Vitamin D Status During Puberty in French Healthy Male Adolescents (original) (raw)

Abstract:

The vitamin D status was determined on one to four occasions either after summer (September–October) or after winter (March–April) in 175 male adolescents (13–17 years), resulting in 394 measurements of serum 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (iPTH). The subjects lived in a rural area to the north of Paris (49° N). After summer the 25(OH)D concentration was 58.5 ± 18.0 nmol/l (mean ± SD), while after winter it had fallen to 20.6 ±6.0 nmol/l (_p_= 0.0001). Meanwhile the iPTH concentration was 2.76 ± 0.97 pmol/l (mean ± SD) after summer and increased to 4.20 ± 1.21 pmol/l after winter (_p_= 0.0001). All the results were pooled and a nonlinear population model with random parameters was used to describe the relationship between serum iPTH and 25(OH)D. When the concentration of 25(OH)D was higher than 83 nmol/l, an iPTH mean ‘plateau’ level at 2.48 pmol/l was reached. When 25(OH)D concentrations fell below 83 nmol/l, the increase in iPTH concentration accelerates, and when the mean 25(OH)D concentration was equal to or lower than 10 nmol/l the mean iPTH level (4.97 pmol/l) was twice as high as the ‘plateau’ value.

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Authors and Affiliations

  1. Service de Biochimie Médicale, , , , , , FR
    J. Guillemant, H. T. Le & S. Guillemant
  2. Service de Biomathématiques et Statistiques Médicales, , , , , , FR
    P. Taupin
  3. INSERM U436, Faculté de Médecine Pitié-Salpêtrière; Paris, , , , , , FR
    N. Taright
  4. AFASEC Service Médical, Chantilly, , , , , , FR
    A. Allemandou
  5. Service de Médecine du Sport, Hôpital de La Pitié, Paris, France, , , , , , FR
    G. Pérès

Authors

  1. J. Guillemant
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  2. P. Taupin
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  3. H. T. Le
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  4. N. Taright
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  5. A. Allemandou
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  6. G. Pérès
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  7. S. Guillemant
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Received: 26 November 1998 / Accepted: 15 February 1999

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Guillemant, J., Taupin, P., Le, H. et al. Vitamin D Status During Puberty in French Healthy Male Adolescents .Osteoporos Int 10, 222–225 (1999). https://doi.org/10.1007/s001980050219

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