Interleukin-6: a potential inflammatory marker after total joint replacement (original) (raw)

Abstract

In a prospective study C-reactive protein (CRP) and interleukin-6 (IL-6) measurements were taken serially in 30 patients before and after 20 total hip arthroplasties (THR) and 10 total knee arthroplasties (TKR). There were no peri- and postoperative complications. Postoperatively the IL-6 serum concentration increased rapidly and peaked 6 h postoperatively at maximum levels (399±140 pg/ml). There was a mean half-life of 15 h and thereafter a rapid return to normal concentrations. In comparison, the postoperative CRP concentration rose more slowly and reached maximum levels (138±54 mg/l) on the second postoperative day. There was thereafter a slow descent with a mean half-life of 62 h. There was no significant difference between the patients with THR and those with TKR (_P_>0.05). IL-6 is therefore a superior marker for the inflammatory phase after THR and TKR.

Résumé

Nous avons contrôlé la ”C-Reactive Protein” (CRP) et l’”Interieukin-6” (IL-6) chez 30 patients avant et après l’implantation de 20 prothèses totales de la hanche et 10 prothèses totales du genou. L’évolution péri- et postopératoire chez tous les patients était sans complications. Les valeurs de la CRP étaient déterminées par turbidimétrie immunologique et les valeurs de l’IL-6 étaient déterminées par dosage immunologique des enzymes. La concentration de IL-6 dans le sérum augmentait très vite après l’opération et atteignait, 6 h après, ses valeurs maximales. Par contre les concentrations du CRP augmentaient moins vite et atteignaient leurs valeurs maximales seulement le 2’jour après l’opération. La détermination de IL-6 s’avère très adaptée pour le contrôle de l’évolution chimique après implantation d’une prothèse totale.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany Tel: +49-241-8089410, Fax: +49-241-8888439, , , , , , DE
    D. C. Wirtz, K.-D. Heller, O. Miltner & K.-W. Zilkens
  2. Department of Urologic Surgery, University of Rostock, Rostock, Germany, , , , , , DE
    J. M. Wolff

Authors

  1. D. C. Wirtz
  2. K.-D. Heller
  3. O. Miltner
  4. K.-W. Zilkens
  5. J. M. Wolff

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Accepted: 1 February 2000

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Wirtz, D., Heller, KD., Miltner, O. et al. Interleukin-6: a potential inflammatory marker after total joint replacement.International Orthopaedics SICOT 24, 194–196 (2000). https://doi.org/10.1007/s002640000136

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