- Weitz J, Koch M, Debus J, Hohler T, Galle PR, Buchler MW (2005) Colorectal cancer. Lancet 365:153–165
Article PubMed Google Scholar
- Graziano F, Cascinu S (2003) Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? Ann Oncol 14:1026–1038
Article PubMed CAS Google Scholar
- McLeod HL, Murray GI (1999) Tumour markers of prognosis in colorectal cancer. Br J Cancer 79:191–203
Article PubMed CAS Google Scholar
- Leichman CG (2001) Predictive and prognostic markers in gastrointestinal cancers. Curr Opin Oncol 13:291–299
Article PubMed CAS Google Scholar
- Eschrich S, Yang I, Bloom G, Kwong KY, Boulware D, Cantor A et al (2005) Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol 23:3526–3535
Article PubMed CAS Google Scholar
- Kuramochi J, Arai T, Ikeda S, Kumagai J, Uetake H, Sugihara K (2006) High Pin1 expression is associated with tumor progression in colorectal cancer. J Surg Oncol 94:155–160
Article PubMed CAS Google Scholar
- Kirimlioglu H, Kirimlioglu V, Yilmaz S, Sagir V, Coban S, Turkmen E et al (2006) Role of matrix metalloproteinase-7 in colorectal adenomas. Dig Dis Sci 51:2068–2072
Article PubMed CAS Google Scholar
- Ponnelle T, Chapusot C, Martin L, Bouvier AM, Plenchette S, Faivre J et al (2005) Cellular localisation of survivin: impact on the prognosis in colorectal cancer. J Cancer Res Clin Oncol 131:504–510
Article PubMed CAS Google Scholar
- Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K, Mori M (2006) Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res 12:3057–3063
Article PubMed CAS Google Scholar
- Horvath L, Henshall S (2001) The application of tissue microarrays to cancer research. Pathology 33:125–129
Article PubMed CAS Google Scholar
- Oving IM, Clevers HC (2002) Molecular causes of colon cancer. Eur J Clin Invest 32:448–457
Article PubMed CAS Google Scholar
- Iczkowski KA, Omara-Opyene AL, Kulkarni TR, Pansara M, Shah GV (2005) Paracrine calcitonin in prostate cancer is linked to CD44 variant expression and invasion. Anticancer Res 25:2075–2083
PubMed CAS Google Scholar
- Chang AJ, Song DH, Wolfe MM (2006) Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation. J Biol Chem 281:14700–14710
Article PubMed CAS Google Scholar
- Ishikawa T, Ichikawa Y, Mitsuhashi M, Momiyama N, Chishima T, Tanaka K et al (1996) Matrilysin is associated with progression of colorectal tumor. Cancer Lett 107:5–10
Article PubMed CAS Google Scholar
- Hipfner DR, Cohen SM (2004) Connecting proliferation and apoptosis in development and disease. Nat Rev Mol Cell Biol 5:805–815
Article PubMed CAS Google Scholar
- Fu M, Wang C, Li Z, Sakamaki T, Pestell RG (2004) Minireview: cyclin D1: normal and abnormal functions. Endocrinology 145:5439–5447
Article PubMed CAS Google Scholar
- Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG et al (1995) Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int J Cancer 62:610–618
Article PubMed CAS Google Scholar
- Umekita Y, Souda M, Yoshida H (2006) Expression of maspin in colorectal cancer. In Vivo 20:797–800
PubMed CAS Google Scholar
- Boltze C (2005) Loss of maspin is a helpful prognosticator in colorectal cancer: a tissue microarray analysis. Pathol Res Pract 200:783–790
Article PubMed CAS Google Scholar
- Massague J, Blain SW, Lo RS (2000) TGFb signaling in growth control, cancer, and heritable disorders. Cell 103:295–309
Article PubMed CAS Google Scholar
- Akhurst RJ (2004) TGF beta signaling in health and disease. Nat Genet 36:790–792
Article PubMed CAS Google Scholar
- Campbell-Thompson M, Lynch IJ, Bhardwaj B (2001) Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res 61:632–640
PubMed CAS Google Scholar
- Konstantinopoulos PA, Kominea A, Vandoros G, Sykiotis GP, Andricopoulos P, Varakis I et al (2003) Oestrogen receptor β (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon denocarcinoma paralleling the tumour’s dedifferentiation. Eur J Cancer 39:1251–1258
Article PubMed CAS Google Scholar
- Mills A (2005) P53: links to the past, bridge to the future. Genes Dev 19:2091–2099
Article PubMed CAS Google Scholar
- Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307–310
Article PubMed CAS Google Scholar
- Thompson N, Lyons J (2005) Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 5:350–356
Article PubMed CAS Google Scholar
- Greene FL, Page DL, Fleming ID et al (2002) AJCC: cancer staging handbook: from the AJCC cancer staging manual, 6th edn. Springer, New York
Google Scholar
- Sobin LH, Wittekind C (eds) (2002) UICC: TNM classification of malignant tumours. Wiley, London
- Schraml P, Kononen J, Bubendorf L, Moch H, Bissig H, Nocito A et al (1999) Tissue microarrays for gene amplification surveys in many different tumor types. Clin Cancer Res 5:1966–1975
PubMed CAS Google Scholar
- Mucci NR, Akdas G, Manely S, Rubin MA (2000) Neuroendocrine expression in metastatic prostate cancer: evaluation of high throughput tissue microarrays to detect heterogeneous protein expression. Hum Pathol 31:406–414
Article PubMed CAS Google Scholar
- Richter J, Wagner U, Kononen J, Fijan A, Bruderer J, Schmid U et al (2000) High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol 157:787–794
PubMed CAS Google Scholar
- Benson AB 3rd, Schrag D, Somerfield MR, Cohen AM, Figueredo AT, Flynn PJ et al (2004) American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 22:3408–3419
Article PubMed Google Scholar
- Johnson PM, Porter GA, Ricciardi R, Baxter NN (2006) Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. J Clin Oncol 24:3570–3575
Article PubMed Google Scholar
- Nakashima K, Shimada H, Ochiai T, Kuboshima M, Kuroiwa N, Okazumi S et al (2004) Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma. Int J Cancer 112:1029–1035
Article PubMed CAS Google Scholar
- Kanai Y, Ushijima S, Saito Y, Nakanishi Y, Sakamoto M, Hirohashi S (2001) MRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers. J Cancer Res Clin Oncol 127:697–706
PubMed CAS Google Scholar
- Alberti S, Miotti S, Stella M, Klein CE, Fornaro M, Menard S et al (1992) Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2. Hybridoma 11:539–545
Article PubMed CAS Google Scholar
- Miotti S, Canevari S, Menard S, Mezzanzanica D, Porro G, Pupa SM et al (1987) Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity. Int J Cancer 39:297–303
Article PubMed CAS Google Scholar
- Fradet Y, Cordon-Cardo C, Thomson T, Daly ME, Whitmore WF Jr, Lloyd KO et al (1984) Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies. Proc Natl Acad Sci U S A 81:224–228
Article PubMed CAS Google Scholar
- Lipinski M, Parks DR, Rouse RV, Herzenberg LA (1981) Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc Natl Acad Sci U S A 78:5147–5150
Article PubMed CAS Google Scholar
- White PS, Forus A, Matise TC, Schutte BC, Spieker N, Stanier P et al (1999) Report of the fifth international workshop on human chromosome 1 mapping 1999. Cytogenet Cell Genet 87:143–171
Article PubMed CAS Google Scholar
- El Sewedy T, Fornaro M, Alberti S (1998) Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. Int J Cancer 75:324–330
Article PubMed Google Scholar
- Suzuki A, Hayashida M, Ito T, Kawasaki H, Nakano T, Miura M et al (2000) Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation. Oncogene 19:3225–3234
Article PubMed CAS Google Scholar
- Sarela AI, Macadam RC, Farmery SM, Markham AF, Guillou PJ (2000) Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 46:645–650
Article PubMed CAS Google Scholar
- Rodel F, Hoffmann J, Grabenbauer GG, Papadopoulos T, Weiss C, Gunther K et al (2002) High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. Strahlenther Onkol 178:426–435
Article PubMed Google Scholar
- Rodel F, Hoffmann J, Distel L, Herrmann M, Noisternig T, Papadopoulos T et al (2005) Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res 65:4881–4887
Article PubMed Google Scholar
- Ryan BM, Konecny GE, Kahlert S, Wang HJ, Untch M, Meng G et al (2006) Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1. Ann Oncol 17:597–604
Article PubMed CAS Google Scholar
- Kato J, Kuwabara Y, Mitani M, Shinoda N, Sato A, Toyama T et al (2001) Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy. Int J Cancer 95:92–95
Article PubMed CAS Google Scholar
- Takai N, Miyazaki T, Nishida M, Nasu K, Miyakawa I (2002) Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma. Cancer Lett 184:105–116
Article PubMed CAS Google Scholar
- Altieri DC (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3:46–54
Article PubMed CAS Google Scholar
- Li F (2003) Survivin study: what is the next wave? J Cell Physiol 197:8–29
Article PubMed CAS Google Scholar
- Yang D, Welm A, Bishop JM (2004) Cell survival in the absence of survivin. Proc Natl Acad Sci U S A 101:15100–15105
Article PubMed CAS Google Scholar
- Okada H, Mak TW (2004) Pathways of apoptotic and nonapoptotic death in tumour cells. Nat. Rev. Cancer 4:592–603
Article PubMed CAS Google Scholar
- Kawasaki H, Toyoda M, Shinohara H, Okuda J, Watanabe I, Yamamoto T et al (2001) Expression of survivin correlates with apoptosis, proliferation and angiogenesis during human colorectal carcinogenesis. Cancer 91:2026–2032
Article PubMed CAS Google Scholar
- Blanc-Brude OP, Mesri M, Wall NR, Plescia J, Dohi T, Altieri DC (2003) Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Cancer Res 9:2683–2692
CAS Google Scholar
- Ambrosini G, Adida C, Altieri DC (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917–921
Article PubMed CAS Google Scholar
- Sternlicht MD, Werb Z (2001) How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17:463–516
Article PubMed CAS Google Scholar
- Vihinen P, Kahari VM (2002) Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 99:157–166
Article PubMed CAS Google Scholar
- Gu ZD, Li JY, Li M, Gu J, Shi XT, Ke Y et al (2005) Matrix metalloproteinases expression correlates with survival in patients with esophageal squamous cell carcinoma. Am J Gastroenterol 100:1835–1843
Article PubMed CAS Google Scholar
- Yamamoto H, Itoh F, Adachi Y, Fukushima H, Itoh H, Sasaki S et al (1999) Messenger RNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human hepatocellular carcinoma. Jpn J Clin Oncol 29:58–62
Article PubMed CAS Google Scholar
- Yamashita K, Azumano I, Mai M, Okada Y (1998) Expression and tissue localization of matrix metalloproteinase 7 (matrilysin) in human gastric carcinomas. Implications for vessel invasion and metastasis. Int J Cancer 79:187–194
Article PubMed CAS Google Scholar
- Leeman MF, Curran S, Murray GI (2003) New insights into the roles of matrix metalloproteinases in colorectal cancer development and progression. J Pathol 201:528–534
Article PubMed CAS Google Scholar
- Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P et al (1999) The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 18:2883–2891
Article PubMed CAS Google Scholar
- Zeng ZS, Shu WP, Cohen AM, Guillem JG (2002) Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases. Clin Cancer Res 8:144–148
PubMed CAS Google Scholar