Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain (original) (raw)
Roberts RM, Mathialagan N, Duffy JY, Smith GW. Regulation and regulatory role of proteinase inhibitors. Crit Rev Eukaryot Gene Expr. 1995;5:385–436. CASPubMed Google Scholar
Ferencík M, Stvrtinová V, Hulín I, Novák M. Inflammation–a lifelong companion: attempt at a non-analytical holistic view. Folia Microbiol (Praha). 2007;52:159–73. Article Google Scholar
Kobayashi H, Suzuki M, Hirashima Y, Terao T. The protease inhibitor bikunin, a novel anti-metastatic agent. Biol Chem. 2003;384:749–54. ArticleCASPubMed Google Scholar
Vincent JP, Lazdunski M. Trypsin-pancreatic trypsin inhibitor association: dynamics of the interaction and role of disulfide bridges. Biochemistry. 1972;11:2967–77. ArticleCASPubMed Google Scholar
Astrup T, Nissen U. Urinary trypsin inhibitor (Mingin): transformation into a new trypsin inhibitor by acid hydrolysis or by sialidase. Nature. 1964;203:255–7. ArticleCASPubMed Google Scholar
Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem. 1997;272:6370–6. ArticleCASPubMed Google Scholar
Salem HT, Obiekwe BC, Al-Ani AT, Seppälä M, Chard T. Molecular heterogeneity of placental protein 5 (PP5) in late pregnancy serum and plasma: evidence for a heparin-PP5 polymer. Clin Chim Acta. 1980;107:211–5. ArticleCASPubMed Google Scholar
Ascenzi P, Bocedi A, Bolognesi M, Spallarossa A, Coletta M, De Cristofaro R, Menegatti E. The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein. Curr Protein Pept Sci. 2003;4:231–51. ArticleCASPubMed Google Scholar
Day JR, Landis RC, Taylor KM. Aprotinin and the protease-activated receptor 1 thrombin receptor: antithrombosis, inflammation, and stroke reduction. Semin Cardiothorac Vasc Anesth. 2006;10:132–42. ArticleCASPubMed Google Scholar
Rattenholl A, Steinhoff M. Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease. Drug News Perspect. 2008;21:369–81. ArticleCASPubMed Google Scholar
Mercer PF, Deng X, Chambers RC. Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury. Ann N Y Acad Sci. 2007;1096:86–8. ArticleCASPubMed Google Scholar
Kristeller JL, Roslund BP, Stahl RF. Benefits and risks of aprotinin use during cardiac surgery. Pharmacotherapy. 2008;28:112–24. ArticleCASPubMed Google Scholar
Dietrich W. Efficacy and safety of aprotinin in cardiac surgery. Orthopedics. 2004;27:s659–62. Google Scholar
Planès C, Caughey GH. Regulation of the epithelial Na+ channel by peptidases. Curr Top Dev Biol. 2007;78:23–46. ArticlePubMedCAS Google Scholar
He H, Li W, Tseng DY, Zhang S, Chen SY, Day AJ, Tseng SC. Biochemical characterization and function of complexes formed by hyaluronan and the heavy chains of inter-alpha-inhibitor (HC*HA) purified from extracts of human amniotic membrane. J Biol Chem. 2009;284:20136–46. ArticleCASPubMed Google Scholar
Yoneda M, Suzuki S, Kimata K. Hyaluronic acid associated with the surfaces of cultured fibroblasts is linked to a serum-derived 85-kDa protein. J Biol Chem. 1990;265:5247–57. CASPubMed Google Scholar
Salier JP, Rouet P, Raguenez G, Daveau M. The inter-alpha-inhibitor family: from structure to regulation. Biochem J. 1996;315:1–9. CASPubMed Google Scholar
Chen L, Mao SJ, McLean LR, Powers RW, Larsen WJ. Proteins of the inter-alpha-trypsin inhibitor family stabilize the cumulus extracellular matrix through their direct binding with hyaluronic acid. J Biol Chem. 1994;269:28282–7. CASPubMed Google Scholar
Menezes GB, McAvoy EF, Kubes P. Hyaluronan, platelets, and monocytes: a novel pro-inflammatory triad. Am J Pathol. 2009;174:1993–5. ArticleCASPubMed Google Scholar
Jiang D, Liang J, Noble PW. Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol. 2007;23:435–61. ArticleCASPubMed Google Scholar
Zhuo L, Hascall VC, Kimata K. Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex. J Biol Chem. 2004;279:38079–82. ArticleCASPubMed Google Scholar
Forteza R, Casalino-Matsuda SM, Monzon ME, Fries E, Rugg MS, Milner CM, Day AJ. TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release. Am J Respir Cell Mol Biol. 2007;36:20–31. ArticleCASPubMed Google Scholar
Milner CM, Higman VA, Day AJ. TSG-6: a pluripotent inflammatory mediator? Biochem Soc Trans. 2006;34:446–50. ArticleCASPubMed Google Scholar
Rugg MS, Willis AC, Mukhopadhyay D, Hascall VC, Fries E, Fülöp C, Milner CM, Day AJ. Characterization of complexes formed between TSG-6 and inter-alpha-inhibitor that act as intermediates in the covalent transfer of heavy chains onto hyaluronan. J Biol Chem. 2005;280:25674–86. ArticleCASPubMed Google Scholar
Garantziotis S, Hollingsworth JW, Ghanayem RB, Timberlake S, Zhuo L, Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M, Day AJ. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem. 2002;277:51068–76. Article Google Scholar
Kehlen A, Pachnio A, Thiele K, Langner J. Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6. Arthritis Res Ther. 2003;5:R186–92. ArticleCASPubMed Google Scholar
Agrawal A, Singh PP, Bottazzi B, Garlanda C, Mantovani A. Pattern recognition by pentraxins. Adv Exp Med Biol. 2009;653:98–116. ArticlePubMed Google Scholar
Lee GW, Lee TH, Vilcek J. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol. 1993;150:1804–12. CASPubMed Google Scholar
Scarchilli L, Camaioni A, Bottazzi B, Negri V, Doni A, Deban L, Bastone A, Salvatori G, Mantovani A, Siracusa G, Salustri A. PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion. J Biol Chem. 2007;282:30161–70. ArticleCASPubMed Google Scholar
Souza DG, Amaral FA, Fagundes CT, Coelho FM, Arantes RM, Sousa LP, Matzuk MM, Garlanda C, Mantovani A, Dias AA, Teixeira MM. The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice. Am J Pathol. 2009;174:1309–18. ArticleCASPubMed Google Scholar
Adair JE, Stober V, Sobhany M, Zhuo L, Roberts JD, Negishi M, Kimata K, Garantziotis S. Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. J Biol Chem. 2009;284:16922–30. ArticleCASPubMed Google Scholar
Jessen TE, Odum L, Johnsen AH. In vivo binding of human inter-alpha-trypsin inhibitor free heavy chains to hyaluronic acid. Biol Chem Hoppe-Seyler. 1994;375:521–6. CASPubMed Google Scholar
Selbi W, Day AJ, Rugg MS, Fülöp C, de la Motte CA, Bowen T, Hascall VC, Phillips AO. Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells. J Am Soc Nephrol. 2006;17:1553–67. ArticleCASPubMed Google Scholar
Hinshelwood J, Spencer DI, Edwards YJ, Perkins SJ. Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionization affinity mass spectrometry and homology modelling: implications for the activity of factor B. J Mol Biol. 1999;294:587–99. ArticleCASPubMed Google Scholar
Hamm A, Veeck J, Bektas N, Wild PJ, Hartmann A, Heindrichs U, Kristiansen G, Werbowetski-Ogilvie T, Del Maestro R, Knuechel R, Dahl E. Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysi. BMC Cancer. 2008;8:25. ArticlePubMedCAS Google Scholar
Wu R, Cui X, Lim YP, Bendelja K, Zhou M, Simms HH, Wang P. Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis. Crit Care Med. 2004;32:1747–52. ArticleCASPubMed Google Scholar
Yang S, Lim YP, Zhou M, Salvemini P, Schwinn H, Josic D, Koo DJ, Chaudry IH, Wang P. Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med. 2002;30:617–22. ArticleCASPubMed Google Scholar
Wachter E, Hochstrasser K. Kunitz-type proteinase inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IV. The amino acid sequence of the human urinary trypsin inhibitor isolated by affinity chromatography. Hoppe Seylers Z Physiol Chem. 1981;362:1351–5. CASPubMed Google Scholar
Fries E, Blom AM. Bikunin-not just a plasma proteinase inhibitor. Int J Biochem Cell Biol. 2000;32:125–37. ArticleCASPubMed Google Scholar
Yoshida E, Sumi H, Tsushima H, Maruyama M, Mihara H. Distribution and localization of inter-alpha-trypsin inhibitor and its active component acid-stable proteinase inhibitor: comparative immunohistochemical study. Inflammation. 1991;15:71–9. ArticleCASPubMed Google Scholar
Yoshihara Y, Plaas A, Osborn B, Margulis A, Nelson F, Stewart M, Rugg MS, Milner CM, Day AJ, Nemoto K, Sandy JD. Superficial zone chondrocytes in normal and osteoarthritic human articular cartilages synthesize novel truncated forms of inter-alpha-trypsin inhibitor heavy chains which are attached to a chondroitin sulfate proteoglycan other than bikunin. Osteoarthritis Cartilage. 2008;16:1343–55. ArticleCASPubMed Google Scholar
Itoh H, Tomita M, Kobayashi T, Uchino H, Maruyama H, Nawa Y. Expression of inter-alpha-trypsin inhibitor light chain (bikunin) in human pancreas. J Biochem. 1996;120:271–5. CASPubMed Google Scholar
Lin SD, Takikawa Y, Endo R, Suzuki K. Proinflammatory cytokines up-regulate synthesis and secretion of urinary trypsin inhibitor in human hepatoma HepG2 cells. Hepatol Res. 2004;29:243–8. ArticleCASPubMed Google Scholar
Imada K, Ito A, Kanayama N, Terao T, Mori Y. Urinary trypsin inhibitor suppresses the production of interstitial procollagenase/proMMP-1 and prostromelysin 1/proMMP-3 in human uterine cervical fibroblasts and chorionic cells. FEBS Lett. 1997;417:337–40. ArticleCASPubMed Google Scholar
Zaitsu M, Hamasaki Y, Tashiro K, Matsuo M, Ichimaru T, Fujita I, Tasaki H, Miyazaki S. Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease. J Infect Dis. 2000;181:1101–9. ArticleCASPubMed Google Scholar
Kobayashi H, Suzuki M, Sun GW, Hirashima Y, Terao T. Suppression of urokinase-type plasminogen activator expression from human ovarian cancer cells by urinary trypsin inhibitor. Biochim Biophys Acta. 2000;1481:310–6. CASPubMed Google Scholar
Yamaguchi Y, Ohshiro H, Nagao Y, Odawara K, Okabe K, Hidaka H, Ishihara K, Uchino S, Furuhashi T, Yamada S, Mori K, Ogawa M. Urinary trypsin inhibitor reduces C-X-C chemokine production in rat liver ischemia/reperfusion. J Surg Res. 2000;94:107–15. ArticleCASPubMed Google Scholar
Aosasa S, Ono S, Mochizuki H, Tsujimoto H, Ueno C, Matsumoto A. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock. 2001;15:101–5. ArticleCASPubMed Google Scholar
Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Okabe H. Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression. Am J Physiol Heart Circ Physiol. 2005;288:H1265–71. ArticleCASPubMed Google Scholar
Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Shimozawa N, Okabe H. Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo. Thromb Haemost. 2005;94:136–45. CASPubMed Google Scholar
Wu YJ, Ling Q, Zhou XH, Wang Y, Xie HY, Yu JR, Zheng SS. Urinary trypsin inhibitor attenuates hepatic ischemia-reperfusion injury by reducing nuclear factor-kappa B activation. Hepatobiliary Pancreat Dis Int. 2009;8:53–8. CASPubMed Google Scholar
Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages. J Infect Dis. 2005;191:930–8. ArticleCASPubMed Google Scholar
Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T. Bikunin target genes in ovarian cancer cells identified by microarray analysis. J Biol Chem. 2003;278:14640–6. ArticleCASPubMed Google Scholar
Kanayama N, Maehara K, She L, Belayet HM, Khatun S, Tokunaga N, Terao T. Urinary trypsin inhibitor suppresses vascular smooth muscle contraction by inhibition of Ca2 + influx. Biochim Biophys Acta. 1998;1381:139–46. CASPubMed Google Scholar
Kanayama S, Yamada Y, Onogi A, Shigetomi H, Ueda S, Tsuji Y, Haruta S, Kawaguchi R, Yoshida S, Sakata M, Sado T, Kitanaka T, Oi H, Yagyu T, Kobayashi H. Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils. J Endotoxin Res. 2007;13:369–76. ArticleCASPubMed Google Scholar
Yu JR, Yan S, Liu XS, Wu YJ, Fu PF, Wu LH, Zheng SS. Attenuation of graft ischemia-reperfusion injury by urinary trypsin inhibitor in mouse intestinal transplantation. World J Gastroenterol. 2005;11:1605–9. CASPubMed Google Scholar
Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Yoshino S, Sato H, Yoshikawa T. Protective role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide. Exp Biol Med. (Maywood). 2005;230:281–7. CAS Google Scholar
Zhou LW, Wang YL, Yan XT, He XH. Urinary trypsin inhibitor treatment ameliorates acute lung and liver injury resulting from sepsis in a rat model. Saudi Med J. 2008;29:368–73. PubMed Google Scholar
El Maradny E, Kanayama N, Halim A, Maehara K, Kobayashi T, Terao T. Effects of urinary trypsin inhibitor on myometrial contraction in term and preterm deliveries. Gynecol Obstet Invest. 1996;41:96–102. ArticleCASPubMed Google Scholar
Pugia MJ, Valdes R Jr, Jortani SA. Bikunin (urinary trypsin inhibitor): structure, biological relevance, and measurement. Adv Clin Chem. 2007;44:223–45. ArticleCASPubMed Google Scholar
Rakic JM, Maillard C, Jost M, Bajou K, Masson V, Devy L, Lambert V, Foidart JM, Noel A. Role of plasminogen activator-plasmin system in tumor angiogenesis. Cell Mol Life Sci. 2003;60:463–73. ArticleCASPubMed Google Scholar
Yagyu T, Kobayashi H, Matsuzaki H, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K. Enhanced spontaneous metastasis in bikunin-deficient mice. Int J Cancer. 2006;118:2322–8. ArticleCASPubMed Google Scholar
Tsui KH, Chang PL, Feng TH, Chung LC, Hsu SY, Juang HH. Down-regulation of matriptase by overexpression of bikunin attenuates cell invasion in prostate carcinoma cells. Anticancer Res. 2008;28:1977–83. CASPubMed Google Scholar
Liu J, Guo Q, Chen B, Yu Y, Lu H, Li YY. Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. FEBS Lett. 2006;580:245–50. ArticleCASPubMed Google Scholar
Parr C, Jiang WG. Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells. Int J Cancer. 2006;119:1176–83. ArticleCASPubMed Google Scholar
Kirchhofer D, Peek M, Li W, Stamos J, Eigenbrot C, Kadkhodayan S, Elliott JM, Corpuz RT, Lazarus RA, Moran P. Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. J Biol Chem. 2003;278:36341–9. ArticleCASPubMed Google Scholar
Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N. Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. J Biol Chem. 2002;277:14053–9. ArticleCASPubMed Google Scholar
Itoh H, Kataoka H, Meng JY, Hamasuna R, Kitamura N, Koono M. Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin genes and their promoters. Biochim Biophys Acta. 2001;1519:92–5. CASPubMed Google Scholar
Morris MR, Gentle D, Abdulrahman M, Maina EN, Gupta K, Banks RE, Wiesener MS, Kishida T, Yao M, The B, Latif F, Maher ER. Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. Cancer Res. 2005;65:4598–606. ArticleCASPubMed Google Scholar
Tanaka H, Fukushima T, Yorita K, Kawaguchi M, Kataoka H. Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells. Hum Cell. 2009;22:11–7. ArticlePubMed Google Scholar
Szabo R, Molinolo A, List K, Bugge TH. Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene. 2007;26:1546–56. ArticleCASPubMed Google Scholar
Torres-Collado AX, Kisiel W, Iruela-Arispe ML, Rodríguez-Manzaneque JC. ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2. J Biol Chem. 2006;281:17827–37. ArticleCASPubMed Google Scholar
Chand HS, Foster DC, Kisiel W. Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost. 2005;94:1122–30. CASPubMed Google Scholar
Schmidt AE, Chand HS, Cascio D, Kisiel W, Bajaj SP. Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition. J Biol Chem. 2005;280:27832–8. ArticleCASPubMed Google Scholar
Crawley JT, Lane DA. The haemostatic role of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol. 2008;28:233–42. ArticleCASPubMed Google Scholar
Kato H. Regulation of functions of vascular wall cells by tissue factor pathway inhibitor: basic and clinical aspects. Arterioscler Thromb Vasc Biol. 2002;22:539–48. ArticleCASPubMed Google Scholar
Lanir N, Aharon A, Brenner B. Procoagulant and anticoagulant mechanisms in human placenta. Semin Thromb Hemost. 2003;29:175–84. ArticleCASPubMed Google Scholar
Guo H, Lin Y, Zhang H, Liu J, Zhang N, Li Y, Kong D, Tang Q, Ma D. Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cells. BMC Mol Biol. 2007;8:110. ArticlePubMedCAS Google Scholar
Liu YY, Stack SM, Lakka SS, Khan AJ, Woodley DT, Rao JS, Rao CN. Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin. Arch Biochem Biophys. 1999;370:8–112. Article Google Scholar
Lin YF, Zhang N, Guo HS, Kong DS, Jiang T, Liang W, Zhao ZH, Tang QQ, Ma D. Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway. Apoptosis. 2007;12:2163–73. ArticleCASPubMed Google Scholar
Ivanciu L, Gerard RD, Tang H, Lupu F, Lupu C. Adenovirus-mediated expression of tissue factor pathway inhibitor-2 inhibits endothelial cell migration and angiogenesis. Arterioscler Thromb Vasc Biol. 2007;27:310–6. ArticleCASPubMed Google Scholar
Lwaleed BA, Bass PS. Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 2006;208:327–39. ArticleCASPubMed Google Scholar