Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury (original) (raw)
Argaud L, Gateau-Roesch O, Raisky O, Loufourat J, Dominique R, Ovize M (2005) Postconditioning inhibits mitochondrial permeability transition. Circulation 111:194–197 ArticlePubMedCAS Google Scholar
Beltowski J (2003) Adiponectin and resistin — new hormones of white adipose tissue. Med Sci Monit 9:RA55–RA61 PubMedCAS Google Scholar
Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM (2005) Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 54:146–151 ArticlePubMedCAS Google Scholar
Bullard AJ, Govewalla AP, Yellon DM (2005) Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo. Basic Res Cardiol 100:397–403 ArticlePubMedCAS Google Scholar
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601–605 ArticlePubMedCAS Google Scholar
Efthymiou CA, Mocanu MM, Yellon DM (2005) Atorvastatin and myocardial reperfusion injury: new pleiotropic effect implicating multiple prosurvival signaling. J Cardiovasc Pharmacol 45:247–252 ArticlePubMedCAS Google Scholar
Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597–601 ArticlePubMedCAS Google Scholar
Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T, Onda H, Tatemoto K, Fujino M (1999) Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in colostrum. Biochim Biophys Acta 1452:25–35 ArticlePubMedCAS Google Scholar
Harvey J, Ashford ML (2003) Leptin in the CNS: much more than a satiety signal. Neuropharmacology 44:845–854 ArticlePubMedCAS Google Scholar
Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 61:448–460 ArticlePubMedCAS Google Scholar
Hausenloy DJ, Duchen MR, Yellon DM (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemiareperfusion injury. Cardiovasc Res 60:617–625 ArticlePubMedCAS Google Scholar
Hausenloy DJ, Mocanu MM, Yellon DM (2004) Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning. Cardiovasc Res 63:305–312 ArticlePubMedCAS Google Scholar
Hausenloy DJ, Yellon DM, Mani-Babu S, Duchen MR (2004) Preconditioning protects by inhibiting the mitochondrial permeability transition. Am J Physiol Heart Circ Physiol 287:H841–H849 ArticlePubMedCAS Google Scholar
Hausenloy DJ, Wynne AM, Yellon DM (2007) Ischemic preconditioning targets the reperfusion phase. Basic Res Cardiol 102:445–452 ArticlePubMedCAS Google Scholar
Heusch G (2006) Obesity — a risk factor or a RISK factor for myocardial infarction? Br J Pharmacol 149:1–3 ArticlePubMedCAS Google Scholar
Heusch G, Büchert A, Feldhaus S, Schulz R (2006) No loss of cardioprotection by postconditioning in connexin 43-deficient mice. Basic Res Cardiol 101:354–356 ArticlePubMedCAS Google Scholar
Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, Sugaya T, Matsuzaki H, Yamamoto R, Shiota N, Okunishi H, Kihara M, Umemura S, Sugiyama F, Yagami KI, Kasuya Y, Mochizuki N, Fukamizu A (2004) Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensintype 1 receptor in blood pressure in vivo. J Biol Chem 279:26274–26279 ArticlePubMedCAS Google Scholar
Jacobson J, Duchen MR (2002) Mitochondrial oxidative stress and cell death in astrocytes — requirement for stored Ca2+ and sustained opening of the permeability transition pore. J Cell Sci 115:1175–1188 PubMedCAS Google Scholar
Jonassen AK, Sack MN, Mjøs OD, Yellon DM (2001) Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signalling. Circ Res 89:1191–1198 ArticlePubMedCAS Google Scholar
Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP (2001) ((125)I)- (Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 132:1255–1260 ArticlePubMedCAS Google Scholar
Kawamata Y, Habata Y, Fukusumi S, Hosoya M, Fujii R, Hinuma S, Nishizawa N, Kitada C, Onda H, Nishimura O, Fujino M (2001) Molecular properties of apelin: tissue distribution and receptor binding. Biochim. Biophys Acta 1538:162–171 ArticleCAS Google Scholar
Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548–2556 ArticlePubMedCAS Google Scholar
Kleinz MJ, Davenport AP (2004) Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regul Pept 118:119–125 ArticlePubMedCAS Google Scholar
Kleinz MJ Davenport AP (2005) Emerging roles of apelin in biology and medicine. Pharmacol Ther 107:198–211 ArticlePubMedCAS Google Scholar
Kleinz MJ, Skepper JN, Davenport AP (2005) Immunocytochemical localization of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept 126:233–240 ArticlePubMedCAS Google Scholar
Koerener A, Kratsc J, Kiess W (2005) Adipocytokines: leptin-the classical, resistin- the controversial, adiponectinthe promising, and more to come. Best Practice Res Clin Endocrinol Metab 19:525–546 ArticleCAS Google Scholar
Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR (2003) Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278:39422–39427 ArticlePubMedCAS Google Scholar
Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR, O’Dowd BF (2000) Characterisation of apelin, the ligand for the APJ receptor. J Neurochem 74:34–41 ArticlePubMedCAS Google Scholar
Marber MS, Mestril R, Chi SH, Sayen MR, Yellon DM, Dillmann WH (1995) Overexpression of the rat inducible 70- kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischaemic injury. J Clin Invest 95:1446–1456 ArticlePubMedCAS Google Scholar
Masri B, Knibiehler B, Audigier Y (2005) Apelin signaling: a promising pathway from cloning to pharmacology. Cell Sig 17:415–426 ArticleCAS Google Scholar
Masri B, Lahlou H, Mazarguil H, Knibiehler B, Audigier Y (2004) Apelin (65–77) activates extracellular signalregulated kinases via a PTX-sensitive G protein. Biochem Biophys Res Commun 290:539–545 ArticleCAS Google Scholar
Masri B, Morin N, Cornu M, Knibiehler B, Audigier Y (2004) Apelin (65–77) activates p70S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J 18:1909–1911 PubMedCAS Google Scholar
Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, Herrity NC, Murdock P, Darker JG (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand. J Neurochem 84:1162–1172 ArticlePubMedCAS Google Scholar
O’Dowd B F, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A,George SR,Nguyen T (1993) A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136:355–360 ArticlePubMed Google Scholar
Patel JB, Valencik ML, Pritchett AM, Burnett JC,McDonald JA, Redfield MM (2005) Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload. Am J Physiol Heart Circ Physiol 289:777–784 ArticleCAS Google Scholar
Rajapurohitam V, Gan XT, Kirshenbaum LA, Karmazyn M (2003) The obesity associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res 93:277–279 ArticlePubMedCAS Google Scholar
Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G (2001) Signal transduction of ischemic preconditioning. Cardiovasc Res 52:181–198 ArticlePubMedCAS Google Scholar
Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM (2005) Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. Am J Heart Circ Physiol 289:H237–H242 ArticleCAS Google Scholar
Shibata R, Sato K, Pimental DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K (2005) Adiponectin protects against myocardial ischemiareperfusion injury through AMPK- and COX-2 dependent mechanisms. Nat Med 10:1384–1389 ArticleCAS Google Scholar
Sivaraman V, Mudalagiri NR Di Salvo C, Kolvekar S, Hayward M, Yap J, Keogh B, Hausenloy DJ, Yellon DM (2007) Postconditioning protects human atrial muscle through the activation of the RISK pathway. Basic Res Cardiol 102:453–459 ArticlePubMed Google Scholar
Smith CCT, Mocanu MM, Davidson SM, Wynne AM, Simpkin JC, Yellon DM (2006) Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. Br J Pharmacol 149:5–13 ArticlePubMedCAS Google Scholar
Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L’Huillier I, Aupetit JF, Bonnefoy E, Finet G, André-Fouët X, Ovize M (2005) Postconditioning the human heart. Circulation 112:2085–2088 Article Google Scholar
Sumeray MS, Yellon DM (1998) Characterisation and validation of a murine model of global ischaemia-reperfusion injury. Mol Cell Biochem 186:61–68 ArticlePubMedCAS Google Scholar
Szokodi I, Tavi P, Foldes G (2002) Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 91:434–440 ArticlePubMedCAS Google Scholar
Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, Dakin C, Sajedi A, Ghatei M, Bloom S (2002) The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochem Biophys Res Commun 291:1208–1212 ArticlePubMedCAS Google Scholar
Tajmir P, Ceddia RB, Li RK, Coe IR, Sweeney G (2004) Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways. Endocrinol 145:1550–1555 ArticleCAS Google Scholar
Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K, Fujimiya M (2001) The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept 99:87–92 ArticlePubMedCAS Google Scholar
Tsang A, Hausenloy DJ, Mocanu, MM, Yellon DM (2004) Postconditioning: A form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 95:230–232 ArticlePubMedCAS Google Scholar
Tsang A, Hausenloy DJ, Yellon DM (2005) Myocardial postconditioning: reperfusion injury revisited. Am J Physiol Heart Circ Physiol 289:H2–H7 ArticlePubMedCAS Google Scholar
Vinten-Johansen J, Zhao Z-Q, Zatta AJ, Kin H, Halkos ME, Kerendi F (2005) Postconditioning a new link in nature’s armory against myocardial ischemiareperfusion injury. Basic Res Cardiol 100:295–310 ArticlePubMedCAS Google Scholar
Wang G, Anini Y, Wei W, Qi X, O’Carroll AM, Mochizuki T, Wang HQ, Hellmich MR, Englander EW, Greeley GH (2004) Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion. Endocrinol 145:1342–1348 ArticleCAS Google Scholar
Wityak J, Hobbs FW, Gardner DS, Santella JB 3rd, Petraitis JJ, Sun JH, Favata MF, Daulerio AJ, Horiuchi KY, Copeland RA, Scherle PA, Jaffe BD, Trzaskos JM, Magolda RL, Trainor GL, Duncia J (2004) Beyond UO126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors. Bioorg Med Chem Lett 14:1483–1486 ArticlePubMedCAS Google Scholar
Yellon DM, Baxter GF (1999) Reperfusion injury revisited. Is there a role for growth factor signalling in limiting lethal reperfusion injury? Trends Cardiovasc Med 9:245–249 ArticlePubMedCAS Google Scholar
Yellon DM, Downey JM (2003) Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 83:1113–1151 PubMedCAS Google Scholar
Zabeau L, Lavens D, Peelman, F, Eyckerman, S, Vandekerckhove J, Tavernier J (2003) Ins and outs of leptin receptor activation. FEBS Lett 546:45–50 ArticlePubMedCAS Google Scholar