Association of a new polymorphism in ALOX12 gene with bipolar disorder (original) (raw)

Abstract.

Bipolar disorder (BPD) is characterised by episodes of excitement interspersed with periods of depression. The role of genetic factors in BPD is indicated by studies in monozygotic twins showing 40–70 % of concordance. Studies using genetic markers showed linkage of genes for affective disorders in different chromosome regions, emphasising the polygenic and multifactorial traits. The main goal of our research is to search non-synonymous SNPs (those that result in modifications in protein sequence) in genes that can be associated with psychiatric diseases as suggested by genomic mapping and/or by physiological function of the protein. Using DNA sequencing we could confirm a new non-synonymous SNP in the conservative domain of the ALOX12 gene (17p13.1), suggested by EST alignment. This SNP is an alteration from G to A that leads to a change of an arginine (A) to a glutamine in one of the most important domains of the protein. This SNP was evaluated by DNA sequencing in 182 patients with BPD and 160 control individuals. An increased presence of allele A among patients (60 % in controls and 73.1 % in cases; χ2 = 6.581, P = 0.010; OR = 1.8095, 95 % CI = 1.1477–2.853) was found, suggesting an association of this polymorphism with the BPD in this Brazilian sample.

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Authors and Affiliations

  1. Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil, , , , , , BR
    Cintia Fridman, Élida P. B. Ojopi, Sheila P. Gregório, Elisa H. Ikenaga, Pedro E. M. Guimarães, Homero P. Vallada, Wagner F. Gattaz & Emmanuel Dias Neto
  2. GRUDA, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil, , , , , , BR
    Doris H. Moreno & Frederico N. Demetrio

Authors

  1. Cintia Fridman
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  2. Élida P. B. Ojopi
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  3. Sheila P. Gregório
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  4. Elisa H. Ikenaga
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  5. Doris H. Moreno
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  6. Frederico N. Demetrio
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  7. Pedro E. M. Guimarães
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  8. Homero P. Vallada
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  9. Wagner F. Gattaz
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  10. Emmanuel Dias Neto
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Additional information

Received: 19 September 2002 / Accepted: 24 September 2002

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ID="*"Financial Support: Fundaçáo de Amparo a Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional de Pesquisas (CNPq) and Associação Beneficente Alzira Denise Hertzog da Silva (ABADHS).

Correspondence to Cintia Friedman

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Fridman, C., Ojopi, É., Gregório, S. et al. Association of a new polymorphism in ALOX12 gene with bipolar disorder.European Archives of Psychiatry and Clinical Neurosciences 253, 40–43 (2003). https://doi.org/10.1007/s00406-003-0404-y

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