Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling (original) (raw)

Abstract.

The proto-oncogene protein kinase B (PKB), also known as c-Akt, is a central player in a signaling pathway of which many components have been linked to tumorigenesis. Active forms of PKB as well as of its upstream activator phosphatidylinositol 3-kinase (PI3K) have been found to be responsible for the transforming activities of certain viruses, and the negative regulator of this pathway, PTEN, is a tumor suppressor. The identification of particular downstream targets of PKB has provided us with new insights into the possible mechanism of PI3K/PKB-mediated tumorigenicity. Recently a subfamily of Forkhead transcription factors was identified as additional targets for PI3K/PKB signaling. This review discusses the studies that have led to this conclusion and the possible implications of this finding for our understanding of how PI3K/PKB activity could lead to oncogenesis.

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  1. Laboratory for Physiological Chemistry and Center for Biomedical Genetics, University of Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Geert J.P.L. Kops & Boudewijn M.T. Burgering

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  1. Geert J.P.L. Kops
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  2. Boudewijn M.T. Burgering
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Kops, G., Burgering, B. Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.J Mol Med 77, 656–665 (1999). https://doi.org/10.1007/s001099900050

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