Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways (original) (raw)

Abstract

Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues in response to a wide array of extracellular stimuli. Three distinct groups of MAP kinases have been identified in mammalian cells [extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38]. These MAP kinases are mediators of signal transduction from the cell surface to the nucleus. One nuclear target of these MAP kinase signaling pathways is the transcription factor AP-1. MAP kinases regulate AP-1 transcriptional activity by multiple mechanisms. Here we review recent progress towards understanding AP-1 regulation by the ERK, JNK, and p38 MAP kinase signal transduction pathways.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, , , , , , US
    A. J. Whitmarsh & R. J. Davis

Authors

  1. A. J. Whitmarsh
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  2. R. J. Davis
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Received: 8 May 1996 / Accepted: 19 June 1996

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Whitmarsh, A., Davis, R. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.J Mol Med 74, 589–607 (1996). https://doi.org/10.1007/s001090050063

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