Neurotrophins and B-cell malignancies (original) (raw)

• LeBien TW, Tedder TF (2008) B lymphocytes: how they develop and function. Blood 112:1570–1580
  Article PubMed PubMed Central CAS Google Scholar
• Brack C, Hirama M, Lenhardschuller R, Tonegawa S (1978) Complete immunoglobulin gene is created by somatic recombination. Cell 15:1–14
  Article PubMed CAS Google Scholar
• Gathings WE, Lawton AR, Cooper MD (1977) Immunofluorescent studies of development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans. Eur J Immunol 7:804–810
  Article PubMed CAS Google Scholar
• Lam KP, Kuhn R, Rajewsky K (1997) In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073–1083
  Article PubMed CAS Google Scholar
• Chung JB, Silverman M, Monroe JG (2003) Transitional B cells: step by step towards immune competence. Trends Immunol 24:343–349
  Article PubMed CAS Google Scholar
• Lanzavecchia, A, Bove, S (1985) Specific B lymphocytes efficiently pick up, process and present antigen to T cells. Behring Institute Mitteilungen, pp 82–87
• Jacob J, Kelsoe G, Rajewsky K, Weiss U (1991) Intraclonal generation of antibody mutants in germinal centres. Nature 354:389–392
  Article PubMed CAS Google Scholar
• Kincade PW, Lawton AR, Bockman DE, Cooper MD (1970) Suppression of immunoglobulin G synthesis as a result of antibody-mediated suppression of immunoglobulin M synthesis in chickens. Proc Natl Acad Sci USA 67:1918–1925
  Article PubMed PubMed Central CAS Google Scholar
• Shapiro-Shelef M, Calame K (2005) Regulation of plasma-cell development. Nat Rev Immunol 5:230–242
  Article PubMed CAS Google Scholar
• McHeyzer-Williams LJ, McHeyzer-Williams MG (2005) Antigen-specific memory B cell development. Annu Rev Immunol 23:487–513
  Article PubMed CAS Google Scholar
• Kehry MR (1996) CD40-mediated signaling in B cells—balancing cell survival, growth, and death. J Immunol 156:2345–2348
  PubMed CAS Google Scholar
• Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553–563
  Article PubMed CAS Google Scholar
• Goodnow CC, Adelstein S, Basten A (1990) The need for central and peripheral tolerance in the B cell repertoire. Science 248:1373–1379
  Article PubMed CAS Google Scholar
• Stashenko P, Nadler LM, Hardy R, Schlossman SF (1980) Characterization of a human lymphocyte B specific antigen. Journal of Immunology 125:1678–1685
  CAS Google Scholar
• Tarlinton D, Radbruch A, Hiepe F, Dorner T (2008) Plasma cell differentiation and survival. Curr Opin Immunol 20:162–169
  Article PubMed CAS Google Scholar
• Shaffer AL, Rosenwald A, Staudt LM (2002) Lymphoid malignancies: the dark side of B-cell differentiation. Nat Rev Immunol 2:920–932
  Article PubMed CAS Google Scholar
• Shaffer AL III, Young RM, Staudt LM (2012) Pathogenesis of human B cell lymphomas. Annu Rev Immunol 30(30):565–610
  Article PubMed CAS Google Scholar
• Sabattini E, Bacci F, Sagramoso C, Pileri SA (2010) WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica 102:83–87
  PubMed CAS Google Scholar
• Plawny L, Ries F (2014) Emerging new anticancer biological therapies in 2013 (haematological malignancies). Curr Opin Oncol 26:363–370
  Article PubMed CAS Google Scholar
• Plunkett W, Huang P, Gandhi V (1990) Metabolism and action of fludarabine phosphate. Semin Oncol 17:3–17
  PubMed CAS Google Scholar
• Rauen HM, Reisch A, Schriewer H (1964) On the biochemical mechanism of action of cyclophosphamide. Arzneimittelforschung 14:176–178
  PubMed CAS Google Scholar
• Shaw T, Quan J, Totoritis MC (2003) B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience. Ann Rheum Dis 62(suppl 2):ii55–ii59
  PubMed PubMed Central CAS Google Scholar
• Rudnicka D, Oszmiana A, Finch DK, Strickland I, Schofield DJ, Lowe DC, Sleeman MA, Davis DM (2013) Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent cellular cytotoxicity. Blood 121:4694–4702
  Article PubMed CAS Google Scholar
• McLaughlin P, Grillo-Lopez AJ, Maloney DG, Link BK, Levy R, Czuczman MS, Cabanillas F, Dallaire BK, White CA (1998) Efficacy controls and long-term follow-up of patients (pts) treated with rituximab for relapsed or refractory, low-grade or follicular (R-LG/F) NHL. Blood 92:414A–415A
  Google Scholar
• Smith MR (2003) Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene 22:7359–7368
  Article PubMed CAS Google Scholar
• Rickert RC (2013) New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol 13:578–591
  Article PubMed CAS Google Scholar
• Burger JA (2012) Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape. Curr Opin Oncol 24:643–649
  Article PubMed CAS Google Scholar
• Ponader S, Chen SS, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG, Keating MJ, O’Brien S, Chiorazzi N, Burger JA (2012) The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119:1182–1189
  Article PubMed CAS Google Scholar
• Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn I, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Stilgenbauer S, Cramer P, Aiello M, Johnson DM, Miller LL, Li D, Jahn TM, Dansey RD, Hallek M, O’Brien SM (2014) Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 370:997–1007
  Article PubMed PubMed Central CAS Google Scholar
• Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ, Huang DCS, Hymowitz SG, Jin S, Khaw SL, Kovar PJ, Lam LT, Lee J, Maecker HL, Marsh KC, Mason KD, Mitten MJ, Nimmer PM, Oleksijew A, Park CH, Park C-M, Phillips DC, Roberts AW, Sampath D, Seymour JF, Smith ML, Sullivan GM, Tahir SK, Tse C, Wendt MD, Xiao Y, Xue JC, Zhang H, Humerickhouse RA, Rosenberg SH, Elmore SW (2013) ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 19:202–208
  Article PubMed CAS Google Scholar
• Cheadle EJ, Sheard V, Hombach AA, Chmielewski M, Riet T, Berrevoets C, Schooten E, Lamers C, Abken H, Debets R, Gilham DE (2012) Chimeric antigen receptors for T-cell based therapy. Methods Mol Biol (Clifton, N.J.) 907:645–666
  Article CAS Google Scholar
• Barrett DM, Singh N, Porter DL, Grupp SA, June CH (2014) Chimeric antigen receptor therapy for cancer. Annu Rev Med 65(65):333–347
  Article PubMed PubMed Central CAS Google Scholar
• Brodie C, Sampson SR (1990) Nerve growth factor and fibroblast growth factor influence postfusion expression of Na channels in cultured rat skeletal muscle. J Cell Physiol 144:492–497
  Article PubMed CAS Google Scholar
• Mayerhofer A, Dissen GA, Parrott JA, Hill DF, Mayerhofer D, Garfield RE, Costa ME, Skinner MK, Ojeda SR (1996) Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication between thecal cells. Endocrinology 137:5662–5670
  PubMed CAS Google Scholar
• Levimontalcini R, Hamburger V (1951) Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool 116:321–361
  Article CAS Google Scholar
• Levimontalcini R (1964) Nerve growth factor. Ann N Y Acad Sci 118:149–170
  Article CAS Google Scholar
• Barde YA, Edgar D, Thoenen H (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1:549–553
  PubMed PubMed Central CAS Google Scholar
• Hohn A, Leibrock J, Bailey K, Barde YA (1990) Identification and characterization of a novel member of the nerve growth factor family. Nature 344:339–341
  Article PubMed CAS Google Scholar
• Jones KR, Reichardt LF (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci USA 87:8060–8064
  Article PubMed PubMed Central CAS Google Scholar
• Hallbook F, Ibanez CF, Persson H (1991) Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary. Neuron 6:845–858
  Article PubMed CAS Google Scholar
• Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV, Rosenthal A (1991) Neurotrophin-5—a novel neurotrophic factor that activates Trk and TrkB. Neuron 7:857–866
  Article PubMed CAS Google Scholar
• Acklin C, Stoney K, Rosenfeld RA, Miller JA, Rohde MF, Haniu M (1993) Recombinant human brain-derived neurotrophic factor (rHuBDNF)—disulfide structure and characterization of BDNF expressed in CHO cells. Int J Pept Protein Res 41:548–552
  Article PubMed CAS Google Scholar
• Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, Murphy RA (2001) Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276:12660–12666
  Article PubMed CAS Google Scholar
• Hibbert AP, Morris SJ, Seidah NG, Murphy RA (2003) Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway. J Biol Chem 278:48129–48136
  Article PubMed CAS Google Scholar
• Young M, Oger J, Blanchard MH, Asdourian H, Amos H, Arnason BGW (1975) Secretion of a nerve growth factor by primary chick fibroblast cultures. Science 187:361–362
  Article PubMed CAS Google Scholar
• Hasan W, Pedchenko T, Krizsan-Agbas D, Baum L, Smith PG (2003) Sympathetic neurons synthesize and secrete pro-nerve growth factor protein. J Neurobiol 57:38–53
  Article PubMed CAS Google Scholar
• McDonald NQ, Lapatto R, Murrayrust J, Gunning J, Wlodawer A, Blundell TL (1991) New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature 354:411–414
  Article PubMed CAS Google Scholar
• Jungbluth S, Bailey K, Barde YA (1994) Purification and characterization of a brain-derived neurotrophic factor neurotrophin-3 (BDNF/NT-3) heterodimer. Eur J Biochem 221:677–685
  Article PubMed CAS Google Scholar
• Heymach JV, Shooter EM (1995) The biosynthesis of neurotrophin heterodimers by transfected mammalian cells. J Biol Chem 270:12297–12304
  Article PubMed CAS Google Scholar
• Meakin SO, Shooter EM (1992) The nerve growth factor family of receptors. Trends Neurosci 15:323–331
  Article PubMed CAS Google Scholar
• Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427:843–848
  Article PubMed CAS Google Scholar
• Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, Kraemer RT, Nykjaer A, Hempstead BL (2005) ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75(NTR) and sortilin. J Neurosci 25:5455–5463
  Article PubMed CAS Google Scholar
• Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc B Biol Sci 361:1545–1564
  Article CAS Google Scholar
• Brennan C, Rivas-Plata K, Landis SC (1999) The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo. Nat Neurosci 2:699–705
  Article PubMed CAS Google Scholar
• Clewes O, Fahey MS, Tyler SJ, Watson JJ, Seok H, Catania C, Cho K, Dawbarn D, Allen SJ (2008) Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin. J Neurochem 107:1124–1135
  PubMed CAS Google Scholar
• Boutilier J, Ceni C, Pagdala PC, Forgie A, Neet KE, Barker PA (2008) Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation. J Biol Chem 283:12709–12716
  Article PubMed PubMed Central CAS Google Scholar
• Sobottka B, Reinhardt D, Brockhaus M, Jacobsen H, Metzger F (2008) ProNGF inhibits NGF-mediated TrkA activation in PC12 cells. J Neurochem 107:1294–1303
  Article PubMed CAS Google Scholar
• Demont Y, Corbet C, Page A, Ataman-Onal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H (2012) Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. J Biol Chem 287:1923–1931
  Article PubMed PubMed Central CAS Google Scholar
• Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C (2008) Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Investig Dermatol 128:2031–2040
  Article PubMed CAS Google Scholar
• Fayard B, Loeffler S, Weis J, Vogelin E, Kruttgen A (2005) The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC. J Neurosci Res 80:18–28
  Article PubMed CAS Google Scholar
• Barbacid M (1995) Neurotrophic factors and their receptors. Curr Opin Cell Biol 7:148–155
  Article PubMed CAS Google Scholar
• Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299–309
  Article PubMed CAS Google Scholar
• Klein R, Jing SQ, Nanduri V, Orourke E, Barbacid M (1991) The Trk protooncogene encodes a receptor for nerve growth factor. Cell 65:189–197
  Article PubMed CAS Google Scholar
• Kaplan DR, Stephens RM (1994) Neurotrophin signal transduction by the Trk receptor. J Neurobiol 25:1404–1417
  Article PubMed CAS Google Scholar
• Descamps S, Toillon R, Adriaenssens E, Pawlowski V, Cool S, Nurcombe V, Le Bourhis X, Boilly B, Peyrat J, Hondermarck H (2001) Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J Biol Chem 276:17864–17870
  Article PubMed CAS Google Scholar
• Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, Toillon RA, Oxombre B, Hondermarck H, Le Bourhis X (2009) TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 28:1960–1970
  Article PubMed CAS Google Scholar
• Brodeur GM, Nakagawara A, Yamashiro DJ, Ikegaki N, Liu XG, Azar CG, Lee CP, Evans AE (1997) Expression of TrkA, TrkB and TrkC in human neuroblastomas. J Neurooncol 31:49–55
  Article PubMed CAS Google Scholar
• Perez-Pinera P, Hernandez T, Garcia-Suarez O, de Carlos F, Germana A, del Valle M, Astudillo A, Vega JA (2007) The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas. Mol Cell Biochem 295:19–26
  Article PubMed CAS Google Scholar
• Miknyoczki SJ, Lang D, Huang LY, Klein-Szanto AJP, Dionne CA, Ruggeri BA (1999) Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer 81:417–427
  Article PubMed CAS Google Scholar
• Yang X, Martin TA, Jiang WG (2013) Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Exp Ther Med 6:1475–1481
  PubMed PubMed Central CAS Google Scholar
• Zhang S, Guo D, Luo W, Zhang Q, Zhang Y, Li C, Lu Y, Cui Z, Qiu X (2010) TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells. BMC Cancer 10:43
  Article PubMed PubMed Central CAS Google Scholar
• Eide FF, Vining ER, Eide BL, Zang KL, Wang XY, Reichardt LF (1996) Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci 16:3123–3129
  PubMed PubMed Central CAS Google Scholar
• Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, Konnerth A (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature 426:74–78
  Article PubMed CAS Google Scholar
• Shelton DL, Sutherland J, Gripp J, Camerato T, Armanini MP, Phillips HS, Carroll K, Spencer SD, Levinson AD (1995) Human Trks—molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J Neurosci 15:477–491
  PubMed CAS Google Scholar
• Klein R, Conway D, Parada LF, Barbacid M (1990) The TrkB tyrosine protein kinase gene codes for a 2nd neurogenic receptor that lacks the catalytic kinase domain. Cell 61:647–656
  Article PubMed CAS Google Scholar
• Ohira K, Homma KJ, Hirai H, Nakamura S, Hayashi M (2006) TrkB-T1 regulates the RhoA signaling and actin cytoskeleton in glioma cells. Biochem Biophys Res Commun 342:867–874
  Article PubMed CAS Google Scholar
• Kryl D, Barker PA (2000) TTIP is a novel protein that interacts with the truncated T1 TrkB neurotrophin receptor. Biochem Biophys Res Commun 279:925–930
  Article PubMed CAS Google Scholar
• Roux PP, Barker PA (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 67:203–233
  Article PubMed CAS Google Scholar
• Liepinsh E, Ilag LL, Otting G, Ibanez CF (1997) NMR structure of the death domain of the p75 neurotrophin receptor. EMBO J 16:4999–5005
  Article PubMed PubMed Central CAS Google Scholar
• Gong Y, Cao P, Yu H-j, Jiang T (2008) Crystal structure of the neurotrophin-3 and p75(NTR) symmetrical complex. Nature 454:789–793
  PubMed CAS Google Scholar
• Welcher AA, Bitler CM, Radeke MJ, Shooter EM (1991) Nerve growth factor binding domain of the nerve growth factor receptor. Proc Natl Acad Sci USA 88:159–163
  Article PubMed PubMed Central CAS Google Scholar
• Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PIH, Verveer PJ, Carter BD, Ibanez CF (2009) Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron 62:72–83
  Article PubMed PubMed Central CAS Google Scholar
• Khursigara G, Orlinick JR, Chao MV (1999) Association of the p75 neurotrophin receptor with TRAF6. J Biol Chem 274:2597–2600
  Article PubMed CAS Google Scholar
• Lu B, Pang PT, Woo NH (2005) The yin and yang of neurotrophin action. Nat Rev Neurosci 6:603–614
  Article PubMed CAS Google Scholar
• Allen J, Khwaja F, Byers S, Djakiew D (2005) The p75(NTR) mediates a bifurcated signal transduction cascade through the NF kappa B and JNK pathways to inhibit cell survival. Exp Cell Res 304:69–80
  Article PubMed CAS Google Scholar
• Tsang JYS, Wong KHY, Lai MWH, Lacambra MD, Ko C-W, Chan SK, Lam CCF, Yu AMC, Tan P-H, Tse GM (2012) Nerve growth factor receptor (NGFR): a potential marker for specific molecular subtypes of breast cancer. J Clin Pathol 66:291–296
  Article PubMed CAS Google Scholar
• Krygier S, Djakiew D (2001) Molecular characterization of the loss of p75(NTR) expression in human prostate tumor cells. Mol Carcinog 31:46–55
  Article PubMed CAS Google Scholar
• Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE (1993) Induction of apoptosis by the low affinity NGF receptor. Science 261:345–348
  Article PubMed CAS Google Scholar
• Bredesen DE, Ye X, Tasinato A, Sperandio S, Wang JJL, Assa-Munt N, Rabizadeh S (1998) p75(NTR) and the concept of cellular dependence: seeing how the other half die. Cell Death Differ 5:365–371
  Article PubMed CAS Google Scholar
• Coulson EJ, Reid K, Baca M, Shipham KA, Hulett SM, Kilpatrick TJ, Bartlett PF (2000) Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. J Biol Chem 275:30537–30545
  Article PubMed CAS Google Scholar
• Chao MV (1992) Neurotrophin receptors—a window into neuronal differentiation. Neuron 9:583–593
  Article PubMed CAS Google Scholar
• Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Giallonardo P, Zhang L, Bibel M, Barde Y-A (2010) Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467:59–63
  Article PubMed CAS Google Scholar
• Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395:801–804
  Article PubMed CAS Google Scholar
• Zupan AA, Johnson EM (1991) Evidence for endocytosis-dependent proteolysis in the generation of soluble truncated nerve growth factor receptors by A875 human melanoma cells. J Biol Chem 266:15384–15390
  PubMed CAS Google Scholar
• Tauszig-Delamasure S, Yu L-Y, Cabrera JR, Bouzas-Rodriguez J, Mermet-Bouvier C, Guix C, Bordeaux M-C, Arumae U, Mehlen P (2007) The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proc Natl Acad Sci USA 104:13361–13366
  Article PubMed PubMed Central CAS Google Scholar
• Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, Roigaard H, Gliemann J, Madsen P, Moestrup SK (1997) Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 272:3599–3605
  Article PubMed CAS Google Scholar
• Vega JA, Garcia-Suarez O, Hannestad J, Perez-Perez M, Germana A (2003) Neurotrophins and the immune system. J Anat 203:1–19
  Article PubMed PubMed Central CAS Google Scholar
• Tessarollo L (1998) Pleiotropic functions of neurotrophins in development. Cytokine Growth Factor Rev 9:125–137
  Article PubMed CAS Google Scholar
• Labouyrie E, Parrens M, deMascarel A, Bloch B, Merlio JP (1997) Distribution of NGF receptors in normal and pathologic human lymphoid tissues. J Neuroimmunol 77:161–173
  Article PubMed Google Scholar
• Lambiase A, BracciLaudiero L, Bonini S, Starace G, Delios MM, DeCarli M, Aloe L (1997) Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J Allergy Clin Immunol 100:408–414
  Article PubMed CAS Google Scholar
• Ehrhard PB, Ganter U, Bauer J, Otten U (1993) Expression of functional Trk protooncogene in human monocytes. Proc Natl Acad Sci USA 90:5423–5427
  Article PubMed PubMed Central CAS Google Scholar
• Boven LA, Middel J, Portegies P, Verhoef J, Jansen GH, Nottet H (1999) Overexpression of nerve growth factor and basic fibroblast growth factor in AIDS dementia complex. J Neuroimmunol 97:154–162
  Article PubMed CAS Google Scholar
• Besser M, Wank R (1999) Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors. J Immunol 162:6303–6306
  PubMed CAS Google Scholar
• Schober A, Huber K, Fey J, Unsicker K (1998) Distinct populations of macrophages in the adult rat adrenal gland: a subpopulation with neurotrophin-4-like immunoreactivity. Cell Tissue Res 291:365–373
  Article PubMed CAS Google Scholar
• Torcia M, BracciLaudiero L, Lucibello M, Nencioni L, Labardi D, Rubartelli A, Cozzolino F, Aloe L, Garaci E (1996) Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell 85:345–356
  Article PubMed CAS Google Scholar
• Rosini P, De Chiara G, Lucibello M, Garaci E, Cozzolino F, Torcia M (2000) NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation. Biochem Biophys Res Commun 278:753–759
  Article PubMed CAS Google Scholar
• Fauchais A-L, Lalloue F, Lise M-C, Boumediene A, Preud’homme J-L, Vidal E, Jauberteau M-O (2008) Role of endogenous brain-derived neurotrophic factor and sortilin in B cell survival. J Immunol 181:3027–3038
  Article PubMed CAS Google Scholar
• D’Onofrio M, de Grazia U, Morrone S, Cuomo L, Spinsanti P, Frati L, Gulino A, Ragona G (2000) Expression of neurotrophin receptors in normal and malignant B lymphocytes. Eur Cytokine Netw 11:283–291
  PubMed Google Scholar
• Schuhmann B, Dietrich A, Sel S, Hahn C, Klingenspor M, Lommatzsch M, Gudermann T, Braun A, Renz H, Nockher WA (2005) A role for brain-derived neurotrophic factor in B cell development. J Neuroimmunol 163:15–23
  Article PubMed CAS Google Scholar
• Schenone A, Gill JS, Zacharias DA, Windebank AJ (1996) Expression of high- and low-affinity neurotrophin receptors on human transformed B lymphocytes. J Neuroimmunol 64:141–149
  Article PubMed CAS Google Scholar
• Klein G (1994) Epstein-Barr virus strategy in normal and neoplastic B cells. Cell 77:791–793
  Article PubMed CAS Google Scholar
• Franklin RA, Brodie C, Melamed I, Terada N, Lucas JJ, Gelfand EW (1995) Nerve growth factor induces activation of MAP kinase and p90 (RSK) in human B lymphocytes. J Immunol 154:4965–4972
  PubMed CAS Google Scholar
• Melamed I, Patel H, Gelfand EW (1997) Trk tyrosine kinase dependent activation of Vav/Ras in human B cells by nerve growth factor. Journal of Allergy and Clinical Immunology 99:1181
  Google Scholar
• Kronfeld I, Kazimirsky G, Gelfand EW, Brodie C (2002) NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKC zeta. Eur J Immunol 32:136–143
  Article PubMed CAS Google Scholar
• Labouyrie E, Dubus P, Groppi A, Mahon FX, Ferrer J, Parrens M, Reiffers J, de Mascarel A, Merlio JP (1999) Expression of neurotrophins and their receptors in human bone marrow. Am J Pathol 154:405–415
  Article PubMed PubMed Central CAS Google Scholar
• Raoul C, Henderson CE, Pettmann B (1999) Programmed cell death of embryonic motoneurons triggered through the Fas death receptor. J Cell Biol 147:1049–1061
  Article PubMed PubMed Central CAS Google Scholar
• Begum-Haque S, Christy M, Ochoa-Reparaz J, Nowak EC, Mielcarz D, Hague A, Kasper LH (2011) Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate. J Neuroimmunol 232:136–144
  Article PubMed PubMed Central CAS Google Scholar
• Otten U, Ehrhard P, Peck R (1989) Nerve growth factor induces growth and differentiation of human B lymphocytes. Proc Natl Acad Sci USA 86:10059–10063
  Article PubMed PubMed Central CAS Google Scholar
• Kimata H, Yoshida A, Ishioka C, Kusunoki T, Hosoi S, Mikawa H (1991) Nerve growth factor specifically induces human IgG4 production. Eur J Immunol 21:137–141
  Article PubMed CAS Google Scholar
• Brodie C, Gelfand EW (1992) Functional nerve growth factor receptors on human B lymphocytes—interaction with IL-2. J Immunol 148:3492–3497
  PubMed CAS Google Scholar
• Thorpe LW, Werrbachperez K, Perezpolo JR (1987) Effects of nerve growth factor on the expression of interleukin 2 receptors on cultured human lymphocytes. Ann N Y Acad Sci 496:310–311
  Article PubMed CAS Google Scholar
• Brodie C, Oshiba A, Renz H, Bradley K, Gelfand EW (1996) Nerve growth-factor and anti-CD40 provide opposite signals for the production of IgE in interleukin-4-treated lymphocytes. Eur J Immunol 26:171–178
  Article PubMed CAS Google Scholar
• Abram M, Wegmann M, Fokuhl V, Sonar S, Luger EO, Kerzel S, Radbruch A, Renz H, Zemlin M (2009) Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol 182:4705–4712
  Article PubMed CAS Google Scholar
• Beutel G, Meyer J, Ma LP, Yin SM, Eder M, von Neuhoff N, Wilkens L, Wei J, Hertenstein B, Heil G, Schlegelberger B, Ganser A, Li ZX, Baum C (2005) Expression of the p75 neurotrophin receptor in acute leukaemia. Br J Haematol 131:67–70
  Article PubMed CAS Google Scholar
• Saada S, Marget P, Fauchais AL, Lise MC, Chemin G, Sindou P, Martel C, Delpy L, Vidal E, Jaccard A, Troutaud D, Lalloue F, Jauberteau MO (2012) Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes. J Immunol 189:5293–5303
  Article PubMed CAS Google Scholar
• Bellanger C, Dubanet L, Lise M-C, Fauchais A-L, Bordessoule D, Jauberteau M-O, Troutaud D (2011) Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis. PLoS One 6:27213
  Article CAS Google Scholar
• Sniderhan LF, Garcia-Bates TM, Burgart M, Bernstein SH, Phipps RR, Maggirwar SB (2009) Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma. Exp Hematol 37:1295–1309
  Article PubMed PubMed Central CAS Google Scholar
• Baxter GT, Radeke MJ, Kuo RC, Makrides V, Hinkle B, Hoang R, MedinaSelby A, Coit D, Valenzuela P, Feinstein SC (1997) Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2. J Neurosci 17:2683–2690
  PubMed CAS Google Scholar
• Pearse RN, Swendeman SL, Li Y, Rafii D, Hempstead BL (2005) A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood 105:4429–4436
  Article PubMed CAS Google Scholar
• Xia D, Li W, Zhang L, Qian H, Yao S, Qi X (2014) RNA interference-mediated knockdown of brain-derived neurotrophic factor (BDNF) promotes cell cycle arrest and apoptosis in B-cell lymphoma cells. Neoplasma 61:523–532
  Article PubMed CAS Google Scholar
• Auffray I, Chevalier S, Froger J, Izac B, Vainchenker W, Gascan H, Coulombel L (1996) Nerve growth factor is involved in the supportive effect by bone marrow-derived stromal cells of the factor-dependent human cell line UT-7. Blood 88:1608–1618
  PubMed CAS Google Scholar
• Laurenzi MA, Beccari T, Stenke L, Sjolinder M, Stinchi S, Lindgren JA (1998) Expression of mRNA encoding neurotrophins and neurotrophin receptors in human granulocytes and bone marrow cells—enhanced neurotrophin-4 expression induced by LTB4. J Leukoc Biol 64:228–234
  PubMed CAS Google Scholar