cDermo-1 expression indicates a role in avian skin development (original) (raw)

Abstract

Basic helix-loop-helix (bHLH) transcription factors have been shown to be important regulatory proteins for tissue determination and differentiation. We cloned the chicken homologue of the gene of the murine Twist-related bHLH protein Dermo-1, which we named cDermo-1, and analyzed its sequence and embryonic expression. Our sequence data suggest a decisive role of Dermo-1 proteins in the evolution of amniote skin. We present a detailed analysis of cDermo-1 expression during avian embryonic development. cDermo-1 is first expressed in a variety of mesodermal tissues of the chick embryo including the limb buds, but later becomes restricted to the subectodermal mesenchyme of the integument and the developing feather buds, indicating a role of cDermo-1 during avian skin and feather development.

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Authors and Affiliations

  1. Institute of Anatomy, University of Freiburg, Albertstrasse 17, 79104 Freiburg, Germany e-mail: brandsab@uni-freiburg.de Tel.: 761-203-5086, Fax: 761-203-5091, , , , , , DE
    Martin Scaal & B. Brand-Saberi
  2. Max-Planck-Institute for Immunobiology, Department of Developmental Biology, Stuebeweg 51, 79108 Freiburg, Germany, , , , , , DE
    Ernst-Martin Füchtbauer

Authors

  1. Martin Scaal
  2. Ernst-Martin Füchtbauer
  3. B. Brand-Saberi

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Accepted: 4 September 2000

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Scaal, M., Füchtbauer, EM. & Brand-Saberi, B. cDermo-1 expression indicates a role in avian skin development.Anat Embryol 203, 1–7 (2001). https://doi.org/10.1007/PL00008244

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