 (1992).
   PubMed Google Scholar
5. T. L. Peeters, G. Matthijs, I. Depoortere, T. Cachet, J. Hoogmartens and G. Vantrappen,Erythromycin is a motilin receptor agonist. Am. J. Physiol.257, G470-G474 (1989).
   PubMed Google Scholar
6. G. Plewig and E. Schopf,Anti-inflammatory effects of antimicrobial agents: An in vivo study. J. Invest. Dermatol.65, 532–537 (1975).
   PubMed Google Scholar
7. J. P. Tarayre, M. Aliaga, M. Barbara, G. Villanova, R. Ballester, J. Tisne-Versailles and J. P. Couzinier,Cutaneously applied erythromycin base reduces various types of inflammatory reactions in mouse ear. Int. J. Tissue React.9, 77–85 (1987).
   PubMed Google Scholar
8. T. Barlam and H. C. Neu,In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria. Antimicrob. Agents Chemoter.25, 529–531 (1984).
   Google Scholar
9. M. Campa, I. Zolfino, S. Senesi, N. Bernardini, R. Danesi, M. Ducci, M. Oleggini, R. Di Stefano, F. Mosca, A. Lazzarini and M. Del Tacca,The penetration of roxithromycin into human skin. J. Antimicrob. Chemoter.26, 87–90 (1990).
   Google Scholar
10. M. Del Tacca, R. Danesi, N. Bernardini, M. Ducci, I. Zolfino, S. Senesi, E. Panattoni, M. Gabriele, M. Marcucci, A. Lazzarini and M. Campa,Roxithromycin penetration into gingiva and alveolar bone of odontoiatric patients. Chemotherapy_36_, 332–336 (1990).
    PubMed Google Scholar
11. P. Agache, P. Amblard, G. Moulin, H. Barriere, L. Texier, C. Beylot and H. Bergoend,Roxithromycin in skin and soft tissue infections. J. Antimicrob. Chemother.20 (suppl. B), 153–156 (1987).
    PubMed Google Scholar
12. J. Sasaki,Clinical evaluation of roxithromycin in odontogenic orofacial infections. J. Antimicrob. Chemoter.20 (suppl. B), 167–170 (1987).
    Google Scholar
13. H. Makino, S. Kuzuna, T. Naka, T. Saijo and Y. Maki,Antiinflammatory, analgesic, and antipyretic activities of methyl-7-butyl-4,5,6,7-tetrahydro-3-methylamino-4-6-dioxo-5-propyl-2H-pyrazolo[3,4-d]pyrimidine-2-carboxilate (AA-2379), a novel non-acidic agent. Agents and Actions_25_, 385–393 (1988).
    PubMed Google Scholar
14. S. Kumakura, M. Mishima, S. Kobayashi, H. Shirota, S. Abe, K. Yamada and S. Tsurufuji,Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrageenan-induced inflammation in rats. Agents and Actions_29_, 286–291 (1990).
    PubMed Google Scholar
15. E. Antunes, M. Mariano, G. Cirino, S. Levi and G. de Nucci,Pharmacological characterization of polycation induced rat hindpaw oedema. Br. J. Pharmacol.101, 986–990 (1990).
    PubMed Google Scholar
16. L. M. Brand, K. L. Skare, M. E. Loomans, H. H. Reller, R. J. Schwen, D. A. Lade, R. L. Bohne, C. S. Maddin, D. P. Moorehead, R. Fanelli, C. Chiabrando, M. G. Castelli and H. H. Tai,Anti-inflammatory pharmacology and mechanism of the orally active capsaicin analogs, NE-19550 and NE-28345. Agents and Actions_31_, 329–340 (1990).
    PubMed Google Scholar
17. C. J. E. Niemegeers, W. Van Bruggen, F. Awouters and P. A. J. Janssen,The effects of suprofen in rats with implanted cotton pellets. Arzeim.-Forsch. (Drug Res.)25, 1524–1526 (1975).
    Google Scholar
18. G. A. Higgs, K. G. Mugridge, S. Moncada and J. R. Vane,Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW7555c. Proc. Natl. Acad. Sci. USA_81_, 2890–2892 (1975).
    Google Scholar
19. A. Kitchen,Methods for the assessment of drug action on cellular accumulation. In_Anti-inflammatory Compounds_. In_Clinical Pharmacology_, Vol. 9 (Ed. W. R. N. Williamson) pp. 153–191, Marcel Dekker, New York 1987.
    Google Scholar
20. W. T. Shier and D. J. DuBourdieu,Polycations as prostaglandin synthesis inducers. II. Structure-activity relationships. Prostaglandins_31_, 1145–1157 (1986).
    PubMed Google Scholar
21. L. Needham, P. G. Hellewell, T. J. Williams and J. L. Gordon,Endothelial functional responses and increased vascular permeability induced by polycations. Lab. Invest.59, 538–548 (1988).
    PubMed Google Scholar
22. L. J. Ignarro, M. E. Gold, G. M. Buga, R. E. Byrns, K. S. Wood, G. Chaudhuri and G. Frank,Basic polyamino acids rich in arginine, lysine or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein. Circ. Res.64, 315–329 (1989).
    PubMed Google Scholar
23. C. Vigo, G. P. Lewis and P. J. Piper,Mechanism of inhibition of phospholipase A 2. Biochem. Pharmacol.29, 623–627 (1980).
    PubMed Google Scholar
24. M. Simionescu, N. Simionescu, J. E. Silbert and G. E. Palade,Differential microdomains on the luminal surface of the capillary endothelium. II. Partial characterization of their anionic sites. J. Cell Biol.90, 614–621 (1981).
    PubMed Google Scholar
25. Y. Miyachi, A. Yoshioka, S. Imamura and Y. Niwa,Effect of antibiotics on the generation of reactive oxygen species. J. Invest. Dermatol.86, 449–453 (1986).
    PubMed Google Scholar
26. K. Dalziel, P. J. Dykes and R. Marks,The effects of tetracycline and erythromycin in a model of acne-type inflammation. Br. J. Exp. Path.68, 67–70 (1987).
    Google Scholar
27. M. T. Labro, J. El Benna and C. Babin-Chevaye,Comparison of the in-vitro effect of several macrolides on the oxidative burst of human neutrophils. J. Antimicrob. Chemother.24, 561–572 (1989).
    PubMed Google Scholar

Download references