Effects of 5-HT1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat (original) (raw)
Abstract
In the present study, the effects of 5-HT1A receptor ligands with varying degrees of intrinsic activity at the 5-HT1A receptor were examined in the conditioned emotional response (CER) test and their effects compared to those of the benzodiazepine receptor agonists, diazepam and chlordiazepoxide. Diazepam (3.0 mg/kg) and chlordiazepoxide (3.0 mg/kg), and the 5-HT1A receptor partial agonists, ipsapirone (10.0 mg/kg) and gepirone (3.0 mg/kg), alleviated conditioned suppression of lever pressing. The 5-HT1A receptor partial agonist, buspirone (0.1–1.0 mg/kg), the 5-HT1A receptor agonist, 8-OH-DPAT (0.01– 0.10 mg/kg), and the 5-HT1A receptor antagonist, WAY-100635 (0.03–3.0 mg/kg), had no effects on conditioned fear. Neither enhancing the level of food deprivation nor pretreatment with the amnesic agent scopolamine induced anxiolytic-like effects in the present CER test. The anxiolytic-like effects of ipsapirone in this test were completely reversed by WAY-100635. These results indicate that 5-HT1A agonist, but not antagonist actions, induce an anxiolytic effect in the CER test in rats.
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Authors and Affiliations
- Department of Neuropharmacology, Wyeth Research Ltd, Huntercombe Lane South, Taplow, Maidenhead, Bucks SL6 OPH, UK, , , , , , GB
K. J. Stanhope & C. T. Dourish
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- K. J. Stanhope
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Received: 13 March 1996/Final version: 8 July 1996
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Stanhope, K., Dourish, C. Effects of 5-HT1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat.Psychopharmacology 128, 293–303 (1996). https://doi.org/10.1007/s002130050137
- Issue Date: December 1996
- DOI: https://doi.org/10.1007/s002130050137