Brain dendritic cells: biology and pathology (original) (raw)
Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood–brain barrier. Nat Rev Neurosci 7(1):41–53 PubMedCAS Google Scholar
Agger R, Crowley MT, Witmer-Pack MD (1990) The surface of dendritic cells in the mouse as studied with monoclonal antibodies. Int Rev Immunol 6(2–3):89–101 PubMedCAS Google Scholar
Aleyas AG, George JA, Han YW, Rahman MM, Kim SJ, Han SB, Kim BS, Kim K, Eo SK (2009) Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J Immunol 183(4):2462–2474 PubMedCAS Google Scholar
Ali S, Curtin JF, Zirger JM, Xiong W, King GD, Barcia C, Liu C, Puntel M, Goverdhana S, Lowenstein PR, Castro MG (2004) Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. Mol Ther 10(6):1071–1084 PubMedCAS Google Scholar
Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, Yao K, Dustin ML, Nussenzweig MC, Steinman RM, Liu K (2011) Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med 208(8):1695–1705 PubMedCAS Google Scholar
Axtell RC, Steinman L (2009) Gaining entry to an uninflamed brain. Nat Immunol 10(5):453–455 PubMedCAS Google Scholar
Bachy V, Ballerini C, Gourdain P, Prignon A, Iken S, Antoine N, Rosset M, Carnaud C (2010) Mouse vaccination with dendritic cells loaded with prion protein peptides overcomes tolerance and delays scrapie. J Gen Virol 91(Pt 3):809–820 PubMedCAS Google Scholar
Bailey SL, Schreiner B, McMahon EJ, Miller SD (2007) CNS myeloid DCs presenting endogenous myelin peptides ‘preferentially’ polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol 8(2):172–180 PubMedCAS Google Scholar
Barclay AN, Brown MH (2006) The SIRP family of receptors and immune regulation. Nat Rev Immunol 6(6):457–464 PubMedCAS Google Scholar
Bauer J, Huitinga I, Zhao W, Lassmann H, Hickey WF, Dijkstra CD (1995) The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis. Glia 15(4):437–446 PubMedCAS Google Scholar
Baumjohann D, Lutz MB (2006) Non-invasive imaging of dendritic cell migration in vivo. Immunobiology 211(6–8):587–597 PubMedCAS Google Scholar
Becher B, Antel JP (1996) Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia 18(1):1–10 PubMedCAS Google Scholar
Bechmann I, Galea I, Perry VH (2007) What is the blood–brain barrier (not)? Trends Immunol 28(1):5–11 PubMedCAS Google Scholar
Bechmann I, Kwidzinski E, Kovac AD, Simburger E, Horvath T, Gimsa U, Dirnagl U, Priller J, Nitsch R (2001) Turnover of rat brain perivascular cells. Exp Neurol 168(2):242–249 PubMedCAS Google Scholar
Bechmann I, Priller J, Kovac A, Bontert M, Wehner T, Klett FF, Bohsung J, Stuschke M, Dirnagl U, Nitsch R (2001) Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur J Neurosci 14(10):1651–1658 PubMedCAS Google Scholar
Belz GT, Nutt SL (2012) Transcriptional programming of the dendritic cell network. Nat Rev Immunol 12(2):101–113 PubMedCAS Google Scholar
Billingham RE, Boswell T (1953) Studies on the problem of corneal homografts. Proc R Soc Lond B Biol Sci 141(904):392–406 PubMedCAS Google Scholar
Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM (2002) Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T-cell tolerance. J Exp Med 196(12):1627–1638 PubMedCAS Google Scholar
Bousso P (2008) T-cell activation by dendritic cells in the lymph node: lessons from the movies. Nat Rev Immunol 8(9):675–684 PubMedCAS Google Scholar
Brehin AC, Mouries J, Frenkiel MP, Dadaglio G, Despres P, Lafon M, Couderc T (2008) Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+ B220-BST-2+ leukocyte population. J Immunol 180(10):6760–6767 PubMedCAS Google Scholar
Brown EJ, Frazier WA (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 11(3):130–135 PubMedCAS Google Scholar
Buller KM (2001) Role of circumventricular organs in pro-inflammatory cytokine-induced activation of the hypothalamic-pituitary–adrenal axis. Clin Exp Pharmacol Physiol 28(7):581–589 PubMedCAS Google Scholar
Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried-Blackmore A, Waters EM, Kaunzner UW, Liu K, Lindquist R, Nussenzweig MC, Steinman RM, McEwen BS (2008) CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol 508(5):687–710 PubMed Google Scholar
Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M (2006) Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci USA 103(31):11784–11789 PubMedCAS Google Scholar
Cao S, Li Y, Ye J, Yang X, Chen L, Liu X, Chen H (2011) Japanese encephalitis virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells. Virol J 8:39 PubMedCAS Google Scholar
Carson MJ, Reilly CR, Sutcliffe JG, Lo D (1998) Mature microglia resemble immature antigen-presenting cells. Glia 22(1):72–85 PubMedCAS Google Scholar
Chow A, Brown BD, Merad M (2011) Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol 11(11):788–798 PubMedCAS Google Scholar
Ciavarra RP, Stephens A, Nagy S, Sekellick M, Steel C (2006) Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance? J Immunol 177(1):492–500 PubMedCAS Google Scholar
Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4(4):399–418 PubMed Google Scholar
Conde JR, Streit WJ (2006) Microglia in the aging brain. J Neuropathol Exp Neurol 65(3):199–203 PubMed Google Scholar
Courret N, Darche S, Sonigo P, Milon G, Buzoni-Gatel D, Tardieux I (2006) CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain. Blood 107(1):309–316 PubMedCAS Google Scholar
Coyle PK, Rizvi S (2010) Clinical neuroimmunology: multiple sclerosis and related disorders. Current clinical neurology, Humana Google Scholar
Cserr HF, Harling-Berg CJ, Knopf PM (1992) Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 2(4):269–276 PubMedCAS Google Scholar
D’Agostino PM, Kwak C, Vecchiarelli HA, Toth JG, Miller JM, Masheeb Z, McEwen BS, Bulloch K (2012) Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb. Proc Natl Acad Sci USA 109(16):6175–6180 PubMed Google Scholar
Daffis S, Samuel MA, Suthar MS, Gale M Jr, Diamond MS (2008) Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol 82(21):10349–10358 PubMedCAS Google Scholar
Daffis S, Suthar MS, Szretter KJ, Gale M Jr, Diamond MS (2009) Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog 5(10):e1000607 PubMed Google Scholar
Danielyan L, Schafer R, von Ameln-Mayerhofer A, Bernhard F, Verleysdonk S, Buadze M, Lourhmati A, Klopfer T, Schaumann F, Schmid B, Koehle C, Proksch B, Weissert R, Reichardt HM, van den Brandt J, Buniatian GH, Schwab M, Gleiter CH, Frey WH 2nd (2011) Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Rejuvenation Res 14(1):3–16 PubMedCAS Google Scholar
Danielyan L, Schafer R, von Ameln-Mayerhofer A, Buadze M, Geisler J, Klopfer T, Burkhardt U, Proksch B, Verleysdonk S, Ayturan M, Buniatian GH, Gleiter CH, Frey WH II (2009) Intranasal delivery of cells to the brain. Eur J Cell Biol 88(6):315–324 PubMedCAS Google Scholar
DeBoy CA, Rus H, Tegla C, Cudrici C, Jones MV, Pardo CA, Small D, Whartenby KA, Calabresi PA (2010) FLT-3 expression and function on microglia in multiple sclerosis. Exp Mol Pathol 89(2):109–116 PubMedCAS Google Scholar
Dellmann HD (1998) Structure of the subfornical organ: a review. Microsc Res Tech 41(2):85–97 PubMedCAS Google Scholar
Deshpande P, King IL, Segal BM (2007) Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+ CD4+ T cell-mediated immunosuppression, suggesting dual roles in the disease process. J Immunol 178(11):6695–6699 PubMedCAS Google Scholar
Dilger RN, Johnson RW (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84(4):932–939 PubMedCAS Google Scholar
Elmquist JK, Breder CD, Sherin JE, Scammell TE, Hickey WF, Dewitt D, Saper CB (1997) Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J Comp Neurol 381(2):119–129 PubMedCAS Google Scholar
Engelhardt B, Wolburg-Buchholz K, Wolburg H (2001) Involvement of the choroid plexus in central nervous system inflammation. Microsc Res Tech 52(1):112–129 PubMedCAS Google Scholar
Felger JC, Abe T, Kaunzner UW, Gottfried-Blackmore A, Gal-Toth J, McEwen BS, Iadecola C, Bulloch K (2010) Brain dendritic cells in ischemic stroke: time course, activation state, and origin. Brain Behav Immun 24(5):724–737 PubMedCAS Google Scholar
Fischer HG, Bonifas U, Reichmann G (2000) Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J Immunol 164(9):4826–4834 PubMedCAS Google Scholar
Fischer HG, Reichmann G (2001) Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J Immunol 166(4):2717–2726 PubMedCAS Google Scholar
Flores-Langarica A, Sebti Y, Mitchell DA, Sim RB, MacPherson GG (2009) Scrapie pathogenesis: the role of complement C1q in scrapie agent uptake by conventional dendritic cells. J Immunol 182(3):1305–1313 PubMedCAS Google Scholar
Galea I, Bechmann I, Perry VH (2007) What is immune privilege (not)? Trends Immunol 28(1):12–18 PubMedCAS Google Scholar
Gehrmann J, Matsumoto Y, Kreutzberg GW (1995) Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev 20(3):269–287 PubMedCAS Google Scholar
Geissmann F, Gordon S, Hume DA, Mowat AM, Randolph GJ (2010) Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol 10(6):453–460 PubMedCAS Google Scholar
Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzweig M, Merad M (2009) The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 206(13):3115–3130 PubMedCAS Google Scholar
Goldmann J, Kwidzinski E, Brandt C, Mahlo J, Richter D, Bechmann I (2006) T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa. J Leukoc Biol 80(4):797–801 PubMedCAS Google Scholar
Gottfried-Blackmore A, Kaunzner UW, Idoyaga J, Felger JC, McEwen BS, Bulloch K (2009) Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells. Proc Natl Acad Sci USA 106(49):20918–20923 PubMedCAS Google Scholar
Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman DT, Chenouard N, de Chaumont F, Martino A, Enninga J, Olivo-Marin JC, Mannel D, Zurzolo C (2009) Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol 11(3):328–336 PubMedCAS Google Scholar
Graeber MB, Streit WJ, Buringer D, Sparks DL, Kreutzberg GW (1992) Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain. J Neuropathol Exp Neurol 51(3):303–311 PubMedCAS Google Scholar
Gregerson DS, Sam TN, McPherson SW (2004) The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina. J Immunol 172(11):6587–6597 PubMedCAS Google Scholar
Greter M, Heppner FL, Lemos MP, Odermatt BM, Goebels N, Laufer T, Noelle RJ, Becher B (2005) Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat Med 11(3):328–334 PubMedCAS Google Scholar
Grodums EI (1976) Ultrastructure of mouse periventricular and choroid plexus tissues in experimental vesicular stomatitis virus infection. Arch Virol 51(1–2):75–85 PubMedCAS Google Scholar
Hanly A, Petito CK (1998) HLA-DR-positive dendritic cells of the normal human choroid plexus: a potential reservoir of HIV in the central nervous system. Hum Pathol 29(1):88–93 PubMedCAS Google Scholar
Hart DN, Fabre JW (1981) Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med 154(2):347–361 PubMedCAS Google Scholar
Hayashi K, Ohta S, Kawakami Y, Toda M (2009) Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF. Neurosci Res 64(1):96–103 PubMedCAS Google Scholar
Hayashi T, Nagai S, Fujii H, Baba Y, Ikeda E, Kawase T, Koyasu S (2009) Critical roles of NK and CD8+ T cells in central nervous system listeriosis. J Immunol 182(10):6360–6368 PubMedCAS Google Scholar
Helft J, Ginhoux F, Bogunovic M, Merad M (2010) Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol Rev 234(1):55–75 PubMedCAS Google Scholar
Her Z, Malleret B, Chan M, Ong EK, Wong SC, Kwek DJ, Tolou H, Lin RT, Tambyah PA, Renia L, Ng LF (2010) Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response. J Immunol 184(10):5903–5913 PubMedCAS Google Scholar
Hesske L, Vincenzetti C, Heikenwalder M, Prinz M, Reith W, Fontana A, Suter T (2010) Induction of inhibitory central nervous system-derived and stimulatory blood-derived dendritic cells suggests a dual role for granulocyte-macrophage colony-stimulating factor in central nervous system inflammation. Brain 133(Pt 6):1637–1654 PubMed Google Scholar
Hickey WF (1991) Migration of hematogenous cells through the blood–brain barrier and the initiation of CNS inflammation. Brain Pathol 1(2):97–105 PubMedCAS Google Scholar
Hickey WF, Kimura H (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239(4837):290–292 PubMedCAS Google Scholar
Hickman HD, Takeda K, Skon CN, Murray FR, Hensley SE, Loomis J, Barber GN, Bennink JR, Yewdell JW (2008) Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes. Nat Immunol 9(2):155–165 PubMedCAS Google Scholar
Hogg N, Takacs L, Palmer DG, Selvendran Y, Allen C (1986) The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. Eur J Immunol 16(3):240–248 PubMedCAS Google Scholar
Huneycutt BS, Plakhov IV, Shusterman Z, Bartido SM, Huang A, Reiss CS, Aoki C (1994) Distribution of vesicular stomatitis virus proteins in the brains of BALB/c mice following intranasal inoculation: an immunohistochemical analysis. Brain Res 635(1–2):81–95 PubMedCAS Google Scholar
Jain P, Coisne C, Enzmann G, Rottapel R, Engelhardt B (2010) Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood–brain barrier during experimental autoimmune encephalomyelitis. J Immunol 184(12):7196–7206 PubMedCAS Google Scholar
John B, Ricart B, Tait Wojno ED, Harris TH, Randall LM, Christian DA, Gregg B, De Almeida DM, Weninger W, Hammer DA, Hunter CA (2011) Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis. PLoS Pathog 7(9):e1002246 PubMedCAS Google Scholar
Joiner KA, Dubremetz JF (1993) Toxoplasma gondii: a protozoan for the nineties. Infect Immun 61(4):1169–1172 PubMedCAS Google Scholar
Kaminski M, Bechmann I, Pohland M, Kiwit J, Nitsch R, Glumm J (2012) Migration of monocytes after intracerebral injection at entorhinal cortex lesion site. J Leukoc Biol 92(1):31–39 PubMedCAS Google Scholar
Karman J, Chu HH, Co DO, Seroogy CM, Sandor M, Fabry Z (2006) Dendritic cells amplify T cell-mediated immune responses in the central nervous system. J Immunol 177(11):7750–7760 PubMedCAS Google Scholar
Karman J, Ling C, Sandor M, Fabry Z (2004) Initiation of immune responses in brain is promoted by local dendritic cells. J Immunol 173(4):2353–2361 PubMedCAS Google Scholar
Kaunzner UW, Miller MM, Gottfried-Blackmore A, Gal-Toth J, Felger JC, McEwen BS, Bulloch K (2012) Accumulation of resident and peripheral dendritic cells in the aging CNS. Neurobiol Aging 33(4):681–693 e681 Google Scholar
Kaushik DK, Gupta M, Basu A (2012) Microglial response to viral challenges: every silver lining comes with a cloud. Front Biosci 17:2187–2205 Google Scholar
Keizer GD, Borst J, Visser W, Schwarting R, de Vries JE, Figdor CG (1987) Membrane glycoprotein p150,95 of human cytotoxic T cell clone is involved in conjugate formation with target cells. J Immunol 138(10):3130–3136 PubMedCAS Google Scholar
Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91(2):461–553 PubMedCAS Google Scholar
Kida S, Steart PV, Zhang ET, Weller RO (1993) Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages. Acta Neuropathol 85(6):646–652 PubMedCAS Google Scholar
Kivisakk P, Mahad DJ, Callahan MK, Trebst C, Tucky B, Wei T, Wu L, Baekkevold ES, Lassmann H, Staugaitis SM, Campbell JJ, Ransohoff RM (2003) Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci USA 100(14):8389–8394 PubMed Google Scholar
Koh L, Zakharov A, Johnston M (2005) Integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption? Cerebrospinal Fluid Res 2:6 PubMed Google Scholar
Koido S, Ohana M, Liu C, Nikrui N, Durfee J, Lerner A, Gong J (2004) Dendritic cells fused with human cancer cells: morphology, antigen expression, and T cell stimulation. Clin Immunol 113(3):261–269 PubMedCAS Google Scholar
Kostulas N, Li HL, Xiao BG, Huang YM, Kostulas V, Link H (2002) Dendritic cells are present in ischemic brain after permanent middle cerebral artery occlusion in the rat. Stroke 33(4):1129–1134 PubMed Google Scholar
Lambert H, Hitziger N, Dellacasa I, Svensson M, Barragan A (2006) Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination. Cell Microbiol 8(10):1611–1623 PubMedCAS Google Scholar
Lassmann H, Schmied M, Vass K, Hickey WF (1993) Bone marrow derived elements and resident microglia in brain inflammation. Glia 7(1):19–24 PubMedCAS Google Scholar
Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB (2006) Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med 203(8):1963–1975 PubMedCAS Google Scholar
Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39(1):151–170 PubMedCAS Google Scholar
Li Y, Xu M, Chen L, Zhu J, Ye J, Liu X, Sun Y, Chen H, Cao S (2009) Evaluation of murine bone marrow-derived dendritic cells loaded with inactivated virus as a vaccine against Japanese encephalitis virus. Vaccine 27(43):6004–6010 PubMedCAS Google Scholar
Lindquist RL, Shakhar G, Dudziak D, Wardemann H, Eisenreich T, Dustin ML, Nussenzweig MC (2004) Visualizing dendritic cell networks in vivo. Nat Immunol 5(12):1243–1250 PubMedCAS Google Scholar
Ling C, Sandor M, Fabry Z (2003) In situ processing and distribution of intracerebrally injected OVA in the CNS. J Neuroimmunol 141(1–2):90–98 PubMedCAS Google Scholar
Liu J, Johnson TV, Lin J, Ramirez SH, Bronich TK, Caplan S, Persidsky Y, Gendelman HE, Kipnis J (2007) T cell independent mechanism for copolymer-1-induced neuroprotection. Eur J Immunol 37(11):3143–3154 PubMedCAS Google Scholar
Liu K, Nussenzweig MC (2010) Origin and development of dendritic cells. Immunol Rev 234(1):45–54 PubMedCAS Google Scholar
Liu K, Victora GD, Schwickert TA, Guermonprez P, Meredith MM, Yao K, Chu FF, Randolph GJ, Rudensky AY, Nussenzweig M (2009) In vivo analysis of dendritic cell development and homeostasis. Science 324(5925):392–397 PubMedCAS Google Scholar
Liu XF, Fawcett JR, Thorne RG, DeFor TA, Frey WH 2nd (2001) Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci 187(1–2):91–97 PubMedCAS Google Scholar
Lundh B, Kristensson K, Norrby E (1987) Selective infections of olfactory and respiratory epithelium by vesicular stomatitis and Sendai viruses. Neuropathol Appl Neurobiol 13(2):111–122 PubMedCAS Google Scholar
Mabbott NA, MacPherson GG (2006) Prions and their lethal journey to the brain. Nat Rev Microbiol 4(3):201–211 PubMedCAS Google Scholar
Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA (2001) Malignant glioma: genetics and biology of a grave matter. Genes Dev 15(11):1311–1333 PubMedCAS Google Scholar
Matozaki T, Murata Y, Okazawa H, Ohnishi H (2009) Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway. Trends Cell Biol 19(2):72–80 PubMedCAS Google Scholar
Matyszak MK, Perry VH (1996) A comparison of leucocyte responses to heat-killed bacillus Calmette-Guerin in different CNS compartments. Neuropathol Appl Neurobiol 22(1):44–53 PubMedCAS Google Scholar
Matyszak MK, Perry VH (1996) The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system. Neuroscience 74(2):599–608 PubMedCAS Google Scholar
McGavern DB, Kang SS (2011) Illuminating viral infections in the nervous system. Nat Rev Immunol 11(5):318–329 PubMedCAS Google Scholar
McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD (2005) Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 11(3):335–339 PubMedCAS Google Scholar
McMenamin PG (1999) Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations. J Comp Neurol 405(4):553–562 PubMedCAS Google Scholar
Medawar PB (1944) The behaviour and fate of skin autografts and skin homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council. J Anat 78(Pt 5):176–199 PubMedCAS Google Scholar
Medawar PB (1945) A second study of the behaviour and fate of skin homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council. J Anat 79(Pt 4):157–176 Google Scholar
Medawar PB (1948) Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 29(1):58–69 PubMedCAS Google Scholar
Meerburg BG, Kijlstra A (2009) Changing climate-changing pathogens: Toxoplasma gondii in North-Western Europe. Parasitol Res 105(1):17–24 PubMed Google Scholar
Metlay JP, Witmer-Pack MD, Agger R, Crowley MT, Lawless D, Steinman RM (1990) The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med 171(5):1753–1771 PubMedCAS Google Scholar
Miller SD, McMahon EJ, Schreiner B, Bailey SL (2007) Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann N Y Acad Sci 1103:179–191 PubMedCAS Google Scholar
Mineharu Y, King GD, Muhammad AK, Bannykh S, Kroeger KM, Liu C, Lowenstein PR, Castro MG (2011) Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design. Clin Cancer Res 17(14):4705–4718 PubMedCAS Google Scholar
Mix E, Meyer-Rienecker H, Hartung HP, Zettl UK (2010) Animal models of multiple sclerosis—potentials and limitations. Prog Neurobiol 92(3):386–404 PubMed Google Scholar
Mix E, Meyer-Rienecker H, Zettl UK (2008) Animal models of multiple sclerosis for the development and validation of novel therapies—potential and limitations. J Neurol 255(Suppl 6):7–14 PubMedCAS Google Scholar
Mohan J, Hopkins J, Mabbott NA (2005) Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure. Immunology 116(1):122–133 PubMedCAS Google Scholar
Nagra G, Koh L, Zakharov A, Armstrong D, Johnston M (2006) Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats. Am J Physiol Regul Integr Comp Physiol 291(5):R1383–1389 PubMedCAS Google Scholar
Newman TA, Galea I, van Rooijen N, Perry VH (2005) Blood-derived dendritic cells in an acute brain injury. J Neuroimmunol 166(1–2):167–172 PubMedCAS Google Scholar
Okada K, Yamasoba T, Kiyono H (2011) Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine, vol 72. Recent advances in tonsils and mucosal barriers of the upper airways. In: Proceedings of the 7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways, 2010, Asahikawa, Japan. Karger, Basel, New York
Ou R, Zhang M, Huang L, Flavell RA, Koni PA, Moskophidis D (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J Virol 82(6):2952–2965 PubMedCAS Google Scholar
Pachter JS, de Vries HE, Fabry Z (2003) The blood–brain barrier and its role in immune privilege in the central nervous system. J Neuropathol Exp Neurol 62(6):593–604 PubMedCAS Google Scholar
Pashenkov M, Huang YM, Kostulas V, Haglund M, Soderstrom M, Link H (2001) Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 124(Pt 3):480–492 PubMedCAS Google Scholar
Pashenkov M, Soderstrom M, Huang YM, Link H (2002) Cerebrospinal fluid affects phenotype and functions of myeloid dendritic cells. Clin Exp Immunol 128(2):379–387 PubMedCAS Google Scholar
Pashenkov M, Teleshova N, Kouwenhoven M, Smirnova T, Jin YP, Kostulas V, Huang YM, Pinegin B, Boiko A, Link H (2002) Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections. J Neuroimmunol 122(1–2):106–116 PubMedCAS Google Scholar
Pellegatta S, Poliani PL, Stucchi E, Corno D, Colombo CA, Orzan F, Ravanini M, Finocchiaro G (2010) Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment. Neuro Oncol 12(4):377–388 PubMedCAS Google Scholar
Peters A, Palay SL, Webster Hd (1976) The fine structure of the nervous system: the neurons and supporting cells. Saunders, Philadelphia Google Scholar
Platten M, Steinman L (2005) Multiple sclerosis: trapped in deadly glue. Nat Med 11(3):252–253 PubMedCAS Google Scholar
Postigo AA, Corbi AL, Sanchez-Madrid F, de Landazuri MO (1991) Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18. J Exp Med 174(6):1313–1322 PubMedCAS Google Scholar
Press R, Nennesmo I, Kouwenhoven M, Huang YM, Link H, Pashenkov M (2005) Dendritic cells in the cerebrospinal fluid and peripheral nerves in Guillain–Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J Neuroimmunol 159(1–2):165–176 PubMedCAS Google Scholar
Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011) Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 14(10):1227–1235 PubMedCAS Google Scholar
Prodinger C, Bunse J, Kruger M, Schiefenhovel F, Brandt C, Laman JD, Greter M, Immig K, Heppner F, Becher B, Bechmann I (2011) CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol 121(4):445–458 PubMedCAS Google Scholar
Prusiner SB (1982) Novel proteinaceous infectious particles cause scrapie. Science 216(4542):136–144 PubMedCAS Google Scholar
Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, Kreutzberg GW (1999) Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30(1):77–105 PubMedCAS Google Scholar
Ramagopalan SV, Knight JC, Ebers GC (2009) Multiple sclerosis and the major histocompatibility complex. Curr Opin Neurol 22(3):219–225 PubMedCAS Google Scholar
Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F (2009) C–C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 10(5):514–523 PubMedCAS Google Scholar
Reichmann G, Schroeter M, Jander S, Fischer HG (2002) Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J Neuroimmunol 129(1–2):125–132 PubMedCAS Google Scholar
Rodriguez Boulan E, Sabatini DD (1978) Asymmetric budding of viruses in epithelial monlayers: a model system for study of epithelial polarity. Proc Natl Acad Sci USA 75(10):5071–5075 PubMedCAS Google Scholar
Rosicarelli B, Serafini B, Sbriccoli M, Lu M, Cardone F, Pocchiari M, Aloisi F (2005) Migration of dendritic cells into the brain in a mouse model of prion disease. J Neuroimmunol 165(1–2):114–120 PubMedCAS Google Scholar
Rosset MB, Sacquin A, Lecollinet S, Chaigneau T, Adam M, Crespeau F, Eloit M (2009) Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie. PLoS One 4(3):e4917 PubMed Google Scholar
Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11(11):775–787 PubMedCAS Google Scholar
Santambrogio L, Belyanskaya SL, Fischer FR, Cipriani B, Brosnan CF, Ricciardi-Castagnoli P, Stern LJ, Strominger JL, Riese R (2001) Developmental plasticity of CNS microglia. Proc Natl Acad Sci USA 98(11):6295–6300 PubMedCAS Google Scholar
Schiltz JC, Sawchenko PE (2002) Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults. J Neurosci 22(13):5606–5618 PubMedCAS Google Scholar
Schulz M, Engelhardt B (2005) The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis. Cerebrospinal Fluid Res 2:8 PubMed Google Scholar
Serot JM, Foliguet B, Bene MC, Faure GC (1997) Ultrastructural and immunohistological evidence for dendritic-like cells within human choroid plexus epithelium. NeuroReport 8(8):1995–1998 PubMedCAS Google Scholar
Serrats J, Schiltz JC, Garcia-Bueno B, van Rooijen N, Reyes TM, Sawchenko PE (2010) Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron 65(1):94–106 PubMedCAS Google Scholar
Sethi S, Kerksiek KM, Brocker T, Kretzschmar H (2007) Role of the CD8+ dendritic cell subset in transmission of prions. J Virol 81(9):4877–4880 PubMedCAS Google Scholar
Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K (2007) Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55(4):412–424 PubMed Google Scholar
Skarica M, Wang T, McCadden E, Kardian D, Calabresi PA, Small D, Whartenby KA (2009) Signal transduction inhibition of APCs diminishes Th17 and Th1 responses in experimental autoimmune encephalomyelitis. J Immunol 182(7):4192–4199 PubMedCAS Google Scholar
Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119(1):7–35 PubMed Google Scholar
Steel CD, Hahto SM, Ciavarra RP (2009) Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system. Virology 387(1):117–126 PubMedCAS Google Scholar
Steinman RM (2007) Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat Med 13(10):1155–1159 PubMedCAS Google Scholar
Steinman RM, Dhodapkar M (2001) Active immunization against cancer with dendritic cells: the near future. Int J Cancer 94(4):459–473 PubMedCAS Google Scholar
Stevenson PG, Hawke S, Sloan DJ, Bangham CR (1997) The immunogenicity of intracerebral virus infection depends on anatomical site. J Virol 71(1):145–151 PubMedCAS Google Scholar
Stichel CC, Luebbert H (2007) Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells. Neurobiol Aging 28(10):1507–1521 PubMedCAS Google Scholar
Streit WJ (2006) Microglial senescence: does the brain’s immune system have an expiration date? Trends Neurosci 29(9):506–510 PubMedCAS Google Scholar
Streit WJ, Graeber MB (1993) Heterogeneity of microglial and perivascular cell populations: insights gained from the facial nucleus paradigm. Glia 7(1):68–74 PubMedCAS Google Scholar
Suthar MS, Ma DY, Thomas S, Lund JM, Zhang N, Daffis S, Rudensky AY, Bevan MJ, Clark EA, Kaja MK, Diamond MS, Gale M Jr (2010) IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS Pathog 6(2):e1000757 PubMed Google Scholar
Tenter AM, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30(12–13):1217–1258 PubMedCAS Google Scholar
Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd (2004) Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127(2):481–496 PubMedCAS Google Scholar
Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A (2011) The role of microglia in the healthy brain. J Neurosci 31(45):16064–16069 PubMedCAS Google Scholar
Trifilo MJ, Lane TE (2004) The CC chemokine ligand 3 regulates CD11c+ CD11b+ CD8alpha− dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation. Virology 327(1):8–15 PubMedCAS Google Scholar
van Beek EM, Cochrane F, Barclay AN, van den Berg TK (2005) Signal regulatory proteins in the immune system. J Immunol 175(12):7781–7787 PubMed Google Scholar
van de Beek D, de Gans J, Tunkel AR, Wijdicks EF (2006) Community-acquired bacterial meningitis in adults. N Engl J Med 354(1):44–53 PubMed Google Scholar
Weller RO, Djuanda E, Yow HY, Carare RO (2009) Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 117(1):1–14 PubMedCAS Google Scholar
Williams K, Alvarez X, Lackner AA (2001) Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system. Glia 36(2):156–164 PubMedCAS Google Scholar
Wuest TR, Carr DJ (2008) Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol 181(11):7985–7993 PubMedCAS Google Scholar
Yang I, Han SJ, Kaur G, Crane C, Parsa AT (2010) The role of microglia in central nervous system immunity and glioma immunology. J Clin Neurosci 17(1):6–10 PubMed Google Scholar
Zozulya AL, Ortler S, Lee J, Weidenfeller C, Sandor M, Wiendl H, Fabry Z (2009) Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS. J Neurosci 29(1):140–152 PubMedCAS Google Scholar