Tissue distribution, antigen specificity and effector functions of γδ T cells in human diseases (original) (raw)

References

  1. Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS (1986) Identification of a putative second T-cell receptor. Nature 322:145
    Article PubMed CAS Google Scholar
  2. Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB (1989) Human lymphocytes bearing T cell receptor γδ are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med 169:1277
    Article PubMed CAS Google Scholar
  3. Morita CT, Verma S, Aparicio P, Martinez C, Spits H, Brenner MB (1991) Functionally distinct subsets of human γδ T cells. Eur J Immunol 21:2999
    Article PubMed CAS Google Scholar
  4. Lefranc MP, Rabbitts TH (1990) Genetic organization of the human T-cell receptor γ and δ loci. Res Immunol 141:565
    Article PubMed CAS Google Scholar
  5. Chien YH, Iwashima M, Kaplan KB, Elliott JF, Davis MM (1987) A new T-cell receptor gene located within the α locus and expressed early in T-cell differentiation. Nature 327:677
    Article PubMed CAS Google Scholar
  6. Hata S, Brenner MB, Krangel VIS (1987) Identification of putative human T cell receptor δ complementary DNA clones. Science 238:678
    Article PubMed CAS Google Scholar
  7. Takihara Y, Reimann J, Michalopoulos E, Ciccone E, Moretta L, Mak TW (1989) Diversity and structure of human T cell receptor δ chain genes in peripheral blood γδ-bearing T lymphocytes. J Exp Med 169:393
    Article PubMed CAS Google Scholar
  8. Migone N, Padovan S, Zappador C, Giachino C, Bottaro M, Matullo G, Carbonara C, Libero GD, Casorati G (1995) Restriction of the T-cell receptor Vδ gene repertoire is due to preferential rearrangement and is independent of antigen selection. Immunogenetics 42:323
    Article PubMed CAS Google Scholar
  9. Hata S, Satyanarayana K, Devlin P, Band H, McLean J, Strominger JL, Brenner MB, Krangel MS (1988) Extensive junctional diversity of rearranged human T cell receptor δ genes. Science 240:1541
    Article PubMed CAS Google Scholar
  10. Casorati G, De Libero G, Lanzavecchia A, Migone N (1989) Molecular analysis of human γδ+ clones from thymus and peripheral blood. J Exp Med 170:1521
    Article PubMed CAS Google Scholar
  11. Krangel MS, Yssel H, Brocklehurst C, Spits H (1990) A distinct wave of human T cell receptor γδ lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J Exp Med 172:847
    Article PubMed CAS Google Scholar
  12. Lafaille JJ, Haas W, Coutinho A, Tonegawa S (1990) Positive selection of γδ T cells. Immunol Today 11:75
    Article PubMed CAS Google Scholar
  13. Bonneville M, Ishida I Itohara S, Verbeek S, Berns A, Kanagawa O, Haas W, Tonegawa S (1990) Self-tolerance to transgenic γδ T cells by intrathymic inactivation. Nature 344:163
    Article PubMed CAS Google Scholar
  14. Dent AL, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick SM (1990) Self-reactive γδ T cells are eliminated in the thymus. Nature 343:714
    Article PubMed CAS Google Scholar
  15. De Koning J, Di Molfetto L, Reilly C, Wei Q, Havran WL, Lo D (1997) Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice. J Immunol 158:2558
    Google Scholar
  16. Tsujimura K, Takahashi T, Morita A, Hasegawa NH, Iwase S, Obata Y (1996) Positive selection of γδ CTL by TL antigen expressed in the thymus. J Exp Med 184:2175
    Article PubMed CAS Google Scholar
  17. Kawai K, Kishihara K, Molina TJ, Wallace VA, Mak TW, Ohashi PS (1995) Impaired development of Vγ3 dendritic epidermal T cells in p561ck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med 181:345
    Article PubMed CAS Google Scholar
  18. Pivniouk V, Tsitsikov E, Swinton P, Rathbun G, Alt FW, Geha RS (1998) Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein. SLP-76. Cell 94:229
    Article PubMed CAS Google Scholar
  19. Alberola IJ, Hogquist KA, Swan KA, Bevan MJ, Perlmutter RM (1996) Positive and negative selection invoke distinct signaling pathways. J Exp Med 184:9
    Article Google Scholar
  20. Moore TA, von Freeden, Jeffry U, Murray R, Zlotnik A (1996) Inhibition of γδ T cell development and early thymocyte maturation in IL-7 -/- mice. J Immunol 157:2366
    PubMed CAS Google Scholar
  21. Maki K, Sunaga S, Ikuta K (1996) The V-J recombination of T cell receptor-γ genes is blocked in in-terleukin-7 receptor-deficient mice. J Exp Med 184:2423
    Article PubMed CAS Google Scholar
  22. Kawai K, Suzuki H, Tomiyama K, Minagawa M, Mak TW, Ohashi PS (1998) Requirement of the IL-2 receptor β chain for the development of V_γ_3 dendritic epidermal T cells. J Invest Dermatol 110:961
    Article PubMed CAS Google Scholar
  23. Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E, Wakeham A, Mittruecker HW, Griesser H, Takimoto H, Schmits R, Shahinian A, Ohashi P, Penninger JM, Mak TW (1996) Impaired negative selection of T cells in Hodgkin’s disease antigen CD30-deficient mice. Cell 84:55124
    Article Google Scholar
  24. Guy-Grand D, Cerf-Bensussan N, Malissen B, Malassis-Seris M, Briottet C, Vassalli P (1991) Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 173:471
    Article PubMed CAS Google Scholar
  25. Bandeira A, Mota ST, Itohara S, Degermann S, Heusser C, Tonegawa S, Coutinho A (1990) Localization of γδ T cells to the intestinal epithelium is independent of normal microbial colonization. J Exp Med 172:239
    Article PubMed CAS Google Scholar
  26. Haas W, Pereira P, Tonegawa S (1993) γδ cells. Annu Rev Immunol 11:637
    PubMed CAS Google Scholar
  27. Jarry A, Cerf-Bensussan N, Brousse N, Selz F, Guy GD (1990) Subsets of CD3+ (T cell receptor αβ or γδ) and CD3 lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 20:1097
    Article PubMed CAS Google Scholar
  28. Liu CP, Ueda R, She J, Sancho J, Wang B, Weddell G, Loring J, Kurahara C, Dudley EC, Hayday A, Terhorst C, Huang M (1993) Abnormal T cell development in CD3-φ-/- mutant mice and identification of a novel T cell population in the intestine. EMBO J 12:4863
    PubMed CAS Google Scholar
  29. Page ST, Bogatzki LY, Hamerman JA, Sweenie CH, Hogarth PJ, Malissen M, Perlmutter RM, Pullen AM (1998) Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage. Proc Natl Acad Sei USA 95:9459
    Article CAS Google Scholar
  30. Laky K, Lefrancois L, Freeden-Jeffry U von, Murray R, Puddington L (1998) The role of IL-7 in thymic and extrathymic development of TCR αδ cells. J Immunol 161:707
    PubMed CAS Google Scholar
  31. Yada S, Kishihara K, Kong YY, Nomoto K (1998) Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes. J Immunol 161:2208
    PubMed CAS Google Scholar
  32. Lefrancois L, Goodman T (1989) In vivo modulation of cytolytic activity and Thy-1 expression in TCR-αδ+ intraepithelial lymphocytes. Science 243:1716
    Article PubMed CAS Google Scholar
  33. Van Kerckhove C, Rüssel GJ, Deusch K, Reich K, Bahn AK, DerSimonian H, Brenner MB (1992) Oligoclonality of human intestinal intraepithelial T cells. J Exp Med 175:57
    Article PubMed Google Scholar
  34. Sim GK, Augustin A (1991) Extrathymic positive selection of αδ T cells Vγ4Jγ1 rearrangements with “GxYS” junctions. J Immunol 146:2439
    PubMed CAS Google Scholar
  35. Hayes SM, Sirr A, Jacob S, Sim GK, Augustin A (1996) Role of IL-7 in the shaping of the pulmonary γδ T cell repertoire. J Immunol 156:2723
    PubMed CAS Google Scholar
  36. Hayakawa S, Shiraishi H, Saitoh S, Satoh K (1996) Decidua as a site of extrathymic VγI T-cell differentiation. Am J Reprod Immunol 35:233
    PubMed CAS Google Scholar
  37. Graeme CE, Bhan AK, Harris NL (1993) Immunohistochemical characterization of intraepithelial and subepithelial mononuclear cells of the upper airways. Am J Pathol 143:1416
    Google Scholar
  38. Falini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli MF, Moretta L, Ciccone E (1989) Distribution of T cells bearing different forms of the T cell receptor γδ in normal and pathological human tissues. J Immunol 143:2480
    PubMed CAS Google Scholar
  39. Richmond I, Pritchard GE, Ashcroft T, Corris PA, Walters EH (1993) Distribution of αδ T cells in the bronchial tree of smokers and non-smokers. J Clin Pathol 46:926
    Article PubMed CAS Google Scholar
  40. De Libero G, Rocci MP, Casorati G, Giachino C, Oderda G, Tavassoli K, Migone N (1993) T cell receptor heterogeneity in γδ T cell clones from intestinal biopsies of patients with celiac disease. Eur J Immunol 23:499
    Article PubMed Google Scholar
  41. Tnebel F, Faure F, Mami-Chouaib F, Jitsukawa S, Griscelli A, Genevee C, Roman RS, Hercend T (1988) A novel human Vδ gene expressed predominantly in the TiδA fraction of αδ+ peripheral lymphocytes. Eur J Immunol 18:2021
    Article Google Scholar
  42. Parker CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB (1990) Evidence for extrathymic changes in the T cell receptor γδ repertoire. J Exp Med 171:1597
    Article PubMed CAS Google Scholar
  43. De Libero G (1997) Sentinel function of broadly reactive human γδ T cells. Immunol Today 18:22
    Article PubMed Google Scholar
  44. Pfeffer K, Schoel B, Guile H, Kaufmann SH, Wagner H (1990) Primary responses of human T cells to mycobacteria: a frequent set of αδ T cells are stimulated by protease-resistant ligands. Eur J Immunol 20:1175
    Article PubMed CAS Google Scholar
  45. Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo G, Bonneville M, Fournie JJ (1994) Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science 264:267
    Article PubMed CAS Google Scholar
  46. Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT (1994) Nonpeptide ligands for human αδ T cells. Proc Natl Acad Sei USA 91:8175
    Article CAS Google Scholar
  47. Schoel B, Sprenger S, Kaufmann SHE (1994) Phosphate is essential for stimulation of Vγ9Vδ2 T lymphocytes by mycobacterial low molecular weight ligand. Eur J Immunol 24:1886
    Article PubMed CAS Google Scholar
  48. Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR (1995) Natural and synthetic nonpeptide antigens recognized by human αδ T cells. Nature 375:155
    Article PubMed CAS Google Scholar
  49. Biirk MR, Mori L, De Libero G (1995) Human Vγ9-Vδ2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites. Eur J Immunol 25:2052
    Article Google Scholar
  50. Bukowski JF, Morita CT, Brenner MB (1999) Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11:57
    Article PubMed CAS Google Scholar
  51. aiKunzmann V, Bauer E, Wilhelm M (1999) γδ T-cell stimulation by Pamidronate. N Engl J Med 340:737
    Article Google Scholar
  52. Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA (1999) Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sei USA 96:133
    Article CAS Google Scholar
  53. Bukowski JF, Morita CT, Band H, Brenner MB (1998) Crucial role of TCR γ chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells. J Immunol 161:286
    PubMed CAS Google Scholar
  54. De Libero G, Casorati G, Giachino C, Carbonara C, Migone N, Matzinger P, Lanzavecchia A (1991) Selection by two powerful antigens may account for the presence of the major population of human peripheral γδ T cells. J Exp Med 173:1311
    Article PubMed Google Scholar
  55. Kabelitz D, Bender A, Prospero T, Wesselborg S, Janssen O, Pechhold K (1991) The primary response of human γδ+ T cells to Mycobacterium tuberculosis is restricted to Vγ9-bearing cells. J Exp Med 173:1331
    Article PubMed CAS Google Scholar
  56. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB (1995) Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3:495
    Article PubMed CAS Google Scholar
  57. Lang F, Peyrat MA, Constant P, Davodeau F, David AJ, Poquet Y, Vie H, Fournie JJ, Bonneville M (1995) Early activation of human Vγ9 Vδ2 T cell broad cytotoxicity and TNF production by nonpepti-dic mycobacterial ligands. J Immunol 154:5986
    PubMed CAS Google Scholar
  58. Ciccone E, Viale O, Pende D, Malnati M, Battista FG, Barocci S, Moretta A, Moretta L (1989) Specificity of human T lymphocytes expressing a γδ T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a γδ clone. Eur J Immunol 19:1267
    Article PubMed CAS Google Scholar
  59. Spits H, Paliard X, Engelhard VH, de Vries J (1990) Cytotoxic activity and lymphokine production of T cell receptor (TCR)-cell receptor (TCR)-αβ+ and TCR-γδ+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-γδ+ CTL clones is affected by mutations at positions 152 and 156. J Immunol 144:4156
    PubMed CAS Google Scholar
  60. Rivas A, Koide J, Cleary ML, Engleman EG (1989) Evidence for involvement of the γ, δ T cell antigen receptor in cytotoxicity mediated by human alloantigen-specific T cell clones. J Immunol 142:1840
    PubMed CAS Google Scholar
  61. Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989) Recognition of cluster of differentiation 1 antigens by human CD4−CD8− cytolytic T lymphocytes. Nature 341:447
    Article PubMed CAS Google Scholar
  62. Faure F, Jitsukawa S, Miossec C, Hercend T (1990) CDlc as a target recognition structure for human T lymphocytes: analysis with peripheral blood γδ cells. Eur J Immunol 20:703
    Article PubMed CAS Google Scholar
  63. Del Porto P, Mami Chouaib F, Bruneau JM, Jitsukawa S, Dumas J, Harnois M, Hercend T (1991) TCT 1, a target molecule for γδ T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1. J Exp Med 173:1339
    Article PubMed Google Scholar
  64. Van Kaer L, Wu M, Ichikawa Y, Ito K, Bonneville M, Ostrand-Rosenberg S, Murphy DB, Tonegawa S (1991) Recognition of MHC TL gene products by γδ T cells. Immunol Rev 120:89
    Article PubMed Google Scholar
  65. Bluestone JA, Cron RQ, Cotterman M, Houlden BA, Matis LA (1988) Structure and specificity of T cell receptor γδ on major histocompatibility complex antigen-specific CD3+, CD4−, CD8− T lymphocytes. J Exp Med 168:1899
    Article PubMed CAS Google Scholar
  66. Matis LA, Fry AM, Cron RQ, Cotterman MM, Dick RF, Bluestone JA (1989) Structure and specificity of a class II MFIC alloreactive γδ T cell receptor heterodimer. Science 245:746
    Article PubMed CAS Google Scholar
  67. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH (1994) The nature of major histocompatibility complex recognition by γδ T cells. Cell 76:29
    Article PubMed CAS Google Scholar
  68. Heyborne KD, Cranfill RL, Carding SR, Born WK, O’Brien RL (1992) Characterization of γδ T lymphocytes at the maternal-fetal interface. J Immunol 149:2872
    PubMed CAS Google Scholar
  69. Mincheva-Nilsson L, Baranov V, Yeung MM, Hammarstrom S, Hammarstrom ML (1994) Immuno-morphologic studies of human decidua-associated lymphoid cells in normal early pregnancy. J Immunol 152:2020
    PubMed CAS Google Scholar
  70. Heyborne K, Fu YX, Nelson A, Farr A, O’Brien R, Born W (1994) Recognition of trophoblasts by γδ T cells. J Immunol 153:2918
    PubMed CAS Google Scholar
  71. Kozbor D, Trinchieri G, Monos DS, Isobe M, Russo G, Haney JA, Zmijewski C, Croce CM (1989) Human TCR-γ+/δ+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med 169:1847
    Article PubMed CAS Google Scholar
  72. Holoshitz J, Vila LM, Keroack BJ, McKinley DR, Bayne NK (1992) Dual antigenic recognition by cloned human γδ T cells. J Clin Invest 89:308
    Article PubMed CAS Google Scholar
  73. Del Porto P, D’Amato M, Fiorillo MT, Tuosto L, Piccolella E, Sorrentino R (1994) Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic γδ T cell clone. J Immunol 153:3093
    PubMed Google Scholar
  74. McMenamin C, Pimm C, McKersey M, Holt PG (1994) Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science 265:1869
    Article PubMed CAS Google Scholar
  75. Born W, Hall L, Dallas A, Boymel J, Shinnick T, Young D, Brennan P, O’Brien R (1990) Recognition of a peptide antigen by heat shock-reactive γδ T lymphocytes. Science 249:67
    Article PubMed CAS Google Scholar
  76. Abdel-Motal UM, Berg L, Rosen A, Bengtsson M, Thorpe CJ, Kihlberg J, Dahmen J, Magnusson G, Karlsson KA, Jondal M (1996) Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells. Eur J Immunol 26:544
    Article PubMed CAS Google Scholar
  77. Speir JA, Abdel-Motal UM, Jondal M, Wilson IA (1999) Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL. Immunity 10:51
    Article PubMed CAS Google Scholar
  78. Haregewoin A, Soman G, Horn RC, Finberg RW (1989) Human γδ+ T cells respond to mycobacterial heat-shock protein. Nature 340:309
    Article PubMed CAS Google Scholar
  79. Fisch P, Malkovsky M, Kovats S, Sturm E, Braakman E, Klein BS, Voss SD, Morrissey LW, DeMars R, Welch WJ, Bolhius RLH, Sondel PM (1990) Recognition by human Vγ9/Vδ2 T cells of a GroEL homolog on Daudi Burkitt’s lymphoma cells. Science 250:1269
    Article PubMed CAS Google Scholar
  80. Kaur I, Voss SD, Gupta RS, Schell K, Fisch P, Sondel PM (1993) Human peripheral γδ T cells recognize hsp60 molecules on Daudi Burkitt’s lymphoma cells. J Immunol 150:2046
    PubMed CAS Google Scholar
  81. Rock EP, Sibbald PR, Davis MM, Chien YH (1994) CDR3 length in antigen-specific immune receptors. J Exp Med 179:323
    Article PubMed CAS Google Scholar
  82. Davis MM, Chien Y (1995) Issues concerning the nature of antigen recognition by αβ and γδ T-cell receptors. Immunol Today 16:316
    Article PubMed CAS Google Scholar
  83. Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB (1989) Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature 339:544
    Article PubMed CAS Google Scholar
  84. Mombaerts P, Arnoldi J, Russ F, Tonegawa S, Kaufmann SH (1993) Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 365:53
    Article PubMed CAS Google Scholar
  85. Fu Y-X, Roark CE, Kelly K, Drevets D, Campbell P, O’Brien R, Born W (1994) Immune protection and control of inflammatory tissue necrosis by αδ T cells. J Immunol 153:3101
    PubMed CAS Google Scholar
  86. Jones-Carson J, Vazquez-Torres A, van der Heyde HC, Warner T, Wagner RD, Balish E (1995) αδ T cell induced nitric oxide production enhances resistance to mucosal candidiasis. Nat Med 1:552
    Article PubMed CAS Google Scholar
  87. De Libero G, Flesch I, Kaufmann SH (1988) Mycobacteria-reactive Lyt-2+ T cell lines. Eur J Immunol 18:59
    Article PubMed Google Scholar
  88. Flynn JL, Goldstein M, Triebold KJ, Koller B, Bloom BR (1992) MHC class I restricted T cells are required for resistance to M tuberculosis infection. Proc Natl Acad Sei USA 89:12013
    Article CAS Google Scholar
  89. Kägi D, Lederman B, Biirki K, Hengartner H, Zinkernagel R M (1994) CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity Eur J Immunol 24:3068
    Google Scholar
  90. Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat JP, Sette A, Brenner MB, Porcelli SA, Bloom BR, Modlin RL (1997) Differential effects of cytolytic T cell subsets on intracellular infection. Science 276:1684
    Article PubMed CAS Google Scholar
  91. Stenger S, Hanson DA, Teitelbaum R, Devvan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Boγδan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL (1998) An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282:121
    Article PubMed CAS Google Scholar
  92. Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H (1995) Differential production of interferon-y and interleukin-4 in response to Thl- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373:255
    Article PubMed CAS Google Scholar
  93. Bukowski JF, Morita CT, Brenner MB (1994) Recognition and destruction of virus-infected cells by human γδ CTL. J Immunol 153:5133
    PubMed CAS Google Scholar
  94. Horner AA, Jabara H, Ramesh N, Geha RS (1995) γδ T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J Exp Med 181:1239
    Article PubMed CAS Google Scholar
  95. Shammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA (1997) T cell γδ cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med 1 85:1969
    Article Google Scholar
  96. Tsuji M, Mombaerts P, Lefrancois L, Nussenzweig RS, Zavala F, Tonegawa S (1994) γδ T cells contribute to immunity against the liver stages of malaria in αβ T-cell-deficient mice. Proc Natl Acad Sei USA 91:345
    Article CAS Google Scholar
  97. Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, Bluestone JA, Nomoto K (1992) A protective role of γδ T cells in primary infection with Listeria monocytogenes in mice. J Exp Med 175:49
    Article PubMed CAS Google Scholar
  98. Ladel CH, Hess J, Daugelat S, Mombaerts P, Tonegawa S, Kaufmann SH (1995) Contribution of αβ and γδ T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guerin: studies with T cell receptor-deficient mutant mice. Eur J Immunol 25:838
    Article PubMed CAS Google Scholar
  99. D’Souza CD, Cooper AM, Frank AA, Mazzaccaro RJ, Bloom BR, Orme IM (1997) An anti-inflammatory role for γβ T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J Immunol 158:1217
    PubMed CAS Google Scholar
  100. King DP, Hyde DM, Jackson KA, Novosad DM, Ellis TN, Putney L, Stovall MY, Van Winkle LS, Beaman BL, Ferrick DA (1999) Cutting edge: protective response to pulmonary injury requires γδ T lymphocytes. J Immunol 162:5033
    PubMed CAS Google Scholar
  101. Pelegri C, Kuhnlein P, Büchner E, Schmidt CB, Franch A, Castell M, Hunig T, Emmrich F, Kinne RW (1996) Depletion of γδ T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis. Arthritis Rheum 39:204
    Article PubMed CAS Google Scholar
  102. Peng SL, Madaio MP, Hayday AC, Craft J (1996) Propagation and regulation of systemic autoimmunity by γδ T cells. J Immunol 157:5689
    PubMed CAS Google Scholar
  103. Kobayashi Y, Kawai K, Ito K, Honda H, Sobue G, Yoshikai Y (1997) Aggravation of murine experimental allergic encephalomyelitis by administration of T-cell receptor γδ-specific antibody. J Neuro-immunol 73:169
    CAS Google Scholar
  104. Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K (1996) Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes. J Exp Med 184:2167
    Article PubMed CAS Google Scholar
  105. Bertotto A, Gerli R, Spinozzi F, Muscat C, Scalise F, Castellucci G, Sposito M, Candio F, Vaccaro R (1993) Lymphocytes bearing the γδ T cell receptor in acute Brucella melitensis infection. Eur J Immunol 23:1177
    Article PubMed CAS Google Scholar
  106. Hara T, Mizuno Y, Takaki K, Takada H, Akeda H, Aoki T, Nagata M, Ueda K, Matsuzaki G, Yoshikai Y, Nomoto K (1992) Predominant activation and expansion of Vγ9-bearing γδ T cells in vivo as well as in vitro in Salmonella infection. J Clin Invest 90:204
    Article PubMed CAS Google Scholar
  107. Balbi B, Valle MT, Oddera S, Giunti D, Manca F, Rossi GA, Allegra L (1993) T-lymphocytes with γδ+ Vδ2+ antigen receptors are present in increased proportions in a fraction of patients with tuberculosis or with sarcoidosis. Am Rev Respir Dis 148:1685
    PubMed CAS Google Scholar
  108. Sumida T, Maeda T, Takahashi H, Yoshida S, Yonaka F, Sakamoto A, Tomioka H, Koike T, Yoshida S (1992) Predominant expansion of Vγ9/Vδ2 cells in a tularemia patient. Infect Immun 60:2554
    PubMed CAS Google Scholar
  109. Ueta C, Tsuyuguchi I, Kawasumi H, Takashima T, Toba H, Kishimoto S (1994) Increase of γδ T cells in hospital workers who are in close contact with tuberculosis patients. Infect Immun 62:5434
    PubMed CAS Google Scholar
  110. Ho M, Webster HK, Tongtawe P, Pattanapanyasat K, Weidanz WP (1990) Increased γδ T cells in acute Plasmodium falciparum malaria. Immunol Lett 25:139
    Article PubMed CAS Google Scholar
  111. Nakazawa S, Brown AE, Maeno Y, Smith CD, Aikawa M (1994) Malaria-induced increase of splenic γδ T cells in humans, monkeys, and mice. Exp Parasitol 79:391
    Article PubMed CAS Google Scholar
  112. Caldwell CW, Everett ED, McDonald G, Yesus YW, Roland WE (1995) Lymphocytosis of γδ T cells in human ehrlichiosis. Am J Clin Pathol 103:761
    PubMed CAS Google Scholar
  113. Raziuddin S, Telmasani AW, El-Awad E, Al-Amari O, Al-Yanadi M (1992) γδ T cells and the immune response in visceral leishmaniasis. Eur J Immunol 22:1143
    Article PubMed CAS Google Scholar
  114. Alaibac M, Daga A, Harms G, Morris J, Yu RC, Zwingerberger K, Chu AC (1993) Molecular analysis of the γδ T-cell receptor repertoire in normal human skin and in Oriental cutaneous leishmaniasis. Exp Dermatol 2:106
    Article PubMed CAS Google Scholar
  115. Scalise F, Gerli R, Castellucci G, Spinozzi F, Fabietti G M, Crupi S, Sensi L, Britta R, Vaccaro R, Bertotto A (1992) Lymphocytes bearing the γδ T-cell receptor in acute toxoplasmosis. Immunology 76:668
    PubMed CAS Google Scholar
  116. Flynn JN, Sileghem M (1994) Involvement of γδ T cells in immunity to trypanosomiasis. Immunology 83:86
    PubMed CAS Google Scholar
  117. Hinz T, Wesch D, Friese K, Reckziegel A, Arden B, Kabelitz D (1994) T cell receptor γδ repertoire in HIV-1-infected individuals. Eur J Immunol 24:3044
    Article PubMed CAS Google Scholar
  118. Agostini C, Zambello R, Trentin L, Cerutti A, Bulian P, Crivellaro C, Cipriani A, Semenzato G (1994) γδ T cell receptor subsets in the lung of patients with HIV-1 infection. Cell Immunol 153:194
    Article PubMed CAS Google Scholar
  119. Dechanet J, Merville P, Berge F, Bone-Mane G, Taupin JL, Michel P, Joly P, Bonneville M, Potaux L, Moreau JF (1999) Major expansion of γδ T lymphocytes following cytomegalovirus infection in kidney allograft recipients. J Infect Dis 179:1
    Article PubMed CAS Google Scholar
  120. Fisch P, Malkovsky M, Braakman E, Sturm E, Bolhuis RL, Prieve A, Sosman JA, Lam VA, Sondel PM (1990) γδ T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis. J Exp Med 171:1567
    Article PubMed CAS Google Scholar
  121. Di Fabrizio L, Kimura Y, Ware R, Rogozinski L, Chess L (1991) Specific triggering of γδ receptors by K562 cells activates the γδ TCR and may regulate natural killer-like function. J Immunol 146:2495
    PubMed Google Scholar
  122. Orsini DL, van Gils M, Kooy YM, Struyk L, Klein G, van den Elsen P, Koning F (1994) Functional and molecular characterization of B cell-responsive Vδl+ γδ T cells. Eur J Immunol 24: 3199
    Article PubMed CAS Google Scholar
  123. Kim HT, Nelson EL, Clayberger C, Sanjanwala M, Sklar J, Krensky AM (1995) γδ T cell recognition of tumor Ig peptide. J Immunol 154:1614
    PubMed CAS Google Scholar
  124. Meiio A, Filgueira L, Zuber M, Juretic A, Harder F, Gratzl O, De Libero G, Heberer M, Spagnoli GC (1993) T-cell receptor V-gene usage in neoplasms of the central nervous system. A comparative analysis in cultured tumor infiltrating and peripheral blood T cells. J Neurosurg 78:630
    Article Google Scholar
  125. Flageul B, Bachelez H, Boumsell L, Degos L, Bensussan A (1990) Infiltrating lymphocytes in benign and malignant naevomelanocytic lesions. Nouv Rev Fr Hematol 32:9
    PubMed CAS Google Scholar
  126. Maeurer MJ, Martin D, Walter W, Liu K, Zitvogel L, Halusczcak K, Rabinowich H, Duquesnoy R, Storkus W, Lotze MT (1996) Human intestinal V5l+ lymphocytes recognize tumor cells of epithelial origin. J Exp Med 183:1681
    Article PubMed CAS Google Scholar
  127. Choudhary A, Davodeau F, Moreau A, Peyrat MA, Bonneville M, Jotereau F (1995) Selective lysis of autologous tumor cells by recurrent γδ tumor-infiltrating lymphocytes from renal carcinoma. J Immunol 154:3932
    PubMed CAS Google Scholar
  128. Zocchi MR, Ferrarini M, Migone N, Casorati G (1994) T-cell receptor Vδ gene usage by tumour reactive γδ T lymphocytes infiltrating human lung cancer. Immunology 81:234
    PubMed CAS Google Scholar
  129. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T (1999) Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proc Natl Acad Sei U S A 96:6879
    Article CAS Google Scholar
  130. Groh V, Steinle A, Bauer S, Spies T (1998) Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279:1737
    Article PubMed CAS Google Scholar
  131. Brennan FM, Londei M, Jackson AM. Hercend T, Brenner MB, Maini RN, Feldmann M (1988) T cells expressing γδ chain receptors in rheumatoid arthritis. J Autoimmun 1:319
    Article PubMed CAS Google Scholar
  132. Jacobs MR, Haynes BF (1992) Increase in TCR γδ T lymphocytes in synovia from rheumatoid arthritis patients with active synovitis. J Clin Immunol 12:130
    Article PubMed CAS Google Scholar
  133. Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA (1992) γδ T-cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad Sei U S A 89:4588
    Article CAS Google Scholar
  134. Shimonkevitz R, Colburn C, Burnham JA, Murray RS, Kotzin BL (1993) Clonal expansions of activated γδ T cells in recent-onset multiple sclerosis. Proc Natl Acad Sei USA 90:923
    Article CAS Google Scholar
  135. Nick S, Piled P, Tongiani S, Uematsu Y, Kappos L, De Libero G (1995) T cell receptor γδ repertoire is skewed in cerebrospinal fluid of multiple sclerosis patients: molecular and functional analyses of antigen-reactive γδ clones. Eur J Immunol 25:355
    Article PubMed CAS Google Scholar
  136. Ashihara E, Shimazaki C, Hirata T, Okawa K, Oku N, Goto H, Inaba T, Fujita N, Nakagawa M (1993) Autoimmune thrombocytopenia following peripheral blood stem cell autografting. Bone Marrow Transplant 12:297
    PubMed CAS Google Scholar
  137. Scott CS, Richards SJ, Sivakumaran M, Steed AJ, Norfolk DR, Milligan DW, Short M (1994) Persistent clonal expansions of CD3+ TCR γδ+ and CD3+ TCR αβ+ CD4−CD8− lymphocytes associated with neutropenia. Leuk Lymphoma 14:429
    Article PubMed CAS Google Scholar
  138. Horiuchi T, Hirokawa M, Satoh K, Kitabayashi A, Muira AB (1999) Clonal expansion of γδ T lymphocytes in an HTLV-I carrier, associated with chronic neutropenia and rheumatoid arthritis. Ann Hematol 78:101
    Article PubMed CAS Google Scholar
  139. Halstensen TS, Scott H, Brandtzaeg P (1989) Intraepithelial T cells of the TCR γδ+ CD8− and Vγl/Jδl+ phenotypes are increased in coeliac disease. Scand J Immunol 30:665
    Article PubMed CAS Google Scholar
  140. Spencer J, Isaacson PG, Diss TC, MacDonald TT (1989) Expression of disulfide-linked and non-di-sulfide-linked forms of the T cell receptor γδ heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 19:1335
    Article PubMed CAS Google Scholar
  141. Maki M, Holm K, Collin P, Savilahti E (1991) Increase in γδ T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut 32:1412
    Article PubMed CAS Google Scholar
  142. Kutlu T, Brousse N, Rambaud C, Le DF, Schmitz J, Cerf Bensussan N (1993) Numbers of T cell receptor (TCR) αβ+ but not of TCR γδ+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut 34:208
    Article PubMed CAS Google Scholar
  143. Landau SB, Probert CS, Stevens CA, Balk SP, Blumberg RS (1996) Over-utilization of the Jδ3 gene-segment in Crohn’s disease. J Clin Lab Immunol 48:33
    PubMed CAS Google Scholar
  144. Boismenu R. Havran WL (1994) Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253
    Article PubMed CAS Google Scholar
  145. Soderstrom K, Bucht A, Halapi E, Gronberg A, Magnusson I, Kiessling R (1996) Increased frequency of abnormal γδ T cells in blood of patients with inflammatory bowel diseases. J Immunol 156:2331
    PubMed CAS Google Scholar
  146. McVay LD, Li B, Biancaniello R, Creighton MA, Bachwich D, Lichtenstein G, Rombeau JL, Carding SR (1997) Changes in human mucosal γδ T cell repertoire and function associated with the disease process in inflammatory bowel disease. Mol Med 3:183
    PubMed CAS Google Scholar
  147. Hoshino T, Ohta A, Nakao M, Ota T, Inokuchi T, Matsueda S, Gouhara R, Yamada A, Itoh K, Oizumi K (1996) TCR γδ+ T cells in peripheral blood of patients with adult Still’s disease. J Rheumatol 23:124
    PubMed CAS Google Scholar
  148. Olofsson K, Hellstrom S, Hammarstrom ML (1996) Abundance of intraepithelial γδ T cells in hypertrophic obstructive but not in chronically infected adenoids. Clin Exp Immunol 106:396
    Article PubMed CAS Google Scholar
  149. Vincent MS, Roessner K, Lynch D, Wilson D, Cooper SM, Tschopp J, Sigal LH, Budd RC (1996) Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) γδ T cells in Lyme arthritis. J Exp Med 184:2109
    Article PubMed CAS Google Scholar
  150. Vecchi M, Crosti L, Berti E, Agape D, Cerri A, De Franchis R (1992) Increased jejunal intraepithelial lymphocytes bearing y8 T-cell receptor in dermatitis herpetiformis. Gastroenterology 102:1499
    PubMed CAS Google Scholar
  151. Gerli R, Agea E, Bertotto A, Tognellini R, Flenghi L, Spinozzi F, Velardi A, Grignani F (1991) Analysis of T cells bearing different isotypic forms of the γδ T cell receptor in patients with systemic autoimmune diseases. J Rheumatol 18:1504
    PubMed CAS Google Scholar
  152. Volc-Platzer B, Anegg B, Milota S, Pickl W, Fischer G (1993) Accumulation of γδ T cells in chronic cutaneous lupus erythematosus. J Invest Dermatol 100:84S
    Google Scholar
  153. Rajagopalan S, Zordan T, Tsokos GC, Datta SK (1990) Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4−8− T helper cell lines that express the γδ T-cell antigen receptor. Proc Natl Acad Sei USA 87:7020
    Article CAS Google Scholar
  154. Heng MK, Heng MC (1994) Heat-shock protein 65 and activated γδ T cells in injured arteries. Lancet 344:921
    Article PubMed CAS Google Scholar
  155. Kleindienst R, Xu Q, Willeit J, Waldenberger FR, Weimann S, Wick G (1993) Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing αβ or γδ receptor in human atherosclerotic lesions. Am J Pathol 142:1927
    PubMed CAS Google Scholar
  156. Burk MR, Carena I, Donda A, Mariani F, Mori L, De Libero G (1997) Functional inactivation in the whole population of human Vδ9/Vδ2 T lymphocytes induced by a nonpeptidic antagonist. J Exp Med 185:91
    Article PubMed CAS Google Scholar
  157. Goodier M, Krause JM, Sanni A, Massougbodji A, Sadeler BC, Mitchell GH, Modolell M, Eich-mann K, Langhorne J (1993) γδ T cells in the peripheral blood of individuals from an area of holoen-demic Plasmodium falciparum transmission. Trans R Soc Trop Med Hyg 87:692
    Article PubMed CAS Google Scholar
  158. Carena I, Shamshiev A, Donda A, Colonna M, Libero GD (1997) Major histocompatibility complex class I molecules modulate activation threshold and early signaling of T cell antigen receptor-γδ stimulated by nonpeptidic ligands. J Exp Med 186:1769
    Article PubMed CAS Google Scholar
  159. Janeway CA, Jr, Jones B, Hayday A (1988) Specificity and function of T cells bearing γδ receptors. Immunol Today 9:73
    Article PubMed Google Scholar

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