Rosette-forming glioneuronal tumor of the fourth ventricle (original) (raw)

Abstract

Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle has been reported recently as a novel type of primary CNS neoplasm. We present the case of a 35-year-old male patient with RGNT of the fourth ventricle. The tumor was found incidentally; the patient did not suffer from any neurological symptoms. The tumor mass involved the caudal cerebellar vermis, filled the fourth ventricle and protruded into the caudal part of the mesencephalic aquaeduct. Smaller tumor nodules were visible in the adjacent right cerebellar hemisphere. Histologically, prominent neurocytic rosettes with synaptophysin expression were embedded in a glial tumor component resembling pilocytic astrocytoma. Clinicopathological features of our case closely resemble those reported in the original description. Thus, our case confirms RGNT as a new distinct type of primary CNS neoplasm. Due to its distinct features, adoption of RGNT as a new entity into the WHO classification of tumors should be considered.

Access this article

Log in via an institution

Subscribe and save

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1. A

Similar content being viewed by others

References

1. Kleihues P, Cavenee WK (2000) World Health Organization classification of tumors of the nervous system. WHO/IARC, Lyon
2. Komori T, Scheithauer BW, Anthony DC, et al (1998) Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol 22:1171–1183
   Article CAS PubMed Google Scholar
3. Komori T, Scheithauer BW, Hirose T (2002) A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? Am J Surg Pathol 26:582–591
   Article PubMed Google Scholar

Download references

Acknowledgements

This case study was performed within the Austrian Neuro-Oncology Network (ANN, www.ann.at).

Author information

Authors and Affiliations

1. Institute of Neurology, University of Vienna, AKH 4J, Währinger Gürtel 18–20, POB 48, 1097, Vienna, Austria
   Matthias Preusser, Herbert Budka & Johannes A. Hainfellner
2. Department of Neurosurgery, University of Vienna, Vienna, Austria
   Wolfgang Dietrich & Thomas Czech
3. Department of Neuroradiology, University of Vienna, Vienna, Austria
   Daniela Prayer

Authors

1. Matthias Preusser
   You can also search for this author inPubMed Google Scholar
2. Wolfgang Dietrich
   You can also search for this author inPubMed Google Scholar
3. Thomas Czech
   You can also search for this author inPubMed Google Scholar
4. Daniela Prayer
   You can also search for this author inPubMed Google Scholar
5. Herbert Budka
   You can also search for this author inPubMed Google Scholar
6. Johannes A. Hainfellner
   You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toJohannes A. Hainfellner.

Rights and permissions

About this article

Cite this article

Preusser, M., Dietrich, W., Czech, T. et al. Rosette-forming glioneuronal tumor of the fourth ventricle.Acta Neuropathol 106, 506–508 (2003). https://doi.org/10.1007/s00401-003-0758-2

Download citation

• Received: 25 June 2003
• Revised: 14 July 2003
• Accepted: 14 July 2003
• Published: 12 August 2003
• Issue Date: November 2003
• DOI: https://doi.org/10.1007/s00401-003-0758-2

Keywords