One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosophila (original) (raw)
Abstract
polyhomeotic (ph) is a complex locus in Drosophila defined by two genetic units. Two mutational events are necessary to obtain the null lethal phenotype. Molecular analysis has shown that the ph locus contains two transcriptional units coding for two very similar proteins. Although a strong argument in favor of a strict correlation between the genetic and molecular units can be constructed, there is no direct evidence for the hypothesis. Here, we show for all cases with detectable molecular defects that X-ray-induced generation of an amorphic allele from a pre-existing X-ray-induced hypomorphic allele with a lesion limited to one unit invariably involves a rearrangement in the other unit. This result proves that each genetic unit corresponds to one transcription unit.
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime Subscribe now
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
Author information
Authors and Affiliations
- Laboratoire d'Embryologie Moléculaire-URA 2227, Université Paris Sud, F-91405 Orsay Cedex, France, , , , , , FR
A. Boivin, M.-O. Fauvarque & J.-M. Dura
Authors
- A. Boivin
You can also search for this author inPubMed Google Scholar - M.-O. Fauvarque
You can also search for this author inPubMed Google Scholar - J.-M. Dura
You can also search for this author inPubMed Google Scholar
Additional information
Received: 18 September 1998 / Accepted: 16 November 1998
Rights and permissions
About this article
Cite this article
Boivin, A., Fauvarque, MO. & Dura, JM. One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosophila.Mol Gen Genet 261, 196–200 (1999). https://doi.org/10.1007/s004380050957
- Issue Date: February 1999
- DOI: https://doi.org/10.1007/s004380050957