Ancient Origin of the Parkinson Disease Gene LRRK2 (original) (raw)

References

• Berg D, Schweitzer K, Leitner P, Zimprich A, Lichtner P, Belcredi P, Brussel T, Schulte C, Maass S, Nagele T (2005) Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson’s disease. Brain 128:3000–3011
  PubMed Google Scholar
• Bosgraaf L, Van Haastert PJ (2003) Roc, a Ras/GTPase domain in complex proteins. Biochim Biophys Acta 1643:5–10
  Article PubMed CAS Google Scholar
• Burge C, Karlin S (1997) Prediction of complete gene structures in human genomic DNA. J Mol Biol 268:78–94
  Article PubMed CAS Google Scholar
• Chen-Plotkin AS, Yuan W, Anderson C, Wood EM, Hurtig HI, Clark CM, Miller BL, Lee VM, Trojanowski JQ, Grossman M, Van Deerlin VM (2008) Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology 70:521–527
  Article PubMed CAS Google Scholar
• Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O’Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M (2006) The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet 15:223–232
  Article PubMed CAS Google Scholar
• Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR (2007) Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. J Neurochem 102:93–102
  Article PubMed CAS Google Scholar
• Groves MR, Barford D (1999) Topological characteristics of helical repeat proteins. Curr Opin Struct Biol 9:383–389
  Article PubMed CAS Google Scholar
• Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696–704
  Article PubMed Google Scholar
• Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG (2007) The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp Cell Res 313:3658–3670
  Article PubMed CAS Google Scholar
• Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet 16:678–690
  Article PubMed CAS Google Scholar
• Korr D, Toschi L, Donner P, Pohlenz HD, Kreft B, Weiss B (2006) LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. Cell Signal 18:910–920
  Article PubMed CAS Google Scholar
• Lee SB, Kim W, Lee S, Chung J (2007) Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Biochem Biophys Res Commun 358:534–539
  Article PubMed CAS Google Scholar
• Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z (2007) Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson’s disease R1441C/G mutants. J Neurochem 103:238–247
  Article PubMed CAS Google Scholar
• Lucas JI, Arnau V, Marín I (2006) Comparative genomics and protein domain graph analyses link ubiquitination and RNA metabolism. J Mol Biol 357:9–17
  Article PubMed CAS Google Scholar
• Lucas JI, Marín I (2007) A new evolutionary paradigm for the Parkinson disease gene DJ-1. Mol Biol Evol 24:551–561
  Article PubMed CAS Google Scholar
• MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A (2006) The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52:587–593
  Article PubMed CAS Google Scholar
• Marín I (2006) The Parkinson disease gene LRRK2: evolutionary and structural insights. Mol Biol Evol 23:2423–2433
  Article PubMed Google Scholar
• Marín I, Ferrús A (2002) Comparative genomics of the RBR family, including the Parkinson’s disease-related gene parkin and the genes of the ariadne subfamily. Mol Biol Evol 19:2039–2050
  PubMed Google Scholar
• Marín I, Lucas JI, Gradilla AC, Ferrús A (2004) Parkin and relatives: the RBR family of ubiquitin ligases. Physiol Genomics 17:253–263
  Article PubMed Google Scholar
• Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA (2006) LRRK2 in Parkinson’s disease: protein domains and functional insights. Trends Neurosci 29:286–293
  Article PubMed CAS Google Scholar
• Mushegian AR, Garey JR, Martin J, Liu LX (1998) Large-scale taxonomic profiling of eukaryotic model organisms: a comparison of orthologous proteins encoded by the human, fly, nematode, and yeast genomes. Genome Res 8:590–598
  PubMed CAS Google Scholar
• Nicholas KB, Nicholas HB Jr (1997) GeneDoc: a tool for editing and annotating multiple sequence alignments. Distributed by the author
• Nichols WC, Elsaesser VE, Pankratz N, Pauciulo MW, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T; for the Parkinson Study Group-PROGENI Investigators (2007) LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8. Neurology (in press)
• Putnam NH, Srivastava M, Hellsten U, Dirks B, Chapman J, Salamov A, Terry A, Shapiro H, Lindquist E, Kapitonov VV, Jurka J, Genikhovich G, Grigoriev IV, Lucas SM, Steele RE, Finnerty JR, Technau U, Martindale MQ, Rokhsar DS (2007) Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science 317:86–94
  Article PubMed CAS Google Scholar
• Sakaguchi-Nakashima A, Meir JY, Jin Y, Matsumoto K, Hisamoto N (2007) LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr Biol 17:592–598
  Article PubMed CAS Google Scholar
• Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA (2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 9:1231–1233
  Article PubMed CAS Google Scholar
• Söding J, Remmert M, Biegert A (2006) HHrep: de novo protein repeat detection and the origin of TIM barrels. Nucleic Acids Res 34:W137–W142
  Article PubMed Google Scholar
• Stein LD, Bao Z, Blasiar D, Blumenthal T, Brent MR, Chen N, Chinwalla A, Clarke L, Clee C, Coghlan A, Coulson A, D’Eustachio P, Fitch DH, Fulton LA, Fulton RE, Griffiths-Jones S, Harris TW, Hillier LW, Kamath R, Kuwabara PE, Mardis ER, Marra MA, Miner TL, Minx P, Mullikin JC, Plumb RW, Rogers J, Schein JE, Sohrmann M, Spieth J, Stajich JE, Wei C, Willey D, Wilson RK, Durbin R, Waterston RH (2003) The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol 1:E45
  Article PubMed Google Scholar
• Swofford DL (2003) PAUP*. Phylogenetic Analysis Using Parsimony (*and other methods). Version 4. Sinauer Associates, Sunderland, MA
  Google Scholar
• Tamura K, Dudley J, Nei M, Kumar S (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24:1596–1599
  Article PubMed CAS Google Scholar
• Taylor JP, Mata IF, Farrer MJ (2006) LRRK2: a common pathway for parkinsonism, pathogenesis and prevention? Trends Mol Med 12:76–82
  Article PubMed CAS Google Scholar
• Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, Hinkle KM, Stone JT, Ross OA, Hauser R, Aasly J, Gasser T, Payami H, Wszolek ZK, Farrer MJ (2007) Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson’s disease. Neurogenetics 8:95–102
  Article PubMed CAS Google Scholar
• Thomas B, Beal MF (2007) Parkinson’s disease. Hum Mol Genet Spec No 2:R183–R194
  Google Scholar
• Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997) The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 24:4876–4882
  Article Google Scholar
• West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM (2005) Parkinson’s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci USA 102:16842–16847
  Article PubMed CAS Google Scholar
• Zdobnov EM, Apweiler R (2001) InterProScan—an integration platform for the signature-recognition methods in InterPro. Bioinformatics 17:847–848
  Article PubMed CAS Google Scholar

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