Hypertriglyceridemia as an indicator of the severity of falciparum malaria in returned travelers: a clinical retrospective study (original) (raw)

Abstract

To test the hypothesis that the magnitude of plasma triglyceride changes could be related to the severity of falciparum malaria, we performed a retrospective case-control study from January 1999 to December 2000 among hospitalized patients with fever who were returning to France from the tropics. Plasma triglycerides were measured in patients with severe falciparum malaria (_n_=13), mild falciparum malaria (_n_=169), non-falciparum malaria (_n_=20) and controls (_n_=55). Triglyceride level was significantly higher in the malaria group than in controls [mean values were 2.17±1.43 mmol/l versus 1.30±0.70 mmol/l, respectively (P<0.0001)]. Triglyceride level was also significantly higher in severe than in mild malaria [4.78±1.93 mmol/l versus 1.94±1.11, respectively (_P_<0.00001)]. Hypertriglyceridemia (>1.80 mmol/l) was noted in all the patients with severe malaria, compared to 37% of patients with mild disease (P<0.001). Although further studies are needed, these results define the relevance of hypertriglyceridemia as an indicator of the severity of falciparum malaria.

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Authors and Affiliations

1. Service des Maladies Infectieuses et Tropicales, Hôpital Nord, Chemin des Bourrelly, 13915, Marseille, Cedex 20, France
   Philippe Parola, Fabien Patella, Jean Delmont & Philippe Brouqui
2. Institut de Recherche pour le Développement, Faculté de Médecine, IFR 48, Marseilles, France
   Pierre Gazin
3. Centre de Formation et Recherche en Médecine et Santé Tropicales, Faculté de Médecine, IFR 48, Marseilles, France
   Philippe Parola, Pierre Gazin & Jean Delmont
4. Service des Urgences Médicales, Hôpital Nord, AP-HM, Marseilles, France
   Sékéné Badiaga

Authors

1. Philippe Parola
2. Pierre Gazin
3. Fabien Patella
4. Sékéné Badiaga
5. Jean Delmont
6. Philippe Brouqui

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Correspondence toPhilippe Brouqui.

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Parola, P., Gazin, P., Patella, F. et al. Hypertriglyceridemia as an indicator of the severity of falciparum malaria in returned travelers: a clinical retrospective study.Parasitol Res 92, 464–466 (2004). https://doi.org/10.1007/s00436-003-1012-5

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• Received: 20 July 2003
• Accepted: 11 September 2003
• Published: 12 February 2004
• Issue date: April 2004
• DOI: https://doi.org/10.1007/s00436-003-1012-5

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