Time-course analysis of coproantigens in rats infected and challenged with Fasciola hepatica (original) (raw)
Abstract.
The influence of a challenge infection during an acute or chronic primary infection on _Fasciola hepatica_-coproantigen kinetics was established in rats. Egg-output and IgG humoral responses were also established. Two primary-infected groups were reinfected at different periods, one 4 weeks after primary infection (w.p.i.) (acute phase) and the other 11 w.p.i. (chronic phase). Another group remained without reinfection as a control. Coproantigens were first detected in the group challenged on acute fascioliasis. The highest values of coproantigens were recorded in the group reinfected during acute fascioliasis and the lowest in the group challenged during chronic fascioliasis. The IgG responses to F. hepatica excretory/secretory antigens increased after reinfection. Neither the egg output nor the parasitic burden were significantly different among the three infected groups. Our results indicate that the time of challenge affects the kinetics of coproantigens. Thus, challenge during acute fascioliasis favours the migration of the juvenile flukes from the primary infection to the bile ducts, and is responsible for the earlier presence of coproantigens in these animals. The possible relationship between coproantigen detection and T1 and T2 tegumentary antigens is discussed.
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Authors and Affiliations
- Parasitología y Enfermedades Parasitarias, Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27071-Lugo, Spain
A. Paz-Silva, J. Pedreira, R. Sánchez-Andrade, J. Suárez, P. Díaz, R. Panadero, P. Díez-Baños & P. Morrondo
Authors
- A. Paz-Silva
- J. Pedreira
- R. Sánchez-Andrade
- J. Suárez
- P. Díaz
- R. Panadero
- P. Díez-Baños
- P. Morrondo
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Paz-Silva, A., Pedreira, J., Sánchez-Andrade, R. et al. Time-course analysis of coproantigens in rats infected and challenged with Fasciola hepatica .Parasitol Res 88, 568–573 (2002). https://doi.org/10.1007/s00436-002-0621-8
- Received: 21 November 2001
- Accepted: 09 January 2002
- Published: 22 March 2002
- Issue date: June 2002
- DOI: https://doi.org/10.1007/s00436-002-0621-8