Strategies for antigen choice and priming of dendritic cells influence the polarization and efficacy of antitumor T-cell responses in dendritic cell–based cancer vaccination (original) (raw)
Akasaki Y, Kikuchi T, Homma S, Abe T, Kofe D, Ohno T (2001) Antitumor effect of immunizations with fusions of dendritic and glioma cells in a mouse brain tumor model. J Immunother 24:106 CAS Google Scholar
Amoscato AA, Prenovitz DA, Lotze MT (1998) Rapid extracellular degradation of synthetic class I peptides by human dendritic cells. J Immunol 161:4023 CASPubMed Google Scholar
Bakker ABH, Marland G, Deboer AJ, Huijbens RJF, Danen EHJ, Adema GJ, Figdor CG (1995) Generation of antimelanoma cytotoxic t-lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in-vitro. Cancer Res 55:5330 CASPubMed Google Scholar
Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulandran B, Palucka K (2000) Immunobiology of Dendritic Cells. Annu Rev Immunol 18:767 CASPubMed Google Scholar
Banchereau J, Palucka AK, Dhodapkar M, Burkeholder S, Taquet N, Rolland A, Taquet S, Coquery S, Wittkowski K, Bhardwaj N, Piniero L, Steinman R, Fay J (2001) Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res 61:6451 CASPubMed Google Scholar
Barnden MJ, Allison J, Heath WR, Carbone FR (1998) Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76:34 CASPubMed Google Scholar
Bennett SRM, Carbone FR, Karamalis F, Miller JF, Heath WR (1997) Induction of a CD8(+) cytotoxic T lymphocyte response by cross-priming requires cognate CD4(+) T cell help. J Exp Med 186:65 CASPubMed Google Scholar
Berard F, Blanco P, Davoust J, Neidhart-Berard EM, Nouri-Shirazi M, Taquet N, Rimoldi D, Cerottini J, Banchereaux J, Palucka AK (2000) Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J Exp Med 192:1535 ArticleCASPubMed Google Scholar
Berlyn KA, Schultes B, Leveugle B, Noujaim AA, Alexander RB, Mann DL (2001) Generation of CD4(+) and CD8(+) T lymphocyte responses by dendritic cells armed with PSA/anti-PSA (antigen/antibody) complexes. Clin Immunol 101:276 CASPubMed Google Scholar
Boczkowski D, Nair SK, Snyder D, Gilboa E (1996) Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med 184:465 CASPubMed Google Scholar
Brossart P, Heinrich KS, Stuhler G, Behnke L, Reichardt VL, Stevanovic S, Muhm A, Rammensee HG, Kanz L, Brugger W (1999) Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. Blood 93:4309 CASPubMed Google Scholar
Brossart P, Wirths S, Stuhler G, Reichardt VL, Kanz L, Brugger W (2000) Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 96:3102 CASPubMed Google Scholar
Burdin N, Moingeon P (2001) Cancer vaccines based on dendritic cells loaded with tumor-associated antigens. Cell Biol Toxicol 17:67 ArticleCASPubMed Google Scholar
Chevallier P, Spisek R, Morineau N, Milpied N, Avet-Loiseau H, Harousseau JL. Meflah K, Gregoire M (2001) Induction of leukemia-specific autologous CTLs by leukemia derived dendritic cells or dendritic cells pulsed with autologous killed leukemic blasts: potential implications for immunotherapy of acute myeloid leukemia. Blood 98:3013 Google Scholar
Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N (2001) Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193:233 CASPubMed Google Scholar
Dhodapkar MV, Steinman RM, Sapp M, Desai H, Fossella C, Krasovsky J, Donahoe SM, Dunbar PR, Cerundolo V, Nixon DF, Bhardwaj N (1999) Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest 104:173 CASPubMed Google Scholar
Eggert AAO, Schreurs MWJ, Boerman OC, Oyen WJC, de Boer AJ, Punt CJ, Figdor CG, Adema GJ (1999) Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration. Cancer Res 59:3340 CASPubMed Google Scholar
Ferlazzo G, Semino C, Spaggiari GM, Meta M, Mingari MC, Melioli G (2000) Dendritic cells efficiently cross-prime HLA class I-restricted cytolytic T lymphocytes when pulsed with both apoptotic and necrotic cells but not with soluble cell-derived lysates. Int Immunol 12:1741 CASPubMed Google Scholar
Fields RC, Shimizu K, Mule JJ (1998) Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc Natl Acad Sci U S A 95:9482 ArticleCASPubMed Google Scholar
Fong L, Brockstedt D, Benike C, Wu L, Engleman EG (2001) Dendritic cells injected via different routes induce immunity in cancer patients. J Immunol 166:4254 CASPubMed Google Scholar
Fong L, Engleman EG (2000) Dendritic cells in cancer immunotherapy. Annu Rev Immunol 18:245 CASPubMed Google Scholar
Galea-Lauri J, Darling D, Mufti G, Harrison P, Farzaneh F (2002). Eliciting cytotoxic T lymphocytes against acute myeloid leukemia-derived antigens: evaluation of dendritic cell/leukemia cell hybrids and other antigen loading strategies for dendritic cell-based vaccination. Cancer Immunol Immunother 51:299 ArticleCASPubMed Google Scholar
Galea-Lauri J, Richardson AJ, Latchman DS, Katz DR (1996) Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide—a possible role in immunopathology. J Immunol 157:4109 CASPubMed Google Scholar
Gallucci S, Lolkema M, Matzinger P (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat Med 5:1249 CASPubMed Google Scholar
Gilboa E, Nair SK, Boczkowski D (2000) Cancer immunotherapy with tumor RNA-transfected dendritic cells. Cancer Gene Ther 7:004 Article Google Scholar
Girolomoni G, RicciardiCastagnoli P (1997) Dendritic cells hold promise for immunotherapy. Immunol Today 18:102 ArticleCASPubMed Google Scholar
Gong JL, Chen DS, Kashiwaba M, Kufe D (1997) Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med 3:558 CASPubMed Google Scholar
Gong JL, Koido S, Chen DS, Tanaka Y, Huang L, Avigan D (2002) Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12. Blood 99:2512 ArticleCASPubMed Google Scholar
Gong JL, Nikrui N, Chen DS, Koido S, Wu ZK, Tanaka Y, Cannistra S, Avigan D, Kufe D (2000) Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity. J Immunol 165:1705 CASPubMed Google Scholar
Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S (2002) Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 20:621 ArticleCASPubMed Google Scholar
Gunzer M, Janich S, Varga G, Grabbe S (2001) Dendritic cells and tumor immunity. Semin Immunol 13:291 ArticleCASPubMed Google Scholar
Hoffmann TK, Meidenbauer N, Dworacki G, Kanaya H, Whiteside TL (2000) Generation of tumor specific T lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells. Cancer Res 60:3542 CASPubMed Google Scholar
Holtl L, Rieser C, Papesh C, Ramoner R, Herold M, Klocker H, Radmayr C, Stenzyl A, Bartsch G, Thurner M (1999) Cellular and humoral immune responses in patients with metastatic renal cell carcinoma after vaccination with antigen pulsed dendritic cells. J Urol 161:777 PubMed Google Scholar
Homma S, Toda G, Gong JL, Kufe D, Ohno T (2001) Preventive antitumor activity against hepatocellular carcinoma (HCC) induced by immunization with fusions of dendritic cells and HCC cells in mice. J Gastroenterol 36:764 CASPubMed Google Scholar
Irvine AS, Trinder PKE, Laughton DL, Ketteringham H, McDermott RH, Reid SC, Haines AM, Amir A, Husain R, Doshi R, Young LS, Mountain A (2000) Efficient nonviral transfection of dendritic cells and their use for in vivo immunization. Nat Biotechnol 18:1273 ArticleCASPubMed Google Scholar
Jager E, Ringhoffer M, Karbach J, Arand M, Oesch F, Knuth A (1996) Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8(+) cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo. Int J Cancer 66:470 CASPubMed Google Scholar
Jenne L, Schuler G, Steinkasserer A (2001) Viral vectors for dendritic cell-based immunotherapy. Trends Immunol 22:102 ArticleCASPubMed Google Scholar
Jonuleit H, Giesecke-Tuettenberg A, Tuting T, Thurner-Schuler B, Stuge TB, Paragnik L, Kandemir A, Lee PP, Schuler G, Knop J, Enk JH (2001) A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection. Int J Cancer 93:243 PubMed Google Scholar
Karttunen J, Sanderson S, Shastri N (1992) Detection of rare antigen-presenting cells by the LacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc Natl Acad Sci USA 89:6020 CASPubMed Google Scholar
Kikuchi T, Akasaki Y, Irie M, Homma S, Abe T, Ohno T (2001) Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells. Cancer Immunol Immunother 50:337 ArticleCASPubMed Google Scholar
Kovacsovicsbankowski M, Clark K, Benacerraf B, Rock K (1993) Efficient major histocompatibility complex class-I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A 90:4942 CASPubMed Google Scholar
Kurts C, Miller JFAP, Subramaniam RM, Carbone FR, Heath WR (1998) Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med 188:409 CASPubMed Google Scholar
Labeur MS, Roters B, Pers B, Mehling A, Luger TA, Schwarz T, Grabbe S (1999) Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage. J Immunol 162:168 CASPubMed Google Scholar
Lappin MB, Weiss JM, Delattre V, Mai B, Dittmar H, Maier C, Manke K, Grabbe S, Martin S, Simon JC (1999) Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology 98:181 CASPubMed Google Scholar
Li J, Holmes LM, Franek KJ, Burgin KE, Wagner TE, Wei Y (2001) Purified hybrid cells from dendritic cell and tumor cell fusions are superior activators of antitumor immunity. Cancer Immunol Immunother 50:456 ArticleCASPubMed Google Scholar
Li M, Davey GM, Sutherland RM, Kurts C, Lew AM, Hirst C, Carbone FM, Heath WR (2001) Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol 166:6099 CASPubMed Google Scholar
Ludewig B, McCoy K, Pericin M, Ochsenbein AF, Dumrese T, Odermatt B, Toes REM, Melief CJ, Hengartner H, Zinkernagel RM (2001) Rapid peptide turnover and inefficient presentation of exogenous antigen critically limit the activation of self- reactive CTL by dendritic cells. J Immunol 166:3678 CASPubMed Google Scholar
Lutz MB, Kukutsch N, Ogilvie ALJ, Rossner S, Koch F, Romani N, Schuler G (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223:77 CASPubMed Google Scholar
Lutz MB, Suri RM, Niimi M, Ogilvie ALJ, Kukutsch NA, Rossner S, Schuler G, Austyn JM (2000) Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 30:1813 CASPubMed Google Scholar
Luykx-de Bakker SA, de Gruijl TD, Scheper RJ, Wagstaff J, Pinedo HM (1999) Dendritic cells: a novel therapeutic modality. Ann Oncol 10:21 Article Google Scholar
Mackensen A, Herbst B, Chen JL, Kohler G, Noppen C, Herr W, Spagnoli G, Cerundolo V, Lindemann A (2000) Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells. Int J Cancer 86:385 CASPubMed Google Scholar
Mayordomo JI, Zorina T, Storkus WJ, Zitvogel L, celluzzi C, Falo LD, Melief CJ, Ildstad ST, Kast WM, Deleo AB, Lotze MT (1995) Bone-marrow-derived dendritic cells pulsed with synthetic tumor peptides elicit protective and therapeutic antitumor immunity. Nat Med 1:1297 CASPubMed Google Scholar
Minev BR, Chavez FL, Dudouet BM, Mitchell MS (2000) Synthetic insertion signal sequences enhance MHC class I presentation of a peptide from the melanoma antigen MART-1. Eur J Immunol 30:2115 CASPubMed Google Scholar
Moore MW, Carbone FR, Bevan MJ (1988) Introduction of soluble-protein into the class-I pathway of antigen processing and presentation. Cell 54:777 CASPubMed Google Scholar
Mule JJ (2000) Dendritic cells: at the clinical crossroads. J Clin Invest 105:707 CASPubMed Google Scholar
Murphy GP, Tjoa BA, Simmons SJ, Ragde H, Rogers M, Elgamal A, Kenny GM, Troychak MJ, Salgaller ML, Boynton AL (1999) Phase II prostate cancer vaccine trial: report of a study involving 37 patients with disease recurrence following primary treatment. Prostate 39:54 ArticleCASPubMed Google Scholar
Navabi H, Jasani B, Adams M, Evans AS, Mason M, Crosby T, Borysiewicz L (1997) Generation of in vitro autologous human cytotoxic T-cell response to E7 and HER-2/neu oncogene products using ex-vivo peptide loaded dendritic cells. Dendritic Cells in Fundamental and Clinical Immunology, vol 3. 417:583 Google Scholar
Nestle FO, Alijagic S, Gilliet M, Sun YS, Grabbe S, Dummer R, Burg G, Schadendorf D (1998) Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med 4:328 CASPubMed Google Scholar
Nestle FO (2000) Dendritic cell vaccination for cancer therapy. Oncogene 19:6673 CASPubMed Google Scholar
Nouri-Shirazi M, Banchereau J, Bell D, Burkeholder S, Kraus ET, Davoust J, Palucka KA (2000) Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J Immunol 165:3797 PubMed Google Scholar
Paczesny S, Beranger S, Salzmann JL, Klatzmann D, Colombo BM (2000) Protection of mice against leukemia after vaccination with dendritic cells loaded with apoptotic leukemia cells. Cancer Gene Ther 7:1402 Google Scholar
Paglia P, Chiodoni C, Rodolfo M, Colombo MP (1996) Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J Exp Med 183:317 CASPubMed Google Scholar
Panelli MC, Wunderlich J, Jeffries J, Wang E, Mixon A, Rosenberg SA, Marincola FM (2000) Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. J Immunother 23:487 CASPubMed Google Scholar
Porgador A, Snyder D, Gilboa E (1996) Induction of antitumor immunity using bone marrow-generated dendritic cells. J Immunol 156:2918 CASPubMed Google Scholar
Porgador A, Yewdell JW, Deng YP, Bennink JR, Germain RN (1997) Localization, quantitation, and in situ detection of specific peptide MHC class I complexes using a monoclonal antibody. Immunity 6:715 CASPubMed Google Scholar
Reichardt VL, Okada CY, Liso A, Benike CJ, Stockerl-Goldstein KE, Engleman EG, Blume KG, Levy R (1999) Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma—a feasibility study. Blood 93:2411 CASPubMed Google Scholar
Rosenberg SA, Yang JC, Schwartzentruber DJ, Hwu P, Marincola FM, Topalian SL, Einhom JH, White DE (1998) Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med 4:321 CASPubMed Google Scholar
Sauter B, Albert M, Francisco L, Bhardwaj N (1999) Consequences of cell death: exposure to necrotic but not apoptotic cells induces the maturation of immunostimulatory dendritic cells. J Invest Dermatol 113:035 Google Scholar
Schreurs FWJ, Eggert AAO, Punt CJA, Figdor CG, Adema GJ (2000) Dendritic cell-based vaccines: from mouse models to clinical cancer immunotherapy. Crit Rev Oncogenesis 11:1 CASPubMed Google Scholar
Schuler G, Steinman RM (1997) Dendritic cells as adjuvants for immune-mediated resistance to tumors. J Exp Med 186:1183 CASPubMed Google Scholar
Shastri N, Gonzalez F (1993) Endogenous generation and presentation of the ovalbumin peptide/k(b) complex to T-cells. J Immunol 150:2724 CASPubMed Google Scholar
Shu SY, Cohen P (2001) Tumor-dendritic cell fusion technology and immunotherapy strategies. J Immunother 24:99 ArticleCAS Google Scholar
Small EJ, Fratesi P, Reese DM, Strang G, Laus R, Peshwa MV, Valone FH (2000) Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells. J Clin Oncol 18:3894 CASPubMed Google Scholar
Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, Vile R, Gastineau D, Wettstein P, Chen LP (2002) Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res 62:1884 CASPubMed Google Scholar
Thurner B, Haendle I, Roder C, Dieckmann D, Keikavoussi P, Jonuleit H, Schuler G (1999) Vaccination with Mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med 190:1669 CASPubMed Google Scholar
Timmerman JM, Czerwinski DK, Davis TA, Hsu FJ, Benike C, Hao ZM, Engleman EG, Levy R (2002) Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients. Blood 99:1517 ArticleCASPubMed Google Scholar
Timmerman JM, Levy R (1999) Dendritic cell vaccines for cancer immunotherapy. Annu Rev Med 50:507 CASPubMed Google Scholar
Trefzer U, Weingart G, Chen YW, Herberth G, Adrian K, Winter H, Audring H, Guo YJ, Sterry W, Walden P (2000) Hybrid cell vaccination for cancer immune therapy: first clinical trial with metastatic melanoma. Int J Cancer 85:618 CASPubMed Google Scholar
Watts C (1997) Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol 15:821 CASPubMed Google Scholar
Zitvogel L, Angevin E, Tursz T (2000) Dendritic cell-based immunotherapy of cancer. Ann Oncol 11:199 ArticlePubMed Google Scholar