α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei (original) (raw)

Abstract.

Advanced silver stains and immunohistochemical reactions against α-synuclein were used to detect Parkinson's disease-related cytoskeletal abnormalities in select lower brain stem nuclei. Various types of inclusion bodies including inconspicuous and heretofore unnoted granular particles and thread-like Lewy neurites were visualized. Of the nuclei investigated (gigantocellular reticular nucleus, bulbar raphe nuclei, coeruleus-subcoeruleus area), only lipofuscin- or neuromelanin-laden neuronal types showed a propensity to develop the pathological changes. Neuronal types devoid of pigment deposits remained free of the cytoskeletal abnormalities. Fine, dust-like particles and small globular Lewy bodies were encountered solely within the limits of intraneuronal lipofuscin or neuromelanin deposits.

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Authors and Affiliations

1. Department of Anatomy, J. W. Goethe-University, Theodor Stern Kai 7, 60590 Frankfurt/Main, Germany, , , , ,
   Eva Braak, Daniele Sandmann-Keil, Udo Rüb, Kimihito Arai & Heiko Braak
2. Department of Physiology, Flindres Medical Center, Bedford Park, SA 5042, Australia, , , , ,
   Wei Ping Gai
3. Department of Neurology MST Hospital Group and Laboratorium Pathologie Oost Nederland, Burg. Edo Bergsmalaan, 7512 AD Enschede, The Netherlands, , , , ,
   Rob A. I. de Vos & Ernst N. H. Jansen Steur

Authors

1. Eva Braak
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2. Daniele Sandmann-Keil
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3. Udo Rüb
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4. Wei Ping Gai
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5. Rob A. I. de Vos
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6. Ernst N. H. Jansen Steur
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7. Kimihito Arai
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8. Heiko Braak
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Braak, E., Sandmann-Keil, D., Rüb, U. et al. α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei.Acta Neuropathol 101, 195–201 (2001). https://doi.org/10.1007/s004010000247

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• Received: 07 July 1999
• Revised: 13 October 1999
• Accepted: 29 March 2000
• Issue Date: March 2001
• DOI: https://doi.org/10.1007/s004010000247