Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs (original) (raw)
Dellinger RP (2003) Cardiovascular management of septic shock. Crit Care Med 31:946–955 ArticlePubMed Google Scholar
Price S, Anning PB, Mitchell JA, Evans TW (1999) Myocardial dysfunction in sepsis: mechanisms and therapeutic implications. Eur Heart J 20:715–724 ArticleCASPubMed Google Scholar
Ince C, Sinaasappel M (1999) Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 27:1369–1377 ArticleCASPubMed Google Scholar
Siegemund M, van Bommel J, Ince C (1999) Assessment of tissue oxygenation. Intensive Care Med 25:1044–1060 ArticleCASPubMed Google Scholar
Brown GC (2001) Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 1504:46–57 CASPubMed Google Scholar
Lopez A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, Silverman MS, Takala J, Donaldson J, Arneson C, Grove G, Grossman S, Grover R (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32:21–30 ArticleCASPubMed Google Scholar
Liaudet L, Rosselet A, Schaller MD, Markert M, Perret C, Feihl F (1998) Nonselective versus selective inhibition of inducible nitric oxide synthase in experimental endotoxic shock. J Infect Dis 177:127–132 CASPubMed Google Scholar
Laszlo F, Whittle BJ (1997) Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. Eur J Pharmacol 334:99–102 ArticleCASPubMed Google Scholar
Strunk V, Hahnenkamp K, Schneuing M, Fischer LG, Rich GF (2001) Selective iNOS inhibition prevents hypotension in septic rats while preserving endothelium-dependent vasodilation. Anesth Analg 92:681–687 CASPubMed Google Scholar
Pittner A, Nalos M, Asfar P, Yang Y, Ince C, Georgieff M, Bruckner UB, Radermacher P, Froba G (2003) Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. Intensive Care Med 29:312–316 PubMed Google Scholar
Stehr A, Ploner F, Tugtekin I, Matejovic M, Theisen M, Zulke C, Georgieff M, Radermacher P, Jauch KW (2003) Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia. Intensive Care Med 29:995–1002 CASPubMed Google Scholar
Matejovic M, Radermacher P, Tugtekin I, Stehr A, Theisen M, Vogt J, Wachter U, Ploner F, Georgieff M, Traeger K (2001) Effects of selective iNOS inhibition on gut and liver O2-exchange and energy metabolism during hyperdynamic porcine endotoxemia. Shock 16:203–210 CASPubMed Google Scholar
Cohen RI, Shapir Y, Davis A, Loona R, Scharf SM (2000) Comparison between selective and nonselective nitric oxide synthase inhibition and phenylephrine in normal and endotoxic swine. Crit Care Med 28:3257–3267 ArticleCASPubMed Google Scholar
Borutaite V, Matthias A, Harris H, Moncada S, Brown GC (2001) Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation. Am J Physiol Heart Circ Physiol 281:H2256–H2260 CASPubMed Google Scholar
Ellis CG, Bateman RM, Sharpe MD, Sibbald WJ, Gill R (2002) Effect of a maldistribution of microvascular blood flow on capillary O2 extraction in sepsis. Am J Physiol 282:H156–H164 CASPubMed Google Scholar
Lam C, Tyml K, Martin C, Sibbald W (1994) Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94:2077–2083 CASPubMed Google Scholar
Tugtekin IF, Radermacher P, Theisen M, Matejovic M, Stehr A, Ploner F, Matura K, Ince C, Georgieff M, Träger K (2001) Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs. Intensive Care Med 27:757–766 ArticleCASPubMed Google Scholar
Revelly JP, Ayuse T, Brienza N, Fessler HE, Robotham JL (1996) Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med 24:1345–1351 ArticleCASPubMed Google Scholar
Revelly J-P, Liaudet L, Frascarolo P, Joseph J-M, Martinet O, Markert M (2000) Effects of norepinephrine on the distribution of intestinal blood flow and tissue adenosine triphosphate content in endotoxic shock. Crit Care Med 28:2500–2506 ArticleCASPubMed Google Scholar
Neviere RR, Pitt-Hyde ML, Piper RD, Sibbald WJ, Potter RF (1999) Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats. Am J Physiol 276:G933–G940 CASPubMed Google Scholar
van der Meer JT, Wang H, Fink MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23:1217–1226 PubMed Google Scholar
Morin M, J, Unno N, Hodin RA, Fink MP (1998) Differential experession of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit Care Med 26:1258–1264 ArticleCASPubMed Google Scholar
Avontuur JAM, Bruining HA, Ince C (1997) Nitric oxide causes dysfunction of coronary autoregulation in endotoxemic rats. Cardiovasc Res 35:368–376 ArticleCASPubMed Google Scholar
Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG (1997) 1400 W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959–4963 CASPubMed Google Scholar
Siegemund M, van Bommel J, Schwarte LA, Emons M, Ince C (2001) Selective blockade of iNOS by 1400 W restores the gut oxygenation in a pig model of low-dose endotoxemia (abstract 48). Intensive Care Med 27:S147 Google Scholar
Schlichtig R, Mehta N, Gayowski TJ (1996) Tissue-arterial PCO2 difference is a better marker of ischemia than intramural pH (pHi) or arterial pH-pHi difference. J Crit Care 11:51–56 ArticleCASPubMed Google Scholar
Sinaasappel M, Ince C (1996) Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo. J Appl Physiol 81:2297–2303 CASPubMed Google Scholar
Vanderkooi JM, Maniara G, Green TJ, Wilson DF (1987) An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem 262:5476–5482 Google Scholar
Shonat RD, Johnson PC (1997) Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study. Am J Physiol 272:H2233–H2240 CASPubMed Google Scholar
Sinaasappel M, van Iterson M, Ince C (1999) Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation. J Physiol (Lond) 514:245–253 Google Scholar
Sinaasapple M, Donkersloot C, van Bommel J, Ince C (1999) PO2 measurements in the rat intestinal microcirculation. Am J Physiol 276:G1515–G1520 PubMed Google Scholar
Flesch M, Kilter H, Cremers B, Laufs U, Sudkamp M, Ortmann M, Muller FU, Bohm M (1999) Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite. J Am Coll Cardiol 33:1062–1070 ArticleCASPubMed Google Scholar
Cohen RI, Hassell AM, Ye X, Marzouk K, Liu SF (2003) Lipopolysaccharide down-regulates inducible nitric oxide synthase expression in swine heart in vivo. Biochem Biophys Res Commun 307:451–458 ArticleCASPubMed Google Scholar
Avontuur JA, Bruining HA, Ince C (1995) Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 76:418–425 CASPubMed Google Scholar
Träger K, Rademacher P, Rieger KM, Vlatten A, Vogt J, Iber T, Adler J, Wachter U, Grover R, Georgieff M, Santak B (1999) Norepinephrine and NG-monomethyl-L-arginine in porcine septic shock. Am J Respir Crit Care Med 159:1758–1765 PubMed Google Scholar
Sielenkämper AW, Meyer J, Kloppenburg H, Eicker K, Van Aken H (2001) The effects of sepsis on gut mucosal blood flow in rats. Eur J Anaesthesiol 18:673–678 ArticlePubMed Google Scholar
Crouser ED, Julian MW, Weinstein DM, Fahy RJ, Bauer JA (2000) Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated. Am J Respir Crit Care Med 161:1705–1712 CASPubMed Google Scholar
Unno N, Wang H, Menconi MJ, Tytgat SH, Larkin V, Smith M, Morin MJ, Chavez A, Hodin RA, Fink MP (1997) Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 113:1246–1257 CASPubMed Google Scholar
Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ (2000) Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology 118:316–327 CASPubMed Google Scholar
Matejovic M, Krouzecky A, Martinkova V, Rokyta R Jr, Kralova H, Treska V, Radermacher P, Novak I (2004) Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock 21:458–465 ArticleCASPubMed Google Scholar
Brown GC (1999) Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411:351–369 CASPubMed Google Scholar
Javeshghani D, Magder S (2001) Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs. Shock 16:304–311 CASPubMed Google Scholar
King CJ, Tytgat S, Delude RL, Fink MP (1999) Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 27:2518–2524 ArticleCASPubMed Google Scholar
Cohen RI, Hassell AM, Marzouk K, Marini C, Liu SF, Scharf SM (2001) Renal effects of nitric oxide in endotoxemia. Am J Respir Crit Care Med 164:1890–1895 CASPubMed Google Scholar
Albertini M, Lafortuna CL, Clement MG, Mazzola S, Radice S, Hussain SN (2002) Effect of NO synthase inhibition on cardiovascular and pulmonary dysfunction in a porcine short-term model of endotoxic shock. Prostaglandins Leukot Essent Fatty Acids 67:365–372 ArticleCASPubMed Google Scholar
Snygg J, Casselbrant A, Pettersson A, Holm M, Fandriks L, Aneman A (2000) Tonometric assessment of jejunal mucosal nitric oxide formation in anaesthetized pigs. Acta Physiol Scand 169:39–45 ArticleCASPubMed Google Scholar
Mehta S, Javeshghani D, Datta P, Levy RD, Magder S (1999) Porcine endotoxemic shock is associated with increased expired nitric oxide. Crit Care Med 27:385–393 ArticleCASPubMed Google Scholar
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377 ArticleCASPubMed Google Scholar