An ultrastructural analysis of platelets, erythrocytes, white blood cells, and fibrin network in systemic lupus erythematosus (original) (raw)

Abstract

The study suggests that patients with systemic lupus erythematosus (SLE) present with distinct inflammatory ultrastructural changes such as platelets blebbing, generation of platelet-derived microparticles, spontaneous formation of massive fibrin network and fusion of the erythrocytes membranes. Lupoid platelets actively interact with other inflammatory cells, particularly with white blood cells (WBCs), and the massive fibrin network facilitates such an interaction. It is possible that the concerted actions of platelets, erythrocytes and WBC, caught in the inflammatory fibrin network, predispose to pro-thrombotic states in patients with SLE.

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Acknowledgments

The authors would like to thank Janette Bester and Natasha Vermeulen for the preparation of the SEM samples.

Conflict of interest

None declared.

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Authors and Affiliations

1. Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia, 0007, South Africa
   Etheresia Pretorius, Jenny du Plooy & Prashilla Soma
2. Department of Rheumatology, Clinical Research Unit, Dudley Group NHS Foundation Trust (A Teaching Trust of the University of Birmingham, UK), Russells Hall Hospital, Dudley, DY1 2HQ, UK
   Armen Yuri Gasparyan

Authors

1. Etheresia Pretorius
2. Jenny du Plooy
3. Prashilla Soma
4. Armen Yuri Gasparyan

Corresponding author

Correspondence toArmen Yuri Gasparyan.

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Pretorius, E., du Plooy, J., Soma, P. et al. An ultrastructural analysis of platelets, erythrocytes, white blood cells, and fibrin network in systemic lupus erythematosus.Rheumatol Int 34, 1005–1009 (2014). https://doi.org/10.1007/s00296-013-2817-x

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• Received: 05 October 2012
• Accepted: 25 June 2013
• Published: 06 July 2013
• Issue date: July 2014
• DOI: https://doi.org/10.1007/s00296-013-2817-x

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