Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics (original) (raw)
References
Barrett PH, Bell BM, Cobelli C, Golde H, Schumitzky A, Vicini P, Foster DM (1998) SAAM II: Simulation, Analysis and Modeling Software for tracer and pharmacokinetics studies. Metabolism 147:484–492 Article Google Scholar
Baumann MH, Ayestas MA Jr, Partilla JS, Sink JR, Shulgin AT, Daley PF, Brandt SD, Rothman RB, Ruoho AE, Cozzi NV (2012) The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 37:1192–1203 ArticlePubMedCAS Google Scholar
Baumann MH, Partilla JS, Lehner KR (2013) Psychoactive “bath salts”: not so soothing. Eur J Pharmacol 698:1–5 ArticlePubMedCAS Google Scholar
Brunt TM, Koeter MW, Niesink RJ, van den Brink W (2012) Linking the pharmacological content of ecstasy tablets to the subjective experiences of drug users. Psychopharmacology (Berl) 220:751–762 ArticleCAS Google Scholar
Chu T, Kumagai Y, DiStefano EW, Cho AK (1996) Disposition of mehylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Biochem Pharmacol 51:789–796 ArticlePubMedCAS Google Scholar
Cozzi NV, Sievert MK, Shulgin AT, Jacobill P, Rhuolo AE (1999) Inhibition of plasma membrane monoamine transporters by betaketoamphetamines. Eur J Pharmacol 381:63–69 ArticlePubMedCAS Google Scholar
Csajka C, Verotta D (2006) Pharmacokinetic–pharmacodynamic modeling: history and perspectives. J Pharmacokinet Pharmacodyn 33:227–279 ArticlePubMedCAS Google Scholar
Dickson AJ, Vorce SP, Levine B, Past MR (2010) Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. J Anal Toxicol 34:162–168 ArticlePubMedCAS Google Scholar
Fonsart J, Menet MC, Debray M, Hirt D, Noble F, Scherrmann JM, Declèves X (2009) Sprague–Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA). Toxicol Appl Pharmacol 241:339–347 ArticlePubMedCAS Google Scholar
Food and Drug Administration Center for Drug Evaluation and Research (2005) Guidance for industry. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. http://www.fda.gov/cder/guidance/index.htm. Accessed October 14, 2012
Hadlock GC, Webb KM, McFadden LM, Chu PW, Ellis JD, Allen SC, Andrenyak DM, Vieira-Brock PL, German CL, Conrad KM, Hoonakker AJ, Gibb JW, Wilkins DG, Hanson GR, Fleckenstein AE (2011) 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. J Pharmacol Exp Ther 339:530–536 ArticlePubMedCAS Google Scholar
Hitchcock SA, Pennington LD (2006) Structure–brain exposure relationships. J Med Chem 49:7559–7583 ArticlePubMedCAS Google Scholar
Hysek CM, Brugger R, Simmler LD, Bruggisser M, Donzelli M, Grouzmann E, Hoener MC, Liechti ME (2012) Effects of the α2-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers. J Pharmacol Exp Ther 340:286–289 ArticlePubMedCAS Google Scholar
Khreit OI, Grant MH, Zhang T, Henderson C, Watson DG, Sutcliffe OB (2013) Elucidation of the phase I and phase II metabolic pathways of (±)-4′-methylmethcathinone (4-MMC) and (±)-4′-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS(2). J Pharm Biomed Anal 72:177–185 ArticlePubMedCAS Google Scholar
López-Arnau R, Martínez-Clemente J, Pubill D, Escubedo E, Camarasa J (2012) Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone. Br J Pharmacol 167:407–420 ArticlePubMed Google Scholar
Martínez-Clemente J, Escubedo E, Pubill D, Camarasa J (2012) Interaction of mephedrone with dopamine and serotonin targets in rats. Eur Neuropsychopharmacol 22:231–236 ArticlePubMed Google Scholar
Maskell PD, De Paoli G, Seneviratne C, Pounde DJ (2011) Mephedrone (4-methylmethcathinone)-related deaths. J Anal Toxicol 35:188–191 ArticlePubMedCAS Google Scholar
Meyer MR, Wilhelm J, Peters FT, Maurer HH (2010) Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry. Anal Bioanal Chem 397:1225–1233 ArticlePubMedCAS Google Scholar
Nagai F, Nonaka R, Satoh K, Kamimura SHK (2007) The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur J Pharmacol 559:132–137 ArticlePubMedCAS Google Scholar
Porchet HC, Benowitz NL, Sheiner LB, Copelan JR (1987) Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics. J Clin Invest 80:466–741 Article Google Scholar
Schechter MD (1990) Rats become acutely tolerant to cathine after amphetamine or cathinone administration. Psychopharmacology (Berl) 101:126–131 ArticleCAS Google Scholar
Schifano F, Albanese A, Fergus S, Stair JL, Deluca P, Corazza O, Davey Z, Corkery J, Siemann H, Scherbaum N, Farre M, Torrens M, Demetrovics Z, Ghodse AH (2011) Mephedrone (4-methylmethcathinone; ‘meow meow’): chemical, pharmacological and clinical issues. Psychopharmacology (Berl) 214:593–602 ArticleCAS Google Scholar
Sheiner LB, Stanki DR, Vozeh S, Miller RD, Ham J (1979) Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to _d_-tubocurarine. Clin Pharmacol Ther 25:358–370 PubMedCAS Google Scholar
Simmler LD, Buser TA, Donzelli M, Schramm Y, Dieu LH, Huwyler J, Chaboz S, Hoener MC, Liechti ME (2013) Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol 168:458–470 ArticlePubMedCAS Google Scholar
Sørensen LK (2011) Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography–electrospray tandem mass spectrometry. J Chromatogr B 879:727–736 Article Google Scholar
Varner KJ, Daigle K, Weed PF, Lewis PB, Mahne SE, Sankaranarayanan A, Winsauer PJ (2013) Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats. Psychopharmacology (Berl) 225:675–685 ArticleCAS Google Scholar
Wilkinson P, Van Dyke C, Jatlow P, Barash P, Byck (1980) Intranasal and oral cocaine kinetics. Clin Pharmacol Ther 27:386–394 ArticlePubMedCAS Google Scholar
Winstock A, Mitcheson L, Ramsey J, Davies S, Puchnarewicz M, Marsden J (2011) Mephedrone: use, subjective effects and health risks. Addiction 106:1991–1996 ArticlePubMed Google Scholar
Wood DM, Davies S, Greene SL, Button J, Holt DW, Ramsey J, Dargan PI (2010a) Case series of individuals with analytically confirmed acute mephedrone toxicity. Clin Toxicol 48:924–927 ArticleCAS Google Scholar
Wood DM, Davies S, Puchnarewicz M, Button J, Archer R, Ovaska H, Ramsey J, Lee T, Holt DW, Dargan PI (2010b) Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity. J Med Toxicol 6:327–330 ArticlePubMed Google Scholar