Connexins in Lens Development and Cataractogenesis (original) (raw)

Access this article

Log in via an institution

Subscribe and save

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

• Addison PK, Berry V, Holden KR, Espinal D, Rivera B, Su H, Srivastava AK, Bhattacharya SS (2006) A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family. Mol Vis 12:791–795
  PubMed CAS Google Scholar
• Baldo GJ, Gong X, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RT (2001) Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J Gen Physiol 118:447–456
  Article PubMed CAS Google Scholar
• Baruch A, Greenbaum D, Levy ET, Nielsen PA, Gilula NB, Kumar NM, Bogyo M (2001) Defining a link between gap junction communication, proteolysis, and cataract formation. J Biol Chem 276:28999–29006
  Article PubMed CAS Google Scholar
• Bassnett S (2004) Lens fiber differentiation. In: Lovicu FJ, Robinson ML (eds), Development of the Ocular Lens. Cambridge: Cambridge University Press, pp 214–244
  Google Scholar
• Beyer EC, Kistler J, Paul DL, Goodenough DA (1989) Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol 108:595–605
  Article PubMed CAS Google Scholar
• Chang B, Wang X, Hawes NL, Ojakian R, Davisson MT, Lo WK, Gong X (2002) A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice. Hum Mol Genet 11:507–513
  Article PubMed CAS Google Scholar
• Fleishman SJ, Unger VM, Yeager M, Ben-Tal N (2004) A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell 15:879–888
  Article PubMed CAS Google Scholar
• Gao J, Sun X, Martinez-Wittinghan FJ, Gong X, White TW, Mathias RT (2004) Connections between connexins, calcium, and cataracts in the lens. J Gen Physiol 124:289–300
  Article PubMed CAS Google Scholar
• Gong X, Baldo GJ, Kumar NM, Gilula NB, Mathias RT (1998) Gap junctional coupling in lenses lacking alpha3 connexin. Proc Natl Acad Sci USA 95:15303–15308
  Article PubMed CAS Google Scholar
• Gong X, Li E, Klier G, Huang Q, Wu Y, Lei H, Kumar NM, Horwitz J, Gilula NB (1997) Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell 91:833–843
  Article PubMed CAS Google Scholar
• Goodenough DA (1992) The crystalline lens. A system networked by gap junctional intercellular communication. Semin Cell Biol 3:49–58
  Article PubMed CAS Google Scholar
• Hansen L, Yao W, Eiberg H, Funding M, Riise R, Kjaer KW, Hejtmancik JF, Rosenberg T (2006) The congenital “ant-egg” cataract phenotype is caused by a missense mutation in connexin46. Mol Vis 12:1033–1039
  PubMed CAS Google Scholar
• Kumar NM, Gilula NB (1996) The gap junction communication channel. Cell 84:381–388
  Article PubMed CAS Google Scholar
• Martinez-Wittinghan FJ, Sellitto C, White TW, Mathias RT, Paul D, Goodenough DA (2004) Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression. Invest Ophthalmol Vis Sci 45:3629–3637
  Article PubMed Google Scholar
• Mathias RT, Rae JL, Baldo GJ (1997) Physiological properties of the normal lens. Physiol Rev 77:21–50
  PubMed CAS Google Scholar
• Piatigorsky J (1981) Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19:134–153
  Article PubMed CAS Google Scholar
• Rong P, Wang X, Niesman I, Wu Y, Benedetti LE, Dunia I, Levy E, Gong X (2002) Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development 129:167–174
  PubMed CAS Google Scholar
• Sellitto C, Li L, White TW (2004) Connexin50 is essential for normal postnatal lens cell proliferation. Invest Ophthalmol Vis Sci 45:3196–3202
  Article PubMed Google Scholar
• Unger VM, Kumar NM, Gilula NB, Yeager M (1999) Three-dimensional structure of a recombinant gap junction membrane channel. Science 283:1176–1180
  Article PubMed CAS Google Scholar
• Vanita V, Hennies HC, Singh D, Nurnberg P, Sperling K, Singh JR (2006) A novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin. Mol Vis 12:1217–1222
  PubMed CAS Google Scholar
• White TW (2002) Unique and redundant connexin contributions to lens development. Science 295:319–320
  Article PubMed CAS Google Scholar
• White TW, Bruzzone R, Wolfram S, Paul DL, Goodenough DA (1994) Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins. J Cell Biol 125:879–892
  Article PubMed CAS Google Scholar
• White TW, Goodenough DA, Paul DL (1998) Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol 143:815–825
  Article PubMed CAS Google Scholar
• Xia CH, Cheng C, Huang Q, Cheung D, Li L, Dunia I, Benedetti LE, Horwitz J, Gong X (2006a) Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. Exp Eye Res 83:688–696
  Article PubMed CAS Google Scholar
• Xia CH, Cheung D, DeRosa AM, Chang B, Lo WK, White TW, Gong X (2006b) Knockin a3 (Cx46) connexin prevents severe cataracts caused by an a8 (Cx50)–G22R mutation. J Cell Sci (in press)
• Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, Beutler B, Lo WK, Gong X (2006c) Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development 133:2033–2040
  Article PubMed CAS Google Scholar
• Yeager M, Nicholson BJ (2000) Structure and biochemistry of gap junction. Adv Mol Cell Biol 30:31–98
  Article CAS Google Scholar

Download references