The impact of malaria on common lipid parameters (original) (raw)

Abstract.

No data are available in the literature to indicate whether low-level Plasmodium falciparum infections induce lipid parameter changes. We hypothesized that low-level P. falciparum infections induce significant changes in common lipid parameters. We retrospectively selected samples from a malaria prophylaxis study to measure the impact of sustained parasite clearance on common lipid parameters [total cholesterol (TChol), high-density lipoprotein (HDL)-cholesterol (HDL-c), low-density lipoprotein (LDL)-cholesterol (LDL-c) and triglycerides (TG)] in 47 apparently healthy schoolchildren whose P. falciparum parasitemia was initially below 1000/µl. After parasite clearance, mean values were significantly increased for Tchol (P<0.001) and HDL-c (P<0.001), unlike LDL-c (_P_=0.93); and TG were significantly decreased from the baseline (_P_=0.004). No significant change was found in a control group. This is the first study showing significant lipid changes related to low-level P. falciparum infections. Further studies are needed to explore the relevance of this finding at the population level in hyperendemic malaria areas.

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Authors and Affiliations

1. Service des Maladies Infectieuses et Tropicales, Hôpital St Jacques, CHU de Besançon, 25030 Besançon cedex, France, , , , ,
   Jean-François Faucher
2. Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon, , , , ,
   Michel Missinou & Peter G. Kremsner
3. Laboratoire de Biochimie, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon, , , , ,
   Edouard Ngou-Milama & Raphaël Ngomo
4. Laboratoire de Parasitologie, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon, , , , ,
   Maryvonne Kombila

Authors

1. Jean-François Faucher
2. Edouard Ngou-Milama
3. Michel Missinou
4. Raphaël Ngomo
5. Maryvonne Kombila
6. Peter G. Kremsner

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Faucher, JF., Ngou-Milama, E., Missinou, M. et al. The impact of malaria on common lipid parameters.Parasitol Res 88, 1040–1043 (2002). https://doi.org/10.1007/s00436-002-0712-6

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• Received: 02 April 2002
• Accepted: 10 June 2002
• Issue date: December 2002
• DOI: https://doi.org/10.1007/s00436-002-0712-6

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