BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation (original) (raw)

• Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R (2000) BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell 102:257–265
  Article PubMed CAS Google Scholar
• Brockdorff N, Ashworth A, Kay GF, McCabe VM, Norris DP, Cooper PJ, Swift S, Rastan S (1992) The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71:515–526
  Article PubMed CAS Google Scholar
• Brown CJ, Willard HF (1994) The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. Nature 368:154–156
  Article PubMed CAS Google Scholar
• Brown CJ, Hendrich BD, Rupert JL, Lafreniere RG, Xing Y, Lawrence J, Willard HF (1992) The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71:527–542
  Article PubMed CAS Google Scholar
• Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM (2004) The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A 101:2357–2362
  Article PubMed CAS Google Scholar
• Chadwick BP, Willard HF (2001) Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum Mol Genet 10:1101–1013
  Article Google Scholar
• Chadwick BP, Willard HF (2002) Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. J Cell Biol 157:1113–1123
  Article PubMed CAS Google Scholar
• Chadwick BP, Willard HF (2003) Barring gene expression after XIST: maintaining facultative heterochromatin on the inactive X. Semin Cell Dev Biol 14:359–367
  Article PubMed CAS Google Scholar
• Chadwick BP, Willard HF (2004) Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc Natl Acad Sci U S A 101:17450–17455
  Article PubMed CAS Google Scholar
• Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, Lee WH (1996) BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res 56:3168–3172
  PubMed CAS Google Scholar
• Clemson CM, McNeil JA, Willard HF, Lawrence JB (1996) XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol 132:1–17
  Article Google Scholar
• Costanzi C, Pehrson JR (1998) Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature 393:599–601
  Article PubMed CAS Google Scholar
• Csankovszki G, Panning B, Bates B, Pehrson JR, Jaenisch R (1999) Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet 22:323–324
  Article PubMed CAS Google Scholar
• Csankovszki G, Nagy A, Jaenisch R (2001) Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J Cell Biol 153:773–784
  Article PubMed CAS Google Scholar
• de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell 7:663–676
  Article PubMed Google Scholar
• Deming PB, Cistulli CA, Zhao H, Graves PR, Piwnica-Worms H, Paules RS, Downes CS, Kaufmann WK (2001) The human decatenation checkpoint. Proc Natl Acad Sci U S A 98:12044–12049
  Article PubMed CAS Google Scholar
• Ehrenhofer-Murray AE (2004) Chromatin dynamics at DNA replication, transcription and repair. Eur J Biochem 271:2335–2349
  Article PubMed CAS Google Scholar
• Fang J, Chen T, Chadwick B, Li E, Zhang Y (2004) Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem 279:52812–52815
  Article PubMed CAS Google Scholar
• Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A (2003) H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell 4:497–508
  Article PubMed CAS Google Scholar
• Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A (2004) H2AX: the histone guardian of the genome. DNA Repair 3:959–967
  Article PubMed CAS Google Scholar
• Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM (2002) BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111:393–405
  Article PubMed CAS Google Scholar
• Gilbert CW, Muldal S, Lajthal LG, Rowley J (1962) Time-sequence of human chromosome duplication. Nature 195:869–873
  Article PubMed CAS Google Scholar
• Hernandez-Munoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M (2005) Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc Natl Acad Sci U S A 102:7635–7640
  Article PubMed CAS Google Scholar
• Jin Y, Xu XL, Yang MC, Wei F, Ayi TC, Bowcock AM, Baer R (1997) Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. Proc Natl Acad Sci U S A 94:12075–12080
  Article PubMed CAS Google Scholar
• Lane TF (2004) BRCA1 and transcription. Cancer Biol Ther 3:528–533
  PubMed CAS Google Scholar
• Lou Z, Minter-Dykhouse K, Chen J (2005) BRCA1 participates in DNA decatenation. Nat Struct Mol Biol 12:589–593
  Article PubMed CAS Google Scholar
• Lowndes NF, Toh GW (2005) DNA repair: the importance of phosphorylating histone H2AX. Curr Biol 15:R99–R102
  Article PubMed CAS Google Scholar
• Lyon MF (1961) Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190:372–373
  Article PubMed CAS Google Scholar
• McManus KJ, Hendzel MJ (2005) ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Cell Biol (Epub ahead of print). DOI 10.1091/mbc.E05-01-0065
• Morishma A, Grumbach MM, Taylor JH (1962) Asynchronous duplication of human chromosomes and the origin of sex chromatin. Proc Natl Acad Sci U S A 48:756–763
  Article Google Scholar
• Neish AS, Anderson SF, Schlegel BP, Wei W, Parvin JD (1998) Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res 26:847–853
  Article PubMed CAS Google Scholar
• Niimi A, Suka N, Harata M, Kikuchi A, Mizuno S (2001) Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA. Chromosoma 110:102–114
  Article PubMed CAS Google Scholar
• Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10:886–895
  Article PubMed CAS Google Scholar
• Plath K, Mlynarczyk-Evans S, Nusinow DA, Panning B (2002) Xist RNA and the mechanism of x chromosome inactivation. Annu Rev Genet 36:233–278
  Article PubMed CAS Google Scholar
• Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B (2004) Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol 167:1025–1035
  Article PubMed CAS Google Scholar
• Rack KA, Chelly J, Gibbons RJ, Rider S, Benjamin D, Lafreniere RG, Oscier D, Hendriks RW, Craig IW, Willard HF, Monaco AP, Buckle VJ (1994) Absence of the XIST gene from late-replicating isodicentric X chromosomes in leukaemia. Hum Mol Genet 3:1053–1059
  Article PubMed CAS Google Scholar
• Rahman N, Stratton MR (1998) The genetics of breast cancer susceptibility. Annu Rev Genet 32:95–121
  Article PubMed CAS Google Scholar
• Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273:5858–5868
  Article PubMed CAS Google Scholar
• Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88:265–275
  Article PubMed CAS Google Scholar
• Shibahara K, Stillman B (1999) Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Cell 96:575–585
  Article PubMed CAS Google Scholar
• Shroff R, Arbel-Eden A, Pilch D, Ira G, Bonner WM, Petrini JH, Haber JE, Lichten M (2004) Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol 14:1703–1711
  Article PubMed CAS Google Scholar
• Skoufias DA, Lacroix FB, Andreassen PR, Wilson L, Margolis RL (2004) Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. Mol Cell 15:977–990
  Article PubMed CAS Google Scholar
• Spector DL, Goldman RD, Leinwand LA (1998) Cells: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
  Google Scholar
• Starita LM, Parvin JD (2003) The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol 15:345–350
  Article PubMed CAS Google Scholar
• Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV, Barrett JC, Burgoyne PS, Deng CX (2004) BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol 14:2135–2142
  Article PubMed CAS Google Scholar
• Vermaak D, Ahmad K, Henikoff S (2003) Maintenance of chromatin states: an open-and-shut case. Curr Opin Cell Biol 15:266–274
  Article PubMed CAS Google Scholar
• Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y (2004) Role of histone H2A ubiquitination in Polycomb silencing. Nature 431:873–878
  Article PubMed CAS Google Scholar
• Wutz A, Jaenisch R (2000) A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell 5:695–705
  Article PubMed CAS Google Scholar
• Xu X, Aprelikova O, Moens P, Deng CX, Furth PA (2003) Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development 130:2001–2012
  Article PubMed CAS Google Scholar
• Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R (2001) BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol 155:911–921
  Article PubMed CAS Google Scholar
• Zhang Z, Shibahara K, Stillman B (2000) PCNA connects DNA replication to epigenetic inheritance in yeast. Nature 408:221–225
  Article PubMed CAS Google Scholar
• Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH (1999) Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 285:747–750
  CAS Google Scholar