Genomic sources of regulatory variation in cis and in trans (original) (raw)

• 416 Accesses
• 53 Citations
• Explore all metrics

Abstract.

Regulatory variation results from genetic changes with both cis and trans acting effects on gene expression. Here I describe the types of genetic variants that alter cis and trans regulation and discuss differences in the potential for cis and trans changes among different classes of genes. I argue that the molecular function of the protein encoded by each gene and how the gene is wired into the genomic regulatory network may influence its propensity for cis and trans regulatory changes.

Access this article

Log in via an institution

Subscribe and save

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

1. Department of Molecular Biology and Genetics, Cornell University, 227 Biotechnology Building, Ithaca, New York, 14853, USA
   P. J. Wittkopp

Authors

1. P. J. Wittkopp
   You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toP. J. Wittkopp.

Additional information

Received 15 February 2005; received after revision 12 April 2005; accepted 26 April 2005

Rights and permissions

About this article

Cite this article

Wittkopp, P.J. Genomic sources of regulatory variation in cis and in trans.CMLS, Cell. Mol. Life Sci. 62, 1779–1783 (2005). https://doi.org/10.1007/s00018-005-5064-9

Download citation

• Published: 17 June 2005
• Issue Date: August 2005
• DOI: https://doi.org/10.1007/s00018-005-5064-9

Key words.