Experience with carbon-11 choline positron emission tomography in prostate carcinoma (original) (raw)

Abstract.

We investigated the potential of carbon-11 choline positron emission tomography (PET) for the detection of lymph node and bone metastases in prostate cancer. A total of 23 patients were studied (known metastases: 8; suspicion of metastases: 3; primary staging: 12). Whole-body PET imaging was performed 5 min after injection of the tracer and completed within 1 h. Focally increased tracer uptake in bone or abdominal lymph node regions was interpreted as representing tumour involvement. All known bone and lymph node metastases could be recognized by [11C]choline PET. One out of ten negative scans for primary staging was false-negative (lymph node <1 cm) and one out of two positive scans was false-positive with regard to lymph node involvement (focal bowel activity). It is concluded that [11C]choline PET is a promising new tool for the primary staging of prostate cancer, with lymph node and bone metastases demonstrating high tracer uptake. Therapeutic management could be influenced by these results in that the technique may permit avoidance of surgical lymph node exploration.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, University of Ulm, Germany, Germany
    Jörg Kotzerke, Bernd Neumaier, Albrecht Guhlmann & Sven N. Reske
  2. Department of Urology, University of Ulm, Germany, Germany
    Jürgen Prang, Björn Volkmer, Klaus Kleinschmidt & Richard Hautmann

Authors

  1. Jörg Kotzerke
  2. Jürgen Prang
  3. Bernd Neumaier
  4. Björn Volkmer
  5. Albrecht Guhlmann
  6. Klaus Kleinschmidt
  7. Richard Hautmann
  8. Sven N. Reske

Additional information

Received 31 March and in revised form 17 May 2000

Electronic Publication

Rights and permissions

About this article

Cite this article

Kotzerke, J., Prang, J., Neumaier, B. et al. Experience with carbon-11 choline positron emission tomography in prostate carcinoma.Eur J Nucl Med 27, 1415–1419 (2000). https://doi.org/10.1007/s002590000309

Download citation