The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence (original) (raw)
Guo Y, Narayan S, Yallampalli C, Singh P (1992) Characterisation of insulin-like growth factor I receptors in human colon cancer. Gastroenterology 102:1101–1108 CASPubMed Google Scholar
Rouyer-Fessard C, Gammeltoft S, Laburthe M (1990) Expression of two types of receptor for insulinlike growth factors in human colonic epithelium. Gastroenterology 98:703–707 CASPubMed Google Scholar
Clemmons D (1998) Role of insulin-like growth factor binding proteins in controlling IGF actions. Mol Cell Endocrinol 140:19–24 ArticleCASPubMed Google Scholar
Kelley K, Youngman O, Gargosky S, Gucev Z, Matsumoto T, Hwa V, NG L, Simpson D, Rosenfeld R (1996) Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int J Biochem Cell Biol 28:619–637 ArticleCASPubMed Google Scholar
Rosenfeld RG, Hwa V, Oh Y (2001) Nomenclature of the insulin-like growth factor-binding protein superfamily. J Clin Endocrinol Metab 86:946 ArticleCAS Google Scholar
Williams A, Collard T, Perks C, Newcomb P, Moorghen M, Holly J, Paraskeva C (2000) Increased p-53 dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells. Cancer Res 66:22–27 Google Scholar
Holly J (1998) Insulin-like growth factor-I and new opportunities for cancer prevention. Lancet 351:1373–1374 ArticleCASPubMed Google Scholar
Holly J, Gunnell D, Davey Smith G (1999) Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer. J Endocrinol 162:321–330 ArticleCASPubMed Google Scholar
Davey Smith G, Gunnell D, Holly J (2000) Cancer and insulin-like growth factor-I. BMJ 321:847–848 ArticlePubMed Google Scholar
Tricoli JV, Ball LB, Karakousis P, Herrera L, Petrelli N, Bell G, Shows T (1986) Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res 46:6169–6173 Google Scholar
Freier S, Weiss O, Eran M, Flyvberg R, Dahan R, Nephesh I, Safra T, Shiloni E, Raz I (1999) Expression of insulin-like growth factors and their receptors in adenocarcinomas of the colon. Gut 44:704–708 CASPubMed Google Scholar
Wu Y, Yakar S, Zhao L, Henninghausen L, LeRoith D (2002) Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62:1030–1035 Google Scholar
Akagi Y, Liu W, Zebrowski B, Xie K, Ellis L (1998) Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res 58:4008–4014 Google Scholar
Warren R, Yuan H, Matli M, Ferrara N, Donner D (1996) Induction of vascular endothelial growth factor by insulin-like growth factor-1 in colorectal cancer. JBC 271:29483–29488 ArticleCAS Google Scholar
Fukuda R, Hirota K, Fan F, Jung Y, Ellis L, Semenza G (2002) Insulin-like growth factor-I alpha induced hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cell lines. J Biol Chem 277(41):38205–38211 Google Scholar
Bustin SA, Dorudi S, Phillips S, Feakins R, Jenkins P (2002) Local expression of insulin-like growth factor-I affects angiogenesis in colorectal cancer. Tumour Biol 23(3):130–138 ArticleCASPubMed Google Scholar
Andre F, Janssens B, Bruyneel E, van Roy F, Gespach C, Mareel M, Bracke M (2004) Alpha-catenin is required for IGF-I induced cellular migration but not invasion in human colon cancer cell lines. Oncogene 23(6):1177–1186 ArticleCASPubMed Google Scholar
Remacle-Bonnet M, Garrouste F, Heller S, Andre F, Marvaldi J, Pommier G (2000) Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumour necrosis factor α-induced mitogen-activated protein-kinase and nuclear factor κB signaling pathways. Cancer Res 60:2007–2017 Google Scholar
Vallee S, Fouchier F, Bremond P, Briand C, Marvaldi J, Champion S (2003) Insulin-like growth factor-I downregulates nuclear factor kappa activation and upregulates interleukin-8 gene expression induced by tumour necrosis factor alpha. Biochem Biophys Res Commun 305(4):831–839 Google Scholar
Weber M, Fottner C, Liu S, Jung M, Engelhardt D, Baretton G (2004) Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 95(10):2086–2095 Google Scholar
Hakam A, Yeatman T, Lu L, Mora L, Marcet G, Nicosia S, Karl R, Coppola D (1999) Expression of insulin-like growth factor-I receptor in human colorectal cancer. Human Pathol 30(10):1128–1133 ArticleCAS Google Scholar
Singh P, Guo YS, Narayan S, Chandrasekhar Y (1991) IGF-I and IGF-I receptor in mouse colon cancer cells. In Vitro Cell Dev Biol 27A:755–758 CASPubMed Google Scholar
Resnicoff M (1998) Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor (review). Int J Mol Med 1:883–888 CASPubMed Google Scholar
Resnicoff M, Baserga R (1998) The role of the insulin-like growth factor I receptor in transformation and apoptosis. Ann N Y Acad Sci 842:76–81 CASPubMed Google Scholar
LeRoith D, Baserga R, Helman L, Roberts C (2001) Insulin-like growth factors and cancer. Ann Intern Med 122:54–59 Google Scholar
LeRoith D, Roberts C (2003) The insulin-like growth factor system and cancer. Cancer Lett 195:127–137 CASPubMed Google Scholar
Baserga R (1995) The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res 55:249–252 Google Scholar
Baserga R, Resnicoff M, Dews M (1997) The IGF-I receptor and cancer. Endocrine 7:99–102 CASPubMed Google Scholar
Baserga R, Peruzzi F, Reiss K (2003) The IGF-I receptor in cancer biology. Int J Cancer 107(6):873–877 Google Scholar
Sandhu M, Dunger D, Giovannelli G (2002) Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biological interactions and colorectal cancer. J Natl Cancer Inst 94(13):972–980 CASPubMed Google Scholar
Moschos S, Mantzoros C (2002) The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology 63:317–332 ArticleCASPubMed Google Scholar
Sachdev D, Hartnell J, Lee A, Zhang X, Yee D (2003) A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J Biol Chem 279(6):5017 5024 Google Scholar
Reinmuth N, Fan F, Liu W, Parikh A, Stoelzing O, Jung Y, Bucana C, Radinsky R, Gallick G, Ellis L (2002) Impact of insulin-like growth factor receptor-I function on angiogenesis, growth and metastasis of colon cancer. Lab Invest 82:1377–1389 CASPubMed Google Scholar
Sekharam M, Nasir A, Kaiser H, Coppola D (2003) Insulin-like growth factor I receptor activates c-SRC and molecular transformation and motility of colon cancers in vitro. Anticancer Res 23(2B):1517–1524 Google Scholar
Sekharam M, Zhao H, Sun M, Fang Q, Zhang Q, Yuan Z, Dan H, Boulware D, Cheng J, Coppola D (2004) Insulin-like growth factor-I receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. Cancer Res 63(22):7708–7716 Google Scholar
Long L, Nip J, Brodt P (2001) Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-I: a regulatory mechanism for carcinoma cells metastatic to the liver. Cancer Res 54:3732–3737 Google Scholar
Reiss K, Ferber A, Travali S, Porcu P, Phillips P, Baserga R (2001) The protooncogene c-myb increases the expression of insulin-like growth factor-1 and the insulin-like growth factor-1 receptor messenger RNAs by a transcriptional change. Cancer Res 51(21):5997–6000 Google Scholar
Werner H (1998) Dysregulation of the type 1 IGF receptor as a paradigm in tumor progression. Mol Cell Endocrinol 141:1–5 ArticleCASPubMed Google Scholar
Webster NJ, Resnik JL, Reichart DB, Strauss B, Strauss M, Seely BL (1996) Repression of the insulin receptor promoter by the tumour suppression gene product p-53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res 56:2781–2788 Google Scholar
Ohlsson C, Kley N, Werner H, LeRoith D (1998) p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology 139:1101–1107 ArticleCASPubMed Google Scholar
Abramovitch S, Werner H (2003) Functional and physical interactions between the BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. Horm Metab Res 35(11–12):758–762 ArticleCASPubMed Google Scholar
Yu H, Rohan T (2000) Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 92(18):1472–1489 ArticleCASPubMed Google Scholar
Mishra L, Bass B, Ooi B, Sidawy A, Korman L (1998) Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I and IGF binding protein-2 in human colorectal cancers. Growth Horm IGF Res 8:473–479 CASPubMed Google Scholar
Michell M, Dent S, Langman M, Eggo M (2001) Insulin-like growth factor binding proteins as mediators of IGF-I effects on colon cancer cell proliferation. Growth Factors 14:269–277 Google Scholar
Collard T, Guy M, Butt A, Perks C, Holly J, Paraskeva C, Williams A (2003) Transcriptional upregulation of the insulin-like growth factor binding protein-3 by sodium butyrate increases IGF-dependent apoptosis in human adenoma-derived epithelial cells. Carcinogenesis 24(3):393–401 ArticleCASPubMed Google Scholar
Grimberg A (2000) p53 and IGFBP-3: apoptosis and cancer protection. Mol Genet Metab 70:85–98 ArticleCASPubMed Google Scholar
Baciuchka M, Remacle-Bonnet M, Garrouste F, Favre R, Sastre B, Pommier G (1998) Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) proteolysis in patients with colorectal cancer: possible association with the metastatic potential of the tumor. Int J Cancer 79:460–467 Google Scholar
Miyamoto S, Yano K, Sugimoto S, Ishii G, Hasebe T, Endoh Y, Koda M, Goya M, Chiba T, Ochiai A (2004) Matrix metalloproteinase-7 facilitates insulin-like growth factor-I (IGF-I) bioavailability through its proteinase activity on insulin-like growth factor binding protein-3. Cancer Res 64(2):665–671 Google Scholar
Singh P, Dai B, Dhruva B, Widen SG (1994) Episomal expression of sense and antisense insulin-like growth factor (IGF)-binding protein-4 complementary DNA alters the mitogenic response of a human colon cancer cell line (HT-29) by mechanisms that are independent of and dependent upon IGF-I. Cancer Res 54:6563–6570 Google Scholar
Diehl D, Hoeflich A, Wolf E, Lahm H (2004) Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. Cancer Res 64(5):1600–1603 Google Scholar
Kubler B, Cowell S, Zapf J, Braukle T (1998) Proteolysis of insulin-like growth factor binding proteins by a novel 50-kilodalton metalloproteinase in human pregnancy serum. Endocinology 139:1556–1563 ArticleCAS Google Scholar
Conover C, Oxvig C, Overgaard M, Christiansen M, Giudice L (1999) Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A. J Clin Endocrinol Metab 84(12):4743–4745 Article Google Scholar
Conover C (2001) A unique receptor-independent mechanism by which insulin-like growth factor I regulates the availability of insulin-like growth factor binding proteins in normal and transformed human fibroblasts. J Clin Invest 88:1354–1361 Google Scholar
Kuemmerle J, Teng B (2000) Regulation of IGFBP-4 levels in human intestinal muscle muscle by an IGF-I activated, confluence dependent protease. Am J Physiol Gastrointest Liver Physiol 279:G975–G982 CASPubMed Google Scholar
Lawrence J, Oxvig C, Overgaard M, Sottrup-Jensen L (1999) The insulin-like growth factor (IGF) dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 96:3149–3153 ArticleCASPubMed Google Scholar
Street M, Miraki-Moud F, Sanderson I, Savage M, Giovannelli G, Bernasconi S, Camacho-Hubner C (2003) Interleukin-1 beta (IL-1 beta) and Il-6 modulate insulin-like growth factor binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells. J Endocrinol 179(3):405–415 ArticleCASPubMed Google Scholar
Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman H, Kajstura, Rubin R, Zoltick P, Baserga R (2001) The insulin like growth factor I receptor protects tumour cells from apoptosis in vivo. Cancer Res 55:2463–2469 Google Scholar
Ma J, Pollak M, Giovannucci E, Chan JM, Tao Y, Hennekens C, Stampfer MJ (2000) A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men. Growth Horm IGF Res 10(Suppl A):S28–S29 ArticlePubMed Google Scholar
Giovannucci E, Pollak M, Platz EA, Willett WC, Stampfer MJ, Majeed N, Colditz GA, Speizer FE, Hankinson SE (2000) Insulin-like growth factor I (IGF-I), IGF-binding protein-3 and the risk of colorectal adenoma and cancer in the Nurses’ Health Study. Growth Horm IGF Res 10(Suppl A):S30–S31 ArticlePubMed Google Scholar
Renehan AG, O’Connell J, O’Hallorun D, Shanahan F, Potten C, O’Dwyer ST, Shalet S (2003) Acromegaly and colorectal cancer: a comprehensive review of the epidemiology, biological mechanisms and clinical implications. Horm Metab Res 35:712–725 ArticleCASPubMed Google Scholar
Nomura A, Stemmermann G, Lee J, Pollak M (2004) Serum insulin-like grwoth facror I and subsequent risk of colorectal cancer among Japanese–American men. Am J Epidemiol 158(5):424–431 Article Google Scholar
Renehan A, Zwahlen M, Minder C, O’Dwyer S, Shalet S, Egger M (2004) Insulin-like growth factor (IGF)-I, IGF binding protein-3 and cancer risk: systematic review and meta-regression analysis. Lancet 363(9418):1346–1353 ArticleCASPubMed Google Scholar
Delhougne B, Deneux C, Abs R, Chanson P, Fierens H, Laurent-Puig, Duysburgh I, Stevenaert A, Tabarin A, Dewaide J, Gilbert S, Belaiche J, Beckers A (1995) The prevalence of colonic polyps in acromegaly: a colonoscopic and pathological study in 103 patients. J Clin Endocrinol Metab 80:3223–3226 ArticleCASPubMed Google Scholar
Jenkins P, Besser G, Fairclough P (2001) Colorectal neoplasia and acromegaly. Gut 44:585–587 Google Scholar
Orme SM, McNally RJ, Cartwright RA, Belchetz PE (1998) Cancer incidence and mortality in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group. J Endocrinol 148:OC22 Google Scholar
Webb S, Casaneuva F, Wass J (2002) Oncological complications of excess GH in acromegaly. Pituitary 5(1):21–25 ArticleCASPubMed Google Scholar
Cats A, Dullaart R, Kleibeuker J, Kuipers F, Sluiter W, Hardonk M, deVries E (2001) Increased epithelial cell proliferation in the colon of patients with acromegaly. Cancer Res 56:523–526 Google Scholar
Hunt K, Toniolo P, Akhmedkhanov A, Lukanova A, Dechaud H, Rinaldi S, Zeleniuch-Jacquotte A, Shore R, Riboli E, Kaaks R (2002) Insulin-like growth factor-II and colorectal cancer risk in women. Cancer Epidemiol Biomark Prev 11(9):901–905 CAS Google Scholar
Jeong S, Shin K, Shin J, Ku J, Shin Y, Park S, Kin W, Park J (2004) Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. Dis Colon Rectum 46(8):1069–1077 Article Google Scholar
Tedeschi B, Spandoni G, Sanna M, Vernole P, Caporossi D, Cianfarani S (1993) Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone. Hum Genet 91:459–463 ArticleCASPubMed Google Scholar
Cianfarani S, Tedeschi B, Germani D, Prete S, Rossi P, Vernole P, Caporossi D, Boscerini B (1998) In vitro effects of growth hormone (GH) and insulin-like growth factor I and II (IGF-I and IGF-II) on chromosome fragility and p53 protein expression in human lymphocytes. Eur J Clin Investig 28:41–47 ArticleCAS Google Scholar
Bustin SA, Jenkins P (2001) The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med 7(10):447–454 ArticleCASPubMed Google Scholar
Palmqvist R, Hallmans G, Rinaldi S, Biessy C, Stenling R, Riboli E, Kaaks R (2002) Plasma insulin-like growth factor-I, insulin-like growth factor binding protein-3, and risk of colorectal cancer: a prospective study in northern Sweden. Gut 50(5):642–646 ArticleCASPubMed Google Scholar
Palmqvist R, Stattin P, Rinaldi S, Biessy C, Stenling R, Riboli E, Hallman G, Kaaks R (2003) Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden. Int J Cancer 107(1):89–93 Google Scholar
LeRoith D (2003) The insulin-like growth factor system. Exp Diabesity Res 4:205–212 PubMed Google Scholar
Brodt P, Samani A, Navab R (2000) Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy. Biochem Pharmacol 60:1101–1107 ArticleCASPubMed Google Scholar
Adachi Y, Lee C, Coffee K, Yamagata N, Ohm J, Park K, Dikov M, Nadaf S, Arteaga C, Carbone D (2002) Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. Gastroenterology 123(4):1191–1204 ArticleCASPubMed Google Scholar
Perer ES, Madan AK, Shurin A, Zakris E, Romeguera K, Pang Y, Beech DJ (2000) Insulin-like growth factor I receptor antagonism augments response to chemoradiation therapy in colon cancer cells. J Surg Res 94:1–5 ArticleCASPubMed Google Scholar
Furstenberger G, Senn H (2002) Insulin-like growth factors and cancer. Lancet 3(5):298–302 ArticleCAS Google Scholar
Jerome L, Shiry L, Leyland-Jones B (2003) Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions. Endocr Relat Cancer 10:561–578 ArticleCASPubMed Google Scholar
Peters G, Gongoll S, Langner C, Mengel M, Piso P, Klempnauer J, Ruschoff J, Keipe H, von Wasielewski R (2003) IGF-IR, IGF-I and IGF-2 expression as potential prognostic and predictive markers in colorectal cancer. Virchows Arch 443(2):139–145 ArticleCASPubMed Google Scholar
McTiernan A (2003) Interventional studies in exercise and cancer prevention. Med Sci Sports Exerc 35:1841–1845 PubMed Google Scholar
Harvie M, Mercer T, Humphries G (2002) The effects of weight loss and exercise on biomarkers of breast cancer rationale and study design. Dev Nutr 5:91–110 Google Scholar
Ogilvy-Stuart A, Gleeson H (2004) Cancer risk following growth hormone use in childhood: implications for current practice. Drug Safety 27(6):369–382 CASPubMed Google Scholar
Preston-Martin S, Pike M, Ross R, Henderson B (2001) Epidemiologic evidence for the increased cell proliferation model of carcinogenesis. Prog Clin Biol Res 369:21–34 Google Scholar
Manousos O, Souglakos J, Bosetti C, Tzonou A, Chatzidakis V, Trichopoulous D, Adami H, Mantzoros C (1999) IGF-1 and IGF-II in relation to colorectal cancer Int J Cancer 83:15–17 Google Scholar
Bustin SA (2001) Protein shuttles, IGF-I and cancer. Trends Mol Med 7(1):9 ArticleCAS Google Scholar