The cellular functions of clathrin (original) (raw)

Abstract.

Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
    S. J. Royle

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  1. S. J. Royle
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Correspondence toS. J. Royle.

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Received 12 December 2005; received after revision 21 March 2006; accepted 29 March 2006

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Royle, S.J. The cellular functions of clathrin.Cell. Mol. Life Sci. 63, 1823–1832 (2006). https://doi.org/10.1007/s00018-005-5587-0

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