Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart (original) (raw)

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Abstract.

Nicotinic acid adenine dinucleotide phosphate (NAADP), a molecule derived from nicotinamide adenine dinucleotide phosphate (NADP+), is a recently identified nucleotide that activates Ca2+ release from intracellular stores in invertebrate eggs and in mammalian cells. NAADP could function as an intracellular messenger for mobilizing internal Ca2+ stores, however the targets and nature of NAADP-induced Ca2+ release are unknown. We report here that NAADP (3–10 µM) induces Ca2+ release from rat heart microsomes and that NAADP (1–10 µM) activates single ryanodine receptor/calcium release channels (RyR2) from dog heart incorporated into bilayer lipid membranes. The results indicate that NAADP may play a role in cardiac excitation-contraction coupling by acting on RyR2 channels.

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Authors and Affiliations

1. Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 83334 Bratislava, Slovak Republic
   Alexandra Mojžišová, Oľga Križanová, Ľubomíra Žáčiková, Viera Komínková & Karol Ondriaš

Authors

1. Alexandra Mojžišová
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2. Oľga Križanová
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3. Ľubomíra Žáčiková
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4. Viera Komínková
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5. Karol Ondriaš
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Received after revision: 14 September 2000

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Mojžišová, A., Križanová, O., Žáčiková, Ľ. et al. Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart.Pflügers Arch - Eur J Physiol 441, 674–677 (2001). https://doi.org/10.1007/s004240000465

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• Received: 23 June 2000
• Accepted: 04 October 2000
• Published: 03 November 2000
• Issue Date: February 2001
• DOI: https://doi.org/10.1007/s004240000465