Sex Differences in Mutation Rate in Higher Primates Estimated from AMG Intron Sequences (original) (raw)

Abstract.

To study sex differences in mutation rate in primates, we sequenced the third introns of the AMGX and AMGY genes from humans, orangutans, and squirrel monkeys and estimated that the male-to-female ratio of mutation rate is α= 5.14 with the 95% confidence interval (2.42, 16.6). Combining this data set and the data sets from ZFX/ZFY and SMCX/SMCY introns, we obtained an estimate of α= 5.06 with the 95% confidence interval reduced to (3.24, 8.79). The α value is significantly higher in higher primates than in rodents.

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Authors and Affiliations

  1. Human Genetics Center, SPH, University of Texas, P.O. Box 20334, Houston, TX 77225, USA, , , , , , US
    Wei Huang, Benny H.-J. Chang, Xun Gu, David Hewett-Emmett & W.-H. Li

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  1. Wei Huang
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  2. Benny H.-J. Chang
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  3. Xun Gu
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  4. David Hewett-Emmett
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  5. W.-H. Li
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Received: 19 August 1996 / Accepted: 22 November 1996

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Huang, W., Chang, BJ., Gu, X. et al. Sex Differences in Mutation Rate in Higher Primates Estimated from AMG Intron Sequences .J Mol Evol 44, 463 –465 (1997). https://doi.org/10.1007/PL00006166

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