Epilepsy But Not Mobile Phone Frequency (900 MHz) Induces Apoptosis and Calcium Entry in Hippocampus of Epileptic Rat: Involvement of TRPV1 Channels (original) (raw)
Ammari M, Lecomte A, Sakly M, Abdelmelek H, de-Seze R (2008) Exposure to GSM 900 MHz electromagnetic fields affects cerebral cytochrome c oxidase activity. Toxicology 250:70–74 ArticleCASPubMed Google Scholar
Anderson V, Rowley J (2007) Measurements of skin surface temperature during mobile phone use. Bioelectromagnetics 28:159–162 ArticleCASPubMed Google Scholar
Bhaskaran MD, Smith BN (2010) Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy. Exp Neurol 223:529–536 ArticlePubMed CentralCASPubMed Google Scholar
Bortkiewicz A, Gadzicka E, Szymczak W, Zmyślony M (2012) Changes in tympanic temperature during the exposure to electromagnetic fields emitted by mobile phone. Int J Occup Med Environ Health 25:145–150 PubMed Google Scholar
Burkhardt M, Poković K, Gnos M, Schmid T, Kuster N (1996) Numerical and experimental dosimetry of petri dish exposure setups. Bioelectromagnetics 7:483–493 Article Google Scholar
Capri M, Scarcella E, Fumelli C, Bianchi E, Salvioli S, Mesirca P, Agostini C, Antolini A, Schiavoni A, Castellani G, Bersani F, Franceschi C (2004) In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential. Radiat Res 162:211–218 ArticleCASPubMed Google Scholar
Carballo-Quintás M, Martínez-Silva I, Cadarso-Suárez C, Alvarez-Figueiras M, Ares-Pena FJ, López-Martín E (2011) A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains. Neurotoxicology 32:478–494 ArticlePubMed Google Scholar
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824 ArticleCASPubMed Google Scholar
Erdinc OO, Baykul MC, Ozdemir O, Ozkan S, Sirmagul B, Oner SD, Ozdemir G (2003) Electromagnetic waves of 900 MHz in acute pentylenetetrazole model in ontogenesis in mice. Neurol Sci 24:111–116 ArticleCASPubMed Google Scholar
Espino J, Mediero M, Lozano GM, Bejarano I, Ortiz A, García JF, Pariente JA, Rodríguez AB (2009) Reduced levels of intracellular calcium releasing in spermatozoa from asthenozoospermic patients. Reprod Biol Endoc 7:11 Article Google Scholar
Espino J, Bejarano I, Redondo PC, Rosado JA, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2010) Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: evidence for the involvement of mitochondria and bax activation. J Membr Biol 233:105–118 ArticleCASPubMed Google Scholar
Espino J, Bejarano I, Paredes SD, Barriga C, Rodríguez AB, Pariente JA (2011) Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. J Pineal Res 51:195–206 ArticleCASPubMed Google Scholar
Espino J, Pariente JA, Rodríguez AB (2012) Oxidative stress and immunosenescence: therapeutic effects of melatonin. Oxid Med Cell Longev 2012:670294 ArticlePubMed CentralPubMed Google Scholar
Ghazizadeh V, Nazıroğlu M (2014) Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through TRPV1 channel in hippocampus and dorsal root ganglion of rats. Metab Brain Dis 29:787–799 ArticleCASPubMed Google Scholar
Grynkiewicz C, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440–3450 CASPubMed Google Scholar
Hansford RG (1994) Physiological role of mitochondrial Ca2+ transport. J Bioenerg Biomembr 26:495–508 ArticleCASPubMed Google Scholar
Heinemann U, Buchheim K, Gabriel S, Kann O, Kovacs R, Schuchmann S (2002) Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus. Prog Brain Res 135:197–210 ArticleCASPubMed Google Scholar
Jin Z, Zong C, Jiang B, Zhou Z, Tong J, Cao Y (2012) The effect of combined exposure of 900 MHz radiofrequency fields and doxorubicin in HL-60 cells. PLoS ONE 7:e46102 ArticlePubMed CentralCASPubMed Google Scholar
Joubert V, Bourthoumieu S, Leveque P, Yardin C (2008) Apoptosis is induced by radiofrequency fields through the caspase-independent mitochondrial pathway in cortical neurons. Radiat Res 169:38–45 ArticleCASPubMed Google Scholar
Kahya MC, Nazıroğlu M, Çiğ B (2014) Selenium reduces mobile phone (900 MHz)-induced oxidative stress, mitochondrial function, and apoptosis in breast cancer cells. Biol Trace Elem Res 160:285–293
Kesari KK, Siddiqui MH, Meena R, Verma HN, Kumar S (2013) Cell phone radiation exposure on brain and associated biological systems. Indian J Exp Biol 51:187–200 CASPubMed Google Scholar
Köylü H, Mollaoglu H, Ozguner F, Naziroglu M, Delibas N (2006) Melatonin modulates 900 MHz microwave-induced lipid peroxidation changes in rat brain. Tox Ind Health 22:211–216 Article Google Scholar
López-Martín E, Relova-Quinteiro JL, Gallego-Gómez R, Peleteiro-Fernández M, Jorge-Barreiro FJ, Ares-Pena FJ (2006) GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with subconvulsive doses of picrotoxin. Neurosci Lett 398:139–144 ArticlePubMed Google Scholar
Lu YS, Huang BT, Huang YX (2012) Reactive oxygen species formation and apoptosis in human peripheral blood mononuclear cell induced by 900 MHz mobile phone radiation. Oxid Med Cell Longev 2012:740280 PubMed CentralPubMed Google Scholar
Manikonda PK, Rajendra P, Devendranath D, Gunasekaran B, Aradhya RS, Channakeshava, Sashidhar RB, Subramanyam C (2007) Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus. Neurosci Lett 413:145–149 ArticleCASPubMed Google Scholar
Manna SS, Umathe SN (2012) Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. Epilepsy Res 100:113–124 ArticleCASPubMed Google Scholar
Matikka Virtanen H, Keshvari J, Lappalainen R (2010) Temperature changes associated with radiofrequency exposure near authentic metallic implants in the head phantom–a near field simulation study with 900, 1800 and 2450 MHz dipole. Phys Med Biol 55:5867–5881 ArticleCASPubMed Google Scholar
Nazıroğlu M (2007) New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res 32:1990–2001 ArticlePubMed Google Scholar
Nazıroğlu M (2009) Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem Res 34:2181–2191 ArticlePubMed Google Scholar
Nazıroğlu M (2011) TRPM2 cation channels, oxidative stress and neurological diseases: where are we now? Neurochem Res 36:355–366 ArticlePubMed Google Scholar
Nazıroğlu M, Gümral N (2009) Modulator effects of selenium and L-carnitine on wireless devices (2.45 GHz) induced oxidative stress and electroencephalography records in brain of rat. Internat J Radiat Biol 85:680–689 Article Google Scholar
Nazıroğlu M, Yürekli VA (2013) Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements. Cell Mol Neurobiol 33:589–599 ArticlePubMed Google Scholar
Nazıroğlu M, Kutluhan S, Yilmaz M (2008) Selenium and topiramate modulates brain microsomal oxidative stress values, Ca2+-ATPase activity, and EEG records in pentylentetrazol-induced seizures in rats. J Membr Biol 225:39–49 ArticlePubMed Google Scholar
Nazıroğlu M, Özgül C, Çelik Ö, Çiğ B, Sözbir E (2011) Aminoethoxydiphenyl borate and flufenamic acid inhibit Ca2+ influx through TRPM2 channels in rat dorsal root ganglion neurons activated by ADP-ribose and rotenone. J Membr Biol 241:69–75 ArticlePubMed Google Scholar
Nazıroğlu M, Ciğ B, Doğan S, Uğuz AC, Dilek S, Faouzi D (2012a) 2.45 GHz wireless devices induce oxidative stress and proliferation through cytosolic Ca2+ influx in human leukemia cancer cells. Int J Radiat Biol 88:449–456 ArticlePubMed Google Scholar
Nazıroğlu M, Çelik Ö, Özgül C, Çiğ B, Doğan S, Bal R, Gümral N, Rodríguez AB, Pariente JA (2012b) Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2 +) channels in brain and dorsal root ganglion in rat. Physiol Behav 105:683–692 ArticlePubMed Google Scholar
Nazıroğlu M, Dikici DM, Dursun S (2012c) Role of oxidative stress and Ca(2 +) signaling on molecular pathways of neuropathic pain in diabetes: focus on TRP channels. Neurochem Res 37:2065–2075 ArticlePubMed Google Scholar
Nazıroğlu M, Tokat S, Demirci S (2012d) Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2 + signaling molecular pathways in breast cancer. J Recept Signal Transduct Res 32:290–297 ArticlePubMed Google Scholar
Nazıroğlu M, Akay MB, Celik O, Yıldırım MI, Balcı E, Yürekli VA (2013a) Capparis ovata modulates brain oxidative toxicity and epileptic seizures in pentylentetrazol-induced epileptic rats. Neurochem Res 38:780–788 ArticlePubMed Google Scholar
Nazıroğlu M, Çiğ B, Özgül C (2013b) Neuroprotection induced by N-acetylcysteine against cytosolic glutathione depletion induced-Ca2+ influx in dorsal root ganglion neurons of mice: role of TRPV1 channels. Neuroscience 242:151–160 ArticlePubMed Google Scholar
Nazıroğlu M, Yüksel M, Köse SA, Ozkaya MO (2013c) Recent reports of Wi-Fi and mobile phone-induced radiation on oxidative stress and reproductive signaling pathways in females and males. J Membr Biol 246:869–875 ArticlePubMed Google Scholar
Nazıroğlu M, Sahin M, Ciğ B, Aykur M, Erturan I, Ugan Y (2014) Hypericum perforatum modulates apoptosis and calcium mobilization through voltage-gated and TRPM2 calcium channels in neutrophil of patients with behcet’s disease. J Membr Biol 247:253–262 ArticlePubMed Google Scholar
O’Connor RP, Madison SD, Leveque P, Roderick HL, Bootman MD (2010) Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons. PLoS ONE 5:e11828 ArticlePubMed CentralPubMed Google Scholar
Özorak A, Nazıroğlu M, Çelik Ö, Yüksel M, Özçelik D, Özkaya MO, Çetin H, Kahya MC, Kose SA (2013) Wi-Fi (2.45 GHz)- and mobile phone (900 and 1800 MHz)-induced risks on oxidative stress and elements in kidney and testis of rats during pregnancy and the development of offspring. Biol Trace Elem Res 156:221–229 ArticlePubMed Google Scholar
Piacentini R, Ripoli C, Mezzogori D, Azzena GB, Grassi C (2008) Extremely low-frequency electromagnetic fields promote in vitro neurogenesis via upregulation of Ca(v)1-channel activity. J Cell Physiol 215:129–139 ArticleCASPubMed Google Scholar
Platano D, Mesirca P, Paffi A, Pellegrino M, Liberti M, Apollonio F, Bersani F, Aicardi G (2007) Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba2+ currents through voltage-gated calcium channels in rat cortical neurons. Bioelectromagnetics 28:599–607 ArticleCASPubMed Google Scholar
Senol N, Nazıroğlu M, Yürüker V (2014) N-acetylcysteine and selenium modulate oxidative stress, antioxidant vitamin and cytokine values in traumatic brain injury-induced rats. Neurochem Res 39:685–692 ArticleCASPubMed Google Scholar
Sun FJ, Guo W, Zheng DH, Zhang CQ, Li S, Liu SY, Yin Q, Yang H, Shu HF (2013) Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy. J Mol Neurosci 49:182–193 ArticleCASPubMed Google Scholar
Susankova K, Tousova K, Vyklicky L, Teisinger J, Vlachova V (2006) Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current. Mol Pharmacol 70:383–394 CASPubMed Google Scholar
Uğuz AC, Nazıroğlu M (2012) Effects of selenium on calcium signaling and apoptosis in rat dorsal root ganglion neurons induced by oxidative stress. Neurochem Res 37:1631–1638 ArticlePubMed Google Scholar