Medication prescribing in frail older people (original) (raw)
Louria DB (2005) Extraordinary longevity: individual and societal issues. J Am Geriatr Soc 53:S317–S319 ArticlePubMed Google Scholar
Christensen K, Doblhammer G, Rau R, Vaupel JW (2009) Ageing populations: the challenges ahead. Lancet 374:1196–1208 ArticlePubMed Google Scholar
Hajjar ER, Cafiero AC, Hanlon JT (2007) Polypharmacy in elderly patients. Am J Geriatr Pharmacother 5:345–351 ArticlePubMed Google Scholar
Rockwood K, Mitnitski A, Song X, Steen B, Skoog I (2006) Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54:975–979 ArticlePubMed Google Scholar
Fried LP, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol Biol Med Sci 56:M146–M156 ArticleCAS Google Scholar
Rockwood K, Song X, Mitnitski A (2011) Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. Can Med Assoc J 183:E487–E494 Article Google Scholar
Chang SS, Weiss CO, Xue QL, Fried LP (2012) Association between inflammatory-related disease burden and frailty: results from the Women’s Health and Aging Studies (WHAS) I and II. Arch Gerontol Geriatr 54:9–15 ArticlePubMed Google Scholar
Torres OH, Francia E, Longobardi V, Gich I, Benito S, Ruiz D (2006) Short- and long-term outcomes of older patients in intermediate care units. Intensive Care Med 32:1052–1059 ArticlePubMed Google Scholar
Nardi R, Scanelli G, Corrao S, Iori I, Mathieu G, Cataldi Amatrian R (2007) Co-morbidity does not reflect complexity in internal medicine patients. Eur J Intern Med 18(5):359–368 ArticlePubMed Google Scholar
Bandeen-Roche K, Xue QL, Ferrucci L et al (2006) Phenotype of frailty: characterization in the women’s health and aging studies. J Gerontol A Biol Sci Med Sci 61:262–266 ArticlePubMed Google Scholar
Gill TM, Gahbauer EA, Han L, Allore HG (2010) Trajectories of disability in the last year of life. N Engl J Med 362:1173–1180 ArticlePubMedCAS Google Scholar
Hubbard RE, O’Mahony MS, Woodhouse KW (2009) Characterising frailty in the clinical setting—a comparison of different approaches. Age Ageing 38:115–119 ArticlePubMed Google Scholar
Rolfson DB, Majumdar SR, Tahir AS, Tsuyuki RT (2001) Content validation of a frailty checklist derived from comprehensive geriatric assessment. Gerontology 47:119 Article Google Scholar
Studenski S, Hayes RP, Leibowitz RQ et al (2004) Clinical Global Impression of Change in Physical Frailty: development of a measure based on clinical judgment. J Am Geriatr Soc 52:1560–1566 ArticlePubMed Google Scholar
Rockwood K, Mitnitski A (2007) Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 62:722–727 ArticlePubMed Google Scholar
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K (2008) A standard procedure for creating a frailty index. BMC Geriatr 8:24 ArticlePubMed Google Scholar
Singh I, Davis K, Gallacher J, Johansen A, Eeles EMP, Hubbard RE (2012) Predictors of adverse outcome on an acute geriatric rehabilitation ward. Age Ageing 41:242–246 ArticlePubMed Google Scholar
Hubbard RE, Eeles EM, Rockwood MR et al (2011) Assessing balance and mobility to track illness and recovery in older inpatients. J Gen Intern Med 26:1471–1478 ArticlePubMed Google Scholar
Hubbard RE, O’Mahony MS, Savva GM, Calver BL, Woodhouse KW (2009) Inflammation and frailty measures in older people. J Cell Mol Med 13:3103–3109 ArticlePubMed Google Scholar
Fried LP, Xue QL, Cappola AR et al (2009) Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 64:1049–1057 ArticlePubMed Google Scholar
Van Spall HG, Toren A, Kiss A et al (2007) Eligibility criteria of randomised controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA 297:1233–1240 ArticlePubMed Google Scholar
Pitt B, Zannad F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomised Aldactone Evaluation Study. N Eng J Med 341:709–717 ArticleCAS Google Scholar
Bozkurt B, Agoston I, Knowlton AA (2003) Complications of inappropriate use of spironolactone; when an old medicine spirals out of new guidelines. J Am Coll Cardiol 41:211–214 ArticlePubMedCAS Google Scholar
Svensson M, Gustafsson F, Galatius S, Hildebrandt PR, Atar D (2003) Hyperkalaemia and impaired renal function in patients taking spironolactone for congestive heart failure; retrospective study. Br Med J 327:1141–1142 Article Google Scholar
Dinsdale C, Wani M, Steward J, O’Mahony MS (2005) Tolerability of spironolactone as adjunctive treatment for heart failure in patients over 75 years of age. Age Ageing 34:395–398 ArticlePubMed Google Scholar
Martin FC, Brighton P (2008) Frailty: different tools for different purposes? Age Ageing 37(2):129–131 ArticlePubMed Google Scholar
Willcox SM, Himmelstein DU, Woolhandler S (1994) Inappropriate drug prescribing for the community-dwelling elderly. JAMA 272:292–296 ArticlePubMedCAS Google Scholar
Gallagher PF, Barry PJ, Ryan C, Hartigan I, O’Mahony D (2008) Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers’ Criteria. Age Ageing 37:96–101 ArticlePubMed Google Scholar
Somers E, Simmonds D, Whitelaw C, Calver J, Beer C (2010) Quality use of medicines in residential aged care. Aust Fam Phys 39:413–416 Google Scholar
Gurwitz JH, Field TS, Avorn J et al (2000) Incidence and preventability of adverse drug events in nursing homes. Am J Med 109:87–94 ArticlePubMedCAS Google Scholar
The American Geriatrics Society 2012 Beers Criteria Update Expert Panel (2012) American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 60:616–631 Article Google Scholar
Laroche ML, Charmes JP, Nouaille Y, Picard N, Merle L (2007) Is inappropriate medication use a major cause of adverse drug reactions in the elderly? Br J Clin Pharmacol 63(2):177–186 ArticlePubMed Google Scholar
Garner JB (2010) Problems of nonadherence in cardiology and proposals to improve outcomes. Am J Cardiol 105(10):1495–1501 ArticlePubMed Google Scholar
Davies EC, Green CF, Taylor S et al (2009) Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One 4:4439 Article Google Scholar
Inouye SK (1998) Delirium in hospitalized older patients: recognition and risk factors. J Geriatr Psychiatry Neurol 11(3):118–125 PubMedCAS Google Scholar
Tinetti ME, Kumar C (2010) The patient who falls: “It’s always a trade-off”. JAMA 303(3):258–266 ArticlePubMedCAS Google Scholar
Masoro EJ (2010) Physiology of aging. In: Fillit HM, Rockwood K, Woodhouse K (eds) Brocklehurst’s textbook of geriatric medicine and gerontology, 7th edn. Elsevier, Philadelphia, pp 51–59 Chapter Google Scholar
Delafuente JC (2008) Pharmacokinetic and pharmacodynamic alterations in the geriatric patient. Consult Pharm 23:324–334 ArticlePubMed Google Scholar
El Desoky ES (2007) Pharmacokinetic–pharmacodynamic crisis in the elderly. Am J Ther 14:488–498 Article Google Scholar
Mangoni AA, Jackson SHD (2003) Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 57:6–14 Article Google Scholar
Currie GM, Wheat JM, Kiat H (2011) Pharmacokinetic considerations for digoxin in older people. Open Cardiovasc Med J 5:130–135 ArticlePubMedCAS Google Scholar
Gainsborough N, Maskrey VL, Nelson ML, Keating J, Sherwood RA, Jackson SH, Swift CG (1993) The association of age with gastric emptying. Age Ageing 22:37–40 ArticlePubMedCAS Google Scholar
Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K (2010) Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci 65(4):377–381 ArticlePubMed Google Scholar
Weiss M (2008) How does obesity affect residence time dispersion and the shape of drug disposition curves? Thiopental as an example. J Pharmacokinet Pharmacodyn 35(3):325–336 ArticlePubMedCAS Google Scholar
Woodhouse KW, Wynne H, Baillie S, James O, Rawlins MD (1988) Who are the frail elderly? QJM 68:505–506 PubMedCAS Google Scholar
Wynne HA, Cope L, Herd B, James OFW, Rawlins MD, Woodhouse KW (1990) The association of age and frailty with paracetamol conjugation in man. Age Ageing 19:419–424 ArticlePubMedCAS Google Scholar
Wynne HA, Yelland C, Cope LH, Boddy A, Woodhouse KW, Bateman DN (1993) The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide. Age Ageing 22:354–359 ArticlePubMedCAS Google Scholar
Kampmann JP, Hansen JM (1981) Clinical pharmacokinetics of antithyroid drugs. Clin Pharmacokinet 6(6):401–428 ArticlePubMedCAS Google Scholar
Kubo SH, Cody RJ (1985) Clinical pharmacokinetics of the angiotensin converting enzyme inhibitors. Clin Pharmacokinet 10(5):377–391 ArticlePubMedCAS Google Scholar
Yelland C, Summerbell J, Nicholson E, Herd B, Wynne H, Woodhouse KW (1991) The association of age with aspirin esterase activity in human liver. Age Ageing 20(1):16–18 ArticlePubMedCAS Google Scholar
Abou-Hatab K, O’Mahony MS, Patel S, Woodhouse K (2001) Relationship between age and plasma esterases. Age Ageing 30(1):41–45 ArticlePubMedCAS Google Scholar
O’Mahony MS, George G, Westlake H, Woodhouse K (1994) Plasma aspirin esterase activity in elderly patients undergoing elective hip replacement and with fractured neck of femur. Age Ageing 23:338–341 Article Google Scholar
White S, Calver BL, Newsway V et al (2005) Enzymes of drug metabolism during delirium. Age Ageing 34(6):603–608 ArticlePubMed Google Scholar
Abou-Hatab K, Ganeshalingam K, O’Mahony MS, Giurani F, Patel S, Woodhouse K (2001) The effect of community-acquired pneumonia on plasma esterases in older people. Eur J Clin Pharm 57:55–60 ArticleCAS Google Scholar
Abou-Hatab K, O’Mahony MS, Patel S, Carey D, Woodhouse K (2000) Plasma esterase activities in young and old patients undergoing open inguinal hernia repair. Arch Gerontol Geriatr 31:193–198 ArticlePubMedCAS Google Scholar
Summerbell J, Yelland C, Woodhouse KW (1990) The kinetics of plasma aspirin esterase in relation to old age and frailty. Age Ageing 19:128–130 ArticlePubMedCAS Google Scholar
Hubbard RE, O’Mahony MS, Calver BL, Woodhouse KW (2008) Plasma esterases and inflammation in ageing and frailty. Eur J Clin Pharmacol 64(9):895–900 ArticlePubMedCAS Google Scholar
Morgan ET (1997) Regulation of cytochrome p450 during inflammation and infection. Drug Metab Rev 29:1129–1188 ArticlePubMedCAS Google Scholar
Wynne HA, Cope LH, James OFW, Rawlins MD, Woodhouse KW (1989) The effect of age and frailty upon acetonilide clearance in man. Age Ageing 18:415–418 ArticlePubMedCAS Google Scholar
Rowe JW, Andres R, Tobin JD, Norris AM, Shock NW (1976) The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol 31:155–163 ArticlePubMedCAS Google Scholar
Lindeman RD, Tobin J, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33:278–285 PubMedCAS Google Scholar
Shlipak MG, Stehman-Breen C, Fried LF, Song X, Siscovick D, Fried LP et al (2004) The presence of frailty in elderly persons with chronic renal insufficiency. Am J Kidney Dis 43:861–867 ArticlePubMed Google Scholar
Wilhelm-Leen ER, Hall YN, Tamura MK, Chertow GM (2009) Frailty and chronic kidney disease: the Third National Health and Nutrition Evaluation Survey. Am J Med 122(7):664–671, e2 ArticlePubMed Google Scholar
Bao Y, Dalrymple L, Chertow GM, Kaysen GA, Johansen KL (2012) Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med 172:1071–1077 ArticlePubMedCAS Google Scholar
Johansen KL, Chertow GM, Jin C, Kutner NG (2007) Significance of frailty among dialysis patients. J Am Soc Nephrol 18:2960–2967 ArticlePubMed Google Scholar
Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41 ArticlePubMedCAS Google Scholar
O’Riordan S, Ouldred E, Brice S, Jackson SH, Swift CG (2002) Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine. Br J Clin Pharmacol 53:398–402 ArticlePubMed Google Scholar
Levey AS, Bosch J, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461–470 PubMedCAS Google Scholar
Froissart M, Rossert J, Jaquot C, Paillard M, Houillier P (2005) Predictive performance of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 16:763–773 ArticlePubMed Google Scholar
Trifiro G, Spina E (2011) Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systems. Curr Drug Metab 12(7):611–620 ArticlePubMedCAS Google Scholar
Routledge PA, Chapman PH, Davies DM, Rawlins MD (1979) Factors affecting warfarin requirements. A prospective population study. Eur J Clin Pharmacol 15(5):319–322 ArticlePubMedCAS Google Scholar
Pickering G, Jourdan D, Eschalier A, Dubray C (2002) Impact of age, gender and cognitive functioning on pain perception. Gerontology 48:112–118 ArticlePubMed Google Scholar
McLachlan AJ, Bath S, Naganathan V et al (2011) Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol 71(3):351–364 ArticlePubMedCAS Google Scholar
Holmes HM, Hayley DC, Alexander GC, Sachs GA (2006) Reconsidering medication appropriateness for patients late in life. Arch Intern Med 166:605–609 ArticlePubMed Google Scholar
Scott IA, Gray LC, Martin JH, Mitchell CA (2012) Minimizing inappropriate medications in older populations: a 10-step conceptual framework. Am J Med 125(6):529–537 ArticlePubMed Google Scholar
Scott IA, Guyatt GH (2010) Cautionary tales in the interpretation of clinical studies involving older persons. Arch Intern Med 170(7):587–595 ArticlePubMed Google Scholar
Rockwood K, Hubbard R (2004) Frailty and the geriatrician. Age Ageing 33(5):429–430 ArticlePubMed Google Scholar
Rockwood K, Joyce B, Stolee P (1997) Use of goal attainment scaling in measuring clinically important change in cognitive rehabilitation patients. J Clin Epidemiol 50(5):581–588 ArticlePubMedCAS Google Scholar
Fried TR, Tinetti ME, Towle V, O’Leary JR, Iannone L (2011) Effects of benefits and harms on older persons’ willingness to take medication for primary cardiovascular prevention. Arch Intern Med 171:923–928 ArticlePubMed Google Scholar
Eeles EMP, White SV, O’Mahony MS, Bayer AJ, Hubbard RE (2012) The impact of frailty and delirium on mortality in older inpatients. Age Ageing 41(3):412–416 ArticlePubMed Google Scholar
Berthold HK, Gouni-Berthold I (2011) Lipid-lowering drug therapy in elderly patients. Curr Pharm Des 17:877–893 ArticlePubMedCAS Google Scholar
Hines LE, Murphy JE (2011) Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother 9(6):364–377 ArticlePubMedCAS Google Scholar
Hollick RJ, Reid DM (2011) Role of bisphosphonates in the management of postmenopausal osteoporosis: an update on recent safety anxieties. Menopause Int 17(2):66–72 ArticlePubMed Google Scholar