Association between oral cavity cancer and metabolic syndrome (original) (raw)

Abstract

Purpose

Few studies have been conducted on the association between oral cavity cancer and metabolic diseases. This study aimed to investigate the relationship between oral cavity cancer and metabolic diseases.

Methods

This cohort study used the database of the Korean National Health Insurance Service, which contains medical data of 97% of the Korean population. Oral cavity cancer occurred in a total of 2718 patients. Metabolic syndrome was defined according to IDF criteria. The Cox proportional hazard regression model was used.

Results

The HR for oral cavity cancer in patients with metabolic syndrome was 1.113(95% CI 1.006–1.232), which was significantly higher than that in normal patients, especially in males (p = 0.0386). When the number of metabolic syndrome factors was ≥ 3, the HR of oral cavity cancer was 1.191(95% CI 1.026–1.383), which was significantly higher than that of 0 metabolic syndrome factors, especially in males (p = 0.0218). When the number of metabolic syndrome factors was ≥ 3, the HR for oral cavity cancer was 1.439(95% CI 1.066–1.942), which was significantly higher than that of 0 metabolic syndrome factors, especially in males aged < 50 years (p = 0.0173).

Conclusion

Metabolic syndrome increases the risk of oral cavity cancer only in males. In addition, the incidence of oral cavity cancer increased as the number of factors constituting metabolic syndrome increased, only in young males aged < 50 years. Thus, metabolic syndrome is an important risk factor for oral cavity cancer, particularly in young males.

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Data availability

Datasets generated during the current study are available in the database of the Korean National Health Insurance Service (KNHIS).

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Acknowledgements

This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (No. 2020R1A5A2019413) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI20C1205)."

Funding

This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (No. 2020R1A5A2019413) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI20C1205)."

Author information

Author notes

1. Gang Won Choi and Hyeon-Kyoung Cheong are first authors contributed equally to this study.
2. In-Hwan Oh and Young-Gyu Eun have contributed equally to this study.

Authors and Affiliations

1. Department of Otolaryngology Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, South Korea
   Gang Won Choi, Soo Young Choi, Young Chan Lee & Young-Gyu Eun
2. Department of Internal Medicine, School of Medicine, Korea University, Ansan, South Korea
   Hyeon-Kyoung Cheong
3. Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea
   In-Hwan Oh

Authors

1. Gang Won Choi
2. Hyeon-Kyoung Cheong
3. Soo Young Choi
4. Young Chan Lee
5. In-Hwan Oh
6. Young-Gyu Eun

Contributions

GWC study design, writing, data collection and analysis, revising the article, final approval of the version. H-KC study design, writing, data collection and analysis, revising the article, final approval of the version. SYC data collection and analysis, revising the article. YCL study design, revising the article. I-HO study design, data collection and analysis, revising the article, final approval of the version, supervising this study. Y-GE study design, data collection and analysis, revising the article, final approval of the version, supervising this study.

Corresponding author

Correspondence toYoung-Gyu Eun.

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The authors have no relevant financial or non-financial interests to disclose.

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Approval was obtained from IRB board of our institute (299-11-002-002). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Choi, G.W., Cheong, HK., Choi, S.Y. et al. Association between oral cavity cancer and metabolic syndrome.J Cancer Res Clin Oncol 149, 4005–4013 (2023). https://doi.org/10.1007/s00432-022-04288-4

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• Received: 14 June 2022
• Accepted: 14 August 2022
• Published: 29 August 2022
• Version of record: 29 August 2022
• Issue date: July 2023
• DOI: https://doi.org/10.1007/s00432-022-04288-4

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