Analysis of the expression level of α-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy (original) (raw)

Abstract.

To determine whether multiple system atrophy (MSA) is associated with altered expression levels of the α-synuclein messenger RNA (mRNA), we performed quantitative reverse transcription polymerase chain reaction for α-synuclein mRNA using postmortem brain samples from 11 cases of MSA and 14 age-matched control subjects. The brain specimens used in this study contained both the gray matter and white matter, which were dissected from the frontal, temporal or occipital lobe. The expression levels of α-synuclein mRNA in the brain specimens of MSA cases were not different from those of the control subjects. These results suggest that the transcriptional regulation of the α-synuclein gene is unlikely to be affected in MSA brains.

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Authors and Affiliations

  1. Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan, , , , ,
    Tetsutaro Ozawa, Kaoru Okuizumi, Takeshi Ikeuchi & Shoji Tsuji
  2. Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan, , , , ,
    Koichi Wakabayashi
  3. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan, , , , ,
    Hitoshi Takahashi

Authors

  1. Tetsutaro Ozawa
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  2. Kaoru Okuizumi
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  3. Takeshi Ikeuchi
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  4. Koichi Wakabayashi
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  5. Hitoshi Takahashi
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  6. Shoji Tsuji
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Revised, accepted: 10 January 2001

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Ozawa, T., Okuizumi, K., Ikeuchi, T. et al. Analysis of the expression level of α-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy.Acta Neuropathol 102, 188–190 (2001). https://doi.org/10.1007/s004010100367

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